JP5201723B2 - ケラチノサイト増殖促進剤 - Google Patents
ケラチノサイト増殖促進剤 Download PDFInfo
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- JP5201723B2 JP5201723B2 JP2008092455A JP2008092455A JP5201723B2 JP 5201723 B2 JP5201723 B2 JP 5201723B2 JP 2008092455 A JP2008092455 A JP 2008092455A JP 2008092455 A JP2008092455 A JP 2008092455A JP 5201723 B2 JP5201723 B2 JP 5201723B2
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- 229910052726 zirconium Inorganic materials 0.000 description 1
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Description
抗酸化作用(特許文献6)、および顆粒球・マクロファージコロニー刺激因子(GM-CSF)産生抑制作用(特許文献7)等知られている。しかしながら、これらの刊行物には、マメ科フジ属植物の抽出物がケラチノサイト増殖促進作用を有し、それを有効成分とする発毛剤、育毛剤に利用できるとの記載はなく、さらに示唆ないし、教示すらされていない。
(A)マメ科フジ属植物の抽出物を有効成分とするケラチノサイト増殖促進剤からなる群から選ばれる薬効成分の1種または2種以上
(B)美白剤、抗酸化剤、抗炎症剤、細胞賦活剤、保湿剤、抹消血管血流促進剤からなる群から選ばれる薬効成分の1種または2種以上
、Wisteria fruticosaが挙げられるが、フジ属に属する植物であれば特にこの植物に限定されるものではない。
(1)安息香酸系紫外線吸収剤
例えば、パラアミノ安息香酸(以下、PABAと略す)、PABAモノグリセリンエステル、N,N−ジプロポキシPABAエチルエステル、N,N−ジエトキシPABAエチルエステル、N,N−ジメチルPABAエチルエステル、N,N−ジメチルPABAブチルエステル、N,N−ジメチルPABAエチルエステルなど。
(2)アントラニル酸系紫外線吸収剤
例えば、ホモメンチル−N−アセチルアントラニレートなど。
(3)サリチル酸系紫外線吸収剤
例えば、アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p−イソプロパノールフェニルサリシレートなど。
(4)ケイ皮酸系紫外線吸収剤
例えば、オクチルシンナメート、エチル−4−イソプロピルシンナメート、メチル−2,5−ジイソプロピルシンナメート、エチル−2,4−ジイソプロピルシンナメート、メチル−2,4−ジイソプロピルシンナメート、プロピル−p−メトキシシンナメート、イソプロピル−p−メトキシシンナメート、イソアミル−p−メトキシシンナメート、オクチル−p−メトキシシンナメート(2−エチルヘキシル−p−メトキシシンナメート)、2−エトキシエチル−p−メトキシシンナメート、シクロヘキシル−p−メトキシシンナメート、エチル−α−シアノ−β−フェニルシンナメート、2−エチルヘキシル−α−シアノ−β−フェニルシンナメート、グリセリルモノ−2−エチルヘキサノイル−ジパラメトキシシンナメートなど。
(5)トリアジン系紫外線吸収剤
例えば、ビスレゾルシニルトリアジン。
さらに具体的には、ビス{〔4−(2−エチルヘキシロキシ)−2−ヒドロキシ〕フェニル}−6−(4−メトキシフェニル)1,3,5−トリアジン、2,4,6−トリス{4−(2−エチルヘキシロキシカルボニル)アニリノ}1,3,5−トリアジンなど。
(6)その他の紫外線吸収剤
例えば、3−(4’−メチルベンジリデン)−d,l−カンファー、3−ベンジリデン−d,l−カンファー、2−フェニル−5−メチルベンゾキサゾール、2,2’−ヒドロキシ−5−メチルフェニルベンゾトリアゾール、2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、2−(2’−ヒドロキシ−5’−メチルフェニルベンゾトリアゾール、ジベンザラジン、ジアニソイルメタン、4−メトキシ−4’−t−ブチルジベンゾイルメタン、5−(3,3−ジメチル−2−ノルボルニリデン)−3−ペンタン−2−オン、ジモルホリノピリダジノン等のピリダジン誘導体など。
〔植物抽出物の調製例〕
(1)山藤(Wisteria brachybotrys)の花5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、山藤の花の抽出物を得た。このとき、乾燥固形物量は、0.48重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(2)野田藤(Wisteria floribunda)の花5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、野田藤の花の抽出物を得た。このとき、乾燥固形物量は、0.55重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(3)山藤(Wisteria brachybotrys
)の葉5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、山藤の葉の抽出物を得た。このとき、乾燥固形物量は、0.59重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(4)酸化防止剤の代表として、ニンジンの抽出物を用いた。その製法は、オタネニンジンPanax
ginseng C.A.Meyetの5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、ニンジンの抽出物を得た。このとき、乾燥固形物量は、1.24重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(5)美白剤の代表として、レゾルシン(Wako 試薬特級)を用いて以下の実験を行った。
