JP5480812B2 - アイメリアに対する免疫応答を強化する組成物および方法 - Google Patents
アイメリアに対する免疫応答を強化する組成物および方法 Download PDFInfo
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Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL170938B1 (pl) | 1991-03-05 | 1997-02-28 | Wellcome Found | Sposób wytwarzania szczepionki przeciwko infekcjom Salmonella PL PL |
| US5962406A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| US7405270B2 (en) | 1991-10-25 | 2008-07-29 | Immunex Corporation | CD40-Ligand lacking native-pattern glycosylation |
| CA2121798C (en) | 1991-10-25 | 2007-07-24 | Richard J. Armitage | Novel cytokine |
| US5981724A (en) | 1991-10-25 | 1999-11-09 | Immunex Corporation | DNA encoding CD40 ligand, a cytokine that binds CD40 |
| US5961974A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same |
| CA2143299A1 (en) | 1992-09-04 | 1994-03-17 | Brenda J. Allan | Novel bacterial vaccines using vaccine strains of pathogenic bacteria |
| US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
| JP4242447B2 (ja) * | 1993-01-22 | 2009-03-25 | イミュネックス・コーポレーション | Cd40リガンド遺伝子の突然変異の検出および治療 |
| AU1059095A (en) | 1993-11-24 | 1995-06-13 | Australian National University, The | Treatment of viral disease with cd40l peptide |
| CA2188165C (en) * | 1994-04-28 | 2007-08-28 | Marilyn Kehry | Methods for proliferating and differentiating b cells, and uses thereof |
| NZ305083A (en) | 1995-03-01 | 1999-06-29 | Immunex Corp | Use of cd40 binding proteins (a cd40 ligand or monoclonal antibody that specifically binds to cd40) for stimulating a immune response |
| CA2222914C (en) | 1995-06-07 | 2002-04-02 | Immunex Corporation | Novel cd40l mutein |
| US6713279B1 (en) | 1995-12-07 | 2004-03-30 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
| US6479258B1 (en) | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
| US6306387B1 (en) | 1997-05-29 | 2001-10-23 | The Research Foundation Of State University Of New York | Antigen delivery system |
| US20030045492A1 (en) | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
| US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| CA2223225A1 (en) | 1997-11-28 | 1999-05-28 | Canadian Red Cross Society | Method for inhibiting in vivo immune response |
| CA2313805A1 (en) | 1997-12-19 | 1999-07-01 | Immunex Corporation | Method for reducing susceptibility to hiv infection |
| GB9806449D0 (en) | 1998-03-25 | 1998-05-27 | Peptide Therapeutics Ltd | Attenuated bacteria useful in vaccines |
| US6190669B1 (en) | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
| CA2341349C (en) | 1998-09-04 | 2013-12-10 | Creatogen Aktiengesellschaft | Attenuated cells comprising sp12 mutants, carriers and compositions containing same, methods of production and uses thereof |
| US7300774B1 (en) | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
| EP1067194A1 (en) | 1999-04-16 | 2001-01-10 | F. Hoffmann-La Roche Ag | Vectors containing a gene coding for CD40 and/or CD40L under the control of a cytokine-inducible promoter which is a human acute phase amyloid A gene promoter. Methods for their production and uses thereof |
| JP2003508016A (ja) | 1999-04-16 | 2003-03-04 | エフ.ホフマン−ラ ロシュ アーゲー | Cd40/cd40lキメラポリペプチドをコードする核酸、それらの生成方法及びそれらの使用 |
| US7803765B2 (en) * | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| US7118751B1 (en) * | 1999-10-14 | 2006-10-10 | Trubion Pharmaceuticals, Inc. | DNA vaccines encoding antigen linked to a domain that binds CD40 |
| PT1112747E (pt) | 1999-12-28 | 2004-10-29 | Akzo Nobel Nv | Vacina de salmonella que nao induz anticorpos contra flagelina ou flagelos |
