JP5536913B2 - 血小板凝集抑制剤 - Google Patents
血小板凝集抑制剤 Download PDFInfo
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- JP5536913B2 JP5536913B2 JP2013002210A JP2013002210A JP5536913B2 JP 5536913 B2 JP5536913 B2 JP 5536913B2 JP 2013002210 A JP2013002210 A JP 2013002210A JP 2013002210 A JP2013002210 A JP 2013002210A JP 5536913 B2 JP5536913 B2 JP 5536913B2
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- platelet aggregation
- aggregation inhibitor
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- 239000000106 platelet aggregation inhibitor Substances 0.000 title claims description 38
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Landscapes
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Description
また、カプサイシンやトウガラシ抽出物が血流促進効果を有することが知られているが、これらは刺激が強いため投与方法や投与量に制限があるなど使用方法や用途が限られている。
人の血液に10%濃度になるように3.8%クエン酸ナトリウム液を加え、この血液を1000rpmで10分間遠心分離し、上層部を採取、これを多血小板血漿(PRP)とした。
(血小板凝集阻害率計算法)
PRP+凝集惹起剤のみを加えたときの最大凝集率をAとする。
被験物質+PRP+アラキドン酸を加えたときの最大凝集率をBとする。
凝集阻害率(%)をCとすると
C=100−B/A×100
前記試験方法において、被験物質の濃度が2mMとなる量を添加した条件下で血小板凝集阻害活性を測定した。本発明の有効成分の試験結果を表1に示す。また、本発明の有効成分と類似した構造を有し、かつ充分な活性が得られなかったオクタン酸とウンデカン酸を比較例として同じく表1に示す。
錠剤配合例(質量比)
──────────────────────
本発明の血小板凝集抑制剤 5.0
6%HPC乳糖 80.0
ステアリン酸マグネシウム 4.0
バレイショデンプン 6.0
──────────────────────
軟膏剤配合例(質量比)
─────────────────────────
白色ワセリン 20.0
ステアリルアルコール 22.0
プロピレングリコール 12.0
ラウリル硫酸ナトリウム 1.5
パラベン 0.2
本発明の血小板凝集抑制剤 5.0
精製水 39.3
─────────────────────────
入浴剤配合例(質量比)
――――――――――――――――――――――─
炭酸水素ナトリウム 50.0
硫酸ナトリウム 45.0
本発明の血小板凝集抑制剤 1.3
香料 0.7
色素 3.0
───────────────────────
アイスクリーム配合例(質量比)
────────────────────────
全脂練乳 10.0
生クリーム 9.4
無塩バター 2.0
脱脂粉乳 3.4
砂糖 12.0
安定剤 0.3
乳化剤 0.2
pH調整剤 0.1
カラメル色素 0.1
本発明の血小板凝集抑制剤 0.01
香料 0.01
水 49.0
────────────────────────
クッキー生地配合例(質量比)
────────────────────────
薄力粉 62.5
全粒粉 37.5
ショートニング 30.0
全卵 30.0
砂糖 20.0
水飴 1.0
脱脂粉乳 5.0
食塩 1.2
食用油脂 30.0
重炭酸ソーダ 1.0
重炭酸アンモニウム 1.0
本発明の血小板凝集抑制剤 0.1
香料 0.3
水 11.0
────────────────────────
チョコレート配合例(質量比)
─────────────────────────
カカオ液 12.0
カカオバター 24.0
ショ糖 33.0
フルクリームミルクパウダー 19.0
スキムミルクパウダー 11.4
レシチン 0.5
本発明の血小板凝集抑制剤 0.01
香料 0.1
─────────────────────────
ノンオイルドレッシング配合例(質量比)
─────────────────────────
濃口醤油 10.0
醸造酢 6.0
リンゴ酢 5.0
レモン果汁 4.0
液糖 7.0
食塩 2.0
調味料 7.0
香料 0.2
本発明の血小板凝集抑制剤 0.01
水 50.0
─────────────────────────
飲料配合例(質量比)
――――――――――――――――――――――───
果糖ぶどう糖液糖 60.0
アップル透明果汁 4.3
クエン酸 2.3
クエン酸三ナトリウム 0.8
アスコルビン酸 0.2
スクラロース 0.03
アセスルファムカリウム 0.02
香料 0.99
本発明の血小板凝集抑制剤 0.1
水 31.0
――――――――――――――――――――――───
チューインガム配合例(質量比)
――――――――――――――――――――――─
ガムベース 20.0
砂糖 60.0
ブドウ糖 10.0
水飴 8.0
グリセリン 5.0
香料 0.9
本発明の血小板凝集抑制剤 0.1
───────────────────────
Claims (3)
- 2−デセン酸、4−デセン酸、9−デセン酸から選ばれる少なくとも1つを有効成分として含有する血小板凝集抑制剤。
- 請求項1に記載の血小板凝集抑制剤を有効成分とする血流改善剤。
- 請求項1に記載の血小板凝集抑制剤を有効成分とする抗血栓剤。
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