JP5499171B2 - ヨードプロパルギル化合物の製造方法 - Google Patents
ヨードプロパルギル化合物の製造方法 Download PDFInfo
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- JP5499171B2 JP5499171B2 JP2012526058A JP2012526058A JP5499171B2 JP 5499171 B2 JP5499171 B2 JP 5499171B2 JP 2012526058 A JP2012526058 A JP 2012526058A JP 2012526058 A JP2012526058 A JP 2012526058A JP 5499171 B2 JP5499171 B2 JP 5499171B2
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- Prior art keywords
- compound
- chlorine
- formula
- iodine
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- -1 iodopropargyl compound Chemical class 0.000 title claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 16
- 239000000460 chlorine Substances 0.000 claims abstract description 16
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 15
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 14
- 239000011630 iodine Substances 0.000 claims abstract description 14
- 229910001511 metal iodide Inorganic materials 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 239000003960 organic solvent Substances 0.000 claims description 8
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052794 bromium Inorganic materials 0.000 claims description 4
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 239000003125 aqueous solvent Substances 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 10
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 10
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical group CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 9
- 239000005708 Sodium hypochlorite Substances 0.000 description 9
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000002585 base Substances 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000007800 oxidant agent Substances 0.000 description 5
- JTDBXHIIVZZXDH-UHFFFAOYSA-N prop-2-ynyl n-butylcarbamate Chemical compound CCCCNC(=O)OCC#C JTDBXHIIVZZXDH-UHFFFAOYSA-N 0.000 description 5
- 239000012429 reaction media Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000026045 iodination Effects 0.000 description 4
- 238000006192 iodination reaction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- TVDSBUOJIPERQY-UHFFFAOYSA-N prop-2-yn-1-ol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 3
- 235000009518 sodium iodide Nutrition 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
- SHFJWMWCIHQNCP-UHFFFAOYSA-M hydron;tetrabutylazanium;sulfate Chemical compound OS([O-])(=O)=O.CCCC[N+](CCCC)(CCCC)CCCC SHFJWMWCIHQNCP-UHFFFAOYSA-M 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 239000012948 isocyanate Substances 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- 0 *NC(O*C*C#C)=O Chemical compound *NC(O*C*C#C)=O 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229910019093 NaOCl Inorganic materials 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000011111 cardboard Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000005068 cooling lubricant Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000012770 industrial material Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000011087 paperboard Substances 0.000 description 1
