JP5546452B2 - 成長ホルモン融合タンパク質 - Google Patents
成長ホルモン融合タンパク質 Download PDFInfo
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- JP5546452B2 JP5546452B2 JP2010516562A JP2010516562A JP5546452B2 JP 5546452 B2 JP5546452 B2 JP 5546452B2 JP 2010516562 A JP2010516562 A JP 2010516562A JP 2010516562 A JP2010516562 A JP 2010516562A JP 5546452 B2 JP5546452 B2 JP 5546452B2
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95112207P | 2007-07-20 | 2007-07-20 | |
| US60/951,122 | 2007-07-20 | ||
| GBGB0717985.6A GB0717985D0 (en) | 2007-07-20 | 2007-09-14 | Growth hormone fusion proteins |
| GB0717985.6 | 2007-09-14 | ||
| PCT/GB2008/002406 WO2009013461A1 (en) | 2007-07-20 | 2008-07-16 | Growth hormone fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010534060A JP2010534060A (ja) | 2010-11-04 |
| JP2010534060A5 JP2010534060A5 (enExample) | 2011-09-15 |
| JP5546452B2 true JP5546452B2 (ja) | 2014-07-09 |
Family
ID=38658989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516562A Expired - Fee Related JP5546452B2 (ja) | 2007-07-20 | 2008-07-16 | 成長ホルモン融合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8293709B2 (enExample) |
| EP (1) | EP2170943A1 (enExample) |
| JP (1) | JP5546452B2 (enExample) |
| KR (1) | KR20100043201A (enExample) |
| CN (1) | CN101679504B (enExample) |
| AU (1) | AU2008278907B2 (enExample) |
| CA (1) | CA2693951A1 (enExample) |
| GB (1) | GB0717985D0 (enExample) |
| IL (1) | IL202225A (enExample) |
| RU (1) | RU2473554C2 (enExample) |
| WO (1) | WO2009013461A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0606946D0 (en) * | 2006-04-06 | 2006-05-17 | Asterion Ltd | Polypeptide antagonist |
| GB0717985D0 (en) * | 2007-07-20 | 2007-10-24 | Asterion Ltd | Growth hormone fusion proteins |
| GB0719818D0 (en) * | 2007-10-11 | 2007-11-21 | Asterion Ltd | Growth hormone fusion polypeptides |
| GB201104285D0 (en) * | 2011-03-15 | 2011-04-27 | Asterion Ltd | Modified receptor fusion proteins |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| GB201316592D0 (en) * | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
| WO2016138099A1 (en) | 2015-02-24 | 2016-09-01 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| GB201520021D0 (en) | 2015-11-13 | 2015-12-30 | Asterion Ltd | Fusion polypeptide |
| GB201706781D0 (en) | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| CN113880954B (zh) * | 2021-09-29 | 2024-05-14 | 江苏大学 | 一种重组人生长激素及其构建方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1290170A2 (en) * | 2000-06-16 | 2003-03-12 | Asterion Limited | Binding agents: chimeric ligand/receptor proteins |
| GB2389115B (en) * | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
| US7625998B2 (en) * | 2003-04-09 | 2009-12-01 | Asterion Limited | Cytokine polypeptides and antibodies containing a signal sequence for the attachment of glycosylphosphatidylinositol |
| US20090221477A1 (en) | 2004-07-26 | 2009-09-03 | Asterion Limited | Linkers |
| GB0606946D0 (en) * | 2006-04-06 | 2006-05-17 | Asterion Ltd | Polypeptide antagonist |
| GB0717985D0 (en) * | 2007-07-20 | 2007-10-24 | Asterion Ltd | Growth hormone fusion proteins |
-
2007
- 2007-09-14 GB GBGB0717985.6A patent/GB0717985D0/en not_active Ceased
-
2008
- 2008-07-16 WO PCT/GB2008/002406 patent/WO2009013461A1/en not_active Ceased
- 2008-07-16 JP JP2010516562A patent/JP5546452B2/ja not_active Expired - Fee Related
- 2008-07-16 RU RU2010103157/10A patent/RU2473554C2/ru not_active IP Right Cessation
- 2008-07-16 AU AU2008278907A patent/AU2008278907B2/en not_active Ceased
- 2008-07-16 US US12/669,451 patent/US8293709B2/en not_active Expired - Fee Related
- 2008-07-16 CA CA2693951A patent/CA2693951A1/en not_active Abandoned
- 2008-07-16 EP EP08775945A patent/EP2170943A1/en not_active Withdrawn
- 2008-07-16 CN CN2008800214732A patent/CN101679504B/zh not_active Expired - Fee Related
- 2008-07-16 KR KR1020107002192A patent/KR20100043201A/ko not_active Withdrawn
-
2009
- 2009-11-19 IL IL202225A patent/IL202225A/en not_active IP Right Cessation
-
2012
- 2012-09-14 US US13/620,004 patent/US8470559B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2693951A1 (en) | 2009-01-29 |
| KR20100043201A (ko) | 2010-04-28 |
| CN101679504B (zh) | 2013-06-19 |
| EP2170943A1 (en) | 2010-04-07 |
| AU2008278907B2 (en) | 2012-08-23 |
| US8293709B2 (en) | 2012-10-23 |
| WO2009013461A1 (en) | 2009-01-29 |
| IL202225A (en) | 2013-12-31 |
| AU2008278907A1 (en) | 2009-01-29 |
| RU2010103157A (ru) | 2011-08-27 |
| US8470559B2 (en) | 2013-06-25 |
| US20130023477A1 (en) | 2013-01-24 |
| US20100197582A1 (en) | 2010-08-05 |
| CN101679504A (zh) | 2010-03-24 |
| JP2010534060A (ja) | 2010-11-04 |
| WO2009013461A8 (en) | 2010-01-07 |
| RU2473554C2 (ru) | 2013-01-27 |
| IL202225A0 (en) | 2010-06-16 |
| GB0717985D0 (en) | 2007-10-24 |
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