JP5538691B2 - Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム - Google Patents

Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム Download PDF

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JP5538691B2
JP5538691B2 JP2008186385A JP2008186385A JP5538691B2 JP 5538691 B2 JP5538691 B2 JP 5538691B2 JP 2008186385 A JP2008186385 A JP 2008186385A JP 2008186385 A JP2008186385 A JP 2008186385A JP 5538691 B2 JP5538691 B2 JP 5538691B2
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protein
binding sequence
l7ae
mrna
rna
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JP2009142259A5 (enExample
JP2009142259A (ja
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丹 井上
博英 齊藤
哲大 小林
知明 原
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Japan Science and Technology Agency
National Institute of Japan Science and Technology Agency
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Japan Science and Technology Agency
National Institute of Japan Science and Technology Agency
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Priority to JP2008186385A priority Critical patent/JP5538691B2/ja
Priority to PCT/JP2008/071213 priority patent/WO2009066757A1/ja
Priority to US12/743,853 priority patent/US9255274B2/en
Priority to EP08851746.1A priority patent/EP2221367B1/en
Publication of JP2009142259A publication Critical patent/JP2009142259A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2008186385A 2007-11-22 2008-07-17 Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム Active JP5538691B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008186385A JP5538691B2 (ja) 2007-11-22 2008-07-17 Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム
PCT/JP2008/071213 WO2009066757A1 (ja) 2007-11-22 2008-11-21 Ｒｎａ－蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム
US12/743,853 US9255274B2 (en) 2007-11-22 2008-11-21 Protein-responsive translational regulatory system using RNA-protein interacting motif
EP08851746.1A EP2221367B1 (en) 2007-11-22 2008-11-21 Protein-responsive translation control system utilizing rna-protein interaction motif

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007303662 2007-11-22
JP2007303662 2007-11-22
JP2008186385A JP5538691B2 (ja) 2007-11-22 2008-07-17 Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム

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JP2009142259A JP2009142259A (ja) 2009-07-02
JP2009142259A5 JP2009142259A5 (enExample) 2011-09-01
JP5538691B2 true JP5538691B2 (ja) 2014-07-02

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JP2008186385A Active JP5538691B2 (ja) 2007-11-22 2008-07-17 Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム

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US (1) US9255274B2 (enExample)
EP (1) EP2221367B1 (enExample)
JP (1) JP5538691B2 (enExample)
WO (1) WO2009066757A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5308787B2 (ja) * 2007-11-22 2013-10-09 独立行政法人科学技術振興機構 機能性ｒｎａ−蛋白質複合体の分子デザイン
US10227596B2 (en) 2012-07-16 2019-03-12 Kyoto University Translational control system using RNA-protein interaction motif
WO2014014122A1 (en) 2012-07-16 2014-01-23 Kyoto University Translational control system using rna-protein interaction motif
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN106574292B (zh) 2014-01-10 2021-07-09 国立大学法人京都大学 利用作为指示剂的miRNA的表达区分期望的细胞类型的方法
US11351271B2 (en) * 2014-09-08 2022-06-07 Massachusetts Institute Of Technology RNA-based logic circuits with RNA binding proteins, aptamers and small molecules
JP6877752B2 (ja) * 2015-12-02 2021-05-26 国立大学法人京都大学 細胞内在性タンパク質の識別方法
EP3653710A4 (en) 2017-07-12 2021-04-14 Kyoto University HIGH-EXPRESSION mRNA SWITCH
EP3955951A4 (en) * 2019-04-18 2023-09-13 The Board of Trustees of the Leland Stanford Junior University SYSTEMS AND METHODS FOR DESIGNING RNA NANOSTRUCTURES AND THEIR USES
JPWO2023100955A1 (enExample) * 2021-11-30 2023-06-08
WO2023201631A1 (en) * 2022-04-21 2023-10-26 Tsinghua University Methods for manipulating quantitative gene expression and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2746997A (en) 1996-05-07 1997-11-26 Pharmacia & Upjohn Company Teichoic acid enzymes and assays
US20020169306A1 (en) 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
US9534224B2 (en) 2002-11-15 2017-01-03 Trustees Of Boston University Cis/trans riboregulators
JP2005341865A (ja) 2004-06-02 2005-12-15 Kyoto Univ 核酸プローブ、核酸検出方法、核酸分析用デバイス、および反応速度を制御する方法
TWI311152B (en) 2004-09-17 2009-06-21 Boehringer Ingelheim Rcv Gmbh & Co K Host-vector system for antibiotic-free cole1 plasmid propagation

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Publication number Publication date
US20110040077A1 (en) 2011-02-17
EP2221367A1 (en) 2010-08-25
WO2009066757A1 (ja) 2009-05-28
US9255274B2 (en) 2016-02-09
EP2221367A4 (en) 2011-12-07
JP2009142259A (ja) 2009-07-02
EP2221367B1 (en) 2017-07-12

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