JP5401540B2 - 硝酸酸化物供与プロスタミド類 - Google Patents

硝酸酸化物供与プロスタミド類 Download PDF

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JP5401540B2
JP5401540B2 JP2011508009A JP2011508009A JP5401540B2 JP 5401540 B2 JP5401540 B2 JP 5401540B2 JP 2011508009 A JP2011508009 A JP 2011508009A JP 2011508009 A JP2011508009 A JP 2011508009A JP 5401540 B2 JP5401540 B2 JP 5401540B2
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independently
alkyl
alkenyl
alkynyl
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Japanese (ja)
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JP2011519910A5 (OSRAM
JP2011519910A (ja
Inventor
ベネディニ，フランチェスカ
ビオンディ，ステファノ
チロリ，ヴァレリオ
チョン，ウエスリー，クワン，ムン
ドン，リミン
クラウス，アチム，ハンス−ピター
ニコリ，ファビオ
プラサンナ，ガネシュ
ヴァーニア，ウイリアム，フランソワ
ヤン，イー
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ニコックス エス エイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2011508009A 2008-05-09 2009-05-11 硝酸酸化物供与プロスタミド類 Active JP5401540B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5208408P 2008-05-09 2008-05-09
US61/052,084 2008-05-09
US13933308P 2008-12-19 2008-12-19
US61/139,333 2008-12-19
PCT/IB2009/005594 WO2009136281A1 (en) 2008-05-09 2009-05-11 Nitric oxide donating prostamides

Publications (3)

Publication Number Publication Date
JP2011519910A JP2011519910A (ja) 2011-07-14
JP2011519910A5 JP2011519910A5 (OSRAM) 2012-03-15
JP5401540B2 true JP5401540B2 (ja) 2014-01-29

Family

ID=41020929

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011508009A Active JP5401540B2 (ja) 2008-05-09 2009-05-11 硝酸酸化物供与プロスタミド類

Country Status (8)

Country Link
US (1) US8101658B2 (OSRAM)
EP (1) EP2274279B1 (OSRAM)
JP (1) JP5401540B2 (OSRAM)
CN (1) CN102099330B (OSRAM)
AR (1) AR076731A1 (OSRAM)
CA (1) CA2723704C (OSRAM)
ES (1) ES2428387T3 (OSRAM)
WO (1) WO2009136281A1 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011005505A2 (en) * 2009-06-22 2011-01-13 Johnson Matthey Public Limited Company Method for the purification of prostaglandins
AU2012217922B2 (en) * 2011-02-14 2017-05-04 Allergan, Inc. Ester derivatives of bimatoprost compositions and methods
ES2690398T3 (es) 2012-03-07 2018-11-20 Advanced Inhalation Therapies (Ait) Ltd. Inhalación de óxido nítrico para el tratamiento de enfermedades respiratorias
ES2609810T3 (es) 2012-05-31 2017-04-24 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina donadores de óxido nítrico
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
US10047047B2 (en) 2015-03-31 2018-08-14 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
US20180243526A1 (en) 2015-09-09 2018-08-30 Advanced Inhalation Therapies (AIT), Ltd. Nitric oxide inhalation therapy for infants with bronchiolitis
JP7055802B2 (ja) 2016-11-08 2022-04-18 ボシュ・アンド・ロム・インコーポレイテッド 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体
ES2836118T3 (es) 2018-02-21 2021-06-24 Nicox Sa Procedimiento para la preparación de un análogo de prostaglandina donante de óxido nítrico
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
PT3593788T (pt) * 2018-07-12 2021-01-21 Nicox Sa Composições oftalmicas que contêm uma prostamida que liberta de óxido nítrico
ES2964005T3 (es) 2019-08-05 2024-04-03 Nicox Sa Procedimiento de preparación de un análogo de prostaglandina donador de óxido nítrico
PL4288413T3 (pl) 2021-02-03 2025-04-28 Nicox S.A. Sposób wytwarzania analogu prostaglandyny będącego donorem tlenku azotu
EP4404936A1 (en) 2021-09-20 2024-07-31 Nicox SA Nitric oxide releasing prostamide as neuroprotective agent
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
EP4410294A3 (en) 2022-07-07 2024-11-06 Nicox S.A. Industrial process for the preparation of hexanoic acid, 6(nitrooxy)-,(1s,2e)-3-[(1r,2r,3s,5r)-2-[(2z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]3,5-dihydroxycyclopentyl]-1-(2-phenyl ethyl)-2-propen-1-yl ester and high pure product
CN115677549A (zh) * 2022-10-27 2023-02-03 神隆医药（常熟）有限公司 一种贝美前列素手性异构体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US6395787B1 (en) * 2000-02-08 2002-05-28 Allergan Sales, Inc. Ocular hypotensive lipids
TWI298257B (en) * 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
HUE025127T2 (en) * 2002-03-01 2016-01-28 Allergan Inc Production of prostamides
KR100854838B1 (ko) * 2004-01-05 2008-08-29 니콕스 에스. 에이. 프로스타글란딘 나이트로옥시 유도체
WO2007000641A2 (en) 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
US20070015838A1 (en) * 2005-07-14 2007-01-18 Allergan, Inc. Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure

Also Published As

Publication number Publication date
WO2009136281A1 (en) 2009-11-12
EP2274279B1 (en) 2013-07-31
CA2723704A1 (en) 2009-11-12
US20110092590A1 (en) 2011-04-21
CN102099330A (zh) 2011-06-15
EP2274279A1 (en) 2011-01-19
ES2428387T3 (es) 2013-11-07
CN102099330B (zh) 2014-04-30
AR076731A1 (es) 2011-07-06
US8101658B2 (en) 2012-01-24
HK1160835A1 (en) 2012-08-17
JP2011519910A (ja) 2011-07-14
CA2723704C (en) 2017-08-22

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