- 239000003444 phase transfer catalyst Substances 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- QBVXKDJEZKEASM-UHFFFAOYSA-M tetraoctylammonium bromide Chemical compound [Br-].CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC QBVXKDJEZKEASM-UHFFFAOYSA-M 0.000 description 1
- SNNIPOQLGBPXPS-UHFFFAOYSA-M tetraoctylazanium;chloride Chemical compound [Cl-].CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC SNNIPOQLGBPXPS-UHFFFAOYSA-M 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- IPILPUZVTYHGIL-UHFFFAOYSA-M tributyl(methyl)azanium;chloride Chemical compound [Cl-].CCCC[N+](C)(CCCC)CCCC IPILPUZVTYHGIL-UHFFFAOYSA-M 0.000 description 1
- UMMDBKGUDMBUSR-UHFFFAOYSA-M tris-decyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(CCCCCCCCCC)CCCCCCCCCC UMMDBKGUDMBUSR-UHFFFAOYSA-M 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
nは1〜6の整数である)
のヨードプロパルギル化合物の製造方法であって、
塩基の存在下、塩素を用いて、
式(II)
のプロパルギル化合物を、ヨウ素及び/又は金属ヨウ化物と反応させることを特徴とする方法を発見した。
5℃で、4.5gのC12〜C16−アルコールエトキシレート、16.9gのプロパルギルブチルカルバメート(0.107モル)、40.7gのNaI溶液(40%濃度、0.108モル)、及び25.8gのNaOH溶液(50%濃度、0.322モル)を初期仕込みとして、330gの水に添加する。次いで、温度が5℃未満を保つようにして、塩素(10.3g、0.145モル)を反応混合物にゆっくりと添加する。添加が完了したら、その混合物をゆっくりと20℃まで加熱し、この温度で4時間撹拌する。次いで、沈殿した固体をろ過により分離し、水で洗浄し、減圧下で乾燥させる。これにより、26.1gの3−ヨード−2−プロピニルN−ブチルカルバメート(純度:95.4%(HPLC)、ポリヨウ素化化合物:<0.1%(HPLC)、収率:83%)が得られる。
8℃で、10.1gの水酸化ナトリウム(0.244モル)及び19.0gのプロパルギルブチルカルバメート(0.122モル)を初期仕込みとして、48gのメタノール及び50gの水に添加する。この温度で、15.5gのヨウ素(0.061モル)を一部ずつ添加する。次いで、温度が8℃未満を保つようにして、塩素(5.6g、0.079モル)を、反応混合物にゆっくりと添加する。計量しての添加が完了したら、その混合物を、この温度で1時間撹拌し、次いで105gの水を添加する。沈殿した固体をろ過により分離し、水で洗浄し、減圧下で乾燥させる。これにより、28.5gの3−ヨード−2−プロピニルN−ブチルカルバメート(純度:95.0%(HPLC)、ポリヨウ素化化合物:0.3%(HPLC)、収率:79%)が得られる。
5℃で、19.0gのプロパルギルブチルカルバメート(0.122モル)、12.2gの水酸化ナトリウム(0.305モル)、及び18.5gのヨウ化ナトリウム(0.123モル)を初期仕込みとして、50gの水及び48gのメタノールに添加する。次いで、温度が5℃未満を保つようにして、塩素(11.7g、0.165モル)をゆっくりと添加する。計量添加が完了したら、その混合物をこの温度で1時間撹拌し、次いで、ゆっくりと室温まで加熱し、1時間撹拌する。100gの水を添加した後、沈殿した固体をろ過により分離し、水で洗浄し、減圧下で乾燥させる。これにより、29.1gの3−ヨード−2−プロピニルN−ブチルカルバメート(純度:94.7%(HPLC)、ポリヨウ素化化合物:<0.1%(HPLC)、収率:80%)を得る。
Claims (2)
- 式(I)
・C 2 〜C 20 −アルケニル、C 6 〜C 20 −アリール、又はC 3 〜C 20 −シクロアルキルに対して、塩素、臭素、フッ素、メトキシ、エトキシ、ジメチルアミノ、メトキシカルボニル、エトキシカルボニル、ヒドロキシ、又はアシル、あるいは
・C 1 〜C 20 −アルキルに対して、塩素、臭素、フッ素、メトキシ、エトキシ、ジメチルアミノ、メトキシカルボニル、エトキシカルボニル、ヒドロキシ、アシル又はフェニル
から選択される置換基により置換された、C1〜C20−アルキル、C2〜C20−アルケニル、C6〜C20−アリール、又はC3〜C20−シクロアルキルであり、
nは1〜6の整数である)
のヨードプロパルギル化合物の製造方法であって、
塩基の存在下で、塩素を用いて、
式(II)
のプロパルギル化合物を、ヨウ素及び/又は金属ヨウ化物と反応させることを特徴とする方法。 - 前記反応を、少なくとも1種の有機溶剤を含む水性溶媒中で実施することを特徴とする、請求項1に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09169055.2 | 2009-08-31 | ||
EP09169055A EP2289873B1 (de) | 2009-08-31 | 2009-08-31 | Verfahren zur Herstellung von Iodpropargylverbindungen |
PCT/EP2010/062470 WO2011023757A1 (de) | 2009-08-31 | 2010-08-26 | Verfahren zur herstellung von iodpropargylverbindungen |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013503137A JP2013503137A (ja) | 2013-01-31 |
