JP5322247B2 - Method for producing vegetable whitening agent, plant whitening agent and skin external preparation for whitening - Google Patents

Description

  The present invention relates to a plant whitening agent, a method for producing a plant whitening agent, and a skin external preparation for whitening. More specifically, the present invention is effective in preventing and improving pigmentation, stains, freckles, liver spots, etc. after sunburn, and is safe and skin. The present invention relates to a plant-derived whitening agent having an excellent effect on whitening.

  Although there are some unclear points about the mechanism of skin blemishes, etc., in general, melanin pigments are formed due to hormonal abnormalities or ultraviolet light stimulation from sunlight, which abnormally deposits in the skin. It is considered a thing. This melanin pigment, which causes skin coloration, is produced in melanogenic granules (melanosomes) in melanocytes (melanocytes) between the epidermis and dermis, and the generated melanin diffuses to neighboring cells by osmotic action .

  The biochemical reaction in this melanocyte is estimated as follows. That is, a process in which tyrosine, which is an essential amino acid, becomes dopaquinone by the action of the enzyme tyrosinase, which is converted into black melanin through a red pigment and a colorless pigment by enzymatic or non-enzymatic oxidation is a melanin pigment formation process.

As for the above-mentioned whitening agents and skin whitening external preparations for suppressing the production of melanin pigments, various plant-derived extracts have been developed with the expectation of safety and mild irritation to the skin. For example, see Patent Documents 1 to 4).
On the other hand, since the diversity of plant resources and their availability are limited, it can be said that the ingenuity from the viewpoint of production that can fully exploit the ability of plants is very important. From this point of view, an attempt to obtain a plant-derived component by a method different from the conventionally used methods, for example, a supercritical carbon dioxide extraction method (see Patent Document 5) is also being made.

JP-A-8-3109939 JP-A-7-89843 Japanese Patent Laid-Open No. 9-30954 JP 2003-73224 A JP 2005-179226 A

Thus, for plant-derived whitening agents, it is required to find a new plant or a plant that exhibits a new whitening effect by a new production method.
From the background as described above, the present inventors have aimed to provide a safe and highly effective new plant-derived whitening agent, a method for producing the same, and a skin external preparation for whitening by devising the production method.

  As a result of intensive studies in view of such a current situation, the present inventors have found that a plant seed extract obtained by a specific method using seeds of a specific plant has high safety and a remarkable whitening effect. As a result, the present invention has been completed.

  According to the present invention, seeds of one or more plants selected from Thuja plants are pulverized and extracted after aging for 1 week or more at a temperature of 10 to 35 ° C. and a relative humidity of 20 to 90%. It is the manufacturing method of the vegetable whitening agent characterized.

  The plant is preferably Thuja orientalis.

  The present invention pulverizes seeds of one or more plants selected from Rubus genus plants, Vaccinium genus plants, Actinidia genus plants and Perilla genus plants, at a temperature of 10 to 35 ° C and a relative humidity of 20 to 90%. It is a method for producing a plant whitening agent characterized by being extracted after aging for 10 weeks or more.

  The plant is preferably selected from Rubus idaeus, Vaccinium oxycoccos, Vaccinium corymbosum, Vaccinium vitis-idaea, Perilla frutescens and Actinidia chinensis.

Moreover, according to this invention, the plant whitening agent manufactured by one of said methods is provided.
Furthermore, according to this invention, the skin external preparation for whitening formed by mix | blending the said plant whitening agent is provided.

According to the method for producing a plant whitening agent of the present invention, the plant has a safe and excellent whitening action, lightening of pigmentation, stains, freckles, and liver spots after sunburn, and an effect excellent in whitening. A whitening agent can be produced. Moreover, in the manufacturing method of the plant whitening agent of this invention, the whitening agent which has the outstanding whitening effect is obtained by a comparatively easy process.
The plant whitening agent of the present invention has a safe and excellent whitening effect, and has excellent effects on lightening and whitening of pigmentation, stains, freckles, and liver spots after sunburn.
Moreover, the skin external preparation for whitening of this invention has the outstanding whitening effect and dullness improvement effect by mix | blending the plant whitening agent of this invention.

