JP5507549B2 - 脂肪低下のためのペオニフロリン製剤およびその使用 - Google Patents

脂肪低下のためのペオニフロリン製剤およびその使用 Download PDF

Info

Publication number
JP5507549B2
JP5507549B2 JP2011511955A JP2011511955A JP5507549B2 JP 5507549 B2 JP5507549 B2 JP 5507549B2 JP 2011511955 A JP2011511955 A JP 2011511955A JP 2011511955 A JP2011511955 A JP 2011511955A JP 5507549 B2 JP5507549 B2 JP 5507549B2
Authority
JP
Japan
Prior art keywords
fat
formulation
lipolysis
expression
adipocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011511955A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011523950A (ja
JP2011523950A5 (OSRAM
Inventor
バクル・ラビー
Original Assignee
プロファウンド・エイジア・テクノロジー・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by プロファウンド・エイジア・テクノロジー・リミテッド filed Critical プロファウンド・エイジア・テクノロジー・リミテッド
Publication of JP2011523950A publication Critical patent/JP2011523950A/ja
Publication of JP2011523950A5 publication Critical patent/JP2011523950A5/ja
Application granted granted Critical
Publication of JP5507549B2 publication Critical patent/JP5507549B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0452—Specially adapted for transcutaneous muscle stimulation [TMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0008—Destruction of fat cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
JP2011511955A 2008-05-23 2009-05-25 脂肪低下のためのペオニフロリン製剤およびその使用 Expired - Fee Related JP5507549B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/126,246 US7943187B2 (en) 2008-05-23 2008-05-23 Paeoniflorin preparations and uses thereof for fat reduction
US12/126,246 2008-05-23
PCT/CN2009/000569 WO2010127470A1 (en) 2008-05-23 2009-05-25 Paeoniflorin preparations and uses thereof for fat reduction

Publications (3)

Publication Number Publication Date
JP2011523950A JP2011523950A (ja) 2011-08-25
JP2011523950A5 JP2011523950A5 (OSRAM) 2013-05-23
JP5507549B2 true JP5507549B2 (ja) 2014-05-28

Family

ID=41342622

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011511955A Expired - Fee Related JP5507549B2 (ja) 2008-05-23 2009-05-25 脂肪低下のためのペオニフロリン製剤およびその使用

Country Status (9)

Country Link
US (4) US7943187B2 (OSRAM)
EP (1) EP2300018B1 (OSRAM)
JP (1) JP5507549B2 (OSRAM)
KR (1) KR101656536B1 (OSRAM)
CN (1) CN102170888B (OSRAM)
AU (2) AU2009345773A1 (OSRAM)
CA (1) CA2725972A1 (OSRAM)
DK (1) DK2300018T3 (OSRAM)
WO (1) WO2010127470A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943187B2 (en) * 2008-05-23 2011-05-17 Bakr Rabie Paeoniflorin preparations and uses thereof for fat reduction
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
US20130012840A1 (en) * 2010-03-23 2013-01-10 Real Aesthetics Ltd. System and method for accelerating the relative proportion of fat catabolism
CA2827643C (en) 2011-02-18 2019-05-07 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
WO2015061280A1 (en) 2013-10-21 2015-04-30 Alevere Medical Corporation Fused heterocyclic organic compounds, pharmaceutical compositions, and medical uses thereof
WO2017079700A1 (en) * 2015-11-04 2017-05-11 Kythera Biopharmaceuticals, Inc. Treatments of accumulated fat with deoxycholic acid and salts thereof
WO2019156213A1 (ja) 2018-02-09 2019-08-15 琥珀バイオテクノロジー株式会社 グリセロール放出促進剤
KR102392292B1 (ko) 2021-07-21 2022-05-03 중앙대학교 산학협력단 페오니플로린을 포함하는 악액질 및 근손실 예방 또는 치료용 조성물

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6485990A (en) * 1987-09-28 1989-03-30 Tsumura & Co Antihypertestoeronemia agent
US4888354A (en) * 1987-12-21 1989-12-19 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
US5919621A (en) 1991-10-24 1999-07-06 Brown; David B. Methods for diagnosing human male infertility
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
FR2717382B1 (fr) * 1994-03-21 1996-06-07 Fabre Pierre Cosmetique Extraits de Paeonia Lactiflora titré en paeoniflorine utiles en cosmétologie dans le traitement capillaire.
PE17897A1 (es) * 1995-02-17 1997-06-12 Lilly Co Eli Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano
US5698199A (en) * 1995-03-10 1997-12-16 Kao Corporation Lipolysis acceleration method
EP1021191B1 (de) 1997-10-08 2002-06-05 Genesiscosmetics Rights & Licenses Company Limited Straffung und/oder verkleinerung von fettzellen-haltigen körperpartien
US6638064B1 (en) * 2000-06-07 2003-10-28 Robert Scott Nance Flexible endodontic syringe
ES2333849T3 (es) * 2001-04-20 2010-03-02 Alza Corporation Disposicion de microsalientes que presenta un revestimiento que contiene un agente beneficioso.
CN2560367Y (zh) * 2001-08-30 2003-07-16 夏勤 适于喉部和气管滴入药物的针头
US20030175328A1 (en) * 2002-03-06 2003-09-18 Adi Shefer Patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients into the skin
JP2004217583A (ja) * 2003-01-16 2004-08-05 Naris Cosmetics Co Ltd 痩身用皮膚外用剤
US20040191330A1 (en) * 2003-03-31 2004-09-30 Keefe Candace R. Daily skin care regimen
CN1555806A (zh) * 2003-12-31 2004-12-22 昆明同持医药研究有限公司 一种芍药甙注射剂及其制备方法和应用
US20080194496A1 (en) * 2004-05-10 2008-08-14 Lg Household & Health Care Ltd. Skin Aging Treatment Comprising Paeoniflorin
KR100769580B1 (ko) * 2005-03-07 2007-10-23 주식회사 엘지생활건강 자외선에 의한 피부 dna 손상 방지제
KR20050107649A (ko) * 2004-05-10 2005-11-15 주식회사 엘지생활건강 페오니플로린을 포함하는 피부 노화 억제용 조성물
ES2372499T3 (es) 2004-05-19 2012-01-20 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Uso de un detergente para la eliminación no quirúrgica de grasa.
US7530958B2 (en) * 2004-09-24 2009-05-12 Guided Therapy Systems, Inc. Method and system for combined ultrasound treatment
JP4974533B2 (ja) * 2006-01-30 2012-07-11 富士フイルム株式会社 ジスルフィド架橋したタンパク質ナノ粒子
US20080294072A1 (en) * 2007-05-24 2008-11-27 Crutchfield Dermatology Mesotherapy with ultrasound
US7943187B2 (en) * 2008-05-23 2011-05-17 Bakr Rabie Paeoniflorin preparations and uses thereof for fat reduction

