JP5554703B2 - 自己免疫疾患の治療のための組成物および方法 - Google Patents

自己免疫疾患の治療のための組成物および方法 Download PDF

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JP5554703B2
JP5554703B2 JP2010513952A JP2010513952A JP5554703B2 JP 5554703 B2 JP5554703 B2 JP 5554703B2 JP 2010513952 A JP2010513952 A JP 2010513952A JP 2010513952 A JP2010513952 A JP 2010513952A JP 5554703 B2 JP5554703 B2 JP 5554703B2
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antibody
tlr2
receptor
toll
antagonist
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JP2010531846A5 (enExample
JP2010531846A (ja
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マーク ヘファーナン
ルーク オニール
ピーター マックーリク
ブライアン キーオ
クリストファー ロシェル
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オプソナ セラピューティクス リミテッド
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
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JP2010513952A 2007-06-28 2008-06-27 自己免疫疾患の治療のための組成物および方法 Active JP5554703B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IE2007/0468 2007-06-28
IE20070468 2007-06-28
US3837208P 2008-03-20 2008-03-20
US61/038,372 2008-03-20
IE20080209 2008-03-20
IE2008/0209 2008-03-20
PCT/EP2008/058339 WO2009000929A2 (en) 2007-06-28 2008-06-27 Composition and method for treatment of autoimmune disease

Publications (3)

Publication Number Publication Date
JP2010531846A JP2010531846A (ja) 2010-09-30
JP2010531846A5 JP2010531846A5 (enExample) 2011-08-04
JP5554703B2 true JP5554703B2 (ja) 2014-07-23

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JP2010513952A Active JP5554703B2 (ja) 2007-06-28 2008-06-27 自己免疫疾患の治療のための組成物および方法

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US (1) US8580255B2 (enExample)
EP (1) EP2170392A2 (enExample)
JP (1) JP5554703B2 (enExample)
CN (1) CN101808662A (enExample)
AU (1) AU2008267151B2 (enExample)
CA (1) CA2691784C (enExample)
WO (1) WO2009000929A2 (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
US20100278817A1 (en) 2007-07-05 2010-11-04 Opsona Therapeutics Ltd. Compounds and methods for the treatment of renal disease
WO2011156451A2 (en) * 2010-06-08 2011-12-15 The Cleveland Clinic Foundation Compositions and methods for modulating toll-like receptor 2 activation
US9981018B2 (en) 2010-06-08 2018-05-29 The Cleveland Clinic Foundation Compositions and methods for modulating toll-like receptor 2 activation
CA2805989A1 (en) * 2010-07-19 2012-01-26 Yeda Research And Development Co. Ltd. Peptides based on the transmembrane domain of a toll-like receptor (tlr) for treatment of tlr-mediated diseases
AU2012223366B2 (en) 2011-03-03 2017-02-23 Quark Pharmaceuticals, Inc. Oligonucleotide modulators of the toll-like receptor pathway
US9796979B2 (en) 2011-03-03 2017-10-24 Quark Pharmaceuticals Inc. Oligonucleotide modulators of the toll-like receptor pathway
WO2014144686A1 (en) * 2013-03-15 2014-09-18 University Of Florida Research Foundation Compunds for treating neurodegenerative proteinopathies
WO2016154586A1 (en) * 2015-03-26 2016-09-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Toll-like receptor 2 ligands and methods of making and using thereof
EP3307346A4 (en) * 2015-06-15 2019-01-02 Vital Therapies, Inc. Composition and method for inducing anti-inflammatory response
CN112153897B (zh) 2018-01-02 2023-02-03 拉什大学医学中心 用于治疗神经病学和其他病症的组合物和方法
WO2020011869A2 (en) 2018-07-11 2020-01-16 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting tlr2

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9927332D0 (en) 1999-11-18 2000-01-12 Leiv Eiriksson Nyfotek As Novel antibody and uses thereof
US7388080B2 (en) * 2003-08-20 2008-06-17 University Of Massachusetts Selective inhibition of toll-like receptor-2
ATE510853T1 (de) 2003-09-23 2011-06-15 Univ Muenchen Tech Tlr2-antagonistischer antikörper und dessen verwendung
WO2005039504A2 (en) * 2003-10-24 2005-05-06 Eisai Co., Ltd. Compounds and methods for treating toll-like receptor 2-related diseases and conditions
WO2005079419A2 (en) 2004-02-17 2005-09-01 The Regents Of The University Of California Methods of treating immunopathological disorders
ES2348792T3 (es) * 2004-12-10 2010-12-14 Novimmune Sa TERAPIAS COMBINADAS DIRIGIDAS A MÚLTIPLES RECEPTORES TIPO TOLL Y USO DE LAS MISMAS.
TW200641353A (en) * 2005-02-14 2006-12-01 Wyeth Corp Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor
EP2139916A1 (en) * 2007-04-26 2010-01-06 Opsona Therapeutics Limited Toll-like receptor binding epitope and compositions for binding thereto

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Publication number Publication date
CN101808662A (zh) 2010-08-18
AU2008267151A1 (en) 2008-12-31
WO2009000929A3 (en) 2009-02-26
JP2010531846A (ja) 2010-09-30
WO2009000929A2 (en) 2008-12-31
CA2691784A1 (en) 2008-12-31
US8580255B2 (en) 2013-11-12
EP2170392A2 (en) 2010-04-07
CA2691784C (en) 2016-11-01
AU2008267151B2 (en) 2014-02-20
US20100247527A1 (en) 2010-09-30

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