JP5417558B2 - 置換８−［６−アミノ−３−ピリジル］キサンチン類 - Google Patents
置換８−［６−アミノ−３−ピリジル］キサンチン類 Download PDFInfo
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- JP5417558B2 JP5417558B2 JP2009515468A JP2009515468A JP5417558B2 JP 5417558 B2 JP5417558 B2 JP 5417558B2 JP 2009515468 A JP2009515468 A JP 2009515468A JP 2009515468 A JP2009515468 A JP 2009515468A JP 5417558 B2 JP5417558 B2 JP 5417558B2
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- acid
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80503006P | 2006-06-16 | 2006-06-16 | |
| US60/805,030 | 2006-06-16 | ||
| US80556406P | 2006-06-22 | 2006-06-22 | |
| US60/805,864 | 2006-06-22 | ||
| US11/811,823 US7884100B2 (en) | 2006-06-16 | 2007-06-12 | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US11/811,823 | 2007-06-12 | ||
| PCT/US2007/013849 WO2007149277A2 (en) | 2006-06-16 | 2007-06-13 | Substituted 8-[6-amino-3-pyridyl]xanthines |
Publications (3)
| Publication Number | Publication Date |
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| JP2010500284A JP2010500284A (ja) | 2010-01-07 |
| JP2010500284A5 JP2010500284A5 (cg-RX-API-DMAC7.html) | 2010-07-22 |
| JP5417558B2 true JP5417558B2 (ja) | 2014-02-19 |
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| JP2009515468A Expired - Fee Related JP5417558B2 (ja) | 2006-06-16 | 2007-06-13 | 置換８−［６−アミノ−３−ピリジル］キサンチン類 |
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Families Citing this family (8)
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| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| EP1658291B1 (en) * | 2003-08-25 | 2013-10-02 | Dogwood Pharmaceuticals, Inc. | Substituted 8-heteroaryl xanthines |
| US7618962B2 (en) * | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
| US7598379B2 (en) | 2005-02-25 | 2009-10-06 | Pgx Health, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| WO2006091897A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Derivatives of 8-substituted xanthines |
| US7884100B2 (en) | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US7875608B2 (en) * | 2007-12-17 | 2011-01-25 | Thompson Robert D | Substituted 8-[6-amino-3pyridyl]xanthines |
| BR112023023996A2 (pt) * | 2021-05-18 | 2024-01-30 | Adovate Llc | Xantinas de piridil contendo amida cíclica como antagonistas de a2b |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| US6060481A (en) * | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| AU2001238342A1 (en) * | 2000-02-17 | 2001-08-27 | Cv Therapeutics, Inc. | Method for identifying and using A2B adenosine receptor antagonists to mediate mammalian cell proliferation |
| US7304070B2 (en) | 2001-11-09 | 2007-12-04 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| KR100937620B1 (ko) * | 2001-11-09 | 2010-01-20 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Ａ２ｂ 아데노신 수용체 길항제 |
| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| NZ528591A (en) * | 2002-02-01 | 2006-11-30 | King Pharmaceuticals Res & Dev | 8-heteroaryl xanthine adenosine A2B receptor antagonists and their pharmaceutical use |
| US7034070B2 (en) * | 2002-09-27 | 2006-04-25 | Vincent Chuang | Arylalkyl aminofunctional silanes for epoxy laminates |
| US7148229B2 (en) * | 2003-02-19 | 2006-12-12 | Hoffman-La Roche Inc. | Sulfonamide substituted xanthine derivatives |
| EP1658291B1 (en) * | 2003-08-25 | 2013-10-02 | Dogwood Pharmaceuticals, Inc. | Substituted 8-heteroaryl xanthines |
| KR101247528B1 (ko) | 2004-09-01 | 2013-04-15 | 길리애드 사이언시즈, 인코포레이티드 | Ａ２ｂ 아데노신 수용체 길항제를 사용하는 상처 치유 방법 |
| WO2006028840A2 (en) | 2004-09-03 | 2006-03-16 | United States Postal Service | Methods and systems for providing an enterprise supply management portal |
| CN101039677A (zh) * | 2004-10-15 | 2007-09-19 | Cv医药有限公司 | 利用a2b腺苷受体拮抗剂预防和治疗气道重建及肺部炎症的方法 |
| WO2006091897A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Derivatives of 8-substituted xanthines |
| US7598379B2 (en) * | 2005-02-25 | 2009-10-06 | Pgx Health, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| US7618962B2 (en) * | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
| US7601723B2 (en) * | 2005-02-25 | 2009-10-13 | Pgx Health, Llc | Pyridyl substituted xanthines |
| US7625881B2 (en) * | 2005-06-16 | 2009-12-01 | Gilead Palo Alto, Inc. | Prodrugs of A2B adenosine receptor antagonists |
| JP5250848B2 (ja) * | 2006-03-17 | 2013-07-31 | ギリアード サイエンシーズ， インコーポレイテッド | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
| AU2006344750A1 (en) * | 2006-06-15 | 2007-12-27 | Targeted Genetics Corporation | Methods for treating target joints in inflammatory arthritis using AAV vectors encoding a TNF antagonist |
| US7884100B2 (en) | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| US7875608B2 (en) * | 2007-12-17 | 2011-01-25 | Thompson Robert D | Substituted 8-[6-amino-3pyridyl]xanthines |
| CA2718983C (en) * | 2008-03-26 | 2015-12-08 | Advinus Therapeutics Pvt. Ltd. | Heterocyclic compounds as adenosine receptor antagonist |
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2008015954A (es) | 2009-03-06 |
| EA200900010A1 (ru) | 2009-10-30 |
| MY152178A (en) | 2014-08-15 |
| JP2010500284A (ja) | 2010-01-07 |
| US20110082139A1 (en) | 2011-04-07 |
| IL195916A0 (en) | 2009-09-01 |
| BRPI0712001A2 (pt) | 2012-01-10 |
| CA2655598A1 (en) | 2007-12-27 |
| KR101413404B1 (ko) | 2014-06-27 |
| DK2029143T3 (en) | 2015-09-21 |
| US7884100B2 (en) | 2011-02-08 |
| US20080004292A1 (en) | 2008-01-03 |
| HUE026457T2 (en) | 2016-05-30 |
| KR20090029268A (ko) | 2009-03-20 |
| PT2029143E (pt) | 2015-10-20 |
| EP2029143A2 (en) | 2009-03-04 |
| AU2007261568A1 (en) | 2007-12-27 |
| BRPI0712001B1 (pt) | 2020-04-07 |
| CA2655598C (en) | 2014-10-28 |
| EP2029143A4 (en) | 2009-07-15 |
| NZ597222A (en) | 2013-06-28 |
| BRPI0712001B8 (pt) | 2021-05-25 |
| US8258142B2 (en) | 2012-09-04 |
| IL195916A (en) | 2015-06-30 |
| ES2548437T3 (es) | 2015-10-16 |
| EP2029143B1 (en) | 2015-07-08 |
| AU2007261568B2 (en) | 2013-05-16 |
| EA016791B1 (ru) | 2012-07-30 |
| CN103145712A (zh) | 2013-06-12 |
| PL2029143T3 (pl) | 2015-12-31 |
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