CN101657422A - 过渡金属催化的n-氨基吲哚的合成 - Google Patents

过渡金属催化的n-氨基吲哚的合成 Download PDF

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Publication number
CN101657422A
CN101657422A CN200880011689A CN200880011689A CN101657422A CN 101657422 A CN101657422 A CN 101657422A CN 200880011689 A CN200880011689 A CN 200880011689A CN 200880011689 A CN200880011689 A CN 200880011689A CN 101657422 A CN101657422 A CN 101657422A
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CN
China
Prior art keywords
unsubstituted
trisubstituted
alkyl
phenyl
independently mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN200880011689A
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English (en)
Chinese (zh)
Inventor
N·哈兰
M·纳扎雷
A·林登施密德
O·勒克埃克
M·乌尔曼
J·阿朗索
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Sanofi Aventis France
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Sanofi Aventis France
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Publication date
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Publication of CN101657422A publication Critical patent/CN101657422A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880011689A 2007-04-13 2008-03-29 过渡金属催化的n-氨基吲哚的合成 Pending CN101657422A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07007585.8 2007-04-13
EP07007585 2007-04-13

Publications (1)

Publication Number Publication Date
CN101657422A true CN101657422A (zh) 2010-02-24

Family

ID=38457866

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CN200880011689A Pending CN101657422A (zh) 2007-04-13 2008-03-29 过渡金属催化的n-氨基吲哚的合成

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US (1) US8026375B2 (enExample)
EP (1) EP2134682B1 (enExample)
JP (1) JP5412422B2 (enExample)
KR (1) KR20100015546A (enExample)
CN (1) CN101657422A (enExample)
AT (1) ATE537142T1 (enExample)
AU (1) AU2008238379A1 (enExample)
BR (1) BRPI0810199A2 (enExample)
CA (1) CA2683578A1 (enExample)
IL (1) IL201253A0 (enExample)
MX (1) MX2009010536A (enExample)
WO (1) WO2008125207A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093334A (zh) * 2011-02-22 2011-06-15 郑州大学 一组稠环噻吩类化合物的合成方法
TWI646102B (zh) * 2016-12-30 2019-01-01 新加坡商沙特基礎工業愛思開奈克斯林恩私人有限公司 新穎環戊［Ｂ］苯硫基過渡金屬化合物、包含該化合物的過渡金屬催化劑組合物、以及使用該化合物製備乙烯均聚物或乙烯與α-烯烴的共聚物的方法
CN113286832A (zh) * 2018-12-21 2021-08-20 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038A (zh) * 2024-06-05 2024-09-13 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

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US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
KR20150038395A (ko) 2006-04-04 2015-04-08 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 키나제 길항물질
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
BRPI0906473A8 (pt) 2008-01-04 2016-02-10 Intellikine Inc Certas entidades químicas, composições e métodos
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
WO2009114870A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Kinase inhibitors and methods of use
MX2011000216A (es) 2008-07-08 2011-03-29 Intellikine Inc Inhibidores de cinasa y metodos para su uso.
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors
AU2009305669A1 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ， インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
WO2012064973A2 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3238722B1 (en) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones
TWI592411B (zh) 2011-02-23 2017-07-21 英特爾立秦有限責任公司 激酶抑制劑之組合及其用途
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP2734520B1 (en) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PE20141371A1 (es) 2011-08-29 2014-10-13 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CA2886240A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP3964507A1 (en) 2013-10-04 2022-03-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN103755621B (zh) * 2014-01-23 2015-08-05 清华大学 由芳基肼和炔烃制备多取代吲哚的方法
CN106456628A (zh) 2014-03-19 2017-02-22 无限药品股份有限公司 用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10285824B2 (en) 2014-10-28 2019-05-14 Spectrum Spine Ip Holdings, Llc Expandable, adjustable inter-body fusion devices and methods
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3474856B1 (en) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Combination therapies
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2

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DE3852335T2 (de) * 1987-04-24 1995-05-11 Hoechst Roussel Pharma N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
US4983608A (en) 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
DE60016068T2 (de) 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
FR2842196B1 (fr) * 2002-07-15 2006-01-13 Rhodia Polyamide Intermediates Procede de fabrication de composes nitriles a partir de composes a insaturation ethylenique
EP1732612B1 (en) 2004-04-08 2009-09-16 Jado Technologies GmbH Tripartite conjugates containing a structure interacting with cell membrane rafts and their use

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093334A (zh) * 2011-02-22 2011-06-15 郑州大学 一组稠环噻吩类化合物的合成方法
CN102093334B (zh) * 2011-02-22 2013-05-08 郑州大学 一组稠环噻吩类化合物的合成方法
TWI646102B (zh) * 2016-12-30 2019-01-01 新加坡商沙特基礎工業愛思開奈克斯林恩私人有限公司 新穎環戊［Ｂ］苯硫基過渡金屬化合物、包含該化合物的過渡金屬催化劑組合物、以及使用該化合物製備乙烯均聚物或乙烯與α-烯烴的共聚物的方法
CN113286832A (zh) * 2018-12-21 2021-08-20 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038A (zh) * 2024-06-05 2024-09-13 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

Also Published As

Publication number Publication date
ATE537142T1 (de) 2011-12-15
WO2008125207A1 (en) 2008-10-23
EP2134682B1 (en) 2011-12-14
US8026375B2 (en) 2011-09-27
EP2134682A1 (en) 2009-12-23
AU2008238379A1 (en) 2008-10-23
BRPI0810199A2 (pt) 2014-10-14
IL201253A0 (en) 2010-05-31
JP2010523605A (ja) 2010-07-15
US20100168429A1 (en) 2010-07-01
JP5412422B2 (ja) 2014-02-12
KR20100015546A (ko) 2010-02-12
MX2009010536A (es) 2009-10-22
CA2683578A1 (en) 2008-10-23

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