JP5495608B2 - 寄生虫症の治療または予防効果を有するクルクミン類縁体 - Google Patents
寄生虫症の治療または予防効果を有するクルクミン類縁体 Download PDFInfo
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- JP5495608B2 JP5495608B2 JP2009098878A JP2009098878A JP5495608B2 JP 5495608 B2 JP5495608 B2 JP 5495608B2 JP 2009098878 A JP2009098878 A JP 2009098878A JP 2009098878 A JP2009098878 A JP 2009098878A JP 5495608 B2 JP5495608 B2 JP 5495608B2
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- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 239000006218 nasal suppository Substances 0.000 description 1
- 230000013649 negative regulation of histone acetylation Effects 0.000 description 1
- 229960002644 nifurtimox Drugs 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
- 229960004448 pentamidine Drugs 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 230000000654 trypanocidal effect Effects 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
項1
一般式(1):
ビス(アリールメチリデン)アセトン化合物又はその塩が、(1E,4E)-1,5-ジフェニルペンタジエン-3-オン(GO-Y012)、(1E,4E)-1,5-ビス-(4-メトキシフェニル)ペンタジエン-3-オン(GO-Y013)、(1E,4E)-1,5-ビス-(2,3-ジメトキシフェニル)ペンタジエン-3-オン(GO-Y015)、(1E,4E)-1,5-ビス-(2-クロロフェニル)ペンタジエン-3-オン(GO-Y017)、(1E,4E)-1,5-ビス-(4-プロモフェニル)ペンタジエン-3-オン(GO-Y018)、(1E,4E)-1,5-ビス-(2-メトキシフェニル)ペンタジエン-3-オン(GO-Y019)、(1E,4E)-1,5-ビス-(2,3,4-トリメトキシフェニル)ペンタジエン-3-オン(GO-Y020)、(1E,4E)-1,5-ビス-(2,4,5-トリメトキシフェニル)ペンタジエン-3-オン(GO-Y021)、(1E,4E)-1,5-ビス-(3-ヒドロキシ-4-メトキシフェニル)ペンタジエン-3-オン(GO-Y023)、(1E,4E)-1,5-ビス-(4-ヒドロキシ-3,5-ジメトキシフェニル)ペンタジエン-3-オン(GO-Y026)、(1E,4E)-1,5-ビス-(3,5-ビスメトキシメトキシ)フェニルペンタジエン-3-オン(GO-Y030,BDMMMPP)、(1E,4E)-1,5-ビス-(3,5-ジメトキシ-4-メトキシメトキシフェニル)ペンタジエン-3-オン(GO-Y031,BBMMPP)、(1E,4E)-1,5-ビス-(3-ニトロフェニル)-ペンタ-1,4-ジエン-3-オン(GO-Y035)、(1E,4E)-1,5-ビス-(3,5-ジヒドロキシフェニル)ペンタジエン-3-オン(GO-YO38)、(1E,4E)-1,5-ビス-(3,5-ジメトキシ-4-メトキシエトキシメトキシフェニル)ペンタジエン-3-オン(GO-Y039)、(1E,4E)-1,5-ビス-(3,4-ビスメトキシメトキシフェニル)ペンタジエン-3-オン(GO-Y040)、(1E,4E)-1,5-ビス-[4-(2-ヒドロキシエトキシ)-3,5-ジメトキシフェニル]ペンタジエン-3-オン(GO-Y044)、(1E,4E)-1-(3,4-ジメトキシフェニル)-5-(3,4,5-トリメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y046)、(1E,4E)-1-(3,4-ジメトキシフェニル)-5-(4-メトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y047)、(1E,4E)-1,5-ビス-(3,5-ジメトキシ-4-プロピ-2-イニロキシフェニル)ペンタジエン-3-オン(GO