JP5525135B2 - 閉鎖膜付きチューブ容器およびその容器に内容物が充填されたチューブ - Google Patents
閉鎖膜付きチューブ容器およびその容器に内容物が充填されたチューブ Download PDFInfo
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- JP5525135B2 JP5525135B2 JP2008040538A JP2008040538A JP5525135B2 JP 5525135 B2 JP5525135 B2 JP 5525135B2 JP 2008040538 A JP2008040538 A JP 2008040538A JP 2008040538 A JP2008040538 A JP 2008040538A JP 5525135 B2 JP5525135 B2 JP 5525135B2
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- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- JCQBWMAWTUBARI-UHFFFAOYSA-N tert-butyl 3-ethenylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(C=C)C1 JCQBWMAWTUBARI-UHFFFAOYSA-N 0.000 description 1
- 229960002494 tetracaine hydrochloride Drugs 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229950010121 ufenamate Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229950004227 zaltoprofen Drugs 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/44—Closures
- B65D35/46—Closures with valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
- B65D35/28—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for expelling contents
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Tubes (AREA)
- Closures For Containers (AREA)
- Packages (AREA)
Description
(1)消費者がチューブ容器内の内容物を使用するまでは、エアーに触れないように流通、陳列等の販売段階に置かれるが、閉鎖膜を破り、開封後に内容物を押し出して使用した後は、胴部が弾力的に復元しやすく、また針体で形成した穴径が2.0〜8.0mmと大きいため、エアーがチューブ容器内にエアーバックし、内容物と混合しやすい。そのため、短期間に内容物が劣化する。
(2)逆流防止弁を口部に設けたものは、エアーバックを抑制できるが、製造コストが高くなると共に口部の構造が複雑になる。
薬効成分としては特に限定されるものではなく、例えば、抗ヒスタミン剤、抗炎症剤、鎮痒剤、抗真菌剤、角質軟化剤、収斂・皮膚保護剤、局所麻酔剤、保湿剤等が挙げられ、これら薬効成分は単独で用いてもよいし、2種以上を組み合わせてもよい。
抗ヒスタミン剤としては、例えば、ジフェンヒドラミン、塩酸ジフェンヒドラミン、ラウリル硫酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、塩酸イソチペジル等が挙げられる。
抗真菌剤としては、例えば、硝酸ミコナゾール、ビフォナゾール、塩酸クロコナゾール、クロトリマゾール、硝酸エコナゾール、硝酸イソコナゾール、硝酸オキシコナゾール、硝酸スルコナゾール、ケトコナゾール、塩酸ネチコナゾール、ナイスタチン、ピマリシン、シッカニン、トリコマイシン、バリオチン、トルシクラート、トルナフテート、塩酸ブテナフィン、テルビナフィン、複合ウンデシレン酸、シクロピロクスオラミン、エキサラミド、ハロプロジン、フェニルヨードウンデシレン酸等が挙げられる。
角質軟化剤としては、例えば、サリチル酸、尿素等が挙げられる。
収斂・皮膚保護剤としては、例えば、グアイアズレン、ポビドンヨード、ヘパリン類似物質等が挙げられる。
保湿剤としては、例えば、尿素、ヘパリン類似物質、ピロリドンカルボン酸、コラーゲン、γ−オリザノール、γ−リノレイン酸、リノール酸、ビタミンE、ビタミンD、ビタミンA、スクワレン、スクワラン、グリセリン、ポリエチレングリコール、コレステロール、トリグリセリド、セラミド等が挙げられる。
保存剤としては、バラオキシ安息香酸エステル類、塩化ベンザルコニウム等が挙げられる。
安定化剤としては、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、エデト酸塩等が挙げられる。
