JP5468782B2 - 癌治療と幹細胞調節のための方法 - Google Patents

癌治療と幹細胞調節のための方法 Download PDF

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Publication number
JP5468782B2
JP5468782B2 JP2008557240A JP2008557240A JP5468782B2 JP 5468782 B2 JP5468782 B2 JP 5468782B2 JP 2008557240 A JP2008557240 A JP 2008557240A JP 2008557240 A JP2008557240 A JP 2008557240A JP 5468782 B2 JP5468782 B2 JP 5468782B2
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cells
cell
deazaneplanocin
prc2
tumor
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JP2009528345A (ja
JP2009528345A5 (https=
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ユ、チアン
タン、ジン
ジン ヤン、シャオ
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Agency for Science Technology and Research Singapore
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2008557240A 2006-03-02 2006-11-15 癌治療と幹細胞調節のための方法 Expired - Fee Related JP5468782B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77853206P 2006-03-02 2006-03-02
US60/778,532 2006-03-02
PCT/SG2006/000350 WO2007100304A1 (en) 2006-03-02 2006-11-15 Methods for cancer therapy and stem cell modulation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013015684A Division JP2013121974A (ja) 2006-03-02 2013-01-30 癌治療と幹細胞調節のための方法
JP2013213366A Division JP5902138B2 (ja) 2006-03-02 2013-10-11 癌治療と幹細胞調節のための方法

Publications (3)

Publication Number Publication Date
JP2009528345A JP2009528345A (ja) 2009-08-06
JP2009528345A5 JP2009528345A5 (https=) 2010-01-07
JP5468782B2 true JP5468782B2 (ja) 2014-04-09

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Family Applications (3)

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JP2008557240A Expired - Fee Related JP5468782B2 (ja) 2006-03-02 2006-11-15 癌治療と幹細胞調節のための方法
JP2013015684A Pending JP2013121974A (ja) 2006-03-02 2013-01-30 癌治療と幹細胞調節のための方法
JP2013213366A Expired - Fee Related JP5902138B2 (ja) 2006-03-02 2013-10-11 癌治療と幹細胞調節のための方法

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JP2013015684A Pending JP2013121974A (ja) 2006-03-02 2013-01-30 癌治療と幹細胞調節のための方法
JP2013213366A Expired - Fee Related JP5902138B2 (ja) 2006-03-02 2013-10-11 癌治療と幹細胞調節のための方法

Country Status (7)

Country Link
US (2) US8058258B2 (https=)
EP (2) EP1993553B1 (https=)
JP (3) JP5468782B2 (https=)
AU (1) AU2006339445A1 (https=)
SG (1) SG170041A1 (https=)
TW (1) TW200812590A (https=)
WO (1) WO2007100304A1 (https=)