| CA2399790C (en) | 2000-02-02 | 2012-10-30 | Ralph A. Tripp | Cd40 ligand adjuvant for respiratory syncytial virus |
| NZ521425A (en) | 2000-03-17 | 2004-05-28 | Upjohn Co | Vaccine comprising a first attenuated non-reverting mutant Salmonella in which two or more secretion system apparatus genes have been inactivated |
| GB0015426D0 (en) | 2000-06-24 | 2000-08-16 | Univ Southampton | Method for generating soluble highly multimeric proteins |
| WO2002000232A2 (en) | 2000-06-26 | 2002-01-03 | Maxygen, Inc. | Methods and compositions for developing spore display systems for medicinal and industrial applications |
| WO2002036769A2 (en) | 2000-10-31 | 2002-05-10 | F. Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| US6855493B2 (en) * | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| ES2329453T3 (es) | 2001-05-15 | 2009-11-26 | Ortho Mcneil Janssen Pharm | Cebado ex-vivo para generar linfocitos t citotoxicos especificos del ligando cd40 para tratar enfermedades autoinmunitarias y alergicas. |
| ZA200400479B (en) * | 2001-07-06 | 2006-05-31 | Abic Biolog Lab Teva | Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use |
| DE60235044D1 (de) * | 2001-07-06 | 2010-02-25 | Abic Biolog Lab Ltd | REKOMBINANTES, 250 kDa GROSSES ANTIGEN AUS SPOROZOITEN/MEROZOITEN VON EIMERIA MAXIMA CODIERENDE NUKLEINSÄUREN UND IHRE VERWENDUNGEN |
| ITMI20011986A1 (it) | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
| WO2003028441A1 (en) | 2001-10-02 | 2003-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Gene therapy for the prevention of autoimmune disease |
| MXPA04005909A (es) * | 2001-12-21 | 2005-05-17 | Immunex Corp | Polipeptidos recombinantes. |
| AU2003215254A1 (en) * | 2002-02-13 | 2003-09-04 | Immunology Laboratories, Inc. | Compositions and methods for treatment of microbial infections |
| US6923958B2 (en) | 2002-03-02 | 2005-08-02 | The Scripps Research Institute | DNA vaccines encoding CEA and a CD40 ligand and methods of use thereof |
| WO2003096812A1 (en) | 2002-04-15 | 2003-11-27 | Washington University | Regulated attenuation of live vaccines to enhance cross protective immunogenicity |
| US7495090B2 (en) | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
| US20060014248A1 (en) | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
| US20050181994A1 (en) | 2003-01-06 | 2005-08-18 | Xencor, Inc. | Novel variants of CD40L protein |
| US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| WO2005035570A2 (en) | 2003-10-10 | 2005-04-21 | Xencor, Inc. | Variants of cd40l protein |
| US8828957B2 (en) | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
| CA2548347A1 (en) | 2003-12-11 | 2005-06-30 | Sidney Kimmel Cancer Center | Methods for generating immunity to antigen |
| WO2005113598A2 (en) | 2004-05-21 | 2005-12-01 | Xencor, Inc. | Tnf super family members with altered immunogenicity |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| KR101243577B1 (ko) | 2004-10-07 | 2013-03-20 | 아고스 쎄라퓨틱스, 인코포레이티드 | 성숙 수지상 세포 조성물 및 그의 배양 방법 |
| WO2006105972A1 (en) | 2005-04-07 | 2006-10-12 | Universite Libre De Bruxelles | Transgenic organism expressing cd40l and uses thereof |
| WO2006130525A2 (en) | 2005-05-31 | 2006-12-07 | Sidney Kimmel Cancer Center | Methods for immunotherapy of cancer |
| DE602006014720D1 (de) | 2005-10-07 | 2010-07-15 | Proyecto Biomedicina Cima Sl | Immunstimulatorische kombination zur vorbeugung und behandlung von hepatitis c |
| JP2009514536A (ja) | 2005-11-07 | 2009-04-09 | シドニー キンメル キャンサー センター | Cd40リガンド融合蛋白質ワクチン |
