JP5465006B2 - キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物 - Google Patents

キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物 Download PDF

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JP5465006B2
JP5465006B2 JP2009523852A JP2009523852A JP5465006B2 JP 5465006 B2 JP5465006 B2 JP 5465006B2 JP 2009523852 A JP2009523852 A JP 2009523852A JP 2009523852 A JP2009523852 A JP 2009523852A JP 5465006 B2 JP5465006 B2 JP 5465006B2
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cancer
compound
hydrogen
disease
alkyl
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JP2010501478A5 (de
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ウインサンジエ，ニコラ
バルルエンガ，ソフイア
カープラス，マーテイン
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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JP2009523852A 2006-08-11 2007-08-10 キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物 Active JP5465006B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83715406P 2006-08-11 2006-08-11
US60/837,154 2006-08-11
US85873106P 2006-11-13 2006-11-13
US60/858,731 2006-11-13
PCT/US2007/017754 WO2008021213A1 (en) 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90

Publications (3)

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JP2010501478A JP2010501478A (ja) 2010-01-21
JP2010501478A5 JP2010501478A5 (de) 2011-06-30
JP5465006B2 true JP5465006B2 (ja) 2014-04-09

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JP2009523852A Active JP5465006B2 (ja) 2006-08-11 2007-08-10 キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物

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US (2) US8067412B2 (de)
EP (1) EP2136799B1 (de)
JP (1) JP5465006B2 (de)
CN (2) CN101588799B (de)
CA (1) CA2696021C (de)
ES (1) ES2651019T3 (de)
WO (1) WO2008021213A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015110624A (ja) * 2008-01-15 2015-06-18 ユニベルシテ・ドウ・ストラスブール 治療薬として有用なレゾルシン酸ラクトンの合成