It is a figure which shows the measurement result of the amount of melanins when the coconut extract obtained by various collection methods is used. It is a figure which shows the melanin inhibitory effect of the coconut extract which processed on various alkali conditions. Figure showing the amount of melanin when using Vaccinium oxycoccos, Vaccinium vitis-idaea, Rubus idaeus, Actinidia chinensis, Perilla frutescens seed extract (alkaline treated product) and an extract extracted from ground and ripened seeds is there.

The best mode of the present invention will be described below.
As described above, the plants used in the present invention include the Rubus genus Rubus (currant genus), the Rhododendron genus Vaccinium (general genus), the terrestrial genus Actinidia genus (matabic genus), the cypress genus Thuja (black genus), and perilla. The plant of the family Perilla genus (Perilla genus) can be mentioned.

Among them, black berries (Rubus fruticosus), raspberries (Rubus idaeus) and their hybrids can be used as the Rosaceae Rubus genus plants, and those imported from North America and Northern Europe can be used.
As the plant belonging to the genus Vaccinium, there are cranberries (Vaccinium oxycoccos), lingonberries (Vaccinium vitis-idaea), blueberries (Vaccinium corymbosum and Vaccinium ashei), huckleberries (Vaccinium ovatum), etc., which are imported for food North American and Northern European products can be used.
As a member of the genus Actinidia, Kiwi (Actinidia chinensis or Actinidia deliciosa) can be mentioned, and those imported from New Zealand, etc. can be used.
The seeds of these plants can be obtained as a surplus when producing foods such as fruit juice and jam. For some of these plants, seed extracts are commercially available. The product can also be used as a raw material.
The cypress family Thuja is an evergreen coniferous tree, such as Thuja occidentalis and Thuja orientalis. Among them, the seeds of Thuja orientalis are widely used in Chinese medicine as the herbal medicine "Haksinin", which is produced in China. Can be used. Other names for Thuja orientalis include Biota orientalis and Platycladus orientalis.
Perilla family Perilla genus plant includes perilla frutescens, and Japanese cultivated foods can be used.

  As a method for producing a plant whitening agent according to the present invention, a method of subjecting a plant extract obtained by extracting plant seeds to alkali treatment (hereinafter referred to as a first method), and pulverization of plant seeds. In addition, there is a method of extracting after aging for one week or more at a temperature of 10 to 35 ° C. and a relative humidity of 20 to 90% (hereinafter referred to as a second method).

  The extraction solvent used in the first method and the second method may be any volatile solvent that is usually used for extraction, particularly alcohols such as methanol and ethanol, hydrous alcohols, acetone, ethyl acetate, Polar or nonpolar organic solvents such as hexane and ether can be used alone or in combination. Acetone, ethyl acetate and hexane are particularly preferred because they are inexpensive and easy to concentrate under reduced pressure. In addition, extraction with supercritical carbon dioxide can also be used. On the other hand, an extraction solvent containing a large amount of water is not preferable because extraction of the active ingredient is suppressed.

  In the extraction, extraction is performed for a certain period of time with a solvent having a mass of 1 to 100 times, preferably about 1 to 30 times the mass of the seed. The seed to be used can be appropriately pulverized as necessary, but may be used as it is in an unpulverized case when clogging becomes a problem during filtration. It is also possible to repeatedly extract with a small amount of solvent, and a reflux device such as Soxhlet may be used. When extracting with supercritical carbon dioxide, extraction can be performed under a general condition of 20 to 40 MPa at around 40 ° C.

  In the first method of the present invention, the extraction solvent is removed from these extracts, followed by an alkali treatment. In the alkali treatment, 0.2 to 2 times volume of concentrated alkaline aqueous solution is added to the extract after removal of the solvent, and then sufficiently stirred and mixed, and then aged for about 30 minutes to several days. As temperature in the case of mixing, the range of room temperature-70 degreeC is preferable, and the range of 30-60 degreeC is further more preferable. It is desirable to appropriately stir so that the component hydrophilic component and lipophilic component do not separate during aging. Examples of the concentrated alkaline aqueous solution include an aqueous solution composed of NaOH, KOH and the like having a concentration of 1 to 10N.

  When the extract treated with alkali as described above is further neutralized with acid to near neutrality, an oily substance is separated. This oily substance has a very high whitening effect, but is highly safe against the skin. In order to promote oily substance recovery, alcohol, acetone or the like may be appropriately added after the alkali treatment, and further operations such as decolorization, deodorization, desalting and distillation may be added as necessary.

