CA2704422C - Compositions and methods of enhancing immune responses to eimeria - Google Patents

Compositions and methods of enhancing immune responses to eimeria Download PDF

Info

Publication number
CA2704422C
CA2704422C CA2704422A CA2704422A CA2704422C CA 2704422 C CA2704422 C CA 2704422C CA 2704422 A CA2704422 A CA 2704422A CA 2704422 A CA2704422 A CA 2704422A CA 2704422 C CA2704422 C CA 2704422C
Authority
CA
Canada
Prior art keywords
vaccine
seq
polypeptide
subject
trap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2704422A
Other languages
English (en)
French (fr)
Other versions
CA2704422A1 (en
Inventor
Walter Bottje
Billy Hargis
Luc Berghman
Young Min Kwon
Kimberly Cole
Mandy Cox
Sherryll Layton
Said El-Ashram
John Barta
Guillermo Tellez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Guelph
Texas A&M University
University of Arkansas at Little Rock
Original Assignee
University of Guelph
Texas A&M University
University of Arkansas at Little Rock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Guelph, Texas A&M University, University of Arkansas at Little Rock filed Critical University of Guelph
Priority to CA3051748A priority Critical patent/CA3051748C/en
Publication of CA2704422A1 publication Critical patent/CA2704422A1/en
Application granted granted Critical
Publication of CA2704422C publication Critical patent/CA2704422C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/455—Eimeria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA2704422A 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria Active CA2704422C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3051748A CA3051748C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98461207P 2007-11-01 2007-11-01
US60/984,612 2007-11-01
PCT/US2008/082254 WO2009059298A2 (en) 2007-11-01 2008-11-03 Compositions and methods of enhancinc immune responses to eimeria

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3051748A Division CA3051748C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria

Publications (2)

Publication Number Publication Date
CA2704422A1 CA2704422A1 (en) 2009-05-07
CA2704422C true CA2704422C (en) 2019-09-24

Family

ID=40591796

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2704422A Active CA2704422C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria
CA3156538A Active CA3156538C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria
CA3051748A Active CA3051748C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3156538A Active CA3156538C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria
CA3051748A Active CA3051748C (en) 2007-11-01 2008-11-03 Compositions and methods of enhancing immune responses to eimeria

Country Status (14)

Country Link
US (3) US8956849B2 (enExample)
EP (2) EP3097926B1 (enExample)
JP (1) JP5480812B2 (enExample)
CN (2) CN101969990B (enExample)
AU (1) AU2008318357B2 (enExample)
BR (1) BRPI0819229B1 (enExample)
CA (3) CA2704422C (enExample)
DK (2) DK2214701T3 (enExample)
ES (2) ES2761693T3 (enExample)
HU (2) HUE047164T2 (enExample)
NZ (2) NZ601880A (enExample)
PL (2) PL2214701T3 (enExample)
PT (2) PT3097926T (enExample)
WO (1) WO2009059298A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101522210B (zh) * 2006-09-18 2017-03-22 阿肯色大学评议会 增强免疫应答的组合物和方法
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
WO2009059018A1 (en) 2007-10-30 2009-05-07 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to flagellated bacterium
EP3097926B1 (en) * 2007-11-01 2019-10-02 The Board of Trustees of the University of Arkansas Compositions and methods of enhancing immune responses to eimeria
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
KR101638661B1 (ko) 2010-01-21 2016-07-11 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 백신 벡터 및 면역 반응을 강화시키는 방법
PL2579901T3 (pl) * 2010-06-09 2020-02-28 The Board Of Trustees Of The University Of Arkansas Szczepionka i sposoby ograniczania infekcji campylobacter
AU2013203641B2 (en) * 2011-04-13 2014-08-21 Epizyme, Inc. Aryl-or heteroaryl-substituted benzene compounds
US9580482B2 (en) 2012-02-17 2017-02-28 Children's Medical Center Corporation Conformation-stabilized TRAP antigens
BR112015019283B1 (pt) * 2013-02-14 2023-12-19 The Board Of Trustees Of The University Of Arkansas Composições e métodos de aprimoramento de respostas imunes à eiméria ou infecção por eiméria limitadora
MY173901A (en) 2013-03-15 2020-02-26 Texas A & M Univ Sys Compositions and methods of enhancing immune responses to enteric pathogens
US10647946B2 (en) 2015-05-08 2020-05-12 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
BR112018072592A2 (pt) 2016-05-03 2019-04-16 The Board Of Trustees Of The University Of Arkansas vetor de vacina de levedura que inclui polipeptídeos imunoestimulantes e antigênicos, e métodos de uso dos mesmos
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN110468069B (zh) * 2019-08-19 2020-11-06 中国水产科学研究院长江水产研究所 一种干酪乳杆菌yfi-5及其在抗鲤疱疹病毒ii型中的应用
CN113304254A (zh) * 2021-06-07 2021-08-27 吉林大学 一种微小隐孢子虫Cp15重组侵入型乳酸菌活载体疫苗