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
US8212012B2 (en) * 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
CN101588799B (zh) 2006-08-11 2013-09-11 斯特拉斯堡大学 用作激酶抑制剂和hsp90抑制剂的大环化合物
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
BRPI0820958B1 (pt) 2007-12-07 2022-04-05 Eisai R&D Management Co., Ltd Compostos macrolídeos
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
WO2010014617A1 (en) * 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011041593A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
WO2012021974A1 (en) * 2010-08-20 2012-02-23 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
BR112013009614A2 (pt) * 2010-10-22 2016-07-19 Centre Nat Rech Scient conjugados de pochoxime úteis para o tratamento de patologias relacionadas à hsp90
WO2013062923A1 (en) * 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp. MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
WO2016196256A2 (en) * 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
WO2022089449A1 (zh) * 2020-10-26 2022-05-05 山东大学 一种特异性热休克蛋白90α亚型抑制剂制备及其应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196019A (en) 1964-04-06 1965-07-20 Purdue Research Foundation Anabolic and estrogenic compound and process of making
US3239346A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
US3453367A (en) 1966-06-29 1969-07-01 Commercial Solvents Corp Methods for treating inflammation with estrogenic compounds
FR96016E (fr) 1966-06-29 1972-05-19 Commercial Solvents Corp Composé utilisable comme supplément alimentaire pour les animaux.
NL131183C (de) 1966-12-13
US3758511A (en) 1967-01-18 1973-09-11 Merck & Co Inc Preparation of d,1-zearalenones
US3551454A (en) 1967-07-26 1970-12-29 Merck & Co Inc Preparation of optically active (-)-zearalenone and intermediates therefor
US3586701A (en) 1967-08-24 1971-06-22 Commercial Solvents Corp Norzearalane and its production
US3887583A (en) 1968-05-15 1975-06-03 Commercial Solvents Corp Products and process
US3591608A (en) * 1968-11-15 1971-07-06 Ayerst Mckenna & Harrison Macrocyclic ketolactones
US3621036A (en) 1969-02-27 1971-11-16 Merck & Co Inc Derivatives of zearalane
US3704249A (en) 1969-05-01 1972-11-28 Merck & Co Inc Synthesis of the biologically active diastereoisomer of (-) zearalanol
US3860616A (en) 1969-05-01 1975-01-14 Merck & Co Inc Synthesis of d,1-zearalanol
BE757083A (fr) 1970-02-16 1971-03-16 Commercial Solvents Corp Nouveaux produits a activite antibacterienne
BE757082A (fr) 1970-02-16 1971-03-16 Commercial Solvents Corp Procede de preparation de nouveaux produits a activite antibacterienne
US3687982A (en) 1971-03-09 1972-08-29 Commercial Solvents Corp Separation of mixed diastereoisomers of zearalanol
US3957825A (en) 1972-04-25 1976-05-18 Commercial Solvents Corporation Process for synthesizing zearalanone and related compounds
US3810918A (en) 1972-04-25 1974-05-14 Commercial Solvent Corp Synthesis of zearalanone
US3852307A (en) 1972-04-25 1974-12-03 Commercial Solvents Corp Synthesis of zearalanone and related compounds
US3903115A (en) 1972-04-25 1975-09-02 Commercial Solvents Corp Synthesis of zearalanes II and related compounds and intermediates useful in the syntheses thereof
US3836544A (en) 1972-04-25 1974-09-17 Commercial Solvents Corp Synthesis of zearalanes ii and related compounds and intermediates useful in the syntheses thereof
US3901921A (en) 1972-04-25 1975-08-26 Commercial Solvents Corp Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof
US3901922A (en) 1972-04-25 1975-08-26 Commercial Solvents Corp Synthesis of zearalanone and related compounds and intermediates useful in their synthesis
US3925423A (en) 1974-01-22 1975-12-09 Commercial Solvents Corp Resorcyclic acid lactones and their production
US3965275A (en) 1974-02-11 1976-06-22 Commercial Solvents Corporation Composition and method
US3954805A (en) 1974-06-06 1976-05-04 Commercial Solvents Corporation Process for preparing zearalene type compounds
US4035504A (en) 1975-05-12 1977-07-12 Imc Chemical Group, Inc. Method for treating cholesterolemia by administering resorcylic acid lactone derivatives
US4042602A (en) 1976-11-04 1977-08-16 Imc Chemical Group, Inc. Synthesis of dideoxyzearalane and related compounds
US4088658A (en) 1976-11-04 1978-05-09 Imc Chemical Group, Inc. Synthesis of dideoxyzearalane and related compounds
US4228079A (en) 1978-10-30 1980-10-14 W. R. Grace & Co. Dialkoxy monorden derivatives
US4670249A (en) 1985-04-12 1987-06-02 International Minerals & Chemical Corp. Growth-promoting compositions
EP0248916A1 (de) * 1986-06-05 1987-12-16 C.R.C. Compagnia di Ricerca Chimica S.p.A. Verfahren zur Trennung des 3S,7R-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-ones von seinem 3S,7S-Diastereomeren
US4751239A (en) 1987-06-29 1988-06-14 International Minerals & Chemical Corp. 6' Carbonate esters of zearalanol and its derivatives
