JP5197569B2 - 有機化合物 - Google Patents
有機化合物 Download PDFInfo
- Publication number
- JP5197569B2 JP5197569B2 JP2009503206A JP2009503206A JP5197569B2 JP 5197569 B2 JP5197569 B2 JP 5197569B2 JP 2009503206 A JP2009503206 A JP 2009503206A JP 2009503206 A JP2009503206 A JP 2009503206A JP 5197569 B2 JP5197569 B2 JP 5197569B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- dimethyl
- imidazol
- isochroman
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IUHVDUURPYJZJM-UHFFFAOYSA-N CC(C)(C(c(c1ccc2)c2Cl)[n]2c(CO)cnc2)OC1=O Chemical compound CC(C)(C(c(c1ccc2)c2Cl)[n]2c(CO)cnc2)OC1=O IUHVDUURPYJZJM-UHFFFAOYSA-N 0.000 description 1
- HEVQULFMCBIYSA-UHFFFAOYSA-N CC(C)(C(c(cccc1)c1C#N)[n]1cncc1)O Chemical compound CC(C)(C(c(cccc1)c1C#N)[n]1cncc1)O HEVQULFMCBIYSA-UHFFFAOYSA-N 0.000 description 1
- ZAILPAUBNKVZSP-UHFFFAOYSA-N CC(C)(C(c1cc(F)ccc11)[n]2cncc2)OC1=O Chemical compound CC(C)(C(c1cc(F)ccc11)[n]2cncc2)OC1=O ZAILPAUBNKVZSP-UHFFFAOYSA-N 0.000 description 1
- YATVHPCKCBERKE-UHFFFAOYSA-N CC(C)(C(c1ccccc11)O)C1=O Chemical compound CC(C)(C(c1ccccc11)O)C1=O YATVHPCKCBERKE-UHFFFAOYSA-N 0.000 description 1
- GVXWSYQAKZJMLP-UHFFFAOYSA-N CC(C)(C(c1ccccc11)O)NC1=O Chemical compound CC(C)(C(c1ccccc11)O)NC1=O GVXWSYQAKZJMLP-UHFFFAOYSA-N 0.000 description 1
- SUSQCJWBXALQMN-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(C(OC)=O)cnc2)N(C)C1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(C(OC)=O)cnc2)N(C)C1=O SUSQCJWBXALQMN-UHFFFAOYSA-N 0.000 description 1
- LHOIDPGXZSXPBU-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(C(Oc3ccccc3)=O)cnc2)OC1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(C(Oc3ccccc3)=O)cnc2)OC1=O LHOIDPGXZSXPBU-UHFFFAOYSA-N 0.000 description 1
- UNMWABISHJRPMB-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(CN(C)C)cnc2)OC1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(CN(C)C)cnc2)OC1=O UNMWABISHJRPMB-UHFFFAOYSA-N 0.000 description 1
- XJRSHIGXYTZOFP-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)N(C)C1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)N(C)C1=O XJRSHIGXYTZOFP-UHFFFAOYSA-N 0.000 description 1
- DAUSVTMFQVOSSY-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)NC1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)NC1=O DAUSVTMFQVOSSY-UHFFFAOYSA-N 0.000 description 1
- OSFFELAMPCTNLM-UHFFFAOYSA-N CCCCc1cnc[n]1C(C(C)(C)O1)c2ccccc2C1=O Chemical compound CCCCc1cnc[n]1C(C(C)(C)O1)c2ccccc2C1=O OSFFELAMPCTNLM-UHFFFAOYSA-N 0.000 description 1
- IFRMVYDJALWUEU-UHFFFAOYSA-N CCN(CC)C(c(c(C[n]1cncc1)c1F)ccc1F)=O Chemical compound CCN(CC)C(c(c(C[n]1cncc1)c1F)ccc1F)=O IFRMVYDJALWUEU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78710406P | 2006-03-29 | 2006-03-29 | |
| US60/787,104 | 2006-03-29 | ||
| PCT/US2007/064974 WO2007117982A2 (en) | 2006-03-29 | 2007-03-27 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531457A JP2009531457A (ja) | 2009-09-03 |
| JP2009531457A5 JP2009531457A5 (enExample) | 2010-04-22 |
| JP5197569B2 true JP5197569B2 (ja) | 2013-05-15 |
Family
ID=38477291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503206A Expired - Fee Related JP5197569B2 (ja) | 2006-03-29 | 2007-03-27 | 有機化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8153674B2 (enExample) |
| EP (2) | EP2001866A2 (enExample) |
| JP (1) | JP5197569B2 (enExample) |
| KR (1) | KR20080114769A (enExample) |
| CN (1) | CN101410389A (enExample) |
| AU (1) | AU2007234968A1 (enExample) |
| BR (1) | BRPI0709678A2 (enExample) |
| CA (1) | CA2644391A1 (enExample) |
| ES (1) | ES2442347T3 (enExample) |
| MX (1) | MX2008012402A (enExample) |
| RU (1) | RU2008142600A (enExample) |
