JP5524864B2 - ４−（ピロロ［２，３−ｃ］ピリジン−３−イル）ピリミジン−２−アミン誘導体 - Google Patents
４−（ピロロ［２，３−ｃ］ピリジン−３−イル）ピリミジン−２−アミン誘導体 Download PDFInfo
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- JP5524864B2 JP5524864B2 JP2010543386A JP2010543386A JP5524864B2 JP 5524864 B2 JP5524864 B2 JP 5524864B2 JP 2010543386 A JP2010543386 A JP 2010543386A JP 2010543386 A JP2010543386 A JP 2010543386A JP 5524864 B2 JP5524864 B2 JP 5524864B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008005493.3 | 2008-01-22 | ||
| DE102008005493A DE102008005493A1 (de) | 2008-01-22 | 2008-01-22 | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| PCT/EP2008/011098 WO2009092431A1 (de) | 2008-01-22 | 2008-12-23 | 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidin-2-amin-derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510028A JP2011510028A (ja) | 2011-03-31 |
| JP2011510028A5 JP2011510028A5 (enExample) | 2012-02-16 |
| JP5524864B2 true JP5524864B2 (ja) | 2014-06-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543386A Expired - Fee Related JP5524864B2 (ja) | 2008-01-22 | 2008-12-23 | ４−（ピロロ［２，３−ｃ］ピリジン−３−イル）ピリミジン−２−アミン誘導体 |
Country Status (14)
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101723936B (zh) * | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2012160464A1 (en) | 2011-05-26 | 2012-11-29 | Daiichi Sankyo Company, Limited | Heterocyclic compounds as protein kinase inhibitors |
| KR20220143164A (ko) | 2012-11-21 | 2022-10-24 | 피티씨 테라퓨틱스, 인크. | 치환된 리버스 피리미딘 ｂｍｉ-1 저해제 |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| MX370588B (es) | 2013-08-30 | 2019-12-16 | Ptc Therapeutics Inc | Inhibidores de la bmi-1 de pirimidina sustituida. |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| EA033238B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные тиенопиримидина в качестве ингибиторов nik |
| CN107074855B (zh) * | 2014-10-23 | 2019-11-05 | 詹森药业有限公司 | 作为nik抑制剂的新的化合物 |
| ES2704749T3 (es) | 2014-10-23 | 2019-03-19 | Janssen Pharmaceutica Nv | Nuevos derivados de pirazol en calidad de inhibidores de nik |
| KR102523405B1 (ko) | 2014-10-23 | 2023-04-18 | 얀센 파마슈티카 엔.브이. | Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체 |
| WO2020055544A2 (en) | 2018-08-17 | 2020-03-19 | Ptc Therapeutics, Inc. | Method for treating pancreatic cancer |
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| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US20080153869A1 (en) * | 2004-06-14 | 2008-06-26 | Bressi Jerome C | Kinase Inhibitors |
| WO2006050076A1 (en) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| ES2401192T3 (es) * | 2005-09-30 | 2013-04-17 | Vertex Pharmceuticals Incorporated | Deazapurinas útiles como inhibidores de janus cinasas |
| DE102006012617A1 (de) * | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
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2008
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- 2008-12-23 JP JP2010543386A patent/JP5524864B2/ja not_active Expired - Fee Related
- 2008-12-23 AU AU2008348816A patent/AU2008348816B2/en not_active Ceased
- 2008-12-23 EP EP08871371A patent/EP2231664A1/de not_active Withdrawn
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- 2008-12-23 MX MX2010007927A patent/MX2010007927A/es not_active Application Discontinuation
- 2008-12-23 US US12/863,817 patent/US20100292262A1/en not_active Abandoned
- 2008-12-23 CA CA2712612A patent/CA2712612A1/en not_active Abandoned
- 2008-12-23 CN CN200880125171XA patent/CN101918404A/zh active Pending
- 2008-12-23 KR KR1020107018575A patent/KR20100112626A/ko not_active Withdrawn
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- 2010-08-20 ZA ZA2010/05959A patent/ZA201005959B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2712612A1 (en) | 2009-07-30 |
| DE102008005493A8 (de) | 2010-03-25 |
| MX2010007927A (es) | 2010-08-09 |
| JP2011510028A (ja) | 2011-03-31 |
| EP2231664A1 (de) | 2010-09-29 |
| IL206905A0 (en) | 2010-12-30 |
| CN101918404A (zh) | 2010-12-15 |
| AU2008348816B2 (en) | 2011-10-20 |
| AU2008348816A1 (en) | 2009-07-30 |
| US20100292262A1 (en) | 2010-11-18 |
| KR20100112626A (ko) | 2010-10-19 |
| AR070212A1 (es) | 2010-03-25 |
| WO2009092431A1 (de) | 2009-07-30 |
| ZA201005959B (en) | 2011-04-28 |
| DE102008005493A1 (de) | 2009-07-23 |
| BRPI0821936A2 (pt) | 2015-06-16 |
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