JP5412422B2 - Ｎ−アミノインドールの遷移金属触媒合成 - Google Patents

Ｎ−アミノインドールの遷移金属触媒合成 Download PDF

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Publication number
JP5412422B2
JP5412422B2 JP2010502442A JP2010502442A JP5412422B2 JP 5412422 B2 JP5412422 B2 JP 5412422B2 JP 2010502442 A JP2010502442 A JP 2010502442A JP 2010502442 A JP2010502442 A JP 2010502442A JP 5412422 B2 JP5412422 B2 JP 5412422B2
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Japanese (ja)
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JP2010523605A5 (enExample
JP2010523605A (ja
Inventor
ニシュ・ハーランド
エム・ナザリー
アンドレーアス・リンデンシュミット
オマール・ルキーク
マティーアス・ウルマン
ホルヘ・アーローンソウ
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010502442A 2007-04-13 2008-03-29 Ｎ−アミノインドールの遷移金属触媒合成 Expired - Fee Related JP5412422B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07007585 2007-04-13
EP07007585.8 2007-04-13
PCT/EP2008/002519 WO2008125207A1 (en) 2007-04-13 2008-03-29 A transition metal catalyzed synthesis of n-aminoindoles

Publications (3)

Publication Number Publication Date
JP2010523605A JP2010523605A (ja) 2010-07-15
JP2010523605A5 JP2010523605A5 (enExample) 2011-05-06
JP5412422B2 true JP5412422B2 (ja) 2014-02-12

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Family Applications (1)

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JP2010502442A Expired - Fee Related JP5412422B2 (ja) 2007-04-13 2008-03-29 Ｎ−アミノインドールの遷移金属触媒合成

Country Status (12)

Country Link
US (1) US8026375B2 (enExample)
EP (1) EP2134682B1 (enExample)
JP (1) JP5412422B2 (enExample)
KR (1) KR20100015546A (enExample)
CN (1) CN101657422A (enExample)
AT (1) ATE537142T1 (enExample)
AU (1) AU2008238379A1 (enExample)
BR (1) BRPI0810199A2 (enExample)
CA (1) CA2683578A1 (enExample)
IL (1) IL201253A0 (enExample)
MX (1) MX2009010536A (enExample)
WO (1) WO2008125207A1 (enExample)

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US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
MX2010007418A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
JP5788316B2 (ja) 2008-07-08 2015-09-30 インテリカイン， エルエルシー キナーゼインヒビターおよび使用方法
JP5731978B2 (ja) 2008-09-26 2015-06-10 インテリカイン， エルエルシー 複素環キナーゼ阻害剤
US8697709B2 (en) 2008-10-16 2014-04-15 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
WO2011146882A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
EP2663309B1 (en) 2011-01-10 2017-03-15 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
CN102093334B (zh) * 2011-02-22 2013-05-08 郑州大学 一组稠环噻吩类化合物的合成方法
CN106619647A (zh) 2011-02-23 2017-05-10 因特利凯有限责任公司 激酶抑制剂的组合及其用途
EP2734520B1 (en) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CA2846431A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2014052669A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
MX375194B (es) 2012-11-01 2025-03-06 Infinity Pharmaceuticals Inc Tratamiento de cánceres utilizando moduladores de las isoformas de pi3 cinasa.
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG10201902074UA (en) 2013-10-04 2019-04-29 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
CN103755621B (zh) * 2014-01-23 2015-08-05 清华大学 由芳基肼和炔烃制备多取代吲哚的方法
PT3119397T (pt) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10285824B2 (en) 2014-10-28 2019-05-14 Spectrum Spine Ip Holdings, Llc Expandable, adjustable inter-body fusion devices and methods
KR102787845B1 (ko) 2015-09-14 2025-03-31 트웰브 테라퓨틱스, 아이엔씨. 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109640999A (zh) 2016-06-24 2019-04-16 无限药品股份有限公司 组合疗法
KR102038977B1 (ko) * 2016-12-30 2019-11-01 사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디 신규한 시클로펜타[ｂ]티오펜일 전이금속 화합물, 이를 포함하는 전이금속 촉매 조성물, 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
CN121021734A (zh) * 2018-12-21 2025-11-28 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038B (zh) * 2024-06-05 2024-12-03 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

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ES2065324T3 (es) * 1987-04-24 1995-02-16 Hoechst Roussel Pharma N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.
US4983608A (en) 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
DE60016068T2 (de) 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
FR2842196B1 (fr) * 2002-07-15 2006-01-13 Rhodia Polyamide Intermediates Procede de fabrication de composes nitriles a partir de composes a insaturation ethylenique
AU2005231622B2 (en) 2004-04-08 2011-05-26 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use

Also Published As

Publication number Publication date
US20100168429A1 (en) 2010-07-01
US8026375B2 (en) 2011-09-27
EP2134682B1 (en) 2011-12-14
AU2008238379A1 (en) 2008-10-23
CA2683578A1 (en) 2008-10-23
BRPI0810199A2 (pt) 2014-10-14
IL201253A0 (en) 2010-05-31
WO2008125207A1 (en) 2008-10-23
CN101657422A (zh) 2010-02-24
ATE537142T1 (de) 2011-12-15
KR20100015546A (ko) 2010-02-12
JP2010523605A (ja) 2010-07-15
MX2009010536A (es) 2009-10-22
EP2134682A1 (en) 2009-12-23

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