  According to the second method of the present invention, the seeds are appropriately pulverized or pressed in the pre-extraction stage and aged for a certain period of time near room temperature. The aging period is not particularly limited as long as the desired effect can be obtained, but if the aging period is shorter than one week, it is difficult to obtain a sufficient whitening effect. The problem of oxidation and deodorization occurs, which is not preferable. Further, during the aging, it is possible to suppress the odor by adding an antioxidant or replacing the nitrogen as necessary.

  The seeds thus matured are extracted using the extraction solvent / extraction method described above. After extraction, operations such as solvent removal, decolorization, deodorization, and distillation are performed as necessary. The extract obtained by pulverizing and ripening such specific seeds, as well as the above-mentioned alkali-treated extract, has an extremely high whitening effect, but also has high safety against the skin. Indicates.

  In the present invention, it is possible to provide a plant whitening agent that is safe and has an excellent whitening effect comprising an extract prepared by the first method or the second method from plant seeds as shown above. Can provide a skin whitening external preparation containing this whitening agent.

  The compounding quantity of the plant extract in the skin whitening external preparation of this invention is 0.005-3.0 mass% as a dry substance in the external preparation whole quantity, Preferably it is 0.01-1.0 mass%. If the amount is less than 0.005% by mass, the effect referred to in the present invention is not sufficiently exerted, and if it exceeds 3.0% by mass, it is difficult to make a preparation. Moreover, when 1.0 mass% or more is mix | blended, problems, such as a foul odor, will occur easily when preserve | saving for a long term.

  In addition, the skin whitening preparation for whitening of the present invention contains, in addition to the above essential components, moisturizing agents such as glycerin, 1,3-butanediol, and dipropylene glycol, which are usually used in skin preparations such as cosmetics and pharmaceuticals. Agents, antioxidants such as BHT (butylhydroxytoluene), BHA (butylhydroxyanisole), vitamin E and its derivatives, linear silicones, cyclic silicones, ester oils, ether oils, hydrocarbons, oily components such as fatty acids, Ultraviolet absorbers, surfactants, thickeners, alcohols, powder components, colorants, aqueous components, water, various skin nutrients, and the like can be appropriately blended as necessary.

  Others, disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, sequestering agents such as gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, grabrizine , Hot water extract of fire thorn fruit, various herbal medicines, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid, etc. Whitening agents, sugars such as glucose, fructose, mannose, sucrose, trehalose and the like can be appropriately blended.

  The whitening agent of the present invention may be used in various dosage forms, for example, ointments, creams, emulsions, lotions, packs, bath preparations and the like, as long as they are conventionally used for external preparations for skin.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the amount is shown in mass%. In addition, the method (1st method) which performs the alkali treatment to the plant extract obtained by extracting the seed of a plant is a reference example which is not included in the scope of the present invention. Moreover, the example which does not use the Thuja genus plant is a reference example not included in the present invention.
Initially, the test method regarding the melanin production inhibitory effect of the plant extract of this invention and its result are demonstrated.

1. Preparation of sample (1) Preparation of alkali-treated product of seed extract 5 times (v / w) acetone or ethyl acetate (ethyl acetate) of various plant seeds (unground, removing outer shell if necessary) ) Or hexane, followed by extraction at room temperature for 10 days. The residue was previously removed with a nylon mesh (100 mesh), and further filtered with a filter paper. After removing the solvent from the filtrate with a rotary evaporator, 0.5 to 15 N NaOH was added as NaOH in the range of 100 to 300 g / l extract while stirring with a stirring blade (temperature: 50 ° C.). The treatment was performed for 5 hours while stirring at 200 rpm. Thereafter, 5N H ₂ SO ₄ was gradually added, the pH was lowered to around 1 while stirring, and the oily substance that separated was recovered. An equal volume of water was added to the recovered oily substance and washed with water to remove impurities, salts, and excess acid. The oily substance was dried under reduced pressure to obtain an alkali-treated product. As a comparative control, an extract before alkali treatment was used. The Thuja orientalis, extraction with supercritical CO ₂ (20MPa, 40 ℃) was also performed, they were subjected to similar alkali treatment.

(2) Preparation of ground and matured seed extract The seeds of various plants were lightly ground with a blender, sealed in a plastic bottle, and stored at room temperature for 1 to 10 weeks. Next, 10 times (v / w) of acetone, ethyl acetate (ethyl acetate) or hexane was added to the weight of the pulverized product, and the mixture was extracted overnight. After removing the residue by filtration, the filtrate was concentrated to obtain a ground and mature seed extract. As a comparative control, an extract extracted from seeds that had been unground and stored under the same conditions was used.

2. Melanin production inhibitory effect test method and the results The resulting extract was used as a test sample to measure and evaluate the melanin production inhibitory effect by the following method.

(1) Cell culture method Mouse-derived B16 melanoma culture cells were used. The cells were cultured in a MEM medium containing 5% fetal calf serum (manufactured by Thermo Trace) in a CO ₂ incubator (95% air, 5% carbon dioxide) at 37 ° C. The sample solution was dissolved in ethanol to 2.5 (w / v)% and used as a test sample. After 24 hours of culture, the test sample was added so that the final concentration (concentration in terms of extract dry product) was 25 mg / l, and the culture was further continued for 3 days, and the amount of melanin produced was measured by the following method.
Further, arbutin, which has been known to have a melanin production inhibitory effect, was also tested in the same manner as described above.

(2) Measurement 20 × 10 ⁴ B16 melanoma cells were implanted in a 60 mm plastic petri dish and pre-cultured for 24 hours. Thereafter, the medium was replaced with fresh medium, and 50 ul / Well was added to the culture medium. The cells were cultured for 3 days and then collected by trypsinization. The collected cells were dissolved in 1N NaOH, 10% DMSO solution, and the absorbance at 420 nm was measured to obtain the amount of melanin. FIG. 1 shows the measurement results of the amount of melanin when using Thuja orientalis seeds obtained by various sampling methods, ie, coconut seeds. In the figure, (1-1) to (1-10) are examples in which the following were used as samples.

(1-1): 0.1% (final concentration) ethanol only (no drug added)
(1-2): Arbutin (final concentration 25 mg / l, the same concentration)
(1-3): Acetone extract of coconut (unground), untreated with alkali (1-4): Extract of coconut acetone obtained by the method (1) in the column for preparation of the sample Product (1-5): Isotone acetone extract obtained after aging for one week by the method (2) in the sample preparation column (1-6): Method (2) in the sample preparation column Insulin extract (1-7) obtained after ripening for 4 weeks in 1): Acetone extract (1-8) obtained after aging for 10 weeks by the method of (2) in the column for preparation of the sample: Other than not pulverizing the coconut seed, the coconut acetone extract (1-9) obtained after aging for 10 weeks by the method of (2) in the above-mentioned sample preparation column: immediately after pressing the coconut seed, supercritical Choshijin extract (1-11) extracted with CO ₂ (30 MPa, 40 ° C.): After extraction with supercritical CO ₂ (30 MPa, 40 ° C.), the coconut extract obtained by alkali treatment The alkali concentration (NaOH concentration) in the above was 5N.

  FIG. 1 shows that the coconut extract (alkaline-treated product) (1-4), which is one of the embodiments of the present invention, has a markedly increased melanin-suppressing effect compared to the alkali-untreated product (1-3). I understand. In addition, the coconut pulverized and matured extract ((1-5) to (1-7)), which is another example of the present invention, is significantly more melanin than the unpulverized and stored for the same period (1-8). The suppression effect was increasing. The increase in melanin-inhibiting effect by seed crushing and ripening is significantly increased even when the storage period is relatively short (1-5) (1-5), which is superior to the positive control arbutin (1-2). It has an inhibitory effect and is found to be useful as a whitening agent. At the same time, as a result of evaluating the cell viability by the MTT method, the seed extract of the present invention did not show a decrease in the cell viability, and thus the suppression of melanin production in FIG. 1 is not due to cell injury. I can say that.

FIG. 2 is a diagram showing the relationship between the alkali concentration and the melanin suppressing effect when the coconut extract is subjected to alkali treatment. The test method is as follows.
To 1 kg of coconut extract, NaOH was added at a rate of 170 g as aqueous solutions having various alkali strengths. After reacting vigorously at 200 rpm on a 50 ° C. water bath for 3 hours, the oily substance separated when acidified by adding sulfuric acid was collected, and used as a sample to conduct a melanin production inhibitory effect test. .
FIG. 2 shows that the alkali strength during the alkali treatment is preferably between 1 and 10N.

