JP5290744B2 - 糖耐性を改善するためのアミノ酸組成物 - Google Patents
糖耐性を改善するためのアミノ酸組成物 Download PDFInfo
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- JP5290744B2 JP5290744B2 JP2008503149A JP2008503149A JP5290744B2 JP 5290744 B2 JP5290744 B2 JP 5290744B2 JP 2008503149 A JP2008503149 A JP 2008503149A JP 2008503149 A JP2008503149 A JP 2008503149A JP 5290744 B2 JP5290744 B2 JP 5290744B2
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- isoleucine
- body weight
- methionine
- leucine
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Description
本発明の組成物および対応方法は、分枝アミノ酸および硫黄含有アミノ酸の選択された混合物を含有する組成物に関する。本発明の組成物および方法のこれらの及び他の必須の又は随意的な(すなわち、所望により用いうる)要素または限定を以下に詳細に説明する。
本発明の組成物は、経口または非経口投与のための任意の公知の又は適当な製品(産物)形態で製剤化されうる。経口製品形態が好ましく、本発明での使用に適した任意の固体、液体または粉末製剤を包含する。ただし、そのような製剤は、選択された製品形態からの必須成分および他の選択された成分の安全かつ有効な経口運搬を可能にするものでなければならない。
本発明の組成物は、分枝アミノ酸および硫黄含有アミノ酸の選択された混合物を含み、前者にはバリン(VAL)、ロイシン(LEU)およびイソロイシン(ILE)が含まれ、後者にはシステイン(CYS)およびメチオニン(MET)が含まれる。
本発明の組成物は更に、脂肪源、炭水化物源およびタンパク質源を含む1以上の他の多量栄養素を(すべて、本明細書に記載のアミノ酸混合物に加えて)含みうる。
本発明の組成物は更に、該製品の物理的、化学的、美的もしくは加工特性を修飾し又は標的集団において使用された場合に医薬もしくは追加的な栄養成分として機能しうる他の随意的成分を含みうる。多数のそのような随意的成分は公知であるか、または医療用食品または他の栄養製品もしくは医薬剤形における使用に適しており、本発明における組成物においても使用されうる。ただし、そのような随意的成分は経口投与の場合に安全であり、選択された製品形態における必須成分および他の成分に適合しうるものでなければならない。
本発明の組成物には、本明細書に記載のアミノ酸混合物に伴う望ましくない香味を隠し又は最小限に抑えるように製剤化された低カロリー飲料または他の液体が含まれる。
本発明の組成物は、選択された製品形態を製造するための任意の公知の又は有効な製造技術により製造されうる。栄養液または栄養バーのような任意の与えられた製品形態に関する多数のそのような技術が公知であり、本明細書に記載の栄養製品に当業者により容易に適用されうる。
本発明の組成物は、糖耐性不全または糖尿病に罹患した又はそれらの発生のリスクを有する個体において使用されうる。しかし、これらの組成物は、栄養源として、任意の個体において、特に血糖応答低下が望ましい個体において投与されうる。
実施例1ないし3は本発明の栄養液実施形態を例示する。また、本発明の方法に従い該組成物を使用する対応方法も含まれる。各例示組成物の成分を以下の表に示す。特に示さない限り、すべての成分量は産物の1000kgバッチ当たりのkgとして示されている。
実施例4ないし6は、本発明の可能な錠剤実施形態の幾つかを例示する。また、本発明の方法に従い該錠剤を使用する対応方法も含まれる。該錠剤は、製剤分野でよく知られた方法により製造される。
以下の実験は本発明の組成物に関するものであり、糖耐性不全を有するラット(ファティー・ズッカー(Fatty Zucker)ラット)または2型糖尿病を有するラット(ズッカー糖尿病脂肪性(Zucker Diabetic Fatty)ラット)へのこれらの組成物の投与、ならびにそれに続く、各動物における血糖応答の評価を含む。
