JP5478884B2 - 乾燥血小板組成物 - Google Patents

乾燥血小板組成物 Download PDF

Info

Publication number
JP5478884B2
JP5478884B2 JP2008532503A JP2008532503A JP5478884B2 JP 5478884 B2 JP5478884 B2 JP 5478884B2 JP 2008532503 A JP2008532503 A JP 2008532503A JP 2008532503 A JP2008532503 A JP 2008532503A JP 5478884 B2 JP5478884 B2 JP 5478884B2
Authority
JP
Japan
Prior art keywords
platelet
composition
wound
platelets
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008532503A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009509976A5 (https=
JP2009509976A (ja
Inventor
ワグナー，クリストファー，ティー．
コナー，ジェローム
ハーパー，ジョン，アール．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeCell Corp
Original Assignee
LifeCell Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LifeCell Corp filed Critical LifeCell Corp
Publication of JP2009509976A publication Critical patent/JP2009509976A/ja
Publication of JP2009509976A5 publication Critical patent/JP2009509976A5/ja
Application granted granted Critical
Publication of JP5478884B2 publication Critical patent/JP5478884B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
JP2008532503A 2005-09-26 2006-09-26 乾燥血小板組成物 Expired - Fee Related JP5478884B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72085105P 2005-09-26 2005-09-26
US60/720,851 2005-09-26
PCT/US2006/037741 WO2007038629A2 (en) 2005-09-26 2006-09-26 Dry platelet composition

Publications (3)

Publication Number Publication Date
JP2009509976A JP2009509976A (ja) 2009-03-12
JP2009509976A5 JP2009509976A5 (https=) 2009-11-12
JP5478884B2 true JP5478884B2 (ja) 2014-04-23

Family

ID=37900439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008532503A Expired - Fee Related JP5478884B2 (ja) 2005-09-26 2006-09-26 乾燥血小板組成物

Country Status (7)

