JP5502275B2 - 熱反応デバイスおよびその熱反応デバイスの使用方法 - Google Patents

熱反応デバイスおよびその熱反応デバイスの使用方法 Download PDF

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JP5502275B2
JP5502275B2 JP2007511507A JP2007511507A JP5502275B2 JP 5502275 B2 JP5502275 B2 JP 5502275B2 JP 2007511507 A JP2007511507 A JP 2007511507A JP 2007511507 A JP2007511507 A JP 2007511507A JP 5502275 B2 JP5502275 B2 JP 5502275B2
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reaction
channel
microfluidic
reagent
layer
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JP2007537847A (ja
JP2007537847A5 (fr
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フェデリコ グッドセッド，
マーク エー． アンガー，
ジャン ファン，
エマーソン チュエン，
ロバート グロスマン，
フィリップ ラム，
ホウ−プー チョウ，
ジェーク キンブル，
マーティン パイポズィック，
ジェフリー フェイサー，
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フルイディグム コーポレイション
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Priority claimed from US10/837,885 external-priority patent/US7476363B2/en
Priority claimed from US10/876,046 external-priority patent/US20050145496A1/en
Priority claimed from US11/043,895 external-priority patent/US8105553B2/en
Priority claimed from US11/058,106 external-priority patent/US7867763B2/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00389—Feeding through valves
    • B01J2219/004—Pinch valves
    • B01J2219/00403—Pinch valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00718—Type of compounds synthesised
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
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    • B01L2300/18—Means for temperature control
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/06—Valves, specific forms thereof
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    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
JP2007511507A 2004-05-02 2005-05-02 熱反応デバイスおよびその熱反応デバイスの使用方法 Active JP5502275B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10/837,885 2004-05-02
US10/837,885 US7476363B2 (en) 2003-04-03 2004-05-02 Microfluidic devices and methods of using same
US10/876,046 2004-06-23
US10/876,046 US20050145496A1 (en) 2003-04-03 2004-06-23 Thermal reaction device and method for using the same
US11/043,895 US8105553B2 (en) 2004-01-25 2005-01-25 Crystal forming devices and systems and methods for using the same
US11/043,895 2005-01-25
US11/058,106 2005-02-14
US11/058,106 US7867763B2 (en) 2004-01-25 2005-02-14 Integrated chip carriers with thermocycler interfaces and methods of using the same
PCT/US2005/015352 WO2005107938A2 (fr) 2004-05-02 2005-05-02 Dispositif de réaction thermique et méthode d'utilisation de semblable

Related Child Applications (1)

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JP2012020787A Division JP2012085659A (ja) 2004-05-02 2012-02-02 熱反応デバイスおよびその熱反応デバイスの使用方法

Publications (3)

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JP2007537847A JP2007537847A (ja) 2007-12-27
JP2007537847A5 JP2007537847A5 (fr) 2012-03-22
JP5502275B2 true JP5502275B2 (ja) 2014-05-28

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EP (1) EP1796824A4 (fr)
JP (1) JP5502275B2 (fr)
WO (1) WO2005107938A2 (fr)

