JP5539890B2 - ワクチンの免疫賦活作用を向上させる方法 - Google Patents
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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| ES2617510T3 (es) | 2012-04-26 | 2017-06-19 | Riken | Nuevo carbamato de glicolípido y uso del mismo |
| CN117222414A (zh) | 2021-03-01 | 2023-12-12 | 脱落性治疗公司 | 用于激活恒定自然杀伤t-细胞的化合物和用于消除炎性衰老细胞的方法 |
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| US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| TW261533B (https=) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
| EP0666268B1 (en) * | 1992-10-22 | 2000-04-19 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| EP0694558B1 (en) * | 1993-04-15 | 1999-01-27 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| RO117533B1 (ro) * | 1993-05-14 | 2002-04-30 | Cytel Corp San Diego | DERIVATI DE ANALOGI SIALIL LeX INHIBITORI AI ADEZIUNII CELULARE SI COMPOZITIE FARMACEUTICA CU ACESTIA |
| US6054433A (en) * | 1994-11-03 | 2000-04-25 | The Regents Of The University Of California | Methods and compositions for stimulating tissue growth and epithelial moisturization |
| US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
| EP0821068A3 (en) * | 1996-03-29 | 1999-06-02 | Rohm And Haas Company | Novel sphingolipids and a process thereto |
| US6417167B1 (en) * | 1997-02-05 | 2002-07-09 | Kirin Beer Kabushiki Kaisha | Lyophilized compositions containing shingoglycolipid and process for preparing them |
| CN1121223C (zh) | 1997-02-05 | 2003-09-17 | 麒麟麦酒株式会社 | 含有神经鞘糖脂的冷冻干燥组合物及其制造方法 |
| ATE286735T1 (de) | 1997-04-10 | 2005-01-15 | Kirin Brewery | Verwendung von a-glycosylceramiden zur herstellung eines therapeutischen mittelszur behandlung von autoimmunkrankheiten |
| JP2001527046A (ja) | 1997-12-30 | 2001-12-25 | エイプラス サイエンス インベスト アーベー | ガラクトシルセラミド、グルコシルセラミド、ラクトシルセラミド、並びに前糖尿病、糖尿病および／または関連合併症の予防もしくは治療に使用するためのその特定キャッチャー |
| EP1053243B1 (en) * | 1998-02-12 | 2011-03-30 | Emory University | Sphingolipid derivatives and their methods of use |
| SE9900496D0 (sv) * | 1999-02-12 | 1999-02-12 | Pharmatrix Ab | Vaccine formulation |
| JP2003511421A (ja) * | 1999-10-12 | 2003-03-25 | ナショナル リサーチ カウンシル オブ カナダ | 細胞毒性ｔリンパ球（ｃｔｌ）応答を誘発し、そして細胞内病原体及び癌に対してワクチン接種された宿主を保護するための無細胞ワクチンのための免疫調節キャリヤーとしてのアルキオソーム |
| US20030157113A1 (en) | 1999-12-28 | 2003-08-21 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
| AU2001252599A1 (en) * | 2000-04-28 | 2001-11-12 | Orient Cancer Therapy Co., Ltd. | Remedies for cancer |
| JP4410913B2 (ja) * | 2000-06-12 | 2010-02-10 | 壽製薬株式会社 | 新規糖脂質誘導体の製造方法 |
| WO2001098317A2 (en) * | 2000-06-22 | 2001-12-27 | The Brigham And Women's Hospital, Inc. | Alpha-glycosylceramides for treating bacterial and fungal infections |
| WO2002018539A2 (en) * | 2000-08-25 | 2002-03-07 | Lysometrix Corporation | Method for assaying the activity of lysosomal enzymes |
| CN1561389A (zh) | 2001-07-25 | 2005-01-05 | 纽约大学 | 糖基神经酰胺作为用于抗传染病和癌症的疫苗的佐剂的用途 |
| KR100549866B1 (ko) | 2001-08-22 | 2006-02-08 | 고려대학교 산학협력단 | 암치료 및 예방 제제 |
| RU2360699C2 (ru) * | 2001-10-03 | 2009-07-10 | Новартис Вэксинес Энд Дайэгностикс Инк. | Композиции менингококковых вакцин с адъювантами |
| CN1578667A (zh) * | 2001-11-06 | 2005-02-09 | 东方癌症治疗株式会社 | 抗癌组合物 |
