AR076731A1 - Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas - Google Patents
Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticasInfo
- Publication number
- AR076731A1 AR076731A1 ARP090101651A ARP090101651A AR076731A1 AR 076731 A1 AR076731 A1 AR 076731A1 AR P090101651 A ARP090101651 A AR P090101651A AR P090101651 A ARP090101651 A AR P090101651A AR 076731 A1 AR076731 A1 AR 076731A1
- Authority
- AR
- Argentina
- Prior art keywords
- ono2
- alkoxy
- same
- alkyl
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title 2
- 229910004679 ONO2 Inorganic materials 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5208408P | 2008-05-09 | 2008-05-09 | |
| US13933308P | 2008-12-19 | 2008-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076731A1 true AR076731A1 (es) | 2011-07-06 |
Family
ID=41020929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101651A AR076731A1 (es) | 2008-05-09 | 2009-05-07 | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8101658B2 (OSRAM) |
| EP (1) | EP2274279B1 (OSRAM) |
| JP (1) | JP5401540B2 (OSRAM) |
| CN (1) | CN102099330B (OSRAM) |
| AR (1) | AR076731A1 (OSRAM) |
| CA (1) | CA2723704C (OSRAM) |
| ES (1) | ES2428387T3 (OSRAM) |
| WO (1) | WO2009136281A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011005505A2 (en) * | 2009-06-22 | 2011-01-13 | Johnson Matthey Public Limited Company | Method for the purification of prostaglandins |
| AU2012217922B2 (en) * | 2011-02-14 | 2017-05-04 | Allergan, Inc. | Ester derivatives of bimatoprost compositions and methods |
| ES2690398T3 (es) | 2012-03-07 | 2018-11-20 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalación de óxido nítrico para el tratamiento de enfermedades respiratorias |
| ES2609810T3 (es) | 2012-05-31 | 2017-04-24 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina donadores de óxido nítrico |
| US10280138B2 (en) | 2015-03-31 | 2019-05-07 | Nicox S.A. | Nitric oxide donating derivatives of fluprostenol |
| US10047047B2 (en) | 2015-03-31 | 2018-08-14 | Nicox S.A. | Nitric oxide donating derivatives of latanoprost free acid |
| EP3088388A1 (en) | 2015-04-30 | 2016-11-02 | NicOx S.A. | Nitric oxide donating derivatives of prostaglandins |
| US20180243526A1 (en) | 2015-09-09 | 2018-08-30 | Advanced Inhalation Therapies (AIT), Ltd. | Nitric oxide inhalation therapy for infants with bronchiolitis |
| JP7055802B2 (ja) | 2016-11-08 | 2022-04-18 | ボシュ・アンド・ロム・インコーポレイテッド | 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 |
| ES2836118T3 (es) | 2018-02-21 | 2021-06-24 | Nicox Sa | Procedimiento para la preparación de un análogo de prostaglandina donante de óxido nítrico |
| RU2718744C2 (ru) * | 2018-05-17 | 2020-04-14 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Производные простагландина F2альфа для снижения внутриглазного давления |
| PT3593788T (pt) * | 2018-07-12 | 2021-01-21 | Nicox Sa | Composições oftalmicas que contêm uma prostamida que liberta de óxido nítrico |
| ES2964005T3 (es) | 2019-08-05 | 2024-04-03 | Nicox Sa | Procedimiento de preparación de un análogo de prostaglandina donador de óxido nítrico |
| PL4288413T3 (pl) | 2021-02-03 | 2025-04-28 | Nicox S.A. | Sposób wytwarzania analogu prostaglandyny będącego donorem tlenku azotu |
| EP4404936A1 (en) | 2021-09-20 | 2024-07-31 | Nicox SA | Nitric oxide releasing prostamide as neuroprotective agent |
| CN113943266A (zh) * | 2021-11-18 | 2022-01-18 | 广州楷石医药有限公司 | 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途 |
| EP4410294A3 (en) | 2022-07-07 | 2024-11-06 | Nicox S.A. | Industrial process for the preparation of hexanoic acid, 6(nitrooxy)-,(1s,2e)-3-[(1r,2r,3s,5r)-2-[(2z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]3,5-dihydroxycyclopentyl]-1-(2-phenyl ethyl)-2-propen-1-yl ester and high pure product |
| CN115677549A (zh) * | 2022-10-27 | 2023-02-03 | 神隆医药（常熟）有限公司 | 一种贝美前列素手性异构体的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US6395787B1 (en) * | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
| TWI298257B (en) * | 2001-05-31 | 2008-07-01 | Allergan Inc | Hypotensive lipid and timolol compositions and methods of using same |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| HUE025127T2 (en) * | 2002-03-01 | 2016-01-28 | Allergan Inc | Production of prostamides |
| KR100854838B1 (ko) * | 2004-01-05 | 2008-08-29 | 니콕스 에스. 에이. | 프로스타글란딘 나이트로옥시 유도체 |
| WO2007000641A2 (en) | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Prostaglandin derivatives |
| US20070015838A1 (en) * | 2005-07-14 | 2007-01-18 | Allergan, Inc. | Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure |
-
2009
- 2009-05-07 AR ARP090101651A patent/AR076731A1/es active IP Right Grant
- 2009-05-11 CN CN200980127115.4A patent/CN102099330B/zh active Active
- 2009-05-11 ES ES09742454T patent/ES2428387T3/es active Active
- 2009-05-11 CA CA2723704A patent/CA2723704C/en active Active
- 2009-05-11 EP EP09742454.3A patent/EP2274279B1/en active Active
- 2009-05-11 JP JP2011508009A patent/JP5401540B2/ja active Active
- 2009-05-11 WO PCT/IB2009/005594 patent/WO2009136281A1/en not_active Ceased
- 2009-05-11 US US12/991,855 patent/US8101658B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009136281A1 (en) | 2009-11-12 |
| EP2274279B1 (en) | 2013-07-31 |
| CA2723704A1 (en) | 2009-11-12 |
| US20110092590A1 (en) | 2011-04-21 |
| CN102099330A (zh) | 2011-06-15 |
| EP2274279A1 (en) | 2011-01-19 |
| ES2428387T3 (es) | 2013-11-07 |
| CN102099330B (zh) | 2014-04-30 |
| US8101658B2 (en) | 2012-01-24 |
| HK1160835A1 (en) | 2012-08-17 |
| JP2011519910A (ja) | 2011-07-14 |
| JP5401540B2 (ja) | 2014-01-29 |
| CA2723704C (en) | 2017-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |