JP5315051B2 - オロパタジンを含む眼科用経皮吸収型製剤 - Google Patents
オロパタジンを含む眼科用経皮吸収型製剤 Download PDFInfo
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- JP5315051B2 JP5315051B2 JP2008520121A JP2008520121A JP5315051B2 JP 5315051 B2 JP5315051 B2 JP 5315051B2 JP 2008520121 A JP2008520121 A JP 2008520121A JP 2008520121 A JP2008520121 A JP 2008520121A JP 5315051 B2 JP5315051 B2 JP 5315051B2
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- Prior art keywords
- olopatadine
- acid
- preparation
- salt
- patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960004114 olopatadine Drugs 0.000 title claims abstract description 73
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- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
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- SJOXEWUZWQYCGL-UHFFFAOYSA-N salicylic acid menthyl ester Natural products CC(C)C1CCC(C)CC1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-UHFFFAOYSA-N 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
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- 210000001138 tear Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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- 229940033663 thimerosal Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- WYXIGTJNYDDFFH-UHFFFAOYSA-Q triazanium;borate Chemical compound [NH4+].[NH4+].[NH4+].[O-]B([O-])[O-] WYXIGTJNYDDFFH-UHFFFAOYSA-Q 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N trilaurin Chemical compound CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69736805P | 2005-07-08 | 2005-07-08 | |
| US60/697,368 | 2005-07-08 | ||
| PCT/JP2006/314017 WO2007007863A1 (en) | 2005-07-08 | 2006-07-07 | Percutaneously absorptive ophthalmic preparation comprising olopatadine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500398A JP2009500398A (ja) | 2009-01-08 |
| JP2009500398A5 JP2009500398A5 (enExample) | 2009-08-20 |
| JP5315051B2 true JP5315051B2 (ja) | 2013-10-16 |
Family
ID=37022903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008520121A Expired - Fee Related JP5315051B2 (ja) | 2005-07-08 | 2006-07-07 | オロパタジンを含む眼科用経皮吸収型製剤 |
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| US (1) | US8101654B2 (enExample) |
| EP (1) | EP1901708B1 (enExample) |
| JP (1) | JP5315051B2 (enExample) |
| KR (1) | KR20080038335A (enExample) |
| CN (1) | CN101217937A (enExample) |
| ES (1) | ES2437077T3 (enExample) |
| WO (1) | WO2007007863A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1591110B1 (en) * | 2003-01-22 | 2015-03-18 | Senju Pharmaceutical Co., Ltd. | Percutaneous absorption preparation for treating ophthalmic disease, use thereof and method for migration of ophthalmic remedy into topical tissue in eye |
| US20090143359A1 (en) * | 2005-07-08 | 2009-06-04 | Akiharu Isowaki | Percutaneously Absorptive Ophthalmic Preparation Comprising Epinastine |
| KR20090042956A (ko) * | 2006-08-28 | 2009-05-04 | 센주 세이야꾸 가부시키가이샤 | 안과 경피 흡수형 제제 |
| ES2752008T3 (es) * | 2009-10-30 | 2020-04-02 | Intratus Inc | Métodos y composiciones para la liberación sostenida de fármacos |
| US8900626B2 (en) | 2011-06-20 | 2014-12-02 | Senju Usa, Inc. | Transdermal drug delivery system and method of using the same |
| PT2934510T (pt) * | 2012-12-19 | 2021-01-13 | Novartis Ag | Formulações de inibidor de lfa-1 |
| JP2016210780A (ja) * | 2015-05-12 | 2016-12-15 | 参天製薬株式会社 | アゾール系抗真菌薬の眼瞼皮膚への投与 |
| CN106324111A (zh) * | 2015-06-24 | 2017-01-11 | 江苏吉贝尔药业股份有限公司 | 一种盐酸奥洛他定滴眼液的检测方法 |
| TWI825013B (zh) | 2017-04-19 | 2023-12-11 | 日商帝國製藥股份有限公司 | 含有盧帕他定（ｒｕｐａｔａｄｉｎｅ）之貼附劑 |
| CN107823124B (zh) * | 2017-11-09 | 2018-11-27 | 广州博济医药生物技术股份有限公司 | 一种盐酸奥洛他定外用组合物及其乳膏剂 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
| WO1997002038A1 (en) * | 1995-06-30 | 1997-01-23 | Capelli Christopher C | Silver-based pharmaceutical compositions |
| JPH09194396A (ja) * | 1996-01-17 | 1997-07-29 | Pola Chem Ind Inc | 貼付剤用マトリックス |
| AU770975B2 (en) * | 1999-06-18 | 2004-03-11 | Alcon Laboratories, Inc. | Topical ophthalmic mast cell stabilizers for treating allergic eye diseases |
| ES2356704T3 (es) * | 1999-07-15 | 2011-04-12 | Hisamitsu Pharmaceutical Co. Inc. | Preparaciones percutaneamente absobibles. |
| JP4653893B2 (ja) * | 2000-01-27 | 2011-03-16 | 純一 須藤 | 二層型経皮吸収製剤 |
| TWI231759B (en) | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| EP1591110B1 (en) | 2003-01-22 | 2015-03-18 | Senju Pharmaceutical Co., Ltd. | Percutaneous absorption preparation for treating ophthalmic disease, use thereof and method for migration of ophthalmic remedy into topical tissue in eye |
-
2006
- 2006-07-07 JP JP2008520121A patent/JP5315051B2/ja not_active Expired - Fee Related
- 2006-07-07 CN CNA2006800248918A patent/CN101217937A/zh active Pending
- 2006-07-07 KR KR1020087003138A patent/KR20080038335A/ko not_active Ceased
- 2006-07-07 US US11/988,377 patent/US8101654B2/en not_active Expired - Fee Related
- 2006-07-07 EP EP06781092.9A patent/EP1901708B1/en not_active Not-in-force
- 2006-07-07 ES ES06781092.9T patent/ES2437077T3/es active Active
- 2006-07-07 WO PCT/JP2006/314017 patent/WO2007007863A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080038335A (ko) | 2008-05-06 |
| EP1901708A1 (en) | 2008-03-26 |
| EP1901708B1 (en) | 2013-09-11 |
| ES2437077T3 (es) | 2014-01-08 |
| CN101217937A (zh) | 2008-07-09 |
| US20090209632A1 (en) | 2009-08-20 |
| US8101654B2 (en) | 2012-01-24 |
| WO2007007863A1 (en) | 2007-01-18 |
| JP2009500398A (ja) | 2009-01-08 |
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