Country Link
US (3) US20090035289A1 (https=)
EP (1) EP1929289B1 (https=)
JP (1) JP5478884B2 (https=)
AU (1) AU2006294654B2 (https=)
CA (1) CA2623666C (https=)
ES (1) ES2668551T3 (https=)
WO (1) WO2007038629A2 (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2319548B1 (en) * 2008-08-14 2016-06-01 KCI Licensing, Inc. Tissue scaffolds
BRPI0916102A2 (pt) * 2008-11-20 2015-11-03 Lifecell Corp "método para a prevenção da hérnia paraestomal, método para preparar uma hérnia paraestomal e dispositivo para preparar ou reduzir a incidência da hérnia paraestomal"
EP2349089A4 (en) 2008-11-21 2014-01-15 Lifecell Corp REINFORCED BIOLOGICAL MATERIAL
US8469779B1 (en) 2009-01-02 2013-06-25 Lifecell Corporation Method for debristling animal skin
US9649408B1 (en) 2009-11-05 2017-05-16 Lifecell Corporation Systems and methods for sterilization of bone or bone components
AU2011218066B2 (en) * 2010-02-19 2015-04-23 Lifecell Corporation Abdominal wall treatment devices
CN103108661B (zh) * 2010-03-25 2016-01-20 生命细胞公司 再生性组织支架的制备
US9999702B2 (en) 2010-04-09 2018-06-19 Kci Licensing Inc. Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
AU2011276246B2 (en) 2010-07-08 2014-12-04 Lifecell Corporation Method for shaping tissue matrices
TWI422385B (zh) * 2010-10-06 2014-01-11 Central Medical Technologies Inc Hair growth agent containing platelet dry powder
WO2012122524A1 (en) * 2011-03-09 2012-09-13 Worden Charles E Wound healant system and method of use
US8597264B2 (en) 2011-03-24 2013-12-03 Kci Licensing, Inc. Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
EP2508892A1 (de) * 2011-04-04 2012-10-10 Siemens Healthcare Diagnostics Products GmbH Kontrollen und Kit für Thrombozytenaktivitätsteste
EP2696908B1 (en) 2011-04-14 2015-03-11 Lifecell Corporation Regenerative materials
EP3851131A1 (en) 2011-05-31 2021-07-21 LifeCell Corporation Adipose tissue matrices
US9089523B2 (en) 2011-07-28 2015-07-28 Lifecell Corporation Natural tissue scaffolds as tissue fillers
US9549805B2 (en) 2011-12-20 2017-01-24 Lifecell Corporation Flowable tissue products
EP3842078A1 (en) 2011-12-20 2021-06-30 LifeCell Corporation Sheet tissue products
EP2806907B1 (en) 2012-01-24 2018-11-21 LifeCell Corporation Elongated tissue matrices
ES2716993T3 (es) 2012-03-08 2019-06-18 Lifecell Corp Matrices de colágeno y tejido activadas por enzimas
BR112014026090A8 (pt) 2012-04-24 2019-08-27 Lifecell Corp composição de matriz tecidual apta a fluir
TWI448310B (zh) * 2012-05-23 2014-08-11 Medical dressings and their coating methods for frozen freeze - dried platelets
TWI448312B (zh) * 2012-05-23 2014-08-11 An implant of freeze - dried platelets and its coating method
US10363343B2 (en) 2012-07-05 2019-07-30 Lifecell Corporation Tissue-based drain manifolds
US11090338B2 (en) 2012-07-13 2021-08-17 Lifecell Corporation Methods for improved treatment of adipose tissue
EP3332816B1 (en) 2012-09-26 2020-11-04 LifeCell Corporation Processed adipose tissue
EP3659633A1 (en) 2013-02-06 2020-06-03 LifeCell Corporation Methods for localized modification of tissue products
EP2976095B1 (en) * 2013-03-15 2020-12-23 3M Innovative Properties Company Wound healing compositions
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
CN104906052B (zh) * 2014-03-14 2017-09-05 复旦大学附属中山医院 一种自体来源富血小板血浆冻干粉的制备方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
KR20170102319A (ko) * 2014-12-31 2017-09-08 안트로제네시스 코포레이션 혈소판을 분리하는 방법
AU2017216900A1 (en) 2016-02-11 2018-08-09 Lifecell Corporation Methods for stabilizing collagen-containing tissue products against enzymatic degradation
US10792394B2 (en) 2016-06-03 2020-10-06 Lifecell Corporation Methods for localized modification of tissue products
CA3027969A1 (en) 2016-06-16 2017-12-21 Eye Care International, Llc Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces
EP3777907A1 (en) 2016-07-05 2021-02-17 LifeCell Corporation Tissue matrices incorporating multiple tissue types
EP3558405A1 (en) 2016-12-22 2019-10-30 LifeCell Corporation Devices and methods for tissue cryomilling
CN107047538B (zh) * 2017-03-16 2021-04-13 苏州大学 蛋白激酶a激活剂在血小板保存中的应用及血小板保存方法
CN115252910A (zh) 2017-10-18 2022-11-01 生命细胞公司 脂肪组织产品以及产生方法
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
WO2019079672A1 (en) 2017-10-19 2019-04-25 Lifecell Corporation ACELLULAR TISSUE MATRIX PRODUCTS FLUIDS AND METHODS OF PRODUCTION
JP6391872B1 (ja) * 2018-03-30 2018-09-19 セルソース株式会社 成長因子混合物およびその調製方法
WO2020056009A1 (en) * 2018-09-11 2020-03-19 Cellphire, Inc. Blood plasma-containing compositions
CA3121200A1 (en) * 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
WO2020112963A1 (en) 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
CN113473995A (zh) 2018-12-26 2021-10-01 K·E·金姆 用于治疗烧伤、伤口和皮肤病的组合物和方法
IL322149A (en) 2019-05-03 2025-09-01 Cellphire Inc Materials and methods for manufacturing blood products
MX2021014654A (es) 2019-05-30 2022-03-11 Lifecell Corp Implante de mama biologico.
CN114450066A (zh) 2019-08-16 2022-05-06 塞尔菲乐有限公司 作为抗血小板剂逆转剂的血栓小体
JP7058431B2 (ja) * 2019-12-12 2022-04-22 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
CA3170196A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Anti-fibrinolytic loaded platelets
CN111537326B (zh) * 2020-05-07 2023-05-16 天津德祥生物技术股份有限公司 制备冻干血小板的方法及其应用
US12532881B2 (en) 2020-08-19 2026-01-27 Lifecell Corporation Tissue packaging and method of using same
CA3209427A1 (en) * 2021-01-25 2022-07-28 Phamri Norden Ab Method of treating a skin disorder
TW202245814A (zh) 2021-02-17 2022-12-01 美商賽菲爾公司 用於治療抗血小板誘導的凝血病之凍乾血小板衍生物組成物

