JP5461785B2 - 繰り返し感染予防用の医薬組成物 - Google Patents
繰り返し感染予防用の医薬組成物 Download PDFInfo
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- JP5461785B2 JP5461785B2 JP2008093713A JP2008093713A JP5461785B2 JP 5461785 B2 JP5461785 B2 JP 5461785B2 JP 2008093713 A JP2008093713 A JP 2008093713A JP 2008093713 A JP2008093713 A JP 2008093713A JP 5461785 B2 JP5461785 B2 JP 5461785B2
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- Medicinal Preparation (AREA)
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Description
本発明の1つの側面によれば、水、第4級アンモニウム系殺菌剤、多価アルコール、ヒドロキシプロピルセルロース、ヒプロメロース、ポリビニルピロリドンを含む、口腔咽頭用の医薬組成物が提供される。
本発明の前記側面の1つの態様において、水、第4級アンモニウム系殺菌剤、多価アルコール、ヒドロキシプロピルセルロース、ヒプロメロース、およびポリビニルピロリドンを含み、25℃における粘度が2〜50cPであり、好ましくは、3〜40cPであり、より好ましくは、5〜25cPである、口腔咽頭用の含嗽剤が提供される。これにより、適した付着性、滞留性および殺菌力を有し、長期安定性にも優れた、使用感の良い口腔咽頭用の医薬組成物が提供される。
(1)水、第4級アンモニウム系殺菌剤、多価アルコール、ヒドロキシプロピルセルロース、ヒプロメロースおよびポリビニルピロリドンを含む、口腔咽頭用の含嗽剤。
(3)0.001〜1重量%の第4級アンモニウム系殺菌剤、3〜25重量%の多価アルコール、0.01〜5重量%のヒドロキシプロピルセルロース、0.01〜5重量%のヒプロメロース、0.01〜5重量%のポリビニルピロリドンを含む、本明細書に記載の含嗽剤。
本発明の前記側面の1つの態様において、成分中に含まれる脂分・油分が、例えば、5重量%以下、好ましくは3重量%以下であり、より好ましくは配合されていない、本明細書で定義した医薬組成物が提供される。また、本発明の別の態様において、任意成分として含まれる界面活性剤が、例えば、0.1重量%以下、好ましくは配合されていない、本明細書で定義した医薬組成物が提供される。本発明の医薬組成物は、薬剤の患部への付着性および滞留性において優れ、さらに第4級アンモニウム系殺菌剤の効果の妨げとなる界面活性剤の含有量が低いか、または界面活性剤を実質的に含まないために、殺菌力においても優れている。
表1の試薬を使用し、常法に従い、表2〜4の組成を有する組成物(実施例1〜40および比較例1〜18)、各100mLを調製した。
各組成物の、付着性、滞留性および殺菌力を評価するため、ならびに粘度を測定するために、以下の試験を行った。
15名による官能試験により評価した。各組成物を用いてうがいを行い、うがい直後ののどへの付着感を評価した。薬剤が咽頭部周辺に存在することを実感できる場合は○、存在することを実感できない場合および存在することを実感できるが不快である場合を×として評価した。
各組成物の一部(1mL)をガラス板上に滴下し、そのまま23℃、低湿度の一定条件下で7時間放置し、その後のガラス板を45°傾けて流動性を評価した。流動性を保持していた場合は○、乾燥していた場合は×として評価した。
Staphylococcus aureus (NBRC 12732)、Escherichia coli (NBRC 3972)、Pseudomonas aeruginosa (NBRC13275)、およびStreptococcus pyogenes(ATCC 19615)(それぞれ、独立行政法人製品評価技術基盤機構 生物遺伝資源部門(NBRC)より入手)を使用して試験を行った。菌を純培養増菌後、McFarland No. 0.5の濁度となるようにニュートリエントブロスに懸濁させて菌液を調製した。被験組成物を(9.9mL)を滅菌済み試験管に入れ、そこへ菌液0.1mLを添加し、30秒後、60秒後にサンプリングし、段階希釈後カンテン培地で培養し、生菌数を計測した。得られた菌数より、JIS Z 2801抗菌試験方法で定められている試験方法に基づいて抗菌活性値を計算し、抗菌活性値が2.0以上の場合を○、それ未満の場合を×とし、4菌種全てが60秒後までに○となった場合、殺菌効果があると判断した。
ブルックリン社製粘度計(BROOK FIELD、PROGRAMMABLE、DV−II+VISCOMETERなど)およびスピンドル(BROOK FIELD、UL/Y ADAPTER)を使用し、試料16mLをスピンドルアタッチメント内に入れ、温度25℃で、伝導率10%程度になるように、スピンドルの回転数を合わせて数値(cP)を読み取り、小数第1位を四捨五入して粘度の値とした。
[試験例2]
各組成物の繰り返し感染改善効果を評価するために、以下の試験を行った。
各群4名の風邪患者群をつくり、それぞれを、実施例1、比較例9、比較例10、比較例11および比較例18の投与群とした。各患者は被検物質を用いて1日に2回のうがいを行った。自覚症状によりのどの不快感、発熱、倦怠感などの風邪の諸症状の緩解が確認されるまでの日数を記録した。各群の結果を、以下の表11に示す。
[処方例]
表12および13の記載の処方例に従い、口腔咽頭用の医薬組成物を調製した。
Claims (7)
- 水、第4級アンモニウム系殺菌剤、多価アルコール、ヒドロキシプロピルセルロース、ヒプロメロースおよびポリビニルピロリドンを含む、口腔咽頭用の医薬組成物。
- 25℃における粘度が2〜50cPである、請求項1に記載の医薬組成物。
- 0.001〜1重量%の第4級アンモニウム系殺菌剤、3〜25重量%の多価アルコール、0.01〜5重量%のヒドロキシプロピルセルロース、0.01〜5重量%のヒプロメロース、0.01〜5重量%のポリビニルピロリドンを含む、請求項1または2に記載の医薬組成物。
- 第4級アンモニウム系殺菌剤が、塩化セチルピリジニウム、塩化ベンザルコニウム、塩化ベンゼトニウム、および塩化デカリニウムから選択される、請求項1〜3のいずれか1項に記載の医薬組成物。
- 多価アルコールが、プロピレングリコール、グリセリン、ソルビトール、エチレングリコールおよびマンニトールから選択される、請求項1〜4のいずれか1項に記載の医薬組成物。
- 呼吸器感染症の繰り返し感染の予防のために使用する、請求項1〜5のいずれか1項にに記載の医薬組成物。
- 含嗽剤として使用する、請求項6に記載の医薬組成物。
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