CN101679504B - 生长激素融合蛋白 - Google Patents

生长激素融合蛋白 Download PDF

Info

Publication number
CN101679504B
CN101679504B CN2008800214732A CN200880021473A CN101679504B CN 101679504 B CN101679504 B CN 101679504B CN 2008800214732 A CN2008800214732 A CN 2008800214732A CN 200880021473 A CN200880021473 A CN 200880021473A CN 101679504 B CN101679504 B CN 101679504B
Authority
CN
China
Prior art keywords
leu
ser
glu
thr
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800214732A
Other languages
English (en)
Chinese (zh)
Other versions
CN101679504A (zh
Inventor
理查德·罗斯
彼得·阿蒂米克
乔恩·塞耶斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asterion Ltd
Original Assignee
Asterion Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asterion Ltd filed Critical Asterion Ltd
Publication of CN101679504A publication Critical patent/CN101679504A/zh
Application granted granted Critical
Publication of CN101679504B publication Critical patent/CN101679504B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2008800214732A 2007-07-20 2008-07-16 生长激素融合蛋白 Expired - Fee Related CN101679504B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95112207P 2007-07-20 2007-07-20
US60/951,122 2007-07-20
GBGB0717985.6A GB0717985D0 (en) 2007-07-20 2007-09-14 Growth hormone fusion proteins
GB0717985.6 2007-09-14
PCT/GB2008/002406 WO2009013461A1 (en) 2007-07-20 2008-07-16 Growth hormone fusion proteins

Publications (2)

Publication Number Publication Date
CN101679504A CN101679504A (zh) 2010-03-24
CN101679504B true CN101679504B (zh) 2013-06-19

Family

ID=38658989

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800214732A Expired - Fee Related CN101679504B (zh) 2007-07-20 2008-07-16 生长激素融合蛋白

Country Status (11)

Country Link
US (2) US8293709B2 (enExample)
EP (1) EP2170943A1 (enExample)
JP (1) JP5546452B2 (enExample)
KR (1) KR20100043201A (enExample)
CN (1) CN101679504B (enExample)
AU (1) AU2008278907B2 (enExample)
CA (1) CA2693951A1 (enExample)
GB (1) GB0717985D0 (enExample)
IL (1) IL202225A (enExample)
RU (1) RU2473554C2 (enExample)
WO (1) WO2009013461A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606946D0 (en) * 2006-04-06 2006-05-17 Asterion Ltd Polypeptide antagonist
GB0717985D0 (en) * 2007-07-20 2007-10-24 Asterion Ltd Growth hormone fusion proteins
GB0719818D0 (en) * 2007-10-11 2007-11-21 Asterion Ltd Growth hormone fusion polypeptides
GB201104285D0 (en) * 2011-03-15 2011-04-27 Asterion Ltd Modified receptor fusion proteins
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
GB201316592D0 (en) * 2013-09-18 2013-10-30 Levicept Ltd Fusion protein
WO2016138099A1 (en) 2015-02-24 2016-09-01 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
GB201520021D0 (en) 2015-11-13 2015-12-30 Asterion Ltd Fusion polypeptide
GB201706781D0 (en) 2017-04-28 2017-06-14 Univ Sheffield Parathyroid hormone fusion polypeptide
EP3930687A4 (en) 2019-02-25 2023-06-07 The University of Chicago METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS
CN113880954B (zh) * 2021-09-29 2024-05-14 江苏大学 一种重组人生长激素及其构建方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004090135A2 (en) * 2003-04-09 2004-10-21 Asterion Limited Cytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol
CN1604965A (zh) * 2001-12-14 2005-04-06 埃斯特瑞恩有限公司 生长激素融合蛋白
WO2006010891A2 (en) * 2004-07-26 2006-02-02 Asterion Limited Linkers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290170A2 (en) * 2000-06-16 2003-03-12 Asterion Limited Binding agents: chimeric ligand/receptor proteins
GB0606946D0 (en) * 2006-04-06 2006-05-17 Asterion Ltd Polypeptide antagonist
GB0717985D0 (en) * 2007-07-20 2007-10-24 Asterion Ltd Growth hormone fusion proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1604965A (zh) * 2001-12-14 2005-04-06 埃斯特瑞恩有限公司 生长激素融合蛋白
WO2004090135A2 (en) * 2003-04-09 2004-10-21 Asterion Limited Cytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol
WO2006010891A2 (en) * 2004-07-26 2006-02-02 Asterion Limited Linkers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Tandem fusions of growth hormone and its G120R mutated antagonist retain biological activity and demonstrate prolonged plasma half-life;Pradhananga S L et al;《Growth hormone and IGf research》;20040401;第14卷(第2期);全文 *
The human growth hormone(hGH) antagonist G120RhGH dose not antagonize GH in the rat,but has paradoxical agonist activity probably via the prolactin receptor;Mode agneta et al;《Endocrinology》;19961231;第137卷(第2期);第447-454页 *

Also Published As

Publication number Publication date
CA2693951A1 (en) 2009-01-29
KR20100043201A (ko) 2010-04-28
EP2170943A1 (en) 2010-04-07
AU2008278907B2 (en) 2012-08-23
US8293709B2 (en) 2012-10-23
WO2009013461A1 (en) 2009-01-29
IL202225A (en) 2013-12-31
AU2008278907A1 (en) 2009-01-29
RU2010103157A (ru) 2011-08-27
US8470559B2 (en) 2013-06-25
US20130023477A1 (en) 2013-01-24
US20100197582A1 (en) 2010-08-05
CN101679504A (zh) 2010-03-24
JP2010534060A (ja) 2010-11-04
WO2009013461A8 (en) 2010-01-07
RU2473554C2 (ru) 2013-01-27
IL202225A0 (en) 2010-06-16
JP5546452B2 (ja) 2014-07-09
GB0717985D0 (en) 2007-10-24

Similar Documents

Publication Publication Date Title
CN101679504B (zh) 生长激素融合蛋白
JP2566933B2 (ja) 真核細胞融合タンパク質、その生産及び用途、並びに方法
KR100848802B1 (ko) 변형 폴리펩티드
KR20150124955A (ko) 사람 성장 호르몬 유사체를 사용한 소아 성장 호르몬 결핍증의 치료 방법
JP2010505404A (ja) プロラクチンレセプターに対して高親和性を有するペプチド
US20050250185A1 (en) OGH fusion polypeptides and therapeutic uses thereof
CN110546159A (zh) 甲状旁腺激素融合多肽
US10030062B2 (en) Growth hormone fusion proteins with growth hormone receptor agonist activity
Høgset et al. Expression of human parathyroid hormone in Escherichia coli
CN101932600B (zh) 修饰的生长激素多肽
WO2008032059A2 (en) Growth factor

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130619

Termination date: 20160716