JP5315047B2 - ２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法 - Google Patents

２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法 Download PDF

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Publication number
JP5315047B2
JP5315047B2 JP2008513965A JP2008513965A JP5315047B2 JP 5315047 B2 JP5315047 B2 JP 5315047B2 JP 2008513965 A JP2008513965 A JP 2008513965A JP 2008513965 A JP2008513965 A JP 2008513965A JP 5315047 B2 JP5315047 B2 JP 5315047B2
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formula
alkyl
compound
hydrogen atom
aryl
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Japanese (ja)
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JP2008542315A (ja
JP2008542315A5 (enExample
Inventor
ヨーアヒム・グレーザー
ギュンター・ビレン
アードルフ・リンキーズ
トビーアス・メツェンティン
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2008513965A 2005-06-01 2006-05-17 ２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法 Expired - Fee Related JP5315047B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005025225.7 2005-06-01
DE102005025225A DE102005025225A1 (de) 2005-06-01 2005-06-01 Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten
PCT/EP2006/004645 WO2006128585A1 (de) 2005-06-01 2006-05-17 Verfahren zur herstellung von 2-(2-amino-pyrimidin-4-yl)-1h-indol-5-carbonsäure-derivaten

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012275917A Division JP2013121958A (ja) 2005-06-01 2012-12-18 ２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法

Publications (3)

Publication Number Publication Date
JP2008542315A JP2008542315A (ja) 2008-11-27
JP2008542315A5 JP2008542315A5 (enExample) 2009-07-02
JP5315047B2 true JP5315047B2 (ja) 2013-10-16

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JP2008513965A Expired - Fee Related JP5315047B2 (ja) 2005-06-01 2006-05-17 ２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法
JP2012275917A Pending JP2013121958A (ja) 2005-06-01 2012-12-18 ２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法

Family Applications After (1)

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JP2012275917A Pending JP2013121958A (ja) 2005-06-01 2012-12-18 ２−（２−アミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸誘導体の製造方法

Country Status (5)

Country Link
US (3) US8232395B2 (enExample)
EP (2) EP1891049B1 (enExample)
JP (2) JP5315047B2 (enExample)
DE (1) DE102005025225A1 (enExample)
WO (1) WO2006128585A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005025225A1 (de) * 2005-06-01 2006-12-07 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten
CA2807979A1 (en) 2010-08-12 2012-02-16 Sanofi Process for the preparation of enantiomeric forms of 2,3-diaminopropionic acid derivatives
JP6078551B2 (ja) * 2011-12-06 2017-02-08 サノフイ ２−（２−メチルアミノ−ピリミジン−４−イル）−１ｈ−インドール−５−カルボン酸［（ｓ）−１−カルバモイル−２−（フェニル−ピリミジン−２−イル−アミノ）−エチル］−アミドの結晶形
HUE055964T2 (hu) 2012-01-20 2022-01-28 Ge Video Compression Llc Párhuzamos feldolgozást lehetõvé tevõ kódolási koncepciók, transzport demultiplexer és videó bitfolyam
EP3184095A1 (en) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
DE102014225953A1 (de) * 2014-12-16 2016-06-16 Robert Bosch Gmbh Ventilbaugruppe für einen Druckänderungsdämpfer für eine bremskraftgeregelte, hydraulische Fahrzeugbremsanlage, Hydraulikblock für eine solche Fahrzeugbremsanlage und Fahrzeugbremsanlage mit einem solchen Hydraulikblock

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9705035D0 (en) 1997-03-11 1997-04-30 Pharmacia & Upjohn Spa Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
DE19951360A1 (de) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
DE10009000A1 (de) * 2000-02-25 2001-08-30 Basf Ag Verfahren zur Herstellung substituierter Indole
MXPA04007697A (es) * 2002-02-06 2004-11-10 Vertex Pharma Compuestos de heteroarilo utiles como inhibidores de gsk-3.
DE10237723A1 (de) * 2002-08-17 2004-07-08 Aventis Pharma Deutschland Gmbh Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie
US7462638B2 (en) 2002-08-17 2008-12-09 Sanofi-Aventis Deutschland Gmbh Use of IκB-kinase inhibitors in pain therapy
DE10237722A1 (de) 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
CA2542514A1 (en) * 2003-10-23 2005-05-06 Pharmacia Corporation Pyrimidine compounds for the treatment of inflammation
DE102005025225A1 (de) * 2005-06-01 2006-12-07 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten

Also Published As

Publication number Publication date
US8546567B2 (en) 2013-10-01
EP1891049A1 (de) 2008-02-27
US20120271051A1 (en) 2012-10-25
EP1891049B1 (de) 2017-07-19
US20080214813A1 (en) 2008-09-04
EP2226319A1 (de) 2010-09-08
EP2226319B1 (de) 2016-03-16
US20140005392A1 (en) 2014-01-02
JP2008542315A (ja) 2008-11-27
US8232395B2 (en) 2012-07-31
DE102005025225A1 (de) 2006-12-07
WO2006128585A1 (de) 2006-12-07
JP2013121958A (ja) 2013-06-20

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