-Y048)、(1E,4E)-1-(4-メトキシフェニル)-5-(3,4,5-トリメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y049)、(1E,4E)-5-(3,4-ジメトキシフェニル)-1-(3-ヒドロキシ-4-メトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y050)、(1E,4E)-5-(3,4-ジメトキシフェニル)-1-(4-ヒドロキシ-3-メトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y051)、(1E,4E)-5-(3,4-ジメトキシフェニル)-1-[3-(1-エトキシエトキシ)-4-メトキシフェニル]ペンタ-1,4-ジエン-3-オン(GO-Y052)、(1E,4E)-5-(3,4-ジメトキシフェニル)-1-[4-(1-エトキシエトキシ)-3-メトキシフェニル]ペンタ-1,4-ジエン-3-オン(GO-Y053)、(1E,4E)-1-(4-ヒドロキシ-3-メトキシフェニル)-5-(3-メトキシ-4-メトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y055)、(1E,4E)-1-(3-ヒドロキシ-4-メトキシフェニル)-5-(3-メトキシ-4-メトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y056)、(1E,4E)-1-[3-(1-エトキシエトキシ)-4-メトキシフェニル]-5-(3-メトキシ-4-メトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y057)、(1E,4E)-1-[4-(1-エトキシエトキシ)-3-メトキシフェニル]-5-(3-メトキシ-4-メトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y058)、(1E,4E)-1-(3,5-ジメトキシ-4-プロピ-2-イニロキシフェニル)-5-(3,4,5-トリメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y060)、(1E,4E)-1-(3,5-ビス-メトキシメトキシフェニル)-5-(3,5-ジメトキシ-4-プロピ-2-イニロキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y062)、(1E,4E)-1-(3,5-ジメトキシ-4-メトキシメトキシフェニル)-5-(3,5-ジメトキシ-4-プロピ-2-イニロキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y063)、(1E,4E)-1,5-ビス-[4-(2-アジドエトキシ)-3,5-ジメトキシフェニル]ペンタ-1,4-ジエン-3-オン(GO-Y065)、(1E,4E)-1,5-ビス-(3,5-ジメトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y067)、(1E,4E)-1,5-ビス-(3,4-ビスメトキシメトキシ)フェニルペンタジエン-3-オン(GO-035)、(1E,4E)-1,5-ビス-ベンゾ[1,3]ジオキソール-5-イルペンタ-1,4-ジエン-3-オン(GO-949)、(1E,4E)-1,5-ジナフタレン-2-イルペンタ-1,4-ジエン-3-オン(GO-Y011)、(1E,4E)-1,5-ビス-(4-ヒドロキシ-3-メトキシフェニル)ペンタジエン-3-オン(GO-Y022)、(1E,4E)-1,5-ビス-(3-ブロモ-5-メトキシフェニル)ペンタジエン-3-オン(GO-Y033)及びその塩からなる群から選択されたものであることを特徴とする項1に記載の治療薬または予防薬。
である。更に好ましい化合物は、(1E,4E)-1,5-ビス-(2,3-ジメトキシフェニル)ペンタジエン-3-オン(GO-Y015)、(1E,4E)-1,5-ビス-(3-ヒドロキシ-4-メトキシフェニル)ペンタジエン-3-オン(GO-Y023)、(1E,4E)-1,5-ビス-(3,5-ジヒドロキシフェニル)ペンタジエン-3-オン(GO-Y038)、(1E,4E)-5-(3,4-ジメトキシフェニル)-1-(3-ヒドロキシ-4-メトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y050)、(1E,4E)-5-(3,4-ジメトキシフェニル)-1-[3-(1-エトキシエトキシ)-4-メトキシフェニル]ペンタ-1,4-ジエン-3-オン(GO-Y052)、(1E,4E)-1-(3-ヒドロキシ-4-メトキシフェニル)-5-(3-メトキシ-4-メトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y056)、または(1E,4E)-1-[3-(1-エトキシエトキシ)-4-メトキシフェニル]-5-(3-メトキシ-4-メトキシメトキシフェニル)ペンタ-1,4-ジエン-3-オン(GO-Y057)である。