| DE102005054643B3 (de) | 2005-11-10 | 2007-02-15 | Assa Abloy Sicherheitstechnik Gmbh | Schließzylinder |
| WO2007054658A1 (en) | 2005-11-14 | 2007-05-18 | King's College London | Control of immune responses |
| CU23576A1 (es) * | 2006-02-28 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Antígenos vacunales quiméricos contra el virus de la influenza aviar |
| WO2007103048A2 (en) | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| US8802419B2 (en) | 2006-03-02 | 2014-08-12 | University Of Massachusetts | Modified pathogens for use as vaccines |
| FR2898905B1 (fr) * | 2006-03-24 | 2008-05-09 | Rhodia Recherches & Tech | Composition polyisocyanate a proprietes anti-chocs ameliorees |
| US20090246220A1 (en) * | 2006-08-28 | 2009-10-01 | Ertl Hildegund C J | Constructs for enhancing immune responses |
| ES2520026T3 (es) | 2006-09-18 | 2014-11-11 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para potenciar respuestas inmunitarias |
| US20100292309A1 (en) | 2007-03-08 | 2010-11-18 | Mayo Foundation For Medical Education And Research | Inducing immune-mediated tumor cell death |
| CN101024076B (zh) * | 2007-03-29 | 2010-08-18 | 中国农业大学 | 球虫的新用途 |
| CA2963124C (en) * | 2007-07-10 | 2019-10-15 | Apogenix Ag | Tnf superfamily collectin fusion proteins |
| BRPI0818736A2 (pt) | 2007-10-30 | 2017-06-13 | Univ Arkansas | composições e métodos para intensificar imunorrepostas à bactéria flagelada |
| CN101969990B (zh) * | 2007-11-01 | 2014-07-09 | 阿肯色大学评议会 | 增强针对艾美球虫属的免疫反应的组合物和方法 |
| PL2310509T3 (pl) * | 2008-07-21 | 2015-08-31 | Apogenix Ag | Jednołańcuchowe cząsteczki TNFSF |
| US8316310B2 (en) | 2008-08-05 | 2012-11-20 | International Business Machines Corporation | System and method for human identification proof for use in virtual environments |
| EP2184229B1 (en) * | 2008-11-11 | 2012-10-17 | AGUSTAWESTLAND S.p.A. | Helicopter rotor |
| US20100150958A1 (en) * | 2008-12-15 | 2010-06-17 | Vectogen Pty Ltd. | Methods and Compositions for Use of a Coccidiosis Vaccine |
| CN102811734B (zh) * | 2010-01-21 | 2016-02-10 | 阿肯色大学评议会 | 增强免疫应答的疫苗载体和方法 |
| SG10201707813YA (en) * | 2011-10-11 | 2017-11-29 | Medimmune Llc | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
| WO2014043215A1 (en) * | 2012-09-11 | 2014-03-20 | The Texas A&M University System | Bi-specifc diabodies for masking and targeting vaccines |
| DK2911676T3 (da) * | 2012-10-29 | 2020-08-03 | Univ Arkansas | Hidtil ukendte mukosale adjuvanser og afgivelsessystemer |
| US9603915B2 (en) * | 2013-02-14 | 2017-03-28 | The Board of Trustees of the University of Akansas | Compositions and methods of enhancing immune responses to Eimeria or limiting Eimeria infection |
| BR112015023024B1 (pt) * | 2013-03-15 | 2022-04-19 | The Board Of Trustees Of The University Of Arkansas | Vetor de vacina e composições farmacêuticas compreendendo o mesmo |
| US20170196971A1 (en) * | 2014-06-05 | 2017-07-13 | The Board Of Trustees Of The University Of Arkansas | Antibody guided vaccines and methods of use for generation of rapid mature immune responses |
| US20160090603A1 (en) * | 2014-09-30 | 2016-03-31 | Sandia Corporation | Delivery platforms for the domestication of algae and plants |
| AU2017244108B2 (en) * | 2016-03-29 | 2021-03-18 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| SG10201914132RA (en) * | 2016-05-27 | 2020-03-30 | Abbvie Biotherapeutics Inc | Anti-cd40 antibodies and their uses |
| CN109803977B (zh) * | 2016-08-17 | 2023-03-17 | 菲克特生物科学股份有限公司 | 核酸产品及其施用方法 |
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