Also Published As

Publication number Publication date
US20150018906A1 (en) 2015-01-15
CN102170888A (zh) 2011-08-31
US20090292238A1 (en) 2009-11-26
US20170368086A9 (en) 2017-12-28
KR20110138322A (ko) 2011-12-27
WO2010127470A1 (en) 2010-11-11
EP2300018B1 (en) 2017-05-17
EP2300018A1 (en) 2011-03-30
CN102170888B (zh) 2013-06-19
DK2300018T3 (en) 2017-09-11
US20110218163A1 (en) 2011-09-08
AU2015242976A1 (en) 2015-11-05
KR101656536B1 (ko) 2016-09-12
US8491947B2 (en) 2013-07-23
AU2009345773A1 (en) 2010-11-11
CA2725972A1 (en) 2010-11-11
US9901591B2 (en) 2018-02-27
JP2011523950A (ja) 2011-08-25
US20170216333A1 (en) 2017-08-03
US7943187B2 (en) 2011-05-17
EP2300018A4 (en) 2011-07-20
HK1159477A1 (en) 2012-08-03

Similar Documents

Publication Publication Date Title
US9901591B2 (en) Paeoniflorin preparations and uses thereof for fat reduction
Bo et al. A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial
Magkos et al. Metabolic actions of insulin in men and women
Corona et al. The role of testosterone in erectile dysfunction
JP2008519847A (ja) 運動障害の治療方法
JP6951976B2 (ja) 神経筋疾患、神経変性疾患、自己免疫疾患、発達疾患および/または代謝疾患の処置のための、脳由来神経栄養因子(bdnf)の誘導された発現
Nightingale et al. Body composition changes with testosterone replacement therapy following spinal cord injury and aging: A mini review
JP2018516934A (ja) 脂肪量を低減するためのβ−ヒドロキシ−β−メチルブチレート(HMB)の組成物および使用方法
US20110223150A1 (en) Neutraceutical-Based Topical Anxiolytic Agent and Method of Use
CN102580087A (zh) 一种可用于人体局部减肥和美体的原位脂肪细胞系复合抑制剂及其制备方法
US20180055848A1 (en) Combination of Albuterol and Caffeine as Synergistic Treatment for Obesity or Sarcopenia
Al-Mosawi Semmola-Meryon-Duchenne syndrome: possible therapeutic role of nutritional supplements
HK1159477B (en) Paeoniflorin preparations and uses thereof for fat reduction
Hioki et al. Growth hormone administration controls body composition associated with changes of thermogenesis in obese KK-Ay mice
Wu Non-shivering thermogenesis and its current advances in clinical trials targeting obesity
Albrecht-Betancourt et al. Androgen replacement in men with hypogonadism and erectile dysfunction
US20260041700A1 (en) IP-6 And Inositol Nerve Relaxing Transdermal Topical Cream, Gel, Or Ointment For Raynaud's Syndrome
US20190142764A1 (en) Methods for treatment of interstitial cystitis
Rastrelli et al. Treatment of Hypogonadism 31
Chandra et al. SCOPE OF ILE (INTRAVENOUS LIPID EMULSION) AS AN ANTIDOTE IN VETERINARY CLINICAL PRACTICE.
Knack et al. Use of Oxandrolone as Adjunctive Therapy in Right Ischiotibial Injury
Askar et al. Effect of melatonin on body weight and hormones in male rats
US20070042998A1 (en) Medical cosmetic method for reducing adipose tissue and for initiating lipolysis through subcutaneous and intracutaneous injections and customized composition compounded from pharmaceutical agents for use therein
Stob Post exercise protein feeding does not alter molecular markers of translation initiation or measures of skeletal muscle function
Dalbo III The effects of aging on myostatin pathway activity after three sequential bouts of resistance exercise

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120330

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120330

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130328

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130820

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131010

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140217

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140319

R150 Certificate of patent or registration of utility model

Ref document number: 5507549

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees