JP5504253B2 - ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 - Google Patents
ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体 Download PDFInfo
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- JP5504253B2 JP5504253B2 JP2011504317A JP2011504317A JP5504253B2 JP 5504253 B2 JP5504253 B2 JP 5504253B2 JP 2011504317 A JP2011504317 A JP 2011504317A JP 2011504317 A JP2011504317 A JP 2011504317A JP 5504253 B2 JP5504253 B2 JP 5504253B2
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Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Bioinformatics & Cheminformatics (AREA)
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- Engineering & Computer Science (AREA)
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- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/002929 WO2009127218A1 (en) | 2008-04-14 | 2008-04-14 | Derivatives of galantamine as pro-drugs for the treatment of human brain diseases |
Publications (3)
| Publication Number | Publication Date |
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| JP2011516588A JP2011516588A (ja) | 2011-05-26 |
| JP2011516588A5 JP2011516588A5 (https=) | 2014-02-20 |
| JP5504253B2 true JP5504253B2 (ja) | 2014-05-28 |
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| EP (1) | EP2137192B8 (https=) |
| JP (1) | JP5504253B2 (https=) |
| CN (1) | CN102007129B (https=) |
| CA (1) | CA2721007C (https=) |
| DK (1) | DK2137192T3 (https=) |
| ES (1) | ES2463715T3 (https=) |
| PL (1) | PL2137192T3 (https=) |
| WO (1) | WO2009127218A1 (https=) |
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| ES2880399T3 (es) | 2012-07-27 | 2021-11-24 | Neurodyn Life Sciences Inc | Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos |
| ES2700473T3 (es) * | 2012-07-27 | 2019-02-18 | Neurodyn Life Sciences Inc | Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos |
| CA2944017C (en) * | 2014-03-25 | 2022-08-09 | Emicipi Llc | Treatment of rett syndrome |
| EP3122363B1 (en) * | 2014-03-25 | 2021-06-23 | Synaptec Development LLC | Galantamine carbamates for the treatment of autism |
| AU2015258814B2 (en) * | 2014-05-16 | 2018-04-05 | Synaptec Development Llc | Clearance of amyloid ss |
| EP4029867A1 (en) | 2021-01-13 | 2022-07-20 | Alpha Cognition Inc. | Solid forms of galantamine benzoate gluconate |
| EP4186509A1 (en) | 2021-11-26 | 2023-05-31 | Alpha Cognition Inc. | Alpha-1062 for treating traumatic brain injury |
| US12208167B1 (en) * | 2024-02-06 | 2025-01-28 | Alpha Cognition Inc. | Coated tablets for pH-dependent release of benzgalantamine |
| US12551491B1 (en) * | 2025-07-23 | 2026-02-17 | Alpha Cognition Inc. | Dosage regimens for benzgalantamine |
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| EP0363415B1 (en) | 1987-05-04 | 2008-10-15 | Davis, Bonnie | Compounds for the treatment of alzheimer's disease |
| US6150354A (en) | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
| US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323196B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6316439B1 (en) | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| AU1282099A (en) | 1997-10-29 | 1999-05-17 | Bonnie M. Davis | Method for treatment of disorders of attention |
| WO2000032199A1 (de) | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| EP2311463A1 (en) | 1999-12-10 | 2011-04-20 | Bonnie M. Davis | Analogs of galanthamine and lycoramine as modulators of nicotinic receptors |
| ATE263171T1 (de) | 2000-03-31 | 2004-04-15 | Sanochemia Pharmazeutika Ag | Neue derivate und analoga von galanthamin |
| US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| CA2540248C (en) | 2003-09-26 | 2010-12-07 | Scinopharm Taiwan, Ltd. | Resolution of a narwedine amide derivative |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
| EP1777222A1 (en) | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
-
2008
- 2008-04-14 CA CA2721007A patent/CA2721007C/en active Active
- 2008-04-14 JP JP2011504317A patent/JP5504253B2/ja not_active Expired - Fee Related
- 2008-04-14 PL PL08735211T patent/PL2137192T3/pl unknown
- 2008-04-14 WO PCT/EP2008/002929 patent/WO2009127218A1/en not_active Ceased
- 2008-04-14 ES ES08735211.8T patent/ES2463715T3/es active Active
- 2008-04-14 CN CN200880128608.5A patent/CN102007129B/zh active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| DK2137192T3 (da) | 2014-05-26 |
| EP2137192B8 (en) | 2014-06-11 |
| CN102007129B (zh) | 2014-05-07 |
| ES2463715T3 (es) | 2014-05-29 |
| WO2009127218A1 (en) | 2009-10-22 |
| JP2011516588A (ja) | 2011-05-26 |
| EP2137192B1 (en) | 2014-02-19 |
| CN102007129A (zh) | 2011-04-06 |
| EP2137192A1 (en) | 2009-12-30 |
| CA2721007C (en) | 2014-04-29 |
| PL2137192T3 (pl) | 2014-07-31 |
| CA2721007A1 (en) | 2009-10-22 |
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