  FIG. 3 shows another embodiment of the present invention, Vaccinium oxycoccos, Vaccinium corymbosum, Vaccinium vitis-idaea (Vaccinium genus plant), Rubus idaeus (Rubus genus plant), Actinidia chinensis (Actinidia genus plant), Perilla frutescens (Perilla The melanin inhibitory effect evaluation result of the extract extracted from the seed extract (alkali processed material) of the genus plant) and the seed which gave the grinding | pulverization and ripening process is shown. As a comparative example, an extract (alkali untreated product) extracted from unground seeds was used. In the figure, A is an unground seed extract (alkaline untreated, comparative example), B is an unground seed extract (alkaline treated, example), and C is a ground / aged seed extract (room temperature, aging for 10 weeks, conducted) Example). In addition, as a comparative example using a plant that is outside the scope of the present invention, an example of an oil palm (Elaeis guineensis) seed acetone extract is shown in the figure (alkali untreated, alkali treated, ground / ripened seed extract (room temperature Aged for 10 weeks)).

  In any of the examples shown in FIG. 3, a remarkable melanin suppressing effect was observed. On the other hand, the extract (A: comparative example) which was not subjected to pulverization / ripening treatment or alkali treatment and the oil palm (Elaeis guineensis) seed acetone extract were both very low in melanin suppression effect.

  Below, the compounding example of the whitening agent of this invention is given. Thus, the whitening agent of the present invention can be widely incorporated into various skin external preparation formulations.

Formulation Example 1 Cream Stearic Acid 5.0% by mass
Stearyl alcohol 4.0
Isopropyl myristate 18.0
Glycerol monostearate 3.0
Propylene glycol 10.0
Thuja orientalis Acetone extract (alkaline treated product) 0.2
Rubus idaeus acetone extract (alkaline treated product) 0.1
Vaccinium vitis-idaea Acetone extract (alkaline treated product) 0.1
Natural vitamin E 0.05
Caustic potash 0.2
Sodium bisulfite 0.01
Preservative Appropriate amount Perfume Appropriate amount Ion-exchanged water

Formulation Example 2 Cream Stearic Acid 2.0% by mass
Stearyl alcohol 7.0
Hydrogenated Lanolin 2.0
Squalane 5.0
2-Octyldodecyl alcohol 6.0
Polyoxyethylene (25 mol) cetyl alcohol ether 3.0
Glycerin monostearate ester 2.0
Propylene glycol 5.0
Actinidia chinensis Acetone extract (alkaline treated product) 0.5
Sodium bisulfite 0.03
Ethylparaben 0.3
Perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 3 Cream Solid Paraffin 5.0% by mass
Beeswax 10.0
Vaseline 15.0
Liquid paraffin 41.0
Glycerin monostearate ester 2.0
Polyoxyethylene (20 mol) sorbitan monolaurate 2.0
Soap powder 0.1
Borax 0.2
Thuja orientalis ground and aged seed hexane extract 0.2
Sodium bisulfite 0.03
Ethylparaben 0.3
Perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 4 Latex Stearic acid 2.5% by mass
Cetyl alcohol 1.5
Vaseline 5.0
Liquid paraffin 10.0
Polyoxyethylene (10 mol) monooleate 2.0
Polyethylene glycol 1500 3.0
Triethanolamine 1.0
Carboxyvinyl polymer 0.05
Perilla frutescens hexane extract (alkaline treated product) 1.0
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 5 Latex Microcrystalline Wax 1.0% by mass
Beeswax 2.0
Lanolin 20.0
Liquid paraffin 10.0
Squalane 5.0
Sorbitan sesquioleate ester 4.0
Polyoxyethylene (20 mol) sorbitan monooleate 1.0
Propylene glycol 7.0
Vaccinium oxycoccos ground matured acetone extract 0.5
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 6 Pack Dipropylene glycol 5.0% by mass
Polyoxyethylene (60 mol) hydrogenated castor oil 5.0
Thuja orientalis seed extract (alkaline treated product) 0.5
Olive oil 5.0
Tocopherol acetate 0.2
Ethylparaben 0.2
Fragrance 0.2
Sodium bisulfite 0.03
Polyvinyl alcohol 13.0
(Saponification degree 90, polymerization degree 2,000)
Ethanol 7.0
Purified water residue