(6)抗炎症剤の代表として、トウキの根の抽出物を用いた。「トウキ :当帰」とは、セリ科(Umbelliferae)、シシドウ属(Angelica)の植物トウキ(Angelica acutiloba Kitagawa又はその他近縁植物)の根茎・根皮5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、トウキの根の抽出物を得た。このとき、乾燥固形物量は、1.61重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(7)細胞賦活剤の代表として、胡麻の花の抽出物を用いた。その製法は、胡麻(Sesamum indicum)の花を乾燥したもの5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、胡麻の花の抽出物を得た。このとき、乾燥固形物量は、1.40重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(8)保湿剤の代表として、紫根の抽出物を用いた。その製法は、ムラサキ科の多年生草本であるムラサキの根を乾燥させたもの5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、紫根の抽出物を得た。このとき、乾燥固形物量は、2.03重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
(9)末梢血管血流促進剤の代表として、ジオウの根の抽出物を用いた。ジオウ(Rehmannia chinensis)の根茎を乾燥して細かく砕いたもの5gに、含水濃度50容量%エタノール100gを加える。次に60℃で8時間加熱抽出を行った後、濾過することによって、ジオウの根の抽出物を得た。このとき、乾燥固形物量は、2.77重量%であった。この溶液を希釈して濃度を調整し、これを用いて以下の実験を行った。
1.細胞増殖試験
1継代、pDL4の正常ヒト新生児包皮表皮角化細胞(ケラチノサイト:クラボウ社製)を4.5×103ずつ、n=3で96穴のシャーレに播き、100μL Eplife-EDGS培地で3-5日培養後、コンフルエントになったところで培地をハイドロコルチゾン(HC)フリーのEpilife-KG2に変え、表1に示した濃度が最終濃度になるようにサンプルを加えて、48時間培養した。その後、培地を捨て、200μLPBS(-)で2回洗浄し、Cell
Counting kit(同仁化学研究所)を用いて細胞増殖率(%)を測定した。
結果を表1に示す。
共培養評価において被検物質の代わりにエタノールを含む以外は実施例1記載の方法と同様に実施した。結果を表1に示す。
次に、本発明の育毛剤が如何に発毛、育毛効果の点で優れているかを実証するために行った試験結果を示す。
本発明品を配合した育毛剤を実際に使用した場合の効果について評価試験を実施した。
(1)試料
本発明品配合品:後記表3記載の製造例1のヘアトニック
比較品:後記表3記載の本発明品配合品のヘアトニックから藤抽出物を除いた(水を増量)もの
(2)試験方法
試験は薄毛症、脱毛症を訴える20名(35〜55歳)のパネラーを2群に分け、各試料を毎日、朝と夜に頭部にまんべんなく塗布する方法で行った。3ヶ月間使用し続けたパネラーの使用実感をアンケートにて確認した。評価は使用開始3ヶ月目に行い、「脱毛部分の縮小」、「見た目の改善」、「脱毛速度の遅延」、「毛髪の太さ」、「髪にコシがでた」、「白髪の改善」、「抜け毛の減少」の項目に対してどう髪が変化したかの実感を聞き取り、「ある程度効果があった」又は「非常に効果があった」と答えたパネラーの人数の比率をパーセンテージで表2に示した。また、パネラーが、「生え際の見た目」、「頭頂部の見た目」、「全体の見た目」に対してどの程度の改善効果を実感して満足を感じたかをアンケートにて聞き取り、「満足」又は「非常に満足」と答えたパネラーの人数の比率をパーセンテージで表2に示した。
[表3]に示す配合成分及び配合割合を用い、順次混合して比較品と本発明品配合品のヘアトニックをそれぞれ調製した。なお、配合割合は重量%である。
配合成分 配合量(wt%)
(A) ラウリル酸ジエタノールアミド
5.0
プロピレングリコール 5.0
塩化アルキルトリメチルアンモニウム 0.2
グリセリン 0.2
胡麻の花の抽出物 0.1
山藤の花抽出物 1.0
(B) トリクロロカルバニリド
0.2
精製水 88.2
(C) 香料
0.1
(製法)
(A)成分を80℃にて加熱混合後冷却し、(B)成分を添加し、次いで(C)を添加してヘアシャンプーを調製した。
配合成分 配合量(wt%)
(A) 流動パラフィン
10.0
塩化アルキルトリメチルアンモニウム 0.2
セタノール 2.0
野田藤の花抽出物 0.1
(B) 1,3−ブチレングリコール
5.0
トウキの根の抽出物 0.01
精製水 40.0
(C) ニコチン酸トコフェロール
0.02
精製水 40.67
(D) 香料
0.1
(製法)
(A)成分及び(B)成分を80℃に加熱混合し、乳化する。その後40℃付近まで冷却し、(C)成分を添加し、次いで(D)を添加してヘアリンスを調製した。
配合成分 配合量(wt%)
(A)流動パラフィン 30.0
固形パラフィン 1.0
ワセリン 15.0
ポリオキシエチレンセチルエーテル 2.0
ビタミンEアセテート 0.2
(B) 塩酸ジフェンヒドラミン
0.01
プロピレングリコール 5.0
パラオキシ安息香酸エチル 0.5
グリチルリチン酸ジカリウム 0.1
レゾルシン 0.01
紫根の抽出物 1.0
ジオウの根の抽出物 1.0
精製水 34.08
(C)野田藤の花抽出物 10.0
香料 0.1
(製法)
(A)成分を80℃にて混合溶解する。次に予め80℃に加熱溶解しておいた(B)成分を(A)に少しずつ加えクリーム状とした。その後40℃まで冷却し(C)加えてヘアクリームを調製した。
配合成分 配合量(wt%)
(A)流動パラフィン 20.0
固形パラフィン 3.0
ポリオキシエチレンセチルエーテル(B.O15モル) 2.0
(B)山藤の葉の抽出物 2.0
グリセリン 3.0
カルボキシビニルポリマー
0.1
パラオキシ安息香酸エチル 0.5
水酸化ナトリウム 0.1
グリチルリチン酸ジカリウム
0.1
エタノール 10.0
精製水 59.20
(製法)
(A)成分を予め加熱溶解し、成分(B)を順次(A)に混合してヘアエッセンスを調製した。
Claims (1)
- マメ科フジ属植物の花弁を含水濃度50容量%エタノールで抽出した抽出物からなるケラチノサイト増殖促進剤。
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