JP5252404B2 - ピラジン化合物、その使用及び調製方法 - Google Patents
ピラジン化合物、その使用及び調製方法 Download PDFInfo
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- JP5252404B2 JP5252404B2 JP2009524774A JP2009524774A JP5252404B2 JP 5252404 B2 JP5252404 B2 JP 5252404B2 JP 2009524774 A JP2009524774 A JP 2009524774A JP 2009524774 A JP2009524774 A JP 2009524774A JP 5252404 B2 JP5252404 B2 JP 5252404B2
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- Prior art keywords
- alkyl
- compound
- hydroxyl
- substituted
- alkoxy
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- LGDJCYFNLOHIMJ-ONEGZZNKSA-N CC(C)/C=C/c1nnn[nH]1 Chemical compound CC(C)/C=C/c1nnn[nH]1 LGDJCYFNLOHIMJ-ONEGZZNKSA-N 0.000 description 2
- DTBFDAJNODVUMF-VOTSOKGWSA-N CN(CCC1)CCN1c1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 Chemical compound CN(CCC1)CCN1c1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 DTBFDAJNODVUMF-VOTSOKGWSA-N 0.000 description 2
- QYCBAZIYXPUATL-NSCUHMNNSA-N C/C=C/C(NS=O)=O Chemical compound C/C=C/C(NS=O)=O QYCBAZIYXPUATL-NSCUHMNNSA-N 0.000 description 1
- RUNJUHGFPBSQDS-VOTSOKGWSA-N CC(C)(CN)CNc1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 Chemical compound CC(C)(CN)CNc1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 RUNJUHGFPBSQDS-VOTSOKGWSA-N 0.000 description 1
- FUXRFWOLJZOPSF-VOTSOKGWSA-N CN(C)CCNc1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 Chemical compound CN(C)CCNc1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 FUXRFWOLJZOPSF-VOTSOKGWSA-N 0.000 description 1
- QQYNGYCPUGWHFT-VOTSOKGWSA-N CN(CCC1)CCN1c1cncc(-c2cccc(/C=C/C(N)=O)c2)n1 Chemical compound CN(CCC1)CCN1c1cncc(-c2cccc(/C=C/C(N)=O)c2)n1 QQYNGYCPUGWHFT-VOTSOKGWSA-N 0.000 description 1
- FBFMEEORXWZIMK-VOTSOKGWSA-N CN(CCC1)CCN1c1cncc(-c2cccc(/C=C/C(NCCO)=O)c2)n1 Chemical compound CN(CCC1)CCN1c1cncc(-c2cccc(/C=C/C(NCCO)=O)c2)n1 FBFMEEORXWZIMK-VOTSOKGWSA-N 0.000 description 1
- BJOQDHMIQZVJRI-SNAWJCMRSA-N NCCNc1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 Chemical compound NCCNc1cncc(-c2cccc(/C=C/C(O)=O)c2)n1 BJOQDHMIQZVJRI-SNAWJCMRSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07—ORGANIC CHEMISTRY
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82254606P | 2006-08-16 | 2006-08-16 | |
US60/822,546 | 2006-08-16 | ||
PCT/US2007/075946 WO2008022164A2 (en) | 2006-08-16 | 2007-08-15 | Pyrazine compounds, their use and methods of preparation |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010501003A JP2010501003A (ja) | 2010-01-14 |
JP2010501003A5 JP2010501003A5 (pt-PT) | 2010-09-30 |
JP5252404B2 true JP5252404B2 (ja) | 2013-07-31 |
Family
ID=38988263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009524774A Expired - Fee Related JP5252404B2 (ja) | 2006-08-16 | 2007-08-15 | ピラジン化合物、その使用及び調製方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8318723B2 (pt-PT) |
EP (1) | EP2061762B1 (pt-PT) |
JP (1) | JP5252404B2 (pt-PT) |
AT (1) | ATE517868T1 (pt-PT) |
CA (1) | CA2660560A1 (pt-PT) |
WO (1) | WO2008022164A2 (pt-PT) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103214483B (zh) | 2005-12-13 | 2014-12-17 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
EP2740731B1 (en) | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
US8436171B2 (en) * | 2008-02-01 | 2013-05-07 | Akinion Pharmaceuticals Ab | Amino substituted pyrazines as inhibitors or protein kinases |
US20110124630A1 (en) * | 2008-06-19 | 2011-05-26 | Naofumi Mukaida | Stemonamide synthesis intermediate and pharmaceutical composition for prevention and/or treatment of cancer |
TWI496779B (zh) * | 2008-08-19 | 2015-08-21 | Array Biopharma Inc | 作為pim激酶抑制劑之三唑吡啶化合物 |
US8987251B2 (en) | 2008-08-19 | 2015-03-24 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
BRPI1012159B1 (pt) | 2009-05-22 | 2022-01-25 | Incyte Holdings Corporation | Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos |
DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
KR102283091B1 (ko) | 2010-03-10 | 2021-07-30 | 인사이트 홀딩스 코포레이션 | Jak1 저해제로서의 피페리딘4일 아제티딘 유도체 |
EP2574168B9 (en) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
AR083933A1 (es) | 2010-11-19 | 2013-04-10 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
US20120225061A1 (en) | 2011-03-04 | 2012-09-06 | Matthew Burger | Tetrasubstituted cyclohexyl compounds as kinase inhibitors |
UY33930A (es) | 2011-03-04 | 2012-10-31 | Novartis Ag | Inhibidores novedosos de quinasas |
CN103797010B (zh) | 2011-06-20 | 2016-02-24 | 因塞特控股公司 | 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物 |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
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EP1363702A4 (en) | 2001-01-30 | 2007-08-22 | Cytopia Pty Ltd | PROCESS FOR INHIBITING KINASES |
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ES2360703T3 (es) * | 2003-12-03 | 2011-06-08 | Ym Biosciences Australia Pty Ltd | Inhibidores de la tubulina. |
EP1694670A1 (en) * | 2003-12-16 | 2006-08-30 | GPC Biotech AG | Pyrazine derivatives as effective compounds against infectious diseases |
JP2008519814A (ja) * | 2004-11-12 | 2008-06-12 | ガラパゴス・ナムローゼ・フェンノートシャップ | プロテインキナーゼ酵素の活性部位と結合する窒素複素環式芳香族化合物 |
KR20080053954A (ko) * | 2005-11-03 | 2008-06-16 | 아이알엠 엘엘씨 | 단백질 키나제 억제제 |
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ATE517868T1 (de) | 2011-08-15 |
JP2010501003A (ja) | 2010-01-14 |
CA2660560A1 (en) | 2008-02-21 |
WO2008022164A2 (en) | 2008-02-21 |
US8318723B2 (en) | 2012-11-27 |
US20100210627A1 (en) | 2010-08-19 |
EP2061762A2 (en) | 2009-05-27 |
EP2061762B1 (en) | 2011-07-27 |
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