JP5465174B2 - ハイパーサーミアデバイスおよびそのナノ粒子との使用 - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
- A61N1/406—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia using implantable thermoseeds or injected particles for localized hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/02—Radiation therapy using microwaves
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
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Description
(i)その場所においてナノ粒子を導入するステップと、
(ii)ナノ粒子を加熱できる周波数および/または強度を有するデバイスを使用して高周波電磁場を生成するステップとを含む方法を提供する。
1)高周波増幅器に送信される制御された周波数および強度の電磁パルスを生成する高周波電磁場の発生器。この電磁場の周波数は、超長波(VLF)帯域〜超高周波(SHF)帯域にある。
2)発生器の周波数範囲で機能する、広帯域で低ノイズの、高周波信号の高周波電磁場増幅器。
3)高周波電磁場の送信機。これは本発明の範囲を限定するものではなく、増幅器の出力信号から、生成された高周波電磁場の焦点を合わせて空間のある領域に集中できるアンテナからなることができる。
4)直接温度測定システム。
(a)有機分子または生体分子との金属-硫黄結合により官能化された貴金属ナノ粒子(金、パラジウム、銅など)。これらのナノ粒子は、サイズおよび官能化鎖に応じて金属的性質および/または磁気的性質を有し、ヒステリシス、緩和、または誘導電流という種々のメカニズムにより加熱することができる。
(b)金属-配位子結合により官能化された貴金属ナノ粒子。配位子は、特にホスフィンまたはハロゲン化合物であってもよい。ナノ粒子は、配位子と結び付く結果、生体分子により官能化でき、配位子のサイズおよびタイプに応じて金属的性質および/または磁気的性質を有する。これらのナノ粒子は、ヒステリシス、緩和、または誘導電流という種々のメカニズムにより加熱することができる。
(c)界面活性剤分子により保護され、双極子相互作用により安定化した貴金属ナノ粒子。これらのナノ粒子は、サイズに応じて金属的性質を有し、誘導電流というメカニズムにより加熱することができる。
(d)直接官能化されたまたは貴金属の被覆により官能化された磁性ナノ粒子(たとえば、鉄ベース)。これらのナノ粒子は、サイズに応じて磁気的性質を有し、ヒステリシスおよび磁化緩和というメカニズムにより加熱することができる。貴金属の被覆成分は、この節で説明された粒子タイプ(a)と類似したように挙動してもよい。
- 種々の配位子により官能化できる磁気ベースのナノ粒子の場合、同じ加熱を発生させるのに必要な磁場は100kHz〜1GHzの周波数を有さなければならず、磁場の強度は0〜15kA/mである。
- たとえば金またはパラジウムなどの貴金属ナノ粒子は、強磁性挙動の形態ならびに典型的な金属的挙動の要因となりうる種々の配位子、特に生物学的に興味のある化合物により官能化することができる。この場合、これらを加熱するために、これらを1GHzより高い電磁場にさらすことが必要である。この場合、アンテナ/増幅器の組み合わせは、最大10Wの電力を印加しなければならない。
本発明の実施形態は、高周波場発生器Agilent 8648Dという器具のセットからなる。Agilent 8648Dは、9kHz〜4GHzで動作し、解像度は0.001Hzであり、その出力信号は、すべての周波数に対して+10〜-136dBmの電力範囲にある。高周波発生器の出力ポートは、同軸ケーブルによってソリッドステート高周波増幅器(Amplifier Research 5S1G4)の入力ポートに接続される。発生器と増幅器の入出力ポートのそれぞれおよび同軸ケーブルの両端は、N型のコネクタを有し、特に最大10GHzのマイクロ波信号において最小挿入損失(最大0.2dB)を発生させるように設計され、コネクタのインピーダンスは50オームである。
この例で使用されるナノ粒子は以下のとおりである。
(a)トリフェニルホスフィン配位子およびハロゲン化物配位子により官能化された金ナノ粒子。55個の金(Au)原子からなり1.4nmの直径を有するクラスタと、11個の原子からなり0.8nmの直径を有するクラスタについて研究した。これらのナノ粒子を使用して、pH=7.5の市販のHEPES-NaOH緩衝液に溶解した。
(b)チオール基を含む生体分子チオプロニンにより官能化されたように、Brustの合成(非特許文献7)の変法を使用して合成された金ナノ粒子。これらのナノ粒子は水溶性であり、したがって、潜在的な生物学的興味があり、治療上の興味がある生体分子により官能化されたナノ粒子のモデルになる。
上述のデバイスを用いて、示された(aおよびb)2つのタイプの金ナノ粒子の温度の変化を測定し、スパイラルの主要共振周波数に一致する周波数である2.61GHzの電磁場の周波数を印加する。この周波数において、信号の損失が最小限になるように、スパイラルへのエネルギーの最大の移動がある。
2 高周波電磁場の増幅器
3 高周波電磁場の送信機
4 直接温度測定システム
5 ファラデーケージ
6 ナノ粒子
Claims (16)
(a)高周波電磁信号の発生器と、