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU664360B2 (en) 1991-03-05 1995-11-16 Wellcome Foundation Limited, The Expression of recombinant proteins in attenuated bacteria
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
US5961974A (en) * 1991-10-25 1999-10-05 Immunex Corporation Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same
US7405270B2 (en) 1991-10-25 2008-07-29 Immunex Corporation CD40-Ligand lacking native-pattern glycosylation
US5962406A (en) 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5981724A (en) 1991-10-25 1999-11-09 Immunex Corporation DNA encoding CD40 ligand, a cytokine that binds CD40
EP0897983B1 (en) 1991-10-25 2003-05-07 Immunex Corporation Antibody against CD40-L
WO1994005326A1 (en) 1992-09-04 1994-03-17 University Of Saskatchewan Novel bacterial vaccines using vaccine strains of pathogenic bacteria
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
JP4242447B2 (ja) * 1993-01-22 2009-03-25 イミュネックス・コーポレーション Ｃｄ４０リガンド遺伝子の突然変異の検出および治療
AU1059095A (en) 1993-11-24 1995-06-13 Australian National University, The Treatment of viral disease with cd40l peptide
JP3881691B2 (ja) * 1994-04-28 2007-02-14 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｂ細胞の増殖方法及び分化方法並びにその使用
ATE220331T1 (de) 1995-03-01 2002-07-15 Immunex Corp Cd40 bindendes protein zur stimulierung der immunantwort
DE69631331T2 (de) 1995-06-07 2004-11-18 Immunex Corp., Seattle Cd40l mutein
US6479258B1 (en) 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6306387B1 (en) 1997-05-29 2001-10-23 The Research Foundation Of State University Of New York Antigen delivery system
US20030045492A1 (en) 1997-08-13 2003-03-06 Tang De-Chu C. Vaccination by topical application of recombinant vectors
US6969609B1 (en) 1998-12-09 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Serivces Recombinant vector expressing multiple costimulatory molecules and uses thereof
CA2223225A1 (en) 1997-11-28 1999-05-28 Canadian Red Cross Society Method for inhibiting in vivo immune response
AU2004199A (en) 1997-12-19 1999-07-12 Immunex Corporation Method for reducing susceptibility to hiv infection
GB9806449D0 (en) 1998-03-25 1998-05-27 Peptide Therapeutics Ltd Attenuated bacteria useful in vaccines
US6190669B1 (en) 1998-05-13 2001-02-20 University Of Maryland, Baltimore Attenuated mutants of salmonella which constitutively express the Vi antigen
EP1970449B1 (en) 1998-09-04 2010-11-03 Emergent Product Development UK Limited Attenuated salmonella SPI2 mutants as antigen carriers
US7300774B1 (en) 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
CA2369820A1 (en) 1999-04-16 2000-10-26 Frank Dicker Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof
EP1067194A1 (en) 1999-04-16 2001-01-10 F. Hoffmann-La Roche Ag Vectors containing a gene coding for CD40 and/or CD40L under the control of a cytokine-inducible promoter which is a human acute phase amyloid A gene promoter. Methods for their production and uses thereof
US7803765B2 (en) * 1999-05-05 2010-09-28 Phylogica Limited Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
AU1084901A (en) 1999-10-14 2001-04-23 Martha S. Hayden-Ledbetter Dna vaccines encoding antigen linked to a domain that binds cd40
TR200401569T4 (tr) 1999-12-28 2004-07-21 Akzo Nobel N.V. Flagelin ya da flagelle'ya karşı antikorların oluşumuna sebep olmayan salmonelle aşısı