JP5499171B2 true JP5499171B2 (ja) | 2014-05-21 |
Family
ID=41152014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012526058A Expired - Fee Related JP5499171B2 (ja) | 2009-08-31 | 2010-08-26 | ヨードプロパルギル化合物の製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8748652B2 (ja) |
EP (2) | EP2289873B1 (ja) |
JP (1) | JP5499171B2 (ja) |
AT (1) | ATE544746T1 (ja) |
DK (1) | DK2289873T3 (ja) |
ES (1) | ES2379216T3 (ja) |
PL (1) | PL2289873T3 (ja) |
PT (1) | PT2289873E (ja) |
WO (1) | WO2011023757A1 (ja) |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923870A (en) | 1973-07-11 | 1975-12-02 | Troy Chemical Corp | Urethanes of 1-halogen substituted alkynes |
JPS55100354A (en) * | 1979-01-22 | 1980-07-31 | Ici Ltd | Manufacture of iodoalkynylcarbamate |
EP0014032B1 (en) | 1979-01-22 | 1983-03-23 | Imperial Chemical Industries Plc | Process for the preparation of iodoalkynyl carbamates |
FR2461973A1 (fr) * | 1979-07-16 | 1981-02-06 | Solvay | Procede et installation pour la fabrication de solutions aqueuses d'hypochlorite de metal alcalin |
CA2066096A1 (en) * | 1991-04-16 | 1992-10-17 | Atsushi Utsunomiya | Process for the preparation of iodoalkynyl carbamates |
JP3190105B2 (ja) * | 1991-04-16 | 2001-07-23 | 三井化学株式会社 | ヨードアルキニルカーバメイトの製造方法 |
JPH09110820A (ja) * | 1995-10-17 | 1997-04-28 | Mitsui Toatsu Chem Inc | ヨードアルキニルカーバメイトの製造方法 |
US5919992A (en) * | 1996-06-11 | 1999-07-06 | Lonza, Inc. | Synthesis of haloalkynol |
US5693849A (en) | 1996-10-30 | 1997-12-02 | Troy Corporation | Aqueous synthesis of iodopropargyl carbamate |
JP2000256300A (ja) * | 1999-03-15 | 2000-09-19 | Mitsui Chemicals Inc | ヨードアルキニルカーバメートの製造方法 |
EP1651593A4 (en) | 2003-08-04 | 2007-06-13 | H & S Chemical Company Inc | METHOD FOR SYNTHESIZING IODOPROPYNYL BUTYLCARBAMATE IN AQUEOUS SOLUTION OF APPROPRIATE SURFACTANT |
-
2009
- 2009-08-31 ES ES09169055T patent/ES2379216T3/es active Active
- 2009-08-31 PT PT09169055T patent/PT2289873E/pt unknown
- 2009-08-31 PL PL09169055T patent/PL2289873T3/pl unknown
- 2009-08-31 DK DK09169055.2T patent/DK2289873T3/da active
- 2009-08-31 EP EP09169055A patent/EP2289873B1/de active Active
- 2009-08-31 AT AT09169055T patent/ATE544746T1/de active
-
2010
- 2010-08-26 EP EP10745647A patent/EP2473481A1/de not_active Withdrawn
- 2010-08-26 US US13/390,707 patent/US8748652B2/en active Active
- 2010-08-26 JP JP2012526058A patent/JP5499171B2/ja not_active Expired - Fee Related
- 2010-08-26 WO PCT/EP2010/062470 patent/WO2011023757A1/de active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP2289873B1 (de) | 2012-02-08 |
PL2289873T3 (pl) | 2012-04-30 |
ATE544746T1 (de) | 2012-02-15 |
JP2013503137A (ja) | 2013-01-31 |
PT2289873E (pt) | 2012-03-22 |
US8748652B2 (en) | 2014-06-10 |
ES2379216T3 (es) | 2012-04-23 |
DK2289873T3 (da) | 2012-05-14 |
WO2011023757A1 (de) | 2011-03-03 |
EP2473481A1 (de) | 2012-07-11 |
EP2289873A1 (de) | 2011-03-02 |
US20120330051A1 (en) | 2012-12-27 |
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