JP2018505735A - 非侵襲性機械的触覚および/または熱的神経刺激を較正するためのデバイスおよび方法 - Google Patents
非侵襲性機械的触覚および/または熱的神経刺激を較正するためのデバイスおよび方法 Download PDFInfo
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Abstract
Description
xk−1<XF(t)≦xkについて、
xk+3<XF(t)<xk+4について、
式中、l=2,3,4。
Claims (17)
- ニューロンを刺激する装置(1)であって、
患者の身体の表面に機械的触覚および/または熱的刺激(22)を印加するための非侵襲性刺激ユニット(11)であって、前記刺激(22)は、病的に同期した振動性のニューロン活動を有するニューロンを刺激する、非侵襲性刺激ユニット(11)と、
前記刺激されているニューロンのニューロン活動を再現する測定信号(23)を記録するための測定ユニット(12)と、
前記刺激ユニット(11)を制御し、前記測定信号(23)を解析するための制御・解析ユニット(10)と、
を備え、
前記制御・解析ユニット(10)は、
前記刺激ユニット(11)が、ある経路に沿って前記患者の前記身体の前記表面の少なくとも一部を走査し、これを行う中で、刺激を周期的に印加するように、前記刺激ユニット(11)を制御し、
前記刺激の前記周期的印加に応答して記録される前記測定信号を基準として、前記経路に沿って前記患者の前記身体の前記表面上の少なくとも2つの領域を選択し、前記刺激の前記周期的印加と、前記刺激されているニューロンの前記ニューロン活動との間の位相同期はそれぞれ、前記領域内で極大を有し、
前記刺激ユニット(11)が、前記少なくとも2つの選択領域において、時間的にオフセットされるように刺激(40)を印加するように、前記刺激ユニット(11)を制御するように構成されており、
前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
装置(1)。 - 前記制御・解析ユニット(10)は、前記刺激(40)が時間的にオフセットされて印加されるのに応答して記録される前記測定信号(23)を基準にして、前記時間的にオフセットされて印加されている刺激(40)が、前記刺激されているニューロンの前記病的に同期した振動性の活動を低減するか否かをチェックする、
請求項1に記載の装置(1)。 - 前記刺激の前記周期的印加に応答して前記制御・解析ユニット(10)によって選択される前記少なくとも2つの領域は、第1の領域および第2の領域を含み、
前記制御・解析ユニット(10)は、前記刺激(40)が時間的にオフセットされて印加されるのに応答して記録される前記測定信号(23)を基準として、前記時間的にオフセットされて印加されている刺激(40)が前記刺激されているニューロンの前記病的に同期した振動性の活動を低減しないと判定した場合に、前記第2の領域を、前記患者の前記身体の前記表面上で変位させる、
請求項1または2に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記刺激(40)が時間的にオフセットされて印加されるのに応答して記録される前記測定信号(23)を基準にして、前記時間的にオフセットされて印加されている刺激(40)が、前記の長い間刺激されているニューロンの前記病的に同期した振動性の活動を低減すると判定するまで、前記第2の領域を、前記患者の前記身体の前記表面上で変位させる、
請求項3に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記第1および第2の領域における前記時間的にオフセットされた刺激(40)の前記印加後に、前記患者の前記身体の前記表面上の第3の領域を選択し、前記第2の領域および前記第3の領域内では時間的にオフセットされるように刺激(40)を印加する一方、前記第1の領域内では刺激(40)を印加しないように、前記刺激ユニット(11)を制御し、
前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
請求項3または4に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記刺激(40)が前記第2の領域および前記第3の領域において時間的にオフセットされて印加されるのに応答して記録される前記測定信号(23)を基準にして、前記時間的にオフセットされて印加されている刺激(40)が、前記刺激されているニューロンの前記病的に同期した振動性の活動を低減しないと判定した場合に、前記第3の領域を、前記患者の前記身体の前記表面上で変位させる、
請求項5に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記第2の領域および前記第3の領域における前記時間的にオフセットされた刺激(40)の前記印加後に、前記患者の前記身体の前記表面上の1つまたは複数のさらなる領域を選択し、前記選択されている領域のうちの2つにおいて時間的にオフセットされるように刺激(40)を印加する一方、残りの領域内では刺激(40)を印加しないように、前記刺激ユニット(11)を制御し、
前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
請求項5または6に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記第1および第2の領域における前記時間的にオフセットされた刺激(40)の前記印加後に、前記患者の前記身体の前記表面上の第3の領域を選択し、前記第1の領域、前記第2の領域および前記第3の領域内で時間的にオフセットされるように刺激(40)を印加するように、前記刺激ユニット(11)を制御し、
前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
請求項3または4に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記刺激(40)が前記第1の領域、前記第2の領域および前記第3の領域において時間的にオフセットされて印加されるのに応答して記録される前記測定信号(23)を基準にして、前記時間的にオフセットされて印加されている刺激(40)が、前記刺激されているニューロンの前記病的に同期した振動性の活動を低減しないと判定した場合に、前記第3の領域を、前記患者の前記身体の前記表面上で変位させる、
請求項8に記載の装置(1)。 - 前記制御・解析ユニット(10)は、前記時間的にオフセットされた刺激(40)の前記印加後に、前記患者の前記身体の前記表面上の1つまたは複数のさらなる領域を選択し、前記第1の領域、前記第2の領域、前記第3の領域および前記1つまたは複数のさらなる選択領域内で時間的にオフセットされるように刺激(40)を印加するように、前記刺激ユニット(11)を制御し、
前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
請求項8または9に記載の装置(1)。 - 前記刺激ユニット(11)は、アレイ状に配列されており、前記機械的触覚および/または熱的刺激(22)を生成する複数の刺激要素(35)を有する、
請求項1〜10のいずれか一項に記載の装置(1)。 - 活性化グループが、少なくとも部分的に、前記アレイ状にマッピングすることができる特定の形状内に位置する刺激要素(35)を含み、
前記形状は、応答して変化する、前記活性化グループ、および、前記活性化グループによって包含される前記刺激要素(35)の移動を受けて、前記アレイにわたって移動する、
請求項11に記載の装置(1)。 - 前記刺激ユニット(11)による前記患者の前記身体の前記表面の少なくとも一部の前記走査を受けて、前記活性化グループは、前記アレイおよび前記活性化グループによって包含される前記刺激要素(35)にわたって前記経路に沿って移動し、前記周期的刺激を生成する、
請求項12に記載の装置(1)。 - 前記アレイ状に配列されている前記刺激要素(35)は、前記患者の前記身体に固定することができるように構成されているカフ(36)に固定される、
請求項11〜13のいずれか一項に記載の装置(1)。 - 前記装置(1)は入力ユニット(37)を備え、
前記入力ユニット(37)は、ユーザが、前記活性化グループの前記形状、および/または、前記活性化グループが移動する前記経路を入力することができるように構成されている、
請求項12〜14のいずれか一項に記載の装置(1)。 - ニューロンを刺激するための方法(1)であって、
非侵襲性刺激ユニット(11)が、患者の身体の表面に機械的触覚および/または熱的刺激(22)を印加し、前記刺激(22)は、病的に同期した振動性のニューロン活動を有するニューロンを刺激し、
前記刺激されているニューロンのニューロン活動を再現する測定信号(23)が記録され、
前記刺激ユニット(11)が、ある経路に沿って前記患者の前記身体の前記表面の少なくとも一部を走査し、これを行う中で、刺激を周期的に印加し、
前記刺激の前記周期的印加に応答して記録される前記測定信号を基準として、前記経路に沿って前記患者の前記身体の前記表面上の少なくとも2つの領域が選択され、前記刺激の前記周期的印加と、前記刺激されているニューロンの前記ニューロン活動との間の位相同期はそれぞれ、前記領域内で極大を有し、
前記刺激ユニット(11)は、前記少なくとも2つの選択領域において時間的にオフセットされるように刺激(40)を印加し、前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
方法(1)。 - データ処理システム内で実行するためのソフトウェアであって、
非侵襲性刺激ユニット(11)を制御するための制御信号を生成し、前記刺激ユニット(11)は、患者の身体の表面に機械的触覚および/または熱的刺激(22)を印加し、前記刺激(22)は、病的に同期した振動性のニューロン活動を有するニューロンを刺激し、
前記刺激されているニューロンのニューロン活動を再現する測定信号(23)が記録され、
前記刺激ユニット(11)が、ある経路に沿って前記患者の前記身体の前記表面の少なくとも一部を走査し、これを行う中で、刺激を周期的に印加し、
前記刺激の前記周期的印加に応答して記録される前記測定信号を基準として、前記経路に沿って前記患者の前記身体の前記表面上の少なくとも2つの領域が選択され、前記刺激の前記周期的印加と、前記刺激されているニューロンの前記ニューロン活動との間の位相同期はそれぞれ、前記領域内で極大を有し、
前記刺激ユニット(11)は、前記少なくとも2つの選択領域において時間的にオフセットされるように刺激(40)を印加し、
前記刺激は前記刺激されているニューロンの前記ニューロン活動の位相リセットを実行する、
ソフトウェア。
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PCT/EP2016/052389 WO2016128291A1 (de) | 2015-02-09 | 2016-02-04 | Vorrichtung und verfahren zur kalibrierung einer nicht-invasiven mechanisch taktilen und/oder thermischen neurostimulation |
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CN111568375B (zh) * | 2020-05-09 | 2022-07-12 | 四川大学华西第二医院 | 一种儿科神经触觉检查器 |
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