Formulation Example 7 Solid Foundation Talc 43.1% by mass
Kaolin 15.0
Sericite 10.0
Zinc flower 7.0
Titanium dioxide 3.8
Yellow iron oxide 2.9
Black iron oxide 0.2
Squalane 8.0
Isostearic acid 4.0
Monooleic acid POE sorbitan 3.0
Isocetyl octoate 2.0
Thuja orientalis ground and mature seed extract 0.2
Vaccinium oxycoccos seed acetone extract (alkaline treated product) 0.2
Preservative appropriate amount Fragrance proper amount

Formulation Example 8 Emulsification Foundation (Cream Type)
(Prescription)
(Powder part)
Titanium dioxide 10.3% by mass
Sericite 5.4
Kaolin 3.0
Yellow iron oxide 0.8
Bengala 0.3
Black iron oxide 0.2
(Oil phase)
Decamethylcyclopentasiloxane 11.5
Liquid paraffin 4.5
Polyoxyethylene-modified dimethylpolysiloxane 4.0
(Water phase)
Purified water 50.0
1,3-butylene glycol 4.5
Vaccinium corymbosum seed extract (alkaline treated product) 0.2
Sorbitan sesquioleate 3.0
Preservative appropriate amount Fragrance proper amount

Formulation Example 9 Latex Dimethylpolysiloxane 3% by mass
Decamethylcyclopentasiloxane 4
Ethanol 5
Glycerin 6
1,3-butylene glycol 5
Polyoxyethylene methyl glucoside 3
Sunflower oil 1
Squalane 2
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Hydroxypropyl-β-cyclodextrin 0.1
Dipotassium glycyrrhizinate 0.05
Loquat leaf extract 0.1
Sodium L-glutamate 0.05
Fennel extract 0.1
Yeast extract 0.1
Lavender oil 0.1
Giant extract 0.1
Vaccinium corymbosum ground / mature seed extract 0.2
Vaccinium vitis-idaea ground / ripened seed extract 0.2
Dimorpholinopyridazinone 0.1
Xanthan gum 0.1
Carboxyvinyl polymer 0.1
Acrylic acid / alkyl methacrylate copolymer 0.1
(Pemulen TR-1)
Bengala appropriate amount Yellow iron oxide appropriate amount Paraben appropriate amount Purified water Residual

Formulation Example 10 Latex Dimethylpolysiloxane 2% by mass
Decamethylcyclopentasiloxane 25
Dodecamethylcyclohexasiloxane 10
Polyoxyethylene / methylpolysiloxane copolymer 1.5
Trimethylsiloxysilicic acid 1
1,3-butylene glycol 5
Squalane 0.5
Talc 5
Dipotassium glycyrrhizinate 0.1
Actinidia chinensis ground and aged seed extract 0.1
Tocopherol acetate 0.1
Edetate trisodium 0.05
4-t-butyl-4′-methoxydibenzoylmethane 1
2-methoxyhexyl paramethoxycinnamate 5
Diparamethoxycinnamic acid mono-2-ethylhexanoic acid glyceryl 1
Silicone coated fine particle titanium oxide (40 nm) 4
Dimethyl distearyl ammonium hectorite 0.5
Spherical polyethylene powder 3
Phenoxyethanol appropriate amount Purified water Residue Fragrance Appropriate amount

Formulation Example 11 Latex Liquid paraffin 7% by mass
Vaseline 3
Decamethylcyclopentasiloxane 2
Behenyl alcohol 1
Glycerin 5
Dipropylene glycol 7
Polyethylene glycol 1500 2
Jojoba oil 1
Isostearic acid 0.5
Stearic acid 0.5
Behenic acid 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 3
Cetyl 2-ethylhexanoate 3
Glycerol monostearate 1
Polyoxyethylene glyceryl monostearate 1
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.05
L-Arginine 0.1
Royal Jelly Extract 0.1
Yeast extract 0.1
Rubus idaeus ground and aged seed extract 0.1
Perilla frutescens ground and mature seed extract 0.1
Tocopherol acetate 0.1
Acetylated sodium hyaluronate 0.1
Edetate trisodium 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.1
2-Ethylhexyl paramethoxycinnamate 0.1
Carboxyvinyl polymer 0.15
Paraben Appropriate amount Purified water Residue Fragrance Appropriate amount

Formulation Example 12 Cream α-olefin oligomer 10% by mass
Vaseline 1
Microcrystalline wax 3
Decamethylcyclopentasiloxane 5
Glycerin 10
Dipropylene glycol 2
1,3-butylene glycol 2
Erythritol 2
Squalane 1
Glycerin fatty acid ester eicosannic acid condensate 0.1
Isostearic acid 1
Cetyl 2-ethylhexanoate 5
Sodium chloride 0.5
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.05
Koubo extract 0.1
L-ascorbyl magnesium phosphate 2
Tocopherol acetate 0.5
Thiotaurine 0.1
DL-pyrrolidonecarboxylate sodium 1
Turmeric extract 0.1
Vaccinium corymbosum ground and mature seed extract 0.3
Edetate trisodium 0.1
Dimethyl distearyl ammonium hectorite 2
Sodium carboxymethylcellulose 0.1
Paraben appropriate amount Purified water Residue Fragrance Appropriate amount

Formulation Example 13 Cream Liquid Paraffin 8% by mass
Vaseline 3
Dimethylpolysiloxane 2
Stearyl alcohol 3
Behenyl alcohol 2
Glycerin 5
Dipropylene glycol 4
Trehalose 1
Tetra-2-ethylhexanoic acid pentaerythrit 4
Polyisoethylene glyceryl monoisostearate 2
Polyoxyethylene glyceryl monostearate 1
Lipophilic glyceryl monostearate 2
Citric acid 0.05
Sodium citrate 0.05
Potassium hydroxide 0.015
Oil-soluble licorice extract 0.1
Retinol palmitate (1 million units) 0.25
Tocopherol acetate 0.1
Rubus fruticosus ground matured seed extract 0.5
P-hydroxybenzoate appropriate amount phenoxyethanol appropriate amount dibutylhydroxytoluene appropriate amount edetate trisodium 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.01
2-Ethylhexyl paramethoxycinnamate 0.1
β-carotene 0.01
Polyvinyl alcohol 0.5
Hydroxyethyl cellulose 0.5
Carboxyvinyl polymer 0.05
Purified water Residue Perfume Suitable amount

Formulation Example 14 Pack Dipropylene glycol 5.0% by mass
Polyoxyethylene (60 mol) hydrogenated castor oil 5.0
Thuja orientalis seed extract (alkaline treated product) 0.5
Olive oil 5.0
Tocophenol acetate 0.2
Ethylparaben 0.2
Fragrance 0.2
Sodium bisulfite 0.03
Polyvinyl alcohol 13.0
(Saponification degree 90, polymerization degree 2000)
Ethanol 7.0
Purified water residue

Formulation Example 15 Emulsion Foundation Behenyl Alcohol 0.5% by mass
Dipropylene glycol 6
Stearic acid 1
Glycerol monostearate 1
Potassium hydroxide 0.2
Triethanolamine 0.8
DL-α-tocopherol acetate 0.1
P-Hydroxybenzoate appropriate amount Yellow iron oxide 1
α-olefin oligomer 3
Dimethylpolysiloxane (6 mPa.s) 2
Dimethylpolysiloxane (100 mPa.s) 5
Batyl alcohol 0.5
Isostearic acid 1
Behenic acid 0.5
Cetyl 2-ethylhexanoate 10
Polyoxyethylene glyceryl monostearate 1
Titanium oxide 3
Mica titanium / polyalkyl acrylate composite powder 0.5
Surface-treated titanium oxide (MT-062) 10
Polyacrylic acid alkyl coated mica titanium 0.5
Black iron oxide coated mica titanium 0.5
Silicic anhydride 6
2-Ethylhexyl paramethoxycinnamate 2
Bengala appropriate amount Ultramarine blue appropriate amount Black iron oxide appropriate amount Legal dye appropriate amount Xanthan gum 0.1
Bentonite 1
Sodium carboxymethylcellulose 0.1
Actinidia chinensis ground and aged seed extract 0.1
Purified water Residue Fragrance Appropriate amount

Claims (4)

  A plant obtained by crushing seeds of one or more plants selected from Thuja plants, ripening at a temperature of 10 to 35 ° C. and a relative humidity of 20 to 90% for one week or more, and then extracting the seeds Method for producing a sexual whitening agent.   The method for producing a plant whitening agent according to claim 1, wherein the plant is Thuja orientalis. A plant whitening agent produced by the method according to claim 1 or 2 . A skin whitening agent for whitening comprising the plant whitening agent according to claim 3 .

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