JP5396474B2 - 副腎皮質刺激ホルモン放出因子受容体活性のピラジノンモジュレーター - Google Patents

副腎皮質刺激ホルモン放出因子受容体活性のピラジノンモジュレーター Download PDF

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Publication number
JP5396474B2
JP5396474B2 JP2011521135A JP2011521135A JP5396474B2 JP 5396474 B2 JP5396474 B2 JP 5396474B2 JP 2011521135 A JP2011521135 A JP 2011521135A JP 2011521135 A JP2011521135 A JP 2011521135A JP 5396474 B2 JP5396474 B2 JP 5396474B2
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Japan
Prior art keywords
crf
cyclopropyl
mmol
methoxyethyl
calculated
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English (en)
Japanese (ja)
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JP2011529886A (ja
JP2011529886A5 (enExample
Inventor
リチャード・エイ・ハーツ
ビジャイ・ティ・アフジャ
ビベカナンダ・エム・ブルドゥラ
ジョアン・ジェイ・ブロンソン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011521135A 2008-07-31 2009-04-27 副腎皮質刺激ホルモン放出因子受容体活性のピラジノンモジュレーター Expired - Fee Related JP5396474B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8523008P 2008-07-31 2008-07-31
US61/085,230 2008-07-31
PCT/US2009/041793 WO2010014280A1 (en) 2008-07-31 2009-04-27 Pyrazinone modulator of corticotropin-releasing factor receptor activity

Publications (3)

Publication Number Publication Date
JP2011529886A JP2011529886A (ja) 2011-12-15
JP2011529886A5 JP2011529886A5 (enExample) 2012-05-24
JP5396474B2 true JP5396474B2 (ja) 2014-01-22

Family

ID=40651774

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011521135A Expired - Fee Related JP5396474B2 (ja) 2008-07-31 2009-04-27 副腎皮質刺激ホルモン放出因子受容体活性のピラジノンモジュレーター

Country Status (10)

Country Link
US (2) US7932256B2 (enExample)
EP (1) EP2303867B1 (enExample)
JP (1) JP5396474B2 (enExample)
KR (1) KR20110040870A (enExample)
CN (1) CN102171205B (enExample)
AR (1) AR072639A1 (enExample)
AU (1) AU2009277057A1 (enExample)
MX (1) MX2011000754A (enExample)
TW (1) TW201008926A (enExample)
WO (1) WO2010014280A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
RU2015119411A (ru) 2012-11-15 2017-01-10 Рош Инновейшен Сентер Копенгаген А/С Конъюгаты антисмысловых соединений, направленные на аполипопротеин в
WO2014118267A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Lna oligonucleotide carbohydrate conjugates
CN106102740A (zh) 2014-01-21 2016-11-09 纽罗克里生物科学有限公司 治疗先天性肾上腺增生的crf1受体拮抗剂
EP3984523B1 (en) 2018-12-07 2025-09-03 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
WO2021062246A1 (en) 2019-09-27 2021-04-01 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use
IT201900021216A1 (it) 2019-11-14 2021-05-14 Isagro Spa Processo per la preparazione di derivati piridinici e corrispondenti piridil-formammidine
CN112552184B (zh) * 2020-12-18 2022-05-10 诚达药业股份有限公司 一种含环丙基手性胺盐酸盐的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE213495T1 (de) 1996-09-16 2002-03-15 Du Pont Pharm Co Eine resorbierbare röntgenopake markierung enthaltendes chirurgisches implantat und verfahren zum verriegeln desselben in einem körper
NZ520484A (en) * 2000-02-16 2005-03-24 Neurogen Corp Substituted arylpyrazines that are modulators of CRF (corticotropin releasing factor) receptor and methods of treatment using them
HRP20031096A2 (en) * 2001-06-12 2005-08-31 Neurogen Corporation 2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines as crf1 receptor modulators
AU2003278542A1 (en) 2002-11-21 2004-06-15 Pharmacia & Upjohn Company Llc Pyrazine compounds as crf modulators

Also Published As

Publication number Publication date
JP2011529886A (ja) 2011-12-15
US20110166160A1 (en) 2011-07-07
US8372847B2 (en) 2013-02-12
EP2303867B1 (en) 2014-12-17
KR20110040870A (ko) 2011-04-20
CN102171205B (zh) 2013-08-07
AU2009277057A1 (en) 2010-02-04
TW201008926A (en) 2010-03-01
MX2011000754A (es) 2011-02-24
CN102171205A (zh) 2011-08-31
WO2010014280A1 (en) 2010-02-04
US20100029684A1 (en) 2010-02-04
AR072639A1 (es) 2010-09-08
EP2303867A1 (en) 2011-04-06
US7932256B2 (en) 2011-04-26

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