1)賦形剤の例:乳糖、デンプン(含トウモロコシデンプン)、結晶セルロース、微結晶セルロース、結晶セルロース・カロメロースナトリウム、デキストリン、白糖、ブドウ糖、マンニトール、炭酸カルシウム、リン酸カルシウム、硫酸カルシウム、ケイ酸カルシウム、クロスポビドン、乾燥酵母、大豆油不けん化物。
2)結合剤の例:ヒドロキシプロピルセルロース(HPC)、デンプン(含トウモロコシデンプン)、ゼラチン、アラビアゴム、メチルセルロース(MC)、カルボキシメチルセルロース(CMC)、ポリビニルピロリドン(PVP)、エチルセルロース(EC)、ブドウ糖および白糖。
3)崩壊剤の例:デンプン(含トウモロコシデンプン)、寒天、ゼラチン、CMC-Na、CMC-Ca、結晶セルロース、結晶セルロース・カロメロースナトリウム、低置換度HPC、クロスポビドン、炭酸カルシウム、炭酸水素ナトリウム。
4)滑沢剤の例:ステアリン酸マグネシウム、水素添加植物油、タルク、マクロゴール、軽質無水ケイ酸。
5)コーティング剤の例:白糖、HPC、セラック、ゼラチン、グリセリン、ソルビトール、EC、HPC、ヒドロキシプロピルメチルセルロース(HPMC)、PVP、セルロースアセテートフタレート(CAP)、ヒドロキシプロピルメチルセルロースフタレート(HPMCP)、メチルメタアクリレート−メタアクリル酸共重合体、酸化チタン。
(クルクミン類縁体の作製)
実施例に用いたクルクミン類縁体である、GO-Y015、GO-Y023、GO-Y038、GO-Y050、GO-Y052、GO-Y056、およびGO-Y057は特許文献1の記載に基づいて作製した。各化合物の分子式、構造式、計算分子量、及び質量分析による分子量を、図1に示す。また、対照実験としてトリパノソーマ症の第1ステージに対して効果を有するスラミン(Suramin;商品名ゲルマニン(バイエル社、登録商標))および第2ステージに対して効果を有するエフロールニチン(Eflornithine;商品名オルニジル(アベンティスファーマ、登録商標))を比較実験例として用いた。
トリパノソーマ原虫で、ナガナ病の起因原虫(Trypanosoma brucei brucei)のGUTat 3.1株を用い、in vitro薬剤感受性試験を行った。培地として10%非働化牛胎児血清及び種々の補給剤添加したIMDM培地を用い、培養条件は5% CO2、95% air中、37℃下で該実験を行った。すなわち、前培養した原虫浮遊液を原虫数2.0〜2.5×104 個/mLに調整し、96ウェル培養プレートにそれぞれ95 μLずつ分注し、上記クルクミン、クルクミン類縁体化合物、スラミン、およびエフロールニチン溶液を各ウェルにそれぞれ5 μLを添加して72時間培養した。その後、各ウェルにAlamar Blue試薬を10 μLを添加して混和して3〜6時間培養した後に、蛍光マイクロプレートリーダーにて励起波長528 nm(半値幅20 nm)、蛍光波長590 nm(半値幅35nm)での蛍光強度を測定することにより、原虫の増殖の有無を比色定量した。原虫の増殖阻害活性(IC50)は、化合物濃度作用曲線より算出した。
Claims (1)
- (1E,4E)−1,5−ビス−(2,3−ジメトキシフェニル)ペンタジエン−3−オン(GO−Y015)、(1E,4E)−1,5−ビス−(3−ヒドロキシ−4−メトキシフェニル)ペンタジエン−3−オン(GO−Y023)、(1E,4E)−1,5−ビス−(3,5−ジヒドロキシフェニル)ペンタジエン−3−オン(GO−YO38)、(1E,4E)−5−(3,4−ジメトキシフェニル)−1−(3−ヒドロキシ−4−メトキシフェニル)ペンタ−1,4−ジエン−3−オン(GO−Y050)、(1E,4E)−5−(3,4−ジメトキシフェニル)−1−[3−(1−エトキシエトキシ)−4−メトキシフェニル]ペンタ−1,4−ジエン−3−オン(GO−Y052)、(1E,4E)−1−(3−ヒドロキシ−4−メトキシフェニル)−5−(3−メトキシ−4−メトキシメトキシフェニル)ペンタ−1,4−ジエン−3−オン(GO−Y056)、(1E,4E)−1−[3−(1−エトキシエトキシ)−4−メトキシフェニル]−5−(3−メトキシ−4−メトキシメトキシフェニル)ペンタ−1,4−ジエン−3−オン(GO−Y057)、及びそれらの塩からなる群から選択されたものを有効成分とすることを特徴とするトリパノソーマ属またはプラスモディウム属に属する原虫によって引き起こされる疾病に対する、治療薬または予防薬。
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