JP5225271B2 - ゲムシタビンアミドプロドラッグの結晶形、その組成物および使用 - Google Patents
ゲムシタビンアミドプロドラッグの結晶形、その組成物および使用 Download PDFInfo
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- JP5225271B2 JP5225271B2 JP2009516690A JP2009516690A JP5225271B2 JP 5225271 B2 JP5225271 B2 JP 5225271B2 JP 2009516690 A JP2009516690 A JP 2009516690A JP 2009516690 A JP2009516690 A JP 2009516690A JP 5225271 B2 JP5225271 B2 JP 5225271B2
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- difluoro
- oxopentyl
- ribofuranosyl
- propyl
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Biotechnology (AREA)
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- Endocrinology (AREA)
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- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81550806P | 2006-06-21 | 2006-06-21 | |
| US81540706P | 2006-06-21 | 2006-06-21 | |
| US60/815,407 | 2006-06-21 | ||
| US60/815,508 | 2006-06-21 | ||
| PCT/US2007/071613 WO2007149891A2 (en) | 2006-06-21 | 2007-06-20 | Crystalline forms of gemcitabine amide prodrug, compositions and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541344A JP2009541344A (ja) | 2009-11-26 |
| JP2009541344A5 JP2009541344A5 (enExample) | 2010-07-08 |
| JP5225271B2 true JP5225271B2 (ja) | 2013-07-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2009516690A Expired - Fee Related JP5225271B2 (ja) | 2006-06-21 | 2007-06-20 | ゲムシタビンアミドプロドラッグの結晶形、その組成物および使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8114854B2 (enExample) |
| EP (1) | EP2043653B1 (enExample) |
| JP (1) | JP5225271B2 (enExample) |
| KR (1) | KR101108407B1 (enExample) |
| CN (1) | CN101448504B (enExample) |
| AU (1) | AU2007261002B2 (enExample) |
| CA (1) | CA2652633C (enExample) |
| EA (1) | EA014909B1 (enExample) |
| ES (1) | ES2446092T3 (enExample) |
| MX (1) | MX2009000198A (enExample) |
| WO (1) | WO2007149891A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2307003A2 (en) * | 2008-05-16 | 2011-04-13 | Pharma Mar S.A. | Combination therapy with pm00104 and another antitumor agent |
| NZ590058A (en) * | 2008-06-12 | 2012-08-31 | Scinopharm Taiwan Ltd | Crystalline polymorphs of gemcitabine base |
| CN101525361B (zh) | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| JP6420247B2 (ja) | 2012-11-13 | 2018-11-07 | ボーイエン セラピューティクス，インコーポレイティド | ゲムシタビンプロドラッグ及びその使用 |
| US9834576B2 (en) * | 2013-10-29 | 2017-12-05 | Otsuka Pharmaceutical Co., Ltd. | Synthetic route to 2′-deoxy-2′,2′-difluorotetrahydrouridines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100483256B1 (ko) * | 1997-01-24 | 2005-04-15 | 콘파마 아에스 | 젬시타빈 유도체 |
| WO2004041203A2 (en) * | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| ES2310860T3 (es) * | 2004-12-17 | 2009-01-16 | Eli Lilly And Company | Profarmaco amida de gemcitabina, composiciones y uso del mismo. |
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2007
- 2007-06-20 ES ES07798792.3T patent/ES2446092T3/es active Active
- 2007-06-20 CN CN2007800182296A patent/CN101448504B/zh not_active Expired - Fee Related
- 2007-06-20 CA CA2652633A patent/CA2652633C/en not_active Expired - Fee Related
- 2007-06-20 MX MX2009000198A patent/MX2009000198A/es active IP Right Grant
- 2007-06-20 KR KR1020097001286A patent/KR101108407B1/ko not_active Expired - Fee Related
- 2007-06-20 WO PCT/US2007/071613 patent/WO2007149891A2/en not_active Ceased
- 2007-06-20 JP JP2009516690A patent/JP5225271B2/ja not_active Expired - Fee Related
- 2007-06-20 US US12/304,302 patent/US8114854B2/en not_active Expired - Fee Related
- 2007-06-20 EP EP07798792.3A patent/EP2043653B1/en active Active
- 2007-06-20 EA EA200970042A patent/EA014909B1/ru not_active IP Right Cessation
- 2007-06-20 AU AU2007261002A patent/AU2007261002B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007261002A1 (en) | 2007-12-27 |
| EA200970042A1 (ru) | 2009-04-28 |
| MX2009000198A (es) | 2009-01-22 |
| WO2007149891A2 (en) | 2007-12-27 |
| JP2009541344A (ja) | 2009-11-26 |
| EP2043653A2 (en) | 2009-04-08 |
| WO2007149891A3 (en) | 2008-02-14 |
| US8114854B2 (en) | 2012-02-14 |
| EA014909B1 (ru) | 2011-02-28 |
| EP2043653B1 (en) | 2013-12-25 |
| KR20090033447A (ko) | 2009-04-03 |
| CN101448504B (zh) | 2012-04-11 |
| AU2007261002B2 (en) | 2012-03-08 |
| ES2446092T3 (es) | 2014-03-06 |
| KR101108407B1 (ko) | 2012-01-30 |
| CA2652633C (en) | 2014-03-25 |
| CN101448504A (zh) | 2009-06-03 |
| US20090203640A1 (en) | 2009-08-13 |
| CA2652633A1 (en) | 2007-12-27 |
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