JP5275471B2 - 条件付き脱同期化刺激のための装置 - Google Patents
条件付き脱同期化刺激のための装置 Download PDFInfo
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Description
Claims (12)
- − 電気的な第1の刺激(21)を生成する第1の刺激ユニット(11)であって、前記第1の刺激(21)が、患者の脳もしくは脊髄またはその両方に印加されたとき、前記患者の前記脳もしくは前記脊髄またはその両方におけるニューロンの病的に同期した活動を抑制する、第1の刺激ユニット(11)と、
− 光の第2の刺激(22)、音響的な第2の刺激(22)、触覚の第2の刺激(22)、振動性の第2の刺激(22)のうちの1つまたは複数を生成する第2の刺激ユニット(12)と、
− 前記第1の刺激ユニット(11)および前記第2の刺激ユニット(12)を制御する制御ユニット(10)と、
を備えており、
− 前記第1の刺激(21)および前記第2の刺激(22)が、随意に第1の動作モードまたは第2の動作モードにおいて生成され、
− 前記第1の動作モードにおいては前記第2の刺激(22)の少なくとも60%の生成が前記第1の刺激(21)の生成に時間的に連結されており、かつ、前記第2の動作モードにおいては前記第2の刺激(22)の少なくとも60%が前記第1の刺激(21)の生成なしに生成されるように、前記制御ユニット(10)が前記第1の刺激ユニット(11)および前記第2の刺激ユニット(12)を作動させる、
装置(100,300)。 - 単独で印加される前記第2の刺激(22)が、前記脳もしくは前記脊髄またはその両方におけるニューロンの病的に同期した活動を抑制しない、
請求項1に記載の装置(100,300)。 - 前記患者が前記第2の刺激(22)を意識的に知覚することができる、
請求項1または2に記載の装置(100,300)。 - 前記ニューロンの前記病的に同期した活動を再現する測定信号(26)を記録する測定ユニット(15)、
を備えている、請求項1〜3のいずれか1項に記載の装置(300)。 - 前記第2の動作モードにおいて、前記測定信号(26)が指定された第1のしきい値を超えた場合、前記制御ユニット(10)が前記第1の刺激(21)の数を増大させ、前記第1の刺激(21)の生成が前記第2の刺激(22)の生成に時間的に連結されている、
請求項4に記載の装置(300)。 - 前記測定信号(26)が指定された第2のしきい値を超えた場合、前記制御ユニット(10)が前記第2の動作モードから前記第1の動作モードに切り替える、
請求項4または5に記載の装置(300)。 - 前記第1の刺激ユニット(11)が、前記測定信号(26)を第1の刺激(21)として使用する、またはさらなる処理の後に前記測定信号(26)を第1の刺激(21)として使用する、
請求項4〜6のいずれか1項に記載の装置(300)。 - 前記第1の動作モードにおいて、前記第1の刺激(21)が第1の時間間隔(Δt1)の間に生成され、前記第2の刺激(22)が第2の時間間隔(Δt2)の間に生成され、前記第2の時間間隔(Δt2)の少なくとも60%が、それぞれ、前記第1の時間間隔(Δt1)の1つと時間的に重なっている、
請求項1〜7のいずれか1項に記載の装置(100,300)。 - 前記第1の時間間隔(Δt1)の1つと前記第2の時間間隔(Δt2)の1つとの間の時間的な重なり(Δt12)が、前記第2の時間間隔(Δt2)の持続時間の少なくとも10%の持続時間を有する、
請求項8に記載の装置(100,300)。 - 前記第1の刺激ユニット(11)が、前記患者の前記脳もしくは前記脊髄またはその両方に前記第1の刺激(21)を供給する複数の刺激接触面(51,52,53,54)、を備えており、前記第1の刺激(21)が、病的に同期した振動性の活動を有するニューロン集団に印加された場合に、前記ニューロン集団の前記振動性の活動の位相をリセットするように、具体化されている、
請求項1〜9のいずれか1項に記載の装置(100,300)。 - − 電気的な第1の刺激(21)を生成する第1の刺激ユニット(11)であって、前記第1の刺激(21)が、患者の脳もしくは脊髄またはその両方に印加されたとき、前記患者の前記脳もしくは前記脊髄またはその両方におけるニューロンの病的に同期した活動を抑制する、第1の刺激ユニット(11)と、
− 光の第2の刺激(22)、音響的な第2の刺激(22)、触覚の第2の刺激(22)、振動性の第2の刺激(22)のうちの1つまたは複数を生成する第2の刺激ユニット(12)であって、前記第2の刺激(22)が前記患者によって意識的に知覚され得る、第2の刺激ユニット(12)と、
を備えており、
− 学習段階の間、前記第1の刺激(21)および前記第2の刺激(22)が時間的に連結されて前記患者に印加され、これによって前記患者の神経系の条件付けがもたらされ、結果として、前記神経系が、前記第1の刺激(21)なしでの前記第2の刺激(22)の印加に対して、あたかも前記第1の刺激(21)が印加されたかのように反応するようになり、
− 前記学習段階に続く刺激段階の間、前記第2の刺激(22)の少なくとも一部が、前記第1の刺激(21)なしで前記患者に印加される、
装置(100,300)。 - − 電気的な第1の刺激(21)を生成する第1の刺激ユニット(11)であって、前記第1の刺激(21)が、患者の脳もしくは脊髄またはその両方に印加されたとき、前記患者の前記脳もしくは前記脊髄またはその両方におけるニューロンの病的に同期した活動を抑制する、第1の刺激ユニット(11)と、
− 光の第2の刺激(22)、音響的な第2の刺激(22)、触覚の第2の刺激(22)、振動性の第2の刺激(22)のうちの1つまたは複数を生成する第2の刺激ユニット(12)と、
を備えており、
− 前記第1の刺激(21)が第1の時間間隔(Δt1)の間に生成され、前記第2の刺激(22)が第2の時間間隔(Δt2)の間に生成され、
− 前記第1の刺激(21)および前記第2の刺激(22)が、随意に第1の動作モードまたは第2の動作モードにおいて生成され、
− 前記第1の動作モードにおいては前記第2の時間間隔(Δt2)の少なくとも60%が、前記第1の時間間隔(Δt1)の1つと時間的に重なっており、前記第2の動作モードにおいては前記第2の時間間隔(Δt2)の少なくとも60%が、前記第1の時間間隔(Δt1)と重ならない、
装置(100,300)。
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PCT/EP2009/007452 WO2010043413A1 (de) | 2008-10-17 | 2009-10-16 | Vorrichtung und verfahren zur konditionierten desynchronisierenden stimulation |
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