アミノ酸試験製剤および対照を調製する。該対照は22.5%グルコース溶液である。該アミノ酸試験製剤は、別々のチューブにおいて以下のアミノ酸のそれぞれを秤量し溶解することにより調製する。ASP(66.55mg)を1.0mlの1N HCLに溶解する。THR(7.21mg)を1.0mlの水に溶解する。SER(7.97mg)を1.0mlの水に溶解する。GLU(102.3mg)を1.0mlの1N HCLに溶解する。PRO(8.6mg)を1.0mlの水に溶解する。GLY(29.15mg)を1.0mlの1N HCLに溶解する。ALA(33.27mg)を1.0mlの水に溶解する。CYS(5.28mg)を1.0mlの1N HCLに溶解する。VAL(6.68mg)を1.0mlの水に溶解する。MET(3.36mg)を1.0mlの水に溶解する。ILE(7.34mg)を1.0mlの1N HCLに溶解する。LEU(6.58mg)を1.0mlの1N HCLに溶解する。TRY(33.55mg)を1.0mlの1N HCLに溶解する。PHE(20.8mg)を1.0mlの1N HCLに溶解する。HIS(6.9mg)を1.0mlの1N HCLに溶解する。LYS(11.8mg)を1.0mlの水に溶解する。ARG(34.38mg)を1.0mlの水に溶解する。TRP(9.46mg)を1.0mlの1N HCLに溶解する。各アミノ酸添加物をそれ自身の別々のチューブ内に加え、透明な溶液が生じるまでそのチューブ内で混合する。
実験1に記載の対照製剤(22.5%グルコース溶液)およびアミノ酸試験製剤を調製し、ついで、後記のイソロイシン混合物と共にこの第2実験において使用する。
血糖症を改善するのに必要な最小アミノ酸溶液を決定するために、アミノ酸混合物を以下のように調製する(各アミノ酸を秤量し、それをそれ自身の別々のチューブ内に入れる)。CYS(5.28mg)を1.0mlの1N HCLに溶解する。VAL(6.68mg)を1.0mlの水に溶解する。MET(3.36mg)を1.0mlの水に溶解する。LEU(6.58mg)を1.0mlの1N HCLに溶解する。透明な溶液が得られるまで、各チューブを混合する。50mlビーカー内で、ILE(927.5mg)を10ml HCLを溶解する。酸に溶解した全てのアミノ酸のチューブを50mlビーカーに加え(ピペットを使用して移す)、攪拌する。ついで、水に溶解したアミノ酸の全てを該ビーカーに加え(ピペットを介して移す)、ついで25mlの45%グルコース溶液を加える。得られた混合物を、十分に混合するまで攪拌する。該混合物のpHを50%水酸化ナトリウム溶液で約7に調整する。pHを安定化させるためにバッファーを加えてもよい。ついで該混合物を50mlの容積測定フラスコに移し、蒸留水で目的容量にする。得られた混合物を、以下の実験において、22.5%の対照溶液と比較する。
Claims (35)
- 1ないし200mg/kg体重のイソロイシン、
0.001ないし10mg/kg体重のロイシン、
0.001ないし10mg/kg体重のバリン、
0.001ないし10mg/kg体重のシステイン、および
0.001ないし10mg/kg体重のメチオニンを含んでなり、
イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの重量比が、独立して少なくとも10:1である、糖尿病または糖耐性不全に罹患した個体を治療するための組成物。 - 0.01ないし30mg/kg体重のアスパラギン酸、
0.001ないし10mg/kg体重のトレオニン、
0.001ないし10mg/kg体重のセリン、
0.01ないし30mg/kg体重のグルタミン酸、
0.001ないし10mg/kg体重のプロリン、
0.001ないし20mg/kg体重のグリシン、
0.001ないし20mg/kg体重のアラニン、
0.001ないし20mg/kg体重のチロシン、
0.001ないし10mg/kg体重のヒスチジン、
0.001ないし10mg/kg体重のリシン、
0.001ないし20mg/kg体重のアルギニン、および
0.001ないし20mg/kg体重のトリプトファン
の少なくとも1つを更に含む、請求項1の組成物。 - イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの少なくとも1つの重量比が少なくとも100:1である、請求項1の組成物。
- 10mg/kg体重未満のフェニルアラニンを含む、請求項1の組成物。
- ビタミン、ミネラル、炭水化物および脂肪の少なくとも1つを更に含む、請求項1の組成物。
- 全カロリーに対する割合として、10%ないし75%の炭水化物、20ないし85%の脂肪、および5%ないし70%のタンパク質を含む、請求項5の組成物。
- 組成物が経口錠剤である、請求項1の組成物。
- 組成物が経口液体である、請求項1の組成物。
- イソロイシン、ロイシン、バリン、システインおよびメチオニンを含んでなり、独立して少なくとも10:1の、イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの重量比を有する、糖尿病または糖耐性不全に罹患した個体を治療するための組成物。
- イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの重量比が、独立して少なくとも100:1である、請求項9の組成物。
- 少なくとも50:1の、分枝鎖アミノ酸対硫黄含有アミノ酸の重量比を有する、請求項9の組成物。
- 5重量%未満のフェニルアラニンを含む、請求項9の組成物。
- ビタミン、ミネラル、炭水化物および脂肪の少なくとも1つを更に含む、請求項9の組成物。
- 全カロリーに対する割合として、10%ないし75%の炭水化物、20%ないし85%の脂肪、および5%ないし70%のタンパク質を含む、請求項13の組成物。
- 組成物が経口錠剤である、請求項9の組成物。
- 組成物が経口液体である、請求項9の組成物。
- 10ないし200mg/kg体重のイソロイシン、
0.01ないし10mg/kg体重のロイシン、
0.01ないし10mg/kg体重のバリン、
0.01ないし10mg/kg体重のシステイン、および
0.01ないし10mg/kg体重のメチオニンを含んでなる、糖尿病または糖耐性不全に罹患した個体を治療するための組成物であって、
イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの重量比が、独立して少なくとも10:1である前記組成物。 - イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの少なくとも1つの重量比が少なくとも100:1である、請求項17の組成物。
- 10mg/kg体重未満のフェニルアラニンを含む、請求項17の組成物。
- ビタミン、ミネラル、炭水化物および脂肪の少なくとも1つを更に含む、請求項17の組成物。
- 全カロリーに対する割合として、10%ないし75%の炭水化物、20%ないし85%の脂肪、および5%ないし70%のタンパク質を含む、請求項17の組成物。
- 組成物が経口錠剤である、請求項17の組成物。
- 組成物が経口液体である、請求項17の組成物。
- 組成物を経口投与する、請求項1の組成物。
- 個体による炭水化物摂取の1時間以内に組成物を投与する、請求項1の組成物。
- 対象への組成物の投与が、炭水化物摂取後の30分、炭水化物摂取後の60分、炭水化物摂取後の90分および炭水化物摂取後の120分の少なくとも1つのうちに、該組成物の投与を伴わない血糖値と比較して血糖値を少なくとも5%低下させる、請求項25の組成物。
- 対象への組成物の投与が、炭水化物摂取後の60分のうちに、該組成物の投与を伴わない血糖値と比較して血糖値を少なくとも10%低下させる、請求項25の組成物。
- (A)独立して少なくとも10:1の、イソロイシン対ロイシン、イソロイシン対バリン、イソロイシン対システイン、およびイソロイシン対メチオニンの重量比で、イソロイシン、ロイシン、バリン、システインおよびメチオニンを含むアミノ酸混合物を含む、全カロリーに対する割合として2%ないし98%のタンパク質源、ならびに
(B)マルチトール、エリトリトール、ソルビトール、キシリトール、マンニトール、グリセロール、イソマルトおよびラクチトールの少なくとも1つを含む、全カロリーに対する割合として2%ないし98%の炭水化物、
を含んでなり、2.5ないし8.0のpHおよび8.1kcal/100mlないし40kcal/100mlのカロリー密度を有する栄養液。 - 該pHが2.5ないし4.6の範囲である、請求項28の栄養液。
- 該カロリー密度が16kcal/100mlないし32kcal/100mlの範囲である、請求項28の栄養液。
- 脂肪、ミネラルおよびビタミンの少なくとも1つを更に含む、請求項28の栄養液。
- 液が、全カロリーに対する割合として、10%ないし75%の炭水化物、20ないし85%の脂肪、およびアミノ酸混合物を含む5%ないし70%のタンパク質源を含む、請求項31の栄養液。
- 液がアセスルファムK、アスパルテーム、スクラロース、サッカリン、ステビアおよびタガトースの少なくとも1つを更に含む、請求項28の栄養液。
- 液がエリトリトールを含む、請求項28の栄養液。
- 液が1重量%ないし10重量%のエリトリトールを含む、請求項34の栄養液。
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US9913872B2 (en) * | 2013-10-04 | 2018-03-13 | Houn Simon Hsia | Diabetic nutritional composition |
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