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004975A (en) * 1975-12-30 1977-01-25 The United States Of America As Represented By The Secretary Of The Navy Method of isolating and cryopreserving human white cells from whole blood
CA1216518A (en) 1982-11-01 1987-01-13 Gail A. Rock Plasma-free medium for platelet storage
US4676070A (en) 1984-11-30 1987-06-30 The Board Of Regents, The University Of Texas Apparatus and method for cryopreparing biological tissue
US4865871A (en) 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
US4799361A (en) 1983-08-23 1989-01-24 Board Of Regents, The University Of Texas System Method for cryopreparing biological tissue for ultrastructural analysis
US4665088A (en) * 1984-11-14 1987-05-12 The Research Foundation Of State University Of New York (E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides
US4619257A (en) 1984-11-30 1986-10-28 Board Of Regents, The University Of Texas System Apparatus and method for cryopreparing corneal tissue for surgical procedures
US4774088A (en) * 1986-01-08 1988-09-27 The United States Of America As Represented By The Deptment Of Health And Human Services Method and additives for improving the quality and shelf life of stored blood
JPS6360931A (ja) * 1986-08-29 1988-03-17 Noboru Sato 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法
US4764463A (en) * 1986-10-30 1988-08-16 The University Of Tennessee Research Corporation Platelet cyropreservation
US4940581A (en) * 1986-10-30 1990-07-10 The University Of Tennessee Research Corporation Platelet cryopreservation
US5044165A (en) 1986-12-03 1991-09-03 Board Of Regents, The University Of Texas Cryo-slammer
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
DE3717337A1 (de) 1987-05-22 1988-12-15 Hoechst Ag Verfahren zum nachweis der antiaggregatorischen wirkung von vasoaktiven stoffen, speziell von phosphodiesterase- und/oder cyclooxygenase-hemmern
DK293888A (da) * 1987-06-09 1988-12-10 Takeda Chemical Industries Ltd Fenolderivater og deres fremstilling og anvendelse
MX164619B (es) 1988-03-02 1992-09-09 Vicente Parrilla Cerrillo Composicion para el tratamiento de lesiones cutaneas
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
US5958670A (en) * 1988-05-18 1999-09-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5153004A (en) 1989-06-02 1992-10-06 Cryopharm Corporation Freezing and thawing of erythrocytes
US6007978A (en) * 1988-05-18 1999-12-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5043261A (en) * 1989-04-10 1991-08-27 Cryopharm Corporation Lyophilized and reconstituted red blood cell and hemosome compositions
IL90188A0 (en) 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US5045446A (en) 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
JPH02129127A (ja) 1988-11-04 1990-05-17 Sumitomo Seika Chem Co Ltd 改良された赤血球保存液
WO1990006128A1 (en) 1988-12-05 1990-06-14 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
GB8902791D0 (en) * 1989-02-08 1989-03-30 Secr Defence A method of freezing blood
US4964280A (en) 1989-08-17 1990-10-23 Board Of Regents Method and apparatus for cryopreparing biological tissue
US5154007A (en) 1989-08-17 1992-10-13 Board Of Regents University Of Texas System Method and apparatus for cryopreparing biological tissue
IL95912A (en) 1989-10-06 1998-08-16 American Nat Red Cross Method for prolonging the shelf life or red blood cells
DD288316A5 (de) 1989-10-11 1991-03-28 Beziksinstitut F. Blutspende- U. Transfusionswesen,De Verfahren zur regenerierung von gelagerten erythrozytenkonzentraten
