JP5197569B2 - 有機化合物 - Google Patents
有機化合物 Download PDFInfo
- Publication number
- JP5197569B2 JP5197569B2 JP2009503206A JP2009503206A JP5197569B2 JP 5197569 B2 JP5197569 B2 JP 5197569B2 JP 2009503206 A JP2009503206 A JP 2009503206A JP 2009503206 A JP2009503206 A JP 2009503206A JP 5197569 B2 JP5197569 B2 JP 5197569B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- dimethyl
- imidazol
- isochroman
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IUHVDUURPYJZJM-UHFFFAOYSA-N CC(C)(C(c(c1ccc2)c2Cl)[n]2c(CO)cnc2)OC1=O Chemical compound CC(C)(C(c(c1ccc2)c2Cl)[n]2c(CO)cnc2)OC1=O IUHVDUURPYJZJM-UHFFFAOYSA-N 0.000 description 1
- HEVQULFMCBIYSA-UHFFFAOYSA-N CC(C)(C(c(cccc1)c1C#N)[n]1cncc1)O Chemical compound CC(C)(C(c(cccc1)c1C#N)[n]1cncc1)O HEVQULFMCBIYSA-UHFFFAOYSA-N 0.000 description 1
- ZAILPAUBNKVZSP-UHFFFAOYSA-N CC(C)(C(c1cc(F)ccc11)[n]2cncc2)OC1=O Chemical compound CC(C)(C(c1cc(F)ccc11)[n]2cncc2)OC1=O ZAILPAUBNKVZSP-UHFFFAOYSA-N 0.000 description 1
- YATVHPCKCBERKE-UHFFFAOYSA-N CC(C)(C(c1ccccc11)O)C1=O Chemical compound CC(C)(C(c1ccccc11)O)C1=O YATVHPCKCBERKE-UHFFFAOYSA-N 0.000 description 1
- GVXWSYQAKZJMLP-UHFFFAOYSA-N CC(C)(C(c1ccccc11)O)NC1=O Chemical compound CC(C)(C(c1ccccc11)O)NC1=O GVXWSYQAKZJMLP-UHFFFAOYSA-N 0.000 description 1
- SUSQCJWBXALQMN-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(C(OC)=O)cnc2)N(C)C1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(C(OC)=O)cnc2)N(C)C1=O SUSQCJWBXALQMN-UHFFFAOYSA-N 0.000 description 1
- LHOIDPGXZSXPBU-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(C(Oc3ccccc3)=O)cnc2)OC1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(C(Oc3ccccc3)=O)cnc2)OC1=O LHOIDPGXZSXPBU-UHFFFAOYSA-N 0.000 description 1
- UNMWABISHJRPMB-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(CN(C)C)cnc2)OC1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(CN(C)C)cnc2)OC1=O UNMWABISHJRPMB-UHFFFAOYSA-N 0.000 description 1
- XJRSHIGXYTZOFP-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)N(C)C1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)N(C)C1=O XJRSHIGXYTZOFP-UHFFFAOYSA-N 0.000 description 1
- DAUSVTMFQVOSSY-UHFFFAOYSA-N CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)NC1=O Chemical compound CC(C)(C(c1ccccc11)[n]2c(CO)cnc2)NC1=O DAUSVTMFQVOSSY-UHFFFAOYSA-N 0.000 description 1
- OSFFELAMPCTNLM-UHFFFAOYSA-N CCCCc1cnc[n]1C(C(C)(C)O1)c2ccccc2C1=O Chemical compound CCCCc1cnc[n]1C(C(C)(C)O1)c2ccccc2C1=O OSFFELAMPCTNLM-UHFFFAOYSA-N 0.000 description 1
- IFRMVYDJALWUEU-UHFFFAOYSA-N CCN(CC)C(c(c(