| WO (1) | WO2007117982A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA91341C2 (ru) | 2004-07-15 | 2010-07-26 | Амр Текнолоджи, Інк. | Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
| KR20090090395A (ko) * | 2006-12-18 | 2009-08-25 | 노파르티스 아게 | 4-이미다졸릴-1,2,3,4-테트라히드로퀴놀린 유도체 및 알도스테론/11-베타-히드록실라제 억제제로서의 그의 용도 |
| EA200900811A1 (ru) * | 2006-12-18 | 2009-12-30 | Новартис Аг | Имидазолы в качестве ингибиторов альдостеронсинтазы |
| EP2095819A1 (en) | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
| JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| CN102595902B (zh) | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途 |
| MX350717B (es) * | 2011-11-30 | 2017-09-14 | Hoffmann La Roche | Nuevos derivados biciclicos de dihidroisoquinolin-1-ona. |
| EP2639212B1 (en) | 2012-03-13 | 2016-03-09 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin | Enantioselective organic anhydride reactions |
| ES2684050T3 (es) * | 2014-07-24 | 2018-10-01 | Boehringer Ingelheim International Gmbh | Inhibidores de aldosterona sintasa |
| WO2016123275A1 (en) * | 2015-01-30 | 2016-08-04 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
| WO2018165649A1 (en) | 2017-03-10 | 2018-09-13 | Embera Neurotherapeutics, Inc. | Pharmaceutical compositions and uses thereof |
| CN109232607A (zh) * | 2018-09-20 | 2019-01-18 | 沈阳药科大学 | 劳拉替尼的合成方法 |
| CN113767095A (zh) | 2019-05-01 | 2021-12-07 | 勃林格殷格翰国际有限公司 | (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯 |
| AU2022415313A1 (en) | 2021-12-14 | 2024-05-02 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors for treating chronic kidney disease |
| JP2025540715A (ja) * | 2022-11-23 | 2025-12-16 | 上▲海▼翰森生物医▲薬▼科技有限公司 | ピリジン多環系化合物阻害剤、及びその製造方法と使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904300A (en) * | 1987-08-26 | 1990-02-27 | Ciba-Geigy Corp. | Imidazole derivatives |
| DE102004035322A1 (de) * | 2004-07-21 | 2006-02-16 | Universität des Saarlandes | Selektive Hemmstoffe humaner Corticoidsynthasen |
-
2007
- 2007-03-27 BR BRPI0709678-0A patent/BRPI0709678A2/pt not_active Application Discontinuation
- 2007-03-27 KR KR1020087023643A patent/KR20080114769A/ko not_active Withdrawn
- 2007-03-27 EP EP07759422A patent/EP2001866A2/en not_active Withdrawn
- 2007-03-27 CN CNA2007800110014A patent/CN101410389A/zh active Pending
- 2007-03-27 AU AU2007234968A patent/AU2007234968A1/en not_active Abandoned
- 2007-03-27 RU RU2008142600/04A patent/RU2008142600A/ru not_active Application Discontinuation
- 2007-03-27 MX MX2008012402A patent/MX2008012402A/es not_active Application Discontinuation
- 2007-03-27 WO PCT/US2007/064974 patent/WO2007117982A2/en not_active Ceased
- 2007-03-27 EP EP10179603.5A patent/EP2301931B1/en not_active Not-in-force
- 2007-03-27 ES ES10179603.5T patent/ES2442347T3/es active Active
- 2007-03-27 JP JP2009503206A patent/JP5197569B2/ja not_active Expired - Fee Related
- 2007-03-27 US US12/295,155 patent/US8153674B2/en not_active Expired - Fee Related
- 2007-03-27 CA CA002644391A patent/CA2644391A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090182007A1 (en) | 2009-07-16 |
| AU2007234968A1 (en) | 2007-10-18 |
| WO2007117982A2 (en) | 2007-10-18 |
| WO2007117982A3 (en) | 2007-12-13 |
| BRPI0709678A2 (pt) | 2011-07-19 |
| EP2301931B1 (en) | 2013-10-16 |
| RU2008142600A (ru) | 2010-05-10 |
| EP2301931A1 (en) | 2011-03-30 |
| EP2001866A2 (en) | 2008-12-17 |
| JP2009531457A (ja) | 2009-09-03 |
| ES2442347T3 (es) | 2014-02-11 |
| CA2644391A1 (en) | 2007-10-18 |
| MX2008012402A (es) | 2008-10-09 |
| KR20080114769A (ko) | 2008-12-31 |
| CN101410389A (zh) | 2009-04-15 |
| US8153674B2 (en) | 2012-04-10 |
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