また、湿潤剤としては、グリセリン、エチレングリコール、プロピレングリコール、オレイルアルコール、1,3−ブチレングリコール、イソプロピレングリコール、ポリエチレングリコール等の多価アルコールが挙げられる。
なお、液剤、軟膏剤、クリーム剤、クリームゲル剤やゲル剤等の前記チューブ容器に充填される内容物は、公知の方法(例えば、第十五改正日本薬局方 製剤総則等)にしたがって、製造することができる。
3 口上部
4 吐出口(液溜まり部)
5 閉鎖膜
5a 孔
8、18、28、38 胴部
9 キャップ
10 針体
11 アルミニウム層
15 内容物
21 ガスバリア性樹脂層(ポリエチレンテレフタレート)
31 ガスバリア性樹脂層(ナイロン)
Claims (6)
- キャップの針体で穿孔される閉鎖膜を有する口部と、粘度が100〜10000mPa・sの内容物が充填される筒状の胴部とを備えた閉鎖膜付きチューブ容器において、
前記針体の閉鎖膜を穿孔するべき部位の径が2mm以下であり、
前記胴部がアルミニウム層を有しており、
前記針体によって穿孔される閉鎖膜の孔の直径が2mm以下であり、
前記口部の上方に、閉鎖膜の上面を覆うように口上部が設けられており、
その口上部が、前記閉鎖膜に穿孔される孔を囲うように半径方向の内向きに延びる部位と、その内向きに延びる部位の先端から上方に延びる部位とからなり、
その口上部の内部である吐出口の下端に前記閉鎖膜が設けられており、
前記吐出口の径が閉鎖膜に穿孔された孔より大きく、その閉鎖膜の穿孔されていない部位の上面および吐出口の内面により吐出口内に液溜まり部が形成されており、
その液溜まり部の直径が2mm以上で、長さが4mm以上であり、
前記液溜り部に前記口部から押し出された前記内容物が溜まることにより、胴部の復元力によりチューブ容器内に流入するエアーの量を減少させることを特徴とする、閉鎖膜付きチューブ容器。 - 前記胴部のアルミニウム層の肉厚が50μm以下にされている、あるいは、そのアルミニウム層に代えてガスバリア性樹脂層が設けられていることを特徴とする、請求項1記載の閉鎖膜付きチューブ容器。
- 前記液溜り部の直径が2〜3mmで、長さが4〜10mmであることを特徴とする、請求項1又は2記載の閉鎖膜付きチューブ容器。
- 請求項1、2あるいは3のいずれかに記載の閉鎖膜付きチューブ容器と、そのチューブ容器に充填される内容物とからなるチューブ。
- 前記内容物が薬効成分を含むものである請求項4記載のチューブ。
- 前記内容物の薬効成分が抗ヒスタミン剤、抗炎症剤、鎮痒剤、抗真菌剤、角質軟化剤、収斂・皮膚保護剤、局所麻酔剤及び保湿剤からなる群より選ばれる1種以上である請求項5記載のチューブ。
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JP2008040538A JP5525135B2 (ja) | 2008-02-21 | 2008-02-21 | 閉鎖膜付きチューブ容器およびその容器に内容物が充填されたチューブ |
KR1020090008251A KR101589081B1 (ko) | 2008-02-21 | 2009-02-03 | 폐쇄막이 달린 튜브 용기 및 그 용기에 내용물이 충전된 튜브 |
CN2009100078772A CN101549766B (zh) | 2008-02-21 | 2009-02-20 | 带封闭膜的管状容器以及在该容器中填充有内容物的管 |
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JP2009285423A (ja) * | 2008-06-02 | 2009-12-10 | Kowa Co | 外用製剤 |
CN102582924A (zh) * | 2012-02-17 | 2012-07-18 | 上海万汇塑料包装容器有限公司 | 一种新型软管及其生产工艺 |
MX2017012757A (es) * | 2015-04-08 | 2018-01-30 | Fujimori Kogyo Co | Contenedor tubular. |
CN114834719A (zh) * | 2016-04-15 | 2022-08-02 | 京洛株式会社 | 层叠剥离容器 |
CN107912809A (zh) * | 2016-10-10 | 2018-04-17 | 湖南中烟工业有限责任公司 | 一种电子烟烟液胶囊 |
KR200487565Y1 (ko) * | 2017-01-11 | 2018-10-05 | 권민재 | 일회용 미스트 장치 |
CN110371464B (zh) * | 2018-04-12 | 2022-03-25 | 创新产品品牌公司 | 具有改进的锁定帽插入物以减少物质在锁定帽闭合后泄漏的用于层压管的儿童保护锁定帽 |
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JP2009196671A (ja) | 2009-09-03 |
KR101589081B1 (ko) | 2016-01-27 |
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