| US7273853B2 (en) * | 2002-05-13 | 2007-09-25 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| WO2003105769A2 (en) | 2002-06-13 | 2003-12-24 | New York University | Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases |
| US7645873B2 (en) * | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| WO2004094444A1 (en) | 2003-03-20 | 2004-11-04 | Brigham Young University | 6'-amino-6'-deoxygalactosylceramides |
| TWI329130B (en) * | 2003-06-19 | 2010-08-21 | Bestewil Holding Bv | Functionally reconstituted viral membranes containing adjuvant |
| GB0314682D0 (en) | 2003-06-24 | 2003-07-30 | Isis Innovation | Materials and methods relating to the modulation of T cell response to soluble antigen |
| US7771726B2 (en) * | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
| CN1964626A (zh) | 2004-03-31 | 2007-05-16 | 纽约大学 | 新型合成c－糖脂、其合成及其治疗传染病、癌症和自身免疫性疾病的用途 |
| CA2577009C (en) | 2004-08-27 | 2017-05-02 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
| JP5005541B2 (ja) * | 2004-09-03 | 2012-08-22 | ザ ユニヴァーシティー オヴ シカゴ | Ｎｋｔ細胞の活性化方法 |
| JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体 |
| CA2593715C (en) | 2005-01-28 | 2015-05-05 | Brigham Young University | Bacterial glycolipid activation of cd1d-restricted nkt cells |
| KR100764678B1 (ko) | 2005-07-13 | 2007-10-09 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드를 아쥬반트로 포함하는 비강투여용 백신 조성물 |
| EP1945651B1 (en) | 2005-10-25 | 2014-06-25 | The Ludwig Institute for Cancer Research | Analogs of alpha galactosylceramide and uses thereof |
| PL2056842T3 (pl) * | 2006-04-07 | 2013-03-29 | Scripps Research Inst | Modyfikowany galaktozyloceramid do leczenia chorób nowotworowych |
| CN101426523B (zh) | 2006-04-27 | 2013-03-27 | 财团法人首尔大学校产学协力财团 | 基于负载了天然杀伤t细胞的配体、和抗原的b细胞的疫苗 |
| AU2007269299B2 (en) * | 2006-06-30 | 2013-01-17 | Brigham Young University | Adjuvants and methods of use |
| EP1938836A1 (en) | 2006-12-28 | 2008-07-02 | Universite Rene Descartes (Paris V) | Compositions comprising a B subunit of shiga toxin and a means stimulating NKT cells |
| KR100868959B1 (ko) | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| EP2058011A1 (en) | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
| US8207135B2 (en) * | 2007-12-05 | 2012-06-26 | Wittycell | Compositions for and methods of enhancing the immune response to antigens |
| JP5809560B2 (ja) | 2008-10-08 | 2015-11-11 | アビヴァックス | インフルエンザに対して使用するためのワクチン組成物 |
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| PL2190475T3 (pl) | 2016-04-29 |
| KR20100072211A (ko) | 2010-06-30 |
| EP2190475A1 (en) | 2010-06-02 |
| CN101820909A (zh) | 2010-09-01 |
| RU2491090C2 (ru) | 2013-08-27 |
| RU2010111766A (ru) | 2011-10-10 |
| US8916164B2 (en) | 2014-12-23 |
| PT2190475E (pt) | 2016-02-11 |
| ES2558157T3 (es) | 2016-02-02 |
| AU2008360937A1 (en) | 2010-03-04 |
| AU2008360937A2 (en) | 2010-04-29 |
| EP2190475B1 (en) | 2015-10-28 |
| ZA201001477B (en) | 2010-12-29 |
| AU2008360937B2 (en) | 2014-01-16 |
| BRPI0815846A2 (pt) | 2017-05-30 |
| WO2010023498A1 (en) | 2010-03-04 |
| AU2008360937B9 (en) | 2014-02-13 |
| HRP20151356T1 (hr) | 2016-01-01 |
| JP2011518760A (ja) | 2011-06-30 |
| US20100285042A1 (en) | 2010-11-11 |
| WO2010023498A8 (en) | 2010-04-15 |
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