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US9373561B1 (en) 2014-12-18 2016-06-21 International Business Machines Corporation Integrated circuit barrierless microfluidic channel
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2701194B1 (fr) 2004-06-07 2018-08-29 Fluidigm Corporation Procédé et appareil pour l'imagerie d'un dispositif microfluidique sous contrôle de température.
WO2006121997A2 (fr) 2005-05-09 2006-11-16 Idaho Technology, Inc. Analyse biologique autonome
US7913928B2 (en) 2005-11-04 2011-03-29 Alliant Techsystems Inc. Adaptive structures, systems incorporating same and related methods
JP2007189964A (ja) * 2006-01-20 2007-08-02 Toppan Printing Co Ltd 検査基板
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
JP2009540290A (ja) 2006-06-08 2009-11-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Ｄｎａ検出用ミクロ電子工学センサ装置
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
BRPI0718473A2 (pt) * 2006-10-18 2013-12-03 Harvard College Bioensaio de fluxo direto e fluxo lateral baseado em meio poroso modelado, métodos de produção do mesmo, e métodos de uso do mesmo.
CA2669943C (fr) * 2006-11-15 2016-05-31 Idaho Technology, Inc. Analyse biologique auto-contenue haute densite
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
WO2008089493A2 (fr) * 2007-01-19 2008-07-24 Fluidigm Corporation Dispositifs microfluidiques d'efficacité élevée et de précision élevée et procédés
JP2009042103A (ja) * 2007-08-09 2009-02-26 Sony Corp 基板、これを用いた反応処理装置並びに反応制御方法
CA2705213C (fr) 2007-11-07 2016-10-04 The University Of British Columbia Dispositif microfluidique et procede d'utilisation de ce dispositif
WO2009100449A1 (fr) 2008-02-08 2009-08-13 Fluidigm Corporation Procédés de dosage de réseau dynamique
KR20100128340A (ko) 2008-03-27 2010-12-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 종이 기반 마이크로유체 시스템
CN102016595B (zh) 2008-03-27 2014-08-06 哈佛学院院长等 三维微流体装置
WO2009121043A2 (fr) 2008-03-27 2009-10-01 President And Fellows Of Harvard College Fil de coton servant de plate-forme diagnostique pour analyses multiples à bas coûts
CN103203210A (zh) 2008-03-27 2013-07-17 哈佛学院院长等 基于纸的细胞阵列
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
WO2009158631A1 (fr) 2008-06-26 2009-12-30 President And Fellows Of Harvard College Matériaux nanostructurés actionnables, à rapport d'aspect élevé et polyvalent, par réplication
WO2010027870A2 (fr) 2008-08-26 2010-03-11 Fluidigm Corporation Procédés de dosage pour un débit amélioré d'échantillons et/ou de cibles
CN102281950B (zh) * 2008-12-08 2015-05-06 富鲁达公司 可编程微流体数字阵列
WO2010088288A2 (fr) 2009-01-28 2010-08-05 Fluidigm Corporation Détermination de différences du nombre de copies par amplification
ES2612507T3 (es) 2009-03-06 2017-05-17 President And Fellows Of Harvard College Dispositivos microfluídicos y electroquímicos
DE102009015739A1 (de) * 2009-03-31 2010-10-07 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Aufnahme eines Sensors
US8691509B2 (en) 2009-04-02 2014-04-08 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
CN102713621B (zh) 2009-11-23 2016-10-19 西维克公司 用于施行化验的方法和设备
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
CN102821861B (zh) 2010-02-03 2015-03-25 哈佛大学校长及研究员协会 用于多重测定的装置和方法
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
US9523693B2 (en) 2011-04-18 2016-12-20 Biotarget Engagement Interest Group Ab Methods for determining ligand binding to a target protein using a thermal shift assay
GB201106548D0 (en) 2011-04-18 2011-06-01 Evitraproteoma Ab A method for determining ligand binding to a target protein using a thermal shift assahy
CN108342453A (zh) 2011-05-09 2018-07-31 富鲁达公司 基于探针的核酸检测
US9074204B2 (en) 2011-05-20 2015-07-07 Fluidigm Corporation Nucleic acid encoding reactions
CN102320558B (zh) * 2011-09-13 2014-03-26 上海先进半导体制造股份有限公司 全硅基微流体器件的腔体的制造方法
DE102012100824A1 (de) * 2012-02-01 2013-09-05 Albert-Ludwigs-Universität Freiburg Gemultiplexte Digital PCR
US9429500B2 (en) 2012-02-29 2016-08-30 Fluidigm Corporation Methods, systems and devices for multiple single-cell capturing and processing using microfluidics
EP2822689B1 (fr) 2012-03-08 2023-07-26 Cyvek, Inc. Particules micro-tubulaires pour analyses microfluidiques et procédés de fabrication
CA2874343C (fr) 2012-05-21 2021-11-09 Fluidigm Corporation Analyse de particules uniques de populations de particules
US20140200167A1 (en) 2012-08-01 2014-07-17 Nanomdx, Inc. Functionally integrated device for multiplex genetic identification
EP2881457B1 (fr) * 2012-08-03 2019-04-24 Sony Corporation Analyseur d'acide nucléique, micropuce pour l'analyse d'acide nucléique et procédé pour le montage d'une micropuce dans un dispositif
US10767219B2 (en) * 2014-03-11 2020-09-08 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making and using same
US9999100B2 (en) * 2015-04-07 2018-06-12 Cell Id Pte Ltd DC heater
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN108603224B (zh) 2015-12-16 2022-06-28 富鲁达公司 高水平多路复用扩增
WO2018057996A1 (fr) * 2016-09-23 2018-03-29 ArcherDX, Inc. Système fluidique et procédés associés
US20190224683A1 (en) 2016-09-29 2019-07-25 Qiagen Lake Constance Gmbh Sample container arrangement
CN111065463A (zh) * 2017-08-14 2020-04-24 基曼科技有限责任公司 液体分配装置
CN109406442B (zh) * 2018-10-30 2021-01-05 桂林电子科技大学 一种快速测量蛋白质热变性温度的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5241450A (en) * 1992-03-13 1993-08-31 The United States Of America As Represented By The United States Department Of Energy Three dimensional, multi-chip module
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
CA2410090A1 (fr) * 2000-06-15 2001-12-20 Irm, Llc Support de precision automatique
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6508988B1 (en) * 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6960437B2 (en) * 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
EP1975539A2 (fr) * 2001-10-29 2008-10-01 CHART HEAT EXCHANGERS Limited Partnership Échangeurs thermiques
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
JP4355210B2 (ja) * 2001-11-30 2009-10-28 フルイディグム コーポレイション 微小流体デバイスおよび微小流体デバイスの使用方法
US6893613B2 (en) * 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7452712B2 (en) * 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
AU2003291439A1 (en) * 2002-11-08 2004-06-03 Irm, Llc Apparatus and methods to process substrate surface features
AU2004228678A1 (en) * 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9373561B1 (en) 2014-12-18 2016-06-21 International Business Machines Corporation Integrated circuit barrierless microfluidic channel
US9385062B1 (en) 2014-12-18 2016-07-05 International Business Machines Corporation Integrated circuit barrierless microfluidic channel
US9502325B2 (en) 2014-12-18 2016-11-22 International Business Machines Corporation Integrated circuit barrierless microfluidic channel
KR102619157B1 (ko) 2016-01-21 2023-12-28 도쿄엘렉트론가부시키가이샤 약액 공급 장치 및 도포 현상 시스템

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