(b)高周波電磁信号の増幅器と、
(c)高周波電磁信号の送信機と、
(d)温度測定システムとを備え、
前記高周波電磁信号の前記発生器が、高周波電磁信号の生成に加えて、インピーダンス、前記ハイパーサーミアデバイスを通じて放散されるおよび/または反射される高周波電磁信号のエネルギーに関連する反射係数、送信損失、および挿入損失を測定するネットワーク分析デバイスである、ハイパーサーミアデバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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ES200702084A ES2320837B1 (es) | 2007-07-26 | 2007-07-26 | Dispositivo de hipertermia y su utilizacion con nanoparticulas. |
ESP200702084 | 2007-07-26 | ||
PCT/IB2008/002780 WO2009013630A2 (en) | 2007-07-26 | 2008-07-25 | Hyperthermia devices and their uses with nanoparticles |
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JP2010534499A JP2010534499A (ja) | 2010-11-11 |
JP5465174B2 true JP5465174B2 (ja) | 2014-04-09 |
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US (1) | US8463397B2 (ja) |
EP (1) | EP2192953B1 (ja) |
JP (1) | JP5465174B2 (ja) |
AU (1) | AU2008278713B2 (ja) |
CA (1) | CA2694512C (ja) |
ES (2) | ES2320837B1 (ja) |
WO (1) | WO2009013630A2 (ja) |
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US8323694B2 (en) * | 2007-05-09 | 2012-12-04 | Nanoprobes, Inc. | Gold nanoparticles for selective IR heating |
US9844347B2 (en) | 2009-02-13 | 2017-12-19 | The Ohio State University | Electromagnetic system and method |
WO2010093479A2 (en) * | 2009-02-13 | 2010-08-19 | The Ohio State University Research Foundation | Electromagnetic system and method |
US10149982B2 (en) * | 2009-03-11 | 2018-12-11 | University Of South Florida | Prevention and treatment of brain diseases and disorders related to abnormal protein aggregation through electromagnetic field treatment |
JP5706420B2 (ja) | 2009-08-24 | 2015-04-22 | ニュー フェーズ リミテッド | 相変化材料および形状変化材料 |
US20110123452A1 (en) * | 2009-11-25 | 2011-05-26 | Nanoprobes, Inc. | Metal oligomers and polymers and their use in biology and medicine |
WO2011159829A2 (en) * | 2010-06-15 | 2011-12-22 | Old Dominion University Research Foundation | Method and device for treatment of conditions aggravated by amyloid fibrils |
RU2447915C1 (ru) * | 2010-09-02 | 2012-04-20 | Любовь Андреевна Осминкина | Способ усиления действия ультразвука при лечении гипертермией опухолевых тканей путем использования нанокластеров кремния |
US9005151B2 (en) | 2011-09-07 | 2015-04-14 | Choon Kee Lee | Thermal apparatus |
GB2514714A (en) * | 2012-03-29 | 2014-12-03 | Spiration Inc | Apparatuses, methods, and systems for the identification and treatment of pulmonary tissue |
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