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CN101909630A (zh) 2007-11-02 2010-12-08 新加坡科技研究局 预防和治疗肿瘤的方法和化合物
WO2010027935A1 (en) * 2008-09-08 2010-03-11 Merck Sharp & Dohme Corp. Ahcy hydrolase inhibitors for treatment of hyper homocysteinemia
CN102369204A (zh) * 2008-09-26 2012-03-07 新加坡科技研究局 3-脱氮瓶菌素衍生物
WO2010111712A2 (en) * 2009-03-27 2010-09-30 Cold Spring Harbor Laboratory Identification of rnai targets and use of rnai for rational therapy of chemotherapy-resistant leukemia and other cancers
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
SG180031A1 (en) * 2010-10-15 2012-05-30 Agency Science Tech & Res Combination treatment of cancer
EP2646454B1 (en) 2010-12-03 2015-07-08 Epizyme, Inc. 7-deazapurine modulators of histone methyltransferase, and methods of use thereof
CA2819620A1 (en) 2010-12-03 2012-06-21 Epizyme, Inc. Modulators of histone methyltransferase, and methods of use thereof
US8580762B2 (en) 2010-12-03 2013-11-12 Epizyme, Inc. Substituted purine and 7-deazapurine compounds
CA2831403A1 (en) * 2011-05-19 2012-11-22 Glax L.L.C. Compositions and methods for treating and preventing cancer by targeting and inhibiting cancer stem cells
WO2013036846A2 (en) * 2011-09-09 2013-03-14 Koronis Pharmaceuticals, Incorporated N4 derivatives of deoxycytidine prodrugs
US20150038548A1 (en) * 2012-07-09 2015-02-05 Metheor Therapeutics Corporation Oligonucleotide inhibitors of dna methyltransferases and their use in treating diseases
US20150284422A1 (en) 2012-08-10 2015-10-08 Epizyme, Inc. Inhibitors of protein methyltransferase dot1l and methods of use thereof
US9597348B2 (en) 2012-09-06 2017-03-21 Epizyme, Inc. Method of treating leukemia
EP2908913B1 (en) 2012-10-17 2018-10-03 Cedars-Sinai Medical Center Molecular signatures of ovarian cancer
US20160010059A1 (en) * 2013-03-06 2016-01-14 The Regents Of The University Of California EXPANSION OF HEMATOPOIETIC PROGENITOR CELLS BY HISTONE METHYLTRANSFERASE G9a INHIBITION
US9738679B2 (en) 2013-03-15 2017-08-22 Epizyme, Inc. Methods of synthesizing substituted purine compounds
WO2016022563A1 (en) 2014-08-04 2016-02-11 Auburn University Enantiomers of the 1',6'-isomer of neplanocin a
WO2016149299A1 (en) * 2015-03-16 2016-09-22 Epinova Therapeutics Corp. Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation
WO2020055663A1 (en) * 2018-09-11 2020-03-19 The Texas A&M University System L-oligonucleotide inhibitors of polycomb repressive complex 2 (prc2)
WO2020057107A1 (zh) * 2018-09-17 2020-03-26 诺未科技（北京）有限公司 一种组合物及其用途
WO2023249714A1 (en) * 2022-06-24 2023-12-28 Memorial Sloan-Kettering Cancer Center Therapeutic compositions and methods for activating double stranded rna response in cancer patients via dnmt1 targeted therapy

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US510260A (en) * 1893-12-05 Electric-arc-lighting system
US4975434A (en) * 1986-05-27 1990-12-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antiviral and anticancer cyclopentenyl cytosine
US4968690A (en) 1986-05-27 1990-11-06 United States Government As Represented By The Secretary Of The Dept. Of Health And Human Services 3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it
JPH04327587A (ja) 1991-04-26 1992-11-17 Asahi Chem Ind Co Ltd ６’−ｃ−アルキル−３−デアザネプラノシンａ誘導体、その製造法およびその用途
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
JP2002507404A (ja) * 1998-03-27 2002-03-12 ジェネンテク・インコーポレイテッド Ａｐｏ−２リガンド−抗ＨＥＲ−２抗体相乗作用
SE517975C2 (sv) 2000-05-30 2002-08-13 Power Ab C Fackverkskonstruktion av balkar sammansatta till ett tredimensionellt ramverk samt användning av en sådan fackverkskonstruktion
US20050191618A1 (en) 2001-05-18 2005-09-01 Sirna Therapeutics, Inc. RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
ES2378524T3 (es) 2002-09-13 2012-04-13 The Board Of Trustees Of The Leland Stanford Junior University Célula progenitora de megacariocitos de mamífero
AU2003295444A1 (en) 2002-11-15 2004-06-15 The Board Of Trustees Of The University Of Illinois Methods for in vitro expansion of hematopoietic stem cells
US20050245559A1 (en) 2004-01-23 2005-11-03 Koul Hari K Treatment and prevention of prostate cancer
WO2005105136A1 (en) 2004-04-27 2005-11-10 University Of South Florida Nanogene therapy for cell proliferation disorders
ATE511859T1 (de) 2004-07-20 2011-06-15 Schering Corp Apoptoseinduktion in toll-artige rezeptoren exprimierenden tumorzellen

Also Published As

Publication number Publication date
EP2522352A1 (en) 2012-11-14
JP2013121974A (ja) 2013-06-20
US8211869B2 (en) 2012-07-03
EP1993553B1 (en) 2013-05-08
JP2009528345A (ja) 2009-08-06
WO2007100304A1 (en) 2007-09-07
JP2014028853A (ja) 2014-02-13
TW200812590A (en) 2008-03-16
US20120077841A1 (en) 2012-03-29
US20100075915A1 (en) 2010-03-25
SG170041A1 (en) 2011-04-29
EP1993553A1 (en) 2008-11-26
US8058258B2 (en) 2011-11-15
JP5902138B2 (ja) 2016-04-13
AU2006339445A1 (en) 2007-09-07
EP1993553A4 (en) 2010-07-28
EP2522352B1 (en) 2017-01-11

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