CA2652633C - Crystalline forms of gemcitabine amide prodrug, compositions and use thereof - Google Patents
Crystalline forms of gemcitabine amide prodrug, compositions and use thereof Download PDFInfo
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- CA2652633C CA2652633C CA2652633A CA2652633A CA2652633C CA 2652633 C CA2652633 C CA 2652633C CA 2652633 A CA2652633 A CA 2652633A CA 2652633 A CA2652633 A CA 2652633A CA 2652633 C CA2652633 C CA 2652633C
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- Prior art keywords
- difluoro
- oxopentyl
- deoxy
- ribofuranosyl
- aminopyrimidin
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- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81550806P | 2006-06-21 | 2006-06-21 | |
| US81540706P | 2006-06-21 | 2006-06-21 | |
| US60/815,407 | 2006-06-21 | ||
| US60/815,508 | 2006-06-21 | ||
| PCT/US2007/071613 WO2007149891A2 (en) | 2006-06-21 | 2007-06-20 | Crystalline forms of gemcitabine amide prodrug, compositions and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2652633A1 CA2652633A1 (en) | 2007-12-27 |
| CA2652633C true CA2652633C (en) | 2014-03-25 |
Family
ID=38670971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2652633A Expired - Fee Related CA2652633C (en) | 2006-06-21 | 2007-06-20 | Crystalline forms of gemcitabine amide prodrug, compositions and use thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8114854B2 (enExample) |
| EP (1) | EP2043653B1 (enExample) |
| JP (1) | JP5225271B2 (enExample) |
| KR (1) | KR101108407B1 (enExample) |
| CN (1) | CN101448504B (enExample) |
| AU (1) | AU2007261002B2 (enExample) |
| CA (1) | CA2652633C (enExample) |
| EA (1) | EA014909B1 (enExample) |
| ES (1) | ES2446092T3 (enExample) |
| MX (1) | MX2009000198A (enExample) |
| WO (1) | WO2007149891A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2307003A2 (en) * | 2008-05-16 | 2011-04-13 | Pharma Mar S.A. | Combination therapy with pm00104 and another antitumor agent |
| NZ590058A (en) * | 2008-06-12 | 2012-08-31 | Scinopharm Taiwan Ltd | Crystalline polymorphs of gemcitabine base |
| CN101525361B (zh) | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| JP6420247B2 (ja) | 2012-11-13 | 2018-11-07 | ボーイエン セラピューティクス，インコーポレイティド | ゲムシタビンプロドラッグ及びその使用 |
| US9834576B2 (en) * | 2013-10-29 | 2017-12-05 | Otsuka Pharmaceutical Co., Ltd. | Synthetic route to 2′-deoxy-2′,2′-difluorotetrahydrouridines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100483256B1 (ko) * | 1997-01-24 | 2005-04-15 | 콘파마 아에스 | 젬시타빈 유도체 |
| WO2004041203A2 (en) * | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| ES2310860T3 (es) * | 2004-12-17 | 2009-01-16 | Eli Lilly And Company | Profarmaco amida de gemcitabina, composiciones y uso del mismo. |
-
2007
- 2007-06-20 ES ES07798792.3T patent/ES2446092T3/es active Active
- 2007-06-20 CN CN2007800182296A patent/CN101448504B/zh not_active Expired - Fee Related
- 2007-06-20 CA CA2652633A patent/CA2652633C/en not_active Expired - Fee Related
- 2007-06-20 MX MX2009000198A patent/MX2009000198A/es active IP Right Grant
- 2007-06-20 KR KR1020097001286A patent/KR101108407B1/ko not_active Expired - Fee Related
- 2007-06-20 WO PCT/US2007/071613 patent/WO2007149891A2/en not_active Ceased
- 2007-06-20 JP JP2009516690A patent/JP5225271B2/ja not_active Expired - Fee Related
- 2007-06-20 US US12/304,302 patent/US8114854B2/en not_active Expired - Fee Related
- 2007-06-20 EP EP07798792.3A patent/EP2043653B1/en active Active
- 2007-06-20 EA EA200970042A patent/EA014909B1/ru not_active IP Right Cessation
- 2007-06-20 AU AU2007261002A patent/AU2007261002B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007261002A1 (en) | 2007-12-27 |
| EA200970042A1 (ru) | 2009-04-28 |
| MX2009000198A (es) | 2009-01-22 |
| WO2007149891A2 (en) | 2007-12-27 |
| JP2009541344A (ja) | 2009-11-26 |
| EP2043653A2 (en) | 2009-04-08 |
| WO2007149891A3 (en) | 2008-02-14 |
| US8114854B2 (en) | 2012-02-14 |
| EA014909B1 (ru) | 2011-02-28 |
| EP2043653B1 (en) | 2013-12-25 |
| KR20090033447A (ko) | 2009-04-03 |
| CN101448504B (zh) | 2012-04-11 |
| AU2007261002B2 (en) | 2012-03-08 |
| JP5225271B2 (ja) | 2013-07-03 |
| ES2446092T3 (es) | 2014-03-06 |
| KR101108407B1 (ko) | 2012-01-30 |
| CN101448504A (zh) | 2009-06-03 |
| US20090203640A1 (en) | 2009-08-13 |
| CA2652633A1 (en) | 2007-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170620 |