DE60136334D1 (en) 2000-02-02 2008-12-11 Us Health Cd40-ligand als adjuvant für respiratorisches syncytialvirus-impfstoff
DK1267899T3 (da) 2000-03-17 2005-12-12 Pharmacia & Upjohn Co Llc ssa-inaktiverede salmonellavacciner
GB0015426D0 (en) 2000-06-24 2000-08-16 Univ Southampton Method for generating soluble highly multimeric proteins
US20030165538A1 (en) 2000-06-26 2003-09-04 Maxygen Incorporated Methods and compositions for developing spore display systems for medicinal and industrial applications
AU2002221780A1 (en) 2000-10-31 2002-05-15 F.Hoffmann-La Roche Ag Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof
US6855493B2 (en) * 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
EP2107110A3 (en) 2001-05-15 2011-10-26 Ortho-McNeil Pharmaceutical, Inc. Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease
ATE454394T1 (de) * 2001-07-06 2010-01-15 Abic Biolog Lab Ltd Rekombinantes, 250 kda grosses antigen aus sporozoiten/merozoiten von eimeria maxima codierende nukleinsäuren und ihre verwendungen
ZA200400479B (en) * 2001-07-06 2006-05-31 Abic Biolog Lab Teva Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use
ITMI20011986A1 (it) 2001-09-25 2003-03-25 San Raffaele Centro Fond Metodo e composizione per l'attivazione di cellule presentanti l'antigene
WO2003028441A1 (en) 2001-10-02 2003-04-10 The Board Of Trustees Of The Leland Stanford Junior University Gene therapy for the prevention of autoimmune disease
JP4660092B2 (ja) * 2001-12-21 2011-03-30 イミユネツクス・コーポレイシヨン 組換えポリペプチド
DE60325945D1 (de) * 2002-02-13 2009-03-12 Immunology Lab Inc Zusammensetzungen und verfahren für die behandlung von mikroorganismen-infektionen
US6923958B2 (en) 2002-03-02 2005-08-02 The Scripps Research Institute DNA vaccines encoding CEA and a CD40 ligand and methods of use thereof
EP1499191B1 (en) 2002-04-15 2012-05-09 Washington University in St. Louis Regulated attenuation of live vaccines to enhance cross protective immunogenicity
US7495090B2 (en) 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
US20060014248A1 (en) 2003-01-06 2006-01-19 Xencor, Inc. TNF super family members with altered immunogenicity
US20050181994A1 (en) 2003-01-06 2005-08-18 Xencor, Inc. Novel variants of CD40L protein
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
EP1673389A2 (en) 2003-10-10 2006-06-28 Xencor Inc. Novel variants of cd40l protein
US8828957B2 (en) 2003-12-11 2014-09-09 Microvax, Llc Methods for generating immunity to antigen
WO2005058950A2 (en) 2003-12-11 2005-06-30 Sidney Kimmel Cancer Center Methods for generating immunity to antigen
WO2005113598A2 (en) 2004-05-21 2005-12-01 Xencor, Inc. Tnf super family members with altered immunogenicity
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CN101080487B (zh) 2004-10-07 2012-11-14 阿戈斯治疗公司 成熟树突细胞组合物及其培养方法
WO2006105972A1 (en) 2005-04-07 2006-10-12 Universite Libre De Bruxelles Transgenic organism expressing cd40l and uses thereof
US20060286074A1 (en) 2005-05-31 2006-12-21 Yucheng Tang Methods for immunotherapy of cancer
DE602006014720D1 (de) 2005-10-07 2010-07-15 Proyecto Biomedicina Cima Sl Immunstimulatorische kombination zur vorbeugung und behandlung von hepatitis c
JP2009514536A (ja) 2005-11-07 2009-04-09 シドニー キンメル キャンサー センター Ｃｄ４０リガンド融合蛋白質ワクチン
DE102005054643B3 (de) 2005-11-10 2007-02-15 Assa Abloy Sicherheitstechnik Gmbh Schließzylinder