US5118512A (en) * 1990-01-23 1992-06-02 Osteotech, Inc. (A Delaware Corp.) Process for cryopreserving biological materials and materials prepared thereby
JPH05501419A (ja) 1990-05-25 1993-03-18 コーブ　ラボラトリーズ　インコーポレイテッド 生体適合性、両親媒性ポリマー混合物中の細胞、細胞―様物質および小板の凍結乾燥法
CA2051092C (en) * 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5242792A (en) * 1991-02-25 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides
GB9114202D0 (en) 1991-07-01 1991-08-21 Quadrant Holdings Cambridge Blood products
AU672775B2 (en) * 1992-01-21 1996-10-17 Cobe Laboratories Inc. Method of freezing cells and cell-like materials
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
DE69333924T2 (de) * 1992-05-29 2006-08-17 University Of North Carolina At Chapel Hill Im immobilisierten Zustand getrocknete pharmazeutisch verträgliche menschliche Blutplättchen
US5378601A (en) 1992-07-24 1995-01-03 Montefiore Medical Center Method of preserving platelets with apyrase and an antioxidant
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
JP3788522B2 (ja) * 1994-02-22 2006-06-21 日本電信電話株式会社 血球、幹細胞、および血小板の凍結乾燥生成物の製造方法
EP0668013B1 (en) 1994-02-22 2005-04-20 Nippon Telegraph And Telephone Corporation Freeze-dried blood cells, stem cells and platelets and manufacturing method for the same
US6221669B1 (en) * 1994-10-19 2001-04-24 Lifecell Corporation Prolonged preservation of blood platelets
US5919614A (en) * 1994-10-19 1999-07-06 Lifecell Corporation Composition comprising three platelet lesion inhibitors for platelet storage
US5622867A (en) * 1994-10-19 1997-04-22 Lifecell Corporation Prolonged preservation of blood platelets
US5580714A (en) * 1995-03-08 1996-12-03 Celox Laboratories, Inc. Cryopreservation solution
US5601972A (en) * 1995-03-24 1997-02-11 Organ, Inc. Long term storage of red cells in unfrozen solution
US5629145A (en) * 1995-03-24 1997-05-13 Organ, Inc. Cryopreservation of cell suspensions
US5736313A (en) * 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
US6037116A (en) * 1996-06-14 2000-03-14 Biostore New Zealand, Ltd. Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials
US5750330A (en) * 1996-06-19 1998-05-12 Litron Laboratories Method and composition for lyophilizing red blood cells
DE19634313A1 (de) * 1996-08-24 1998-02-26 Behringwerke Ag Methode zur Stabilisierung von Plättchen
US5789151A (en) 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
AT407484B (de) 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
US6139878A (en) * 1998-04-27 2000-10-31 Aventis Behring, Llc Method for preparing a diafiltered stabilized blood product
ES2257050T3 (es) 1998-05-26 2006-07-16 Lifecell Corporation Conservacion por el frio de hematies humanos.
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6045990A (en) * 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
US6176089B1 (en) * 1998-10-27 2001-01-23 Modex Th{acute over (e)}rapeutics Methods and compositions for cryopreservation of cells and tissues
CA2397362A1 (en) * 2000-02-10 2001-08-16 The Regents Of The University Of California Therapeutic platelets and methods
US20020076445A1 (en) 2000-02-10 2002-06-20 Crowe John H. Eukaryotic cells and method for preserving cells
CN101072506B (zh) * 2004-08-12 2010-05-12 塞尔菲乐有限公司 制备冻干血小板的方法、包括冻干血小板的组合物和使用方法
US7846845B2 (en) 2006-10-26 2010-12-07 Applied Materials, Inc. Integrated method for removal of halogen residues from etched substrates in a processing system
MX354786B (es) * 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
AU2009270833B2 (en) * 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders

Also Published As

Publication number Publication date
CA2623666C (en) 2017-10-24
US10179150B2 (en) 2019-01-15
US20170136064A1 (en) 2017-05-18
EP1929289B1 (en) 2018-02-21
EP1929289A2 (en) 2008-06-11
ES2668551T3 (es) 2018-05-18
EP1929289A4 (en) 2009-09-16
AU2006294654A1 (en) 2007-04-05
AU2006294654B2 (en) 2012-05-24
US20090035289A1 (en) 2009-02-05
WO2007038629A2 (en) 2007-04-05
WO2007038629A3 (en) 2007-10-18
CA2623666A1 (en) 2007-04-05
JP2009509976A (ja) 2009-03-12
US20190175655A1 (en) 2019-06-13

Similar Documents

Publication Publication Date Title
JP5478884B2 (ja) 乾燥血小板組成物
US7811558B2 (en) Use of stabilized platelets as hemostatic agent
JP5138372B2 (ja) 凍結乾燥血小板の調製法、凍結乾燥血小板を含む組成物、および使用法
US20220313743A1 (en) Compositions containing amniotic components and methods for preparation and use thereof
CN104955464B (zh) 用于治疗和预防组织损伤和疾病的组合物和方法
JP4445589B2 (ja) 製薬的に許容しうる固定乾燥ヒト血液血小板
EP2686419B1 (en) Allogeneic microvascular tissue for soft tissue treatments
KR20200047797A (ko) 태반 줄기 세포를 사용한 혈관신생
WO2016069897A1 (en) Materials and methods for rescue of ischemic tissue and regeneration of tissue integrity during restriction, engraftment and transplantation
US12582744B2 (en) Dressings comprising platelet lysate
Pietramaggiori et al. Trehalose lyophilized platelets for wound healing
JP2006527229A (ja) 単離された管腔器官及び生体脈管における内皮組織の保存のための方法及び装置
Lim et al. Placental cells and tissues: the transformative rise in advanced wound care
EP2578082A2 (en) Composition for the cold storage of organs
KR20180012793A (ko) 자극된 태반 줄기 세포를 이용한 혈관신생
Kazemi Mehrjerdi et al. Efficacy of autologous platelet-rich plasma (prp) activated by thromboplastin-D on the repair and regeneration of wounds in dogs
Liu et al. RADA16 and SAAP148 Peptide‐Modified Collagen Self‐Assembled Hydrogels for Accelerated Healing of Infected Wounds
Peng et al. Porcine decellularized splenic matrix hydrogel-based vesicle sustained-release System: A dual-regulatory biomaterial for accelerated wound healing via angiogenesis and immune remodeling
ADHYA et al. PROSPECT OF UTILIZING EXPIRED HOMOLOGOUS PLATELET CONCENTRATES AS AN ALTERNATIVE SOURCE OF GROWTH FACTORS AND CYTOKINES IN CLINICAL SETUP FOR BETTER WOUND CARE AND HEALING
Altıntop et al. A novel hemostatic scaffold material and the importance of scaffold formation on ending hemorrhage: An experimental rat study.
TWI300806B (en) Medium and method for preserving platelets, red blood cells, and other non-nulceus cells and platelets-containing composition
ES2923925T3 (es) Formulaciones de células mononucleares de sangre periférica sometidas a hipoxia
JP2024539516A (ja) 創傷治癒のための組成物と方法
ES2821658T3 (es) Dispositivo médico que tiene un revestimiento que comprende ACCS
Alharbi Preserved extracellular matrix in non-enzymatically detached cultured keratinocyte sheets bolsters the healing effects on grafted burn wounds

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090917

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090917

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120612

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120906

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130305

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130604

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130723

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131022

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140114

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140212

R150 Certificate of patent or registration of utility model

Ref document number: 5478884

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees