JP5230050B2 - Ｈｉｖ複製阻害剤 - Google Patents

Ｈｉｖ複製阻害剤 Download PDF

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Publication number
JP5230050B2
JP5230050B2 JP2001582301A JP2001582301A JP5230050B2 JP 5230050 B2 JP5230050 B2 JP 5230050B2 JP 2001582301 A JP2001582301 A JP 2001582301A JP 2001582301 A JP2001582301 A JP 2001582301A JP 5230050 B2 JP5230050 B2 JP 5230050B2
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JP
Japan
Prior art keywords
alkyl
formula
compound
amino
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2001582301A
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English (en)
Japanese (ja)
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JP2003535828A5 (https=
JP2003535828A (ja
Inventor
ククラ，マイケル・ジヨゼフ
ルドビチ，ドナルド・ウイリアム
カバシユ，ロバート・ダブリユー
ド・コルト，バール・リーベン・ダニエル
ヘーレス，ジヤン
ジヤンセン，ポール・アドリアーン・ジヤン
コイマンス，ルシエン・マリア・ヘンリクス
ド・ジヨング，マルク・ルネ
バン・アケン，コーン・ジヤンヌ・アルフオン
クリーフ，アラン
レーンダース，ルーベン・ゲラルドウス・ゲオルゲ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of JP2003535828A publication Critical patent/JP2003535828A/ja
Publication of JP2003535828A5 publication Critical patent/JP2003535828A5/ja
Application granted granted Critical
Publication of JP5230050B2 publication Critical patent/JP5230050B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2001582301A 2000-05-08 2001-05-03 Ｈｉｖ複製阻害剤 Expired - Lifetime JP5230050B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20247200P 2000-05-08 2000-05-08
US60/202,472 2000-05-08
PCT/EP2001/004991 WO2001085700A2 (en) 2000-05-08 2001-05-03 Hiv replication inhibiting pyrimidines and triazines

Publications (3)

Publication Number Publication Date
JP2003535828A JP2003535828A (ja) 2003-12-02
JP2003535828A5 JP2003535828A5 (https=) 2008-06-26
JP5230050B2 true JP5230050B2 (ja) 2013-07-10

Family

ID=22750002

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001582301A Expired - Lifetime JP5230050B2 (ja) 2000-05-08 2001-05-03 Ｈｉｖ複製阻害剤

Country Status (10)

Country Link
US (1) US7276510B2 (https=)
EP (1) EP1282606B1 (https=)
JP (1) JP5230050B2 (https=)
AR (1) AR028423A1 (https=)
AU (1) AU783981C (https=)
CA (1) CA2406562C (https=)
ES (1) ES2542326T3 (https=)
MY (1) MY139506A (https=)
PA (1) PA8516401A1 (https=)
WO (1) WO2001085700A2 (https=)

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US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
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KR101140785B1 (ko) 2002-08-09 2012-05-03 얀센 파마슈티카 엔.브이. 4-〔〔4-〔〔4-（2-시아노에테닐）-2,6-디메틸페닐〕아미노〕-2-피리미디닐〕아미노〕벤조니트릴의 제조방법
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Also Published As

Publication number Publication date
CA2406562A1 (en) 2001-11-15
US20030171374A1 (en) 2003-09-11
AU5633301A (en) 2001-11-20
WO2001085700A2 (en) 2001-11-15
AU783981C (en) 2007-05-03
AR028423A1 (es) 2003-05-07
ES2542326T3 (es) 2015-08-04
US7276510B2 (en) 2007-10-02
MY139506A (en) 2009-10-30
AU783981B2 (en) 2006-01-12
PA8516401A1 (es) 2002-02-21
CA2406562C (en) 2009-09-15
JP2003535828A (ja) 2003-12-02
EP1282606B1 (en) 2015-04-22
WO2001085700A3 (en) 2002-02-07
EP1282606A2 (en) 2003-02-12

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