WO2007054658A1 (en) 2005-11-14 2007-05-18 King's College London Control of immune responses
CU23576A1 (es) * 2006-02-28 2010-09-30 Ct Ingenieria Genetica Biotech Antígenos vacunales quiméricos contra el virus de la influenza aviar
WO2007103048A2 (en) 2006-03-01 2007-09-13 Regents Of The University Of Colorado Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity
WO2007106073A2 (en) 2006-03-02 2007-09-20 University Of Massachusetts Modified pathogens for use as vaccines
FR2898905B1 (fr) * 2006-03-24 2008-05-09 Rhodia Recherches & Tech Composition polyisocyanate a proprietes anti-chocs ameliorees
WO2008027394A2 (en) * 2006-08-28 2008-03-06 The Wistar Institute Of Anatomy And Biology Constructs for enhancing immune responses
CN101522210B (zh) * 2006-09-18 2017-03-22 阿肯色大学评议会 增强免疫应答的组合物和方法
WO2008109825A2 (en) 2007-03-08 2008-09-12 Mayo Foundation For Medical Education And Research Inducing immune-mediated tumor cell death
CN101024076B (zh) * 2007-03-29 2010-08-18 中国农业大学 球虫的新用途
WO2009007120A2 (en) * 2007-07-10 2009-01-15 Apogenix Gmbh Tnf superfamily collectin fusion proteins
WO2009059018A1 (en) 2007-10-30 2009-05-07 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to flagellated bacterium
EP3097926B1 (en) * 2007-11-01 2019-10-02 The Board of Trustees of the University of Arkansas Compositions and methods of enhancing immune responses to eimeria
EP2806029B1 (en) * 2008-07-21 2016-05-25 Apogenix AG TNFSF single chain molecules
US8316310B2 (en) 2008-08-05 2012-11-20 International Business Machines Corporation System and method for human identification proof for use in virtual environments
PT2184229E (pt) * 2008-11-11 2012-12-20 Agustawestland Spa Rotor de helicóptero
US20100150958A1 (en) * 2008-12-15 2010-06-17 Vectogen Pty Ltd. Methods and Compositions for Use of a Coccidiosis Vaccine
KR101638661B1 (ko) * 2010-01-21 2016-07-11 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 백신 벡터 및 면역 반응을 강화시키는 방법
EP2771022B1 (en) * 2011-10-11 2020-07-01 Viela Bio, Inc. Cd40l-specific tn3-derived scaffolds and methods of use thereof
US20140079704A1 (en) * 2012-09-11 2014-03-20 The Texas A&M University System BI-Specific Diabodies For Masking And Targeting Vaccines
ES2809220T3 (es) * 2012-10-29 2021-03-03 Univ Arkansas Nuevos adyuvantes mucosos y sistemas de administración
BR112015019283B1 (pt) * 2013-02-14 2023-12-19 The Board Of Trustees Of The University Of Arkansas Composições e métodos de aprimoramento de respostas imunes à eiméria ou infecção por eiméria limitadora
MY173901A (en) * 2013-03-15 2020-02-26 Texas A & M Univ Sys Compositions and methods of enhancing immune responses to enteric pathogens
BR112016028418A2 (en) * 2014-06-05 2018-02-20 The Board Of Trustees Of The University Of Arkansas adjuvant composition, vaccine, cd40 agonist antibody or a part thereof, pharmaceutical composition, construct, cell, and epitope mapping method of a polypeptide
US20160090603A1 (en) * 2014-09-30 2016-03-31 Sandia Corporation Delivery platforms for the domestication of algae and plants
JP7208010B2 (ja) * 2016-03-29 2023-01-18 ユニバーシティ オブ サザン カリフォルニア 癌を標的とするキメラ抗原受容体
RU2752049C2 (ru) * 2016-05-27 2021-07-22 Эббви Байотерапьютикс Инк. Антитела к cd40 и пути их применения
CN109803977B (zh) * 2016-08-17 2023-03-17 菲克特生物科学股份有限公司 核酸产品及其施用方法

