CN101657422A - 过渡金属催化的n-氨基吲哚的合成 - Google Patents

过渡金属催化的n-氨基吲哚的合成 Download PDF

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Publication number
CN101657422A
CN101657422A CN200880011689A CN200880011689A CN101657422A CN 101657422 A CN101657422 A CN 101657422A CN 200880011689 A CN200880011689 A CN 200880011689A CN 200880011689 A CN200880011689 A CN 200880011689A CN 101657422 A CN101657422 A CN 101657422A
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CN
China
Prior art keywords
unsubstituted
trisubstituted
alkyl
phenyl
independently mono
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CN200880011689A
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English (en)
Chinese (zh)
Inventor
N·哈兰
M·纳扎雷
A·林登施密德
O·勒克埃克
M·乌尔曼
J·阿朗索
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Sanofi SRL
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Sanofi Aventis SpA
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Publication of CN101657422A publication Critical patent/CN101657422A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880011689A 2007-04-13 2008-03-29 过渡金属催化的n-氨基吲哚的合成 Pending CN101657422A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07007585 2007-04-13
EP07007585.8 2007-04-13

Publications (1)

Publication Number Publication Date
CN101657422A true CN101657422A (zh) 2010-02-24

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CN200880011689A Pending CN101657422A (zh) 2007-04-13 2008-03-29 过渡金属催化的n-氨基吲哚的合成

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US (1) US8026375B2 (enExample)
EP (1) EP2134682B1 (enExample)
JP (1) JP5412422B2 (enExample)
KR (1) KR20100015546A (enExample)
CN (1) CN101657422A (enExample)
AT (1) ATE537142T1 (enExample)
AU (1) AU2008238379A1 (enExample)
BR (1) BRPI0810199A2 (enExample)
CA (1) CA2683578A1 (enExample)
IL (1) IL201253A0 (enExample)
MX (1) MX2009010536A (enExample)
WO (1) WO2008125207A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093334A (zh) * 2011-02-22 2011-06-15 郑州大学 一组稠环噻吩类化合物的合成方法
TWI646102B (zh) * 2016-12-30 2019-01-01 新加坡商沙特基礎工業愛思開奈克斯林恩私人有限公司 新穎環戊［Ｂ］苯硫基過渡金屬化合物、包含該化合物的過渡金屬催化劑組合物、以及使用該化合物製備乙烯均聚物或乙烯與α-烯烴的共聚物的方法
CN113286832A (zh) * 2018-12-21 2021-08-20 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038A (zh) * 2024-06-05 2024-09-13 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

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WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
US20080032960A1 (en) 2006-04-04 2008-02-07 Regents Of The University Of California PI3 kinase antagonists
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
MX2010007418A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
JP5788316B2 (ja) 2008-07-08 2015-09-30 インテリカイン， エルエルシー キナーゼインヒビターおよび使用方法
JP5731978B2 (ja) 2008-09-26 2015-06-10 インテリカイン， エルエルシー 複素環キナーゼ阻害剤
US8697709B2 (en) 2008-10-16 2014-04-15 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
WO2011146882A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
EP2663309B1 (en) 2011-01-10 2017-03-15 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
CN106619647A (zh) 2011-02-23 2017-05-10 因特利凯有限责任公司 激酶抑制剂的组合及其用途
EP2734520B1 (en) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CA2846431A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2014052669A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
MX375194B (es) 2012-11-01 2025-03-06 Infinity Pharmaceuticals Inc Tratamiento de cánceres utilizando moduladores de las isoformas de pi3 cinasa.
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG10201902074UA (en) 2013-10-04 2019-04-29 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
CN103755621B (zh) * 2014-01-23 2015-08-05 清华大学 由芳基肼和炔烃制备多取代吲哚的方法
PT3119397T (pt) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10285824B2 (en) 2014-10-28 2019-05-14 Spectrum Spine Ip Holdings, Llc Expandable, adjustable inter-body fusion devices and methods
KR102787845B1 (ko) 2015-09-14 2025-03-31 트웰브 테라퓨틱스, 아이엔씨. 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109640999A (zh) 2016-06-24 2019-04-16 无限药品股份有限公司 组合疗法
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2

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ES2065324T3 (es) * 1987-04-24 1995-02-16 Hoechst Roussel Pharma N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos.
US4983608A (en) 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
DE60016068T2 (de) 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
FR2842196B1 (fr) * 2002-07-15 2006-01-13 Rhodia Polyamide Intermediates Procede de fabrication de composes nitriles a partir de composes a insaturation ethylenique
AU2005231622B2 (en) 2004-04-08 2011-05-26 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093334A (zh) * 2011-02-22 2011-06-15 郑州大学 一组稠环噻吩类化合物的合成方法
CN102093334B (zh) * 2011-02-22 2013-05-08 郑州大学 一组稠环噻吩类化合物的合成方法
TWI646102B (zh) * 2016-12-30 2019-01-01 新加坡商沙特基礎工業愛思開奈克斯林恩私人有限公司 新穎環戊［Ｂ］苯硫基過渡金屬化合物、包含該化合物的過渡金屬催化劑組合物、以及使用該化合物製備乙烯均聚物或乙烯與α-烯烴的共聚物的方法
CN113286832A (zh) * 2018-12-21 2021-08-20 陶氏环球技术有限责任公司 用于烯烃聚合的基于杂环-杂环的iv族过渡金属催化剂
CN116813522A (zh) * 2023-05-04 2023-09-29 广州方中化工有限公司 一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038A (zh) * 2024-06-05 2024-09-13 常州大学 一种n-n轴手性吲哚酰胺类化合物及其合成方法

Also Published As

Publication number Publication date
US20100168429A1 (en) 2010-07-01
JP5412422B2 (ja) 2014-02-12
US8026375B2 (en) 2011-09-27
EP2134682B1 (en) 2011-12-14
AU2008238379A1 (en) 2008-10-23
CA2683578A1 (en) 2008-10-23
BRPI0810199A2 (pt) 2014-10-14
IL201253A0 (en) 2010-05-31
WO2008125207A1 (en) 2008-10-23
ATE537142T1 (de) 2011-12-15
KR20100015546A (ko) 2010-02-12
JP2010523605A (ja) 2010-07-15
MX2009010536A (es) 2009-10-22
EP2134682A1 (en) 2009-12-23

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