US4778821A (en) 1987-07-15 1988-10-18 International Minerals & Chemical Corp. Method for controlling helmintic parasites
US4849447A (en) 1987-10-13 1989-07-18 Pitman-Moore, Inc. Zearalanol derivatives with anabolic activity
US4902711A (en) 1988-01-19 1990-02-20 Pitman-Moore, Inc. 6' Carbamate esters of zearalanol and its derivatives
IE911915A1 (en) 1990-06-06 1991-12-18 Sankyo Co Radicicol derivatives, their preparation and their¹anti-tumor activity
US5650430A (en) 1990-06-06 1997-07-22 Sankyo Company, Limited Radicicol derivatives, their preparation and their anti-tumor activity
JPH06279279A (ja) 1993-03-26 1994-10-04 Tsumura & Co 血管新生阻害剤
JPH06298764A (ja) 1993-04-15 1994-10-25 Kyowa Hakko Kogyo Co Ltd 免疫抑制剤
US5795910A (en) 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
US5731343A (en) 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
AU700840B2 (en) * 1995-04-26 1999-01-14 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
US5710174A (en) 1995-06-07 1998-01-20 Zymo Genetics, Inc. Factor XIIIA inhibitor
JPH09202781A (ja) 1996-01-25 1997-08-05 Sankyo Co Ltd ラディシコール誘導体
EP0889042B1 (de) 1996-10-25 2004-05-06 Kyowa Hakko Kogyo Co., Ltd. Radicicolderivate
JPH10265381A (ja) 1997-03-24 1998-10-06 Sankyo Co Ltd 血管再狭窄予防剤
AU3534499A (en) 1998-04-24 1999-11-16 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
AU779438B2 (en) * 1998-12-24 2005-01-27 Novation Pharmaceuticals Inc. Compounds which affect mRNA stability and uses therefor
JP2000236894A (ja) 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd ラディシコールの製造方法
WO2002002123A1 (en) 2000-06-29 2002-01-10 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
US6946456B2 (en) 2000-07-28 2005-09-20 Sloan-Kettering Institute For Cancer Research Methods for treating cell proliferative disorders and viral infections
AU7815201A (en) 2000-08-04 2002-02-18 Univ Texas Synthetic salicylihalamides, apicularens and derivatives thereof
US6734209B2 (en) 2001-08-03 2004-05-11 Board Of Regents The University Of Texas System Synthetic salicylihalamides, apicularens and derivatives thereof
ATE483693T1 (de) 2000-08-18 2010-10-15 Millennium Pharm Inc N-aryl-ä4-ä7-(alkoxy)chinazolin-4- ylüpiperazinylücarboxamid-verbindungen als pdgf- rezeptoren hemmer
US7115651B2 (en) 2000-08-25 2006-10-03 Sloan-Kettering Institute For Cancer Research Macrocycles and uses thereof
CA2426952C (en) 2000-11-02 2012-06-26 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
US20030211469A1 (en) 2001-07-16 2003-11-13 Lloyd Waxman Inhibiting hepatitis c virus processing and replication
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
JP2003113183A (ja) 2001-10-05 2003-04-18 Kyowa Hakko Kogyo Co Ltd リウマチ治療剤
EP1450784A4 (de) 2001-11-09 2005-02-09 Conforma Therapeutics Corp Hsp90-hemmende zearalanol-verbindungen und verfahren zu ihrer herstellung und verwendung
WO2003050295A2 (en) 2001-12-12 2003-06-19 Conforma Therapeutics Corporation Assays and implements for determining and modulating hsp90 binding activity
GB0202871D0 (en) 2002-02-07 2002-03-27 Cancer Res Ventures Ltd Assays,methods and means
CN104876904A (zh) 2002-03-08 2015-09-02 卫材R&D管理株式会社 用作医药品的大环化合物
WO2003086334A1 (fr) * 2002-04-17 2003-10-23 Taisho Pharmaceutical Co., Ltd. Produit tonique pour la pousse de cheveux
WO2004024142A1 (ja) * 2002-08-29 2004-03-25 Kyowa Hakko Kogyo Co., Ltd. Ｈｓｐ９０ファミリー蛋白質阻害剤
US20060251574A1 (en) 2002-12-12 2006-11-09 Adeela Kamal Cytotoxins and diagnostic imaging agents comprising hsp90 ligands
US7959915B2 (en) 2003-03-12 2011-06-14 Tufts University Inhibitors of extracellular Hsp90
EP1666064A4 (de) 2003-08-22 2008-12-17 Kyowa Hakko Kogyo Kk Mittel zur behandlung von erkrankungen im zusammenhang mit immunoglobulin-gen-translokation
WO2005061481A1 (en) * 2003-12-19 2005-07-07 Sloan-Kettering Institute For Cancer Research Novel ma crocycles and uses thereof
WO2005105077A1 (en) 2004-04-28 2005-11-10 Massachusetts Eye & Ear Infirmary Inflammatory eye disease
WO2006036941A2 (en) 2004-09-27 2006-04-06 Kosan Biosciences Incorporated Specific kinase inhibitors
WO2006119456A2 (en) 2005-05-04 2006-11-09 University Of Vermont And State Agricultural College Methods and compositions for treating toxoplasma
CN101588799B (zh) 2006-08-11 2013-09-11 斯特拉斯堡大学 用作激酶抑制剂和hsp90抑制剂的大环化合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015110624A (ja) * 2008-01-15 2015-06-18 ユニベルシテ・ドウ・ストラスブール 治療薬として有用なレゾルシン酸ラクトンの合成

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CN101588799A (zh) 2009-11-25
US20080146545A1 (en) 2008-06-19
WO2008021213A1 (en) 2008-02-21
US20120077775A1 (en) 2012-03-29
EP2136799A1 (de) 2009-12-30
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CA2696021C (en) 2015-09-29
ES2651019T3 (es) 2018-01-23
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US8450305B2 (en) 2013-05-28
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