Also Published As

Publication number Publication date
PL2214701T3 (pl) 2017-01-31
US10842858B2 (en) 2020-11-24
US20150216954A1 (en) 2015-08-06
EP2214701A2 (en) 2010-08-11
EP3097926A1 (en) 2016-11-30
PT2214701T (pt) 2016-11-02
DK3097926T3 (da) 2019-12-16
CN101969990A (zh) 2011-02-09
ES2599905T3 (es) 2017-02-06
EP2214701A4 (en) 2011-06-01
WO2009059298A2 (en) 2009-05-07
HK1146575A1 (zh) 2011-06-24
HUE030655T2 (en) 2017-05-29
EP3097926B1 (en) 2019-10-02
WO2009059298A3 (en) 2009-09-24
AU2008318357A1 (en) 2009-05-07
CN103893747B (zh) 2016-01-06
CA3156538C (en) 2023-12-12
PL3097926T3 (pl) 2020-04-30
EP2214701B1 (en) 2016-08-03
US8956849B2 (en) 2015-02-17
CA2704422A1 (en) 2009-05-07
CA3051748A1 (en) 2009-05-07
CA3156538A1 (en) 2009-05-07
NZ601880A (en) 2013-12-20
JP2011503003A (ja) 2011-01-27
WO2009059298A8 (en) 2010-08-05
DK2214701T3 (en) 2016-12-12
PT3097926T (pt) 2020-01-08
US20180333474A1 (en) 2018-11-22
BRPI0819229B1 (pt) 2019-01-22
ES2761693T3 (es) 2020-05-20
AU2008318357A2 (en) 2010-06-24
AU2008318357B2 (en) 2015-01-22
HUE047164T2 (hu) 2020-04-28
CA3051748C (en) 2022-07-12
JP5480812B2 (ja) 2014-04-23
CN101969990B (zh) 2014-07-09
CN103893747A (zh) 2014-07-02
US10016493B2 (en) 2018-07-10
NZ585777A (en) 2012-09-28
US20110111015A1 (en) 2011-05-12
BRPI0819229A2 (pt) 2015-05-05

Similar Documents

Publication Publication Date Title
US10842858B2 (en) Compositions and methods of enhancing immune responses to Eimeria
US9125854B2 (en) Compositions and methods of enhancing immune responses to flagellated bacterium
AU2015202009B2 (en) Compositions and methods of enhancing immune responses to eimeria
HK1231742B (en) Compositions and methods of enhancing immune responses to eimeria
HK1231742A1 (en) Compositions and methods of enhancing immune responses to eimeria
HK1231742A (en) Compositions and methods of enhancing immune responses to eimeria
HK1146575B (en) Compositions and methods of enhancing immune responses to eimeria
Bottje et al. ScholarWorks (DUARK
Bottje et al. Click here to let us know how this document benefits you.
HK1146644B (en) Compositions and methods of enhancing immune responses to flagellated bacterium

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20131008