JP5276119B2 - 横隔刺激検出のための方法および装置 - Google Patents
横隔刺激検出のための方法および装置 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
- A61N1/371—Capture, i.e. successful stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36585—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by two or more physical parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3684—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions for stimulating the heart at multiple sites of the ventricle or the atrium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
- A61N1/3706—Pacemaker parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/37—Monitoring; Protecting
- A61N1/371—Capture, i.e. successful stimulation
- A61N1/3712—Auto-capture, i.e. automatic adjustment of the stimulation threshold
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1107—Measuring contraction of parts of the body, e.g. organ, muscle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3684—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions for stimulating the heart at multiple sites of the ventricle or the atrium
- A61N1/36842—Multi-site stimulation in the same chamber
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3684—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions for stimulating the heart at multiple sites of the ventricle or the atrium
- A61N1/36843—Bi-ventricular stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
Description
左心室リード線405は、左心室の近くの冠静脈系内の種々の場所に配置された複数の電極454a〜454dおよび455を組込む。左心室内の複数の場所で、または、選択された単一の場所で心室を刺激することは、たとえば、心不全(HF)を患う患者の心拍出量の増加を実現する可能性がある、かつ/または、他の利益を実現する可能性がある。電気刺激パルスは、心臓機能を増強するタイミングシーケンスおよび出力構成に従って選択された電極によって送出されてもよい。図4は複数の左心室電極を示すが、他の構成では、別法として、または、付加的に、複数の電極が、右心房、左心房、および右心室の1つまたは複数内に設けられてもよい。
Vth=IthZ [1]
として規定されうる。式中、Vthは電極の組合せについての捕捉閾電圧であり、Ithは電極の組合せについての捕捉閾電流であり、Zは電極の組合せのインピーダンスである。
Vth−in=Ith−inZin [2]
として表現されてもよい。式中、Vth−inは最初の電極の組合せについての捕捉閾電圧であり、Ith−inは最初の電極の組合せについての捕捉閾電流であり、Zinは最初の電極の組合せのインピーダンスである。
Vth−ex=Ith−exZex [3]
として表現されてもよい。式中、Vth−exは代替の電極の組合せについての捕捉閾電圧であり、Ith−exは代替の電極の組合せについての捕捉閾電流であり、Zexは代替の電極の組合せのインピーダンスである。
代替の捕捉閾電圧と最初の捕捉閾電圧でとの間の関係は、
Vth−ex=(Vth−in/Zin)Zex [4]
として表現されてもよい。
特定の電極の組合せについての捕捉閾値の推定計算の精度は、測定される電極の組合せが、捕捉閾値がそれについて推定される電極の組合せと同じ極性を有する場合、増加する可能性がある。捕捉閾値推定を含むパラメータ推定方法は、参照によりその全体が本明細書に組込まれる2006年8月17日に出願された米国特許出願第11/505,645号に開示される。
捕捉は、心臓組織の収縮をもたらす電気的脱分極の伝播波面を生成するのに十分なエネルギーを有するペーシングパルスによって生成される。一般的に言うと、ペーシングパルスのエネルギーは、2つのエネルギーパラメータ−ペーシングパルスの振幅とパルスの継続時間−の積である。そのため、ある範囲のパルス幅にわたる捕捉閾電圧は、図6に示すように、捕捉強度−継続時間プロット610で表現されてもよい。
Claims (9)
- 心臓調律管理システムであって、
複数の電極(205)を有する埋め込み型心臓ペーシングデバイス(200)と、
前記複数の電極を通して複数の心臓ペーシングパルスを出力し、前記複数の心臓ペーシングパルスの1つまたは複数のペーシングパラメータを修正するよう構成される回路(230)と、
前記複数の心臓ペーシングパルスの1つまたは複数による横隔神経の刺激を検知し、検知された横隔刺激に基づいて1つまたは複数の信号を供給するよう構成される1つまたは複数のセンサ(210)と、
メモリ(245)に格納されたプログラム命令を実行して、前記システムに、前記1つまたは複数の信号と前記1つまたは複数のペーシングパラメータを比較して、横隔刺激閾値が、最大心臓ペーシングパラメータより高い、および、最小心臓ペーシングパラメータより低い、の少なくとも一方であるかどうかを判定し、前記判定に基づいて情報を格納させるよう構成されるコントローラ(240)であって、前記最大及び最小心臓ペーシングパラメータは各々、プログラムされた制限、または前記心臓ペーシングデバイスのハードウェアに関連する能力制限を構成する、前記コントローラと
