WO2009066757A1 - Ｒｎａ－蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム - Google Patents

Ｒｎａ－蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム Download PDF

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Publication number
WO2009066757A1
WO2009066757A1 PCT/JP2008/071213 JP2008071213W WO2009066757A1 WO 2009066757 A1 WO2009066757 A1 WO 2009066757A1 JP 2008071213 W JP2008071213 W JP 2008071213W WO 2009066757 A1 WO2009066757 A1 WO 2009066757A1
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WIPO (PCT)
Prior art keywords
protein
interaction motif
control system
rna
mrna
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PCT/JP2008/071213
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English (en)
French (fr)
Inventor
Tan Inoue
Hirohide Saito
Tetsuhiro Kobayashi
Tomoaki Hara
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Japan Science And Technology Agency
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Publication date
Application filed by Japan Science And Technology Agency filed Critical Japan Science And Technology Agency
Priority to US12/743,853 priority Critical patent/US9255274B2/en
Priority to EP08851746.1A priority patent/EP2221367B1/en
Publication of WO2009066757A1 publication Critical patent/WO2009066757A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　より応用がしやすく、特異的なオン－オフ制御をすることができる、翻訳制御可能なｍＲＮＡ、かかるｍＲＮＡと特異的に結合したＲＮＡ－蛋白質複合体、および翻訳制御システムを提供することを目的とする。リボソーム結合部位の５’側、またはオープンリーディングフレームの５’側内部に、ＲＮＡ－蛋白質複合体相互作用モチーフ由来の塩基配列を有するｍＲＮＡ、及びリボソーム結合部位の５’側、またはオープンリーディングフレームの５’側内部に、ＲＮＡ－蛋白質複合体相互作用モチーフ由来の塩基配列に相補的な塩基配列を有するｍＲＮＡを提供する。
PCT/JP2008/071213 2007-11-22 2008-11-21 Ｒｎａ－蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム WO2009066757A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/743,853 US9255274B2 (en) 2007-11-22 2008-11-21 Protein-responsive translational regulatory system using RNA-protein interacting motif
EP08851746.1A EP2221367B1 (en) 2007-11-22 2008-11-21 Protein-responsive translation control system utilizing rna-protein interaction motif

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007303662 2007-11-22
JP2007-303662 2007-11-22
JP2008186385A JP5538691B2 (ja) 2007-11-22 2008-07-17 Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム
JP2008-186385 2008-07-17

Publications (1)

Publication Number Publication Date
WO2009066757A1 true WO2009066757A1 (ja) 2009-05-28

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ID=40667579

Family Applications (1)

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PCT/JP2008/071213 WO2009066757A1 (ja) 2007-11-22 2008-11-21 Ｒｎａ－蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム

Country Status (4)

Country Link
US (1) US9255274B2 (ja)
EP (1) EP2221367B1 (ja)
JP (1) JP5538691B2 (ja)
WO (1) WO2009066757A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009142273A (ja) * 2007-11-22 2009-07-02 Japan Science & Technology Agency 機能性ｒｎａ−蛋白質複合体の分子デザイン
WO2015105172A1 (ja) 2014-01-10 2015-07-16 国立大学法人京都大学 ｍｉＲＮＡの発現を指標として所望の細胞種を判別する方法
US9227956B2 (en) 2013-04-17 2016-01-05 Pfizer Inc. Substituted amide compounds
US9458466B2 (en) 2012-07-16 2016-10-04 Kyoto University Translational control system using RNA-protein interaction motif
US10227596B2 (en) 2012-07-16 2019-03-12 Kyoto University Translational control system using RNA-protein interaction motif

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US11351271B2 (en) 2014-09-08 2022-06-07 Massachusetts Institute Of Technology RNA-based logic circuits with RNA binding proteins, aptamers and small molecules
WO2017094878A1 (ja) * 2015-12-02 2017-06-08 国立大学法人京都大学 細胞内在性タンパク質の識別方法
US20210079440A1 (en) 2017-07-12 2021-03-18 Kyoto University HIGH EXPRESSION mRNA SWITCH
EP3955951A4 (en) * 2019-04-18 2023-09-13 The Board of Trustees of the Leland Stanford Junior University SYSTEMS AND METHODS FOR DESIGNING RNA NANOSTRUCTURES AND USES THEREOF
JPWO2023100955A1 (ja) * 2021-11-30 2023-06-08
WO2023201631A1 (en) * 2022-04-21 2023-10-26 Tsinghua University Methods for manipulating quantitative gene expression and uses thereof

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JP2000509605A (ja) * 1996-05-07 2000-08-02 ファルマシア・アンド・アップジョン・カンパニー テイコ酸酵素および検定法
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
AU2003290937A1 (en) * 2002-11-15 2004-06-15 Trustees Of Boston University Cis/trans riboregulators
JP2005341865A (ja) 2004-06-02 2005-12-15 Kyoto Univ 核酸プローブ、核酸検出方法、核酸分析用デバイス、および反応速度を制御する方法
TWI311152B (en) * 2004-09-17 2009-06-21 Boehringer Ingelheim Rcv Gmbh & Co K Host-vector system for antibiotic-free cole1 plasmid propagation

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BAKER CS. ET AL.: "CsrA inhibits translation initiation of Escherichia coli hfq by binding to a single site overlapping the Shine-Dalgarno sequence.", J. BACTERIOL., vol. 189, no. 15, August 2007 (2007-08-01), pages 5472 - 5481, XP003026834 *
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See also references of EP2221367A4 *
TOMOAKI HARA ET AL.: "RNP Motif L7Ae/BoxC/D o Riyo shita Tanpakushitsu Oto Hon'yaku Seigyo System no Kochiku", DAI 10 KAI THE RNA SOCIETY OF JAPAN NENKAI YOSHISHU, 23 July 2008 (2008-07-23), pages 141, XP008142168 *
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009142273A (ja) * 2007-11-22 2009-07-02 Japan Science & Technology Agency 機能性ｒｎａ−蛋白質複合体の分子デザイン
US9458466B2 (en) 2012-07-16 2016-10-04 Kyoto University Translational control system using RNA-protein interaction motif
US10227596B2 (en) 2012-07-16 2019-03-12 Kyoto University Translational control system using RNA-protein interaction motif
US9227956B2 (en) 2013-04-17 2016-01-05 Pfizer Inc. Substituted amide compounds
WO2015105172A1 (ja) 2014-01-10 2015-07-16 国立大学法人京都大学 ｍｉＲＮＡの発現を指標として所望の細胞種を判別する方法
EP3613862A1 (en) 2014-01-10 2020-02-26 Kyoto University Method for distinguishing desired cell type using expression of mirna as indicator

Also Published As

Publication number Publication date
EP2221367A1 (en) 2010-08-25
US9255274B2 (en) 2016-02-09
EP2221367A4 (en) 2011-12-07
JP2009142259A (ja) 2009-07-02
EP2221367B1 (en) 2017-07-12
US20110040077A1 (en) 2011-02-17
JP5538691B2 (ja) 2014-07-02

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