JP5552275B2 - 溶出試験器 - Google Patents
溶出試験器 Download PDFInfo
- Publication number
- JP5552275B2 JP5552275B2 JP2009175345A JP2009175345A JP5552275B2 JP 5552275 B2 JP5552275 B2 JP 5552275B2 JP 2009175345 A JP2009175345 A JP 2009175345A JP 2009175345 A JP2009175345 A JP 2009175345A JP 5552275 B2 JP5552275 B2 JP 5552275B2
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- JP
- Japan
- Prior art keywords
- test
- test container
- heater
- temperature
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000004090 dissolution Methods 0.000 title claims description 21
- 238000012360 testing method Methods 0.000 claims description 164
- 239000012085 test solution Substances 0.000 claims description 43
- 239000003814 drug Substances 0.000 claims description 30
- 229940079593 drug Drugs 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 23
- 230000006835 compression Effects 0.000 claims description 15
- 238000007906 compression Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 238000003825 pressing Methods 0.000 claims description 9
- 238000010828 elution Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 description 30
- 238000004364 calculation method Methods 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000009529 body temperature measurement Methods 0.000 description 7
- 239000011347 resin Substances 0.000 description 7
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- 239000002184 metal Substances 0.000 description 5
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- 230000002093 peripheral effect Effects 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 238000007922 dissolution test Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 229920001155 polypropylene Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
Images
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Sampling And Sample Adjustment (AREA)
Description
TW=(hAL/κ+1)αTO−(hAL/κ)βTA (α及びβは定数)
5 試験容器
6 ヒータ
8 筒状部材
9 押圧部材
10 制御部
10a 温度算出部
10b 加熱制御部
11 第1温度センサ
12 第2温度センサ
16 メモリ
21 反射部材
61 金属線
62 樹脂
63 カバー
64 開口部
82 連結ピン
83 内装部材
85 圧縮ばね
86 付勢部材
Claims (4)
- 半球状底部を有する試験容器内に貯留された試験液を攪拌しつつ、当該試験液に薬剤を溶出させることにより試験を行う溶出試験器であって、
前記試験容器の前記半球状底部に当接し、当該試験容器を下方から支持するとともに、当該試験容器を介して内部の試験液を加熱するヒータを備え、
前記ヒータには、前記試験容器の底部における最も低い位置に対向する部分に、開口部が形成され、前記開口部を介して前記底部から前記試験容器内を観察可能にしたことを特徴とする溶出試験器。 - 前記開口部の下方に設けられ、反射面が前記開口部側を向くように配置された反射部材を備えたことを特徴とする請求項1に記載の溶出試験器。
- 前記試験容器を上方から押さえる押圧部材と、
前記ヒータを上方に向かって付勢する付勢部材とを備えたことを特徴とする請求項1又は2に記載の溶出試験器。 - 前記ヒータの上方に設けられ、前記試験容器の外周を覆うように配置された筒状部材を備え、
前記付勢部材が、圧縮ばねと、前記圧縮ばねに挿通され、当該圧縮ばねを軸線方向に圧縮するようにして前記筒状部材に固定される固定部材とを含むことを特徴とする請求項3に記載の溶出試験器。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009175345A JP5552275B2 (ja) | 2009-07-28 | 2009-07-28 | 溶出試験器 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009175345A JP5552275B2 (ja) | 2009-07-28 | 2009-07-28 | 溶出試験器 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011027620A JP2011027620A (ja) | 2011-02-10 |
JP5552275B2 true JP5552275B2 (ja) | 2014-07-16 |
Family
ID=43636533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009175345A Expired - Fee Related JP5552275B2 (ja) | 2009-07-28 | 2009-07-28 | 溶出試験器 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5552275B2 (ja) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH033436U (ja) * | 1989-05-30 | 1991-01-14 | ||
WO1995023329A1 (en) * | 1994-02-25 | 1995-08-31 | Distek Inc. | Dissolution testing apparatus |
JP3026024U (ja) * | 1995-12-19 | 1996-07-02 | 株式会社日伸理化 | 理化学実験用恒温プレート式攪拌装置の温熱及び冷却用の温度補助カバー具 |
US6962674B2 (en) * | 2001-02-28 | 2005-11-08 | Varian, Inc. | Dissolution test apparatus |
-
2009
- 2009-07-28 JP JP2009175345A patent/JP5552275B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2011027620A (ja) | 2011-02-10 |
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