を備え、前記情報は、少なくとも、前記横隔刺激閾値と、前記プログラムされた制限または前記心臓ペーシングデバイスのハードウェアに関連する能力制限との間の関係を示すものである、心臓調律管理システム。 - 前記最大心臓ペーシングパラメータは、前記心臓ペーシングデバイスが送出するようにプログラムされる最大ペーシングパルス振幅または幅であり、前記最小心臓ペーシングパラメータは、前記心臓ペーシングデバイスが送出するようにプログラムされる最小ペーシングパルス振幅または幅である、請求項1に記載の心臓調律管理システム。
- 前記コントローラは、格納されたプログラム命令を実行して、前記システムに、前記横隔刺激閾値の少なくとも1つが検出され、心臓ペーシングパルスが、前記心臓ペーシングデバイスが送出するようにプログラムされるか、または送出可能な最大振幅または幅で送出されるまで、前記複数のパルスの前記少なくとも一部の送出の間に前記複数の心臓ペーシングパルスの1つまたは複数についてペーシングパルスの振幅または幅パラメータを増分させるようさらに構成される、請求項1に記載の心臓調律管理システム。
- 前記コントローラは、格納されたプログラム命令を実行して、前記システムに、前記ペーシングパルスの振幅または幅パラメータが、心臓捕捉閾値および前記心臓ペーシングデバイスが送出するようにプログラムされるか、または送出可能な最小心臓ペーシング振幅または幅パラメータの少なくとも一方まで減少するまで、前記複数のパルスの少なくとも一部の送出の間に前記複数の心臓ペーシングパルスの1つまたは複数についてペーシングパルスの振幅または幅パラメータを減分させるようさらに構成される、請求項1に記載の心臓調律管理システム。
- 前記コントローラは、格納されたプログラム命令を実行して、前記システムに、前記横隔刺激閾値が、前記最大心臓ペーシングパラメータより高い、および、前記最小心臓ペーシングパラメータより低い、の少なくとも一方であるという判定に基づいて、前記最大心臓ペーシングパラメータおよび前記最小心臓ペーシングパラメータの一方または両方を再プログラムさせるようさらに構成される、請求項1に記載の心臓調律管理システム。
- 前記コントローラは、格納されたプログラム命令を実行して、前記システムに、前記最大心臓ペーシングパラメータおよび前記最小心臓ペーシングパラメータを含むパラメータ範囲制限を選択させ、前記パラメータ範囲制限から外れるペーシングパラメータを有する前記複数の心臓ペーシングパルスの少なくとも1つを送出させるようさらに構成される、請求項1に記載の心臓調律管理システム。
- 前記コントローラは、格納されたプログラム命令を実行して、前記システムに、前記1つまたは複数のセンサ信号の評価と前記複数の心臓ペーシングパルスの1つまたは複数の前記ペーシングパラメータの比較に基づいて、前記パルスの前記少なくとも一部の送出の間に変更される前記複数の心臓ペーシングパルスの前記ペーシングパラメータについて、増分値および減分値の一方または両方を変更させるようさらに構成される、請求項1に記載の心臓調律管理システム。
- 前記最大及び最小心臓ペーシングパラメータは、前記埋め込み型心臓ペーシングデバイスの埋め込み時にプログラムされるパラメータである、請求項1乃至7のいずれか一項に記載の心臓調律管理システム。
- 前記コントローラは、前記横隔刺激閾値が、前記プログラムされた制限、または前記心臓ペーシングデバイスのハードウェアに関連する能力制限よりも大きいと判定された場合、走査を実施する際に横隔刺激を無視して、心臓捕捉閾値を更新するように構成される、請求項1乃至8のいずれか一項に記載の心臓調律管理システム。
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US6574308P | 2008-02-14 | 2008-02-14 | |
US61/065,743 | 2008-02-14 | ||
PCT/US2009/033687 WO2009102726A1 (en) | 2008-02-14 | 2009-02-10 | Method and apparatus for phrenic stimulation detection |
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JP2011510713A JP2011510713A (ja) | 2011-04-07 |
JP5276119B2 true JP5276119B2 (ja) | 2013-08-28 |
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US (4) | US8649866B2 (ja) |
EP (1) | EP2254661B1 (ja) |
JP (1) | JP5276119B2 (ja) |
CN (1) | CN101939051B (ja) |
AU (1) | AU2009214920B2 (ja) |
WO (1) | WO2009102726A1 (ja) |
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EP2254661A1 (en) | 2010-12-01 |
JP2011510713A (ja) | 2011-04-07 |
US8649866B2 (en) | 2014-02-11 |
US9352160B2 (en) | 2016-05-31 |
EP2254661B1 (en) | 2015-10-07 |
CN101939051B (zh) | 2013-07-10 |
AU2009214920A1 (en) | 2009-08-20 |
US20140128933A1 (en) | 2014-05-08 |
US20160250479A1 (en) | 2016-09-01 |
AU2009214920B2 (en) | 2012-02-09 |
US20150190642A1 (en) | 2015-07-09 |
CN101939051A (zh) | 2011-01-05 |
US20090210024A1 (en) | 2009-08-20 |
US9555253B2 (en) | 2017-01-31 |
US8996112B2 (en) | 2015-03-31 |
WO2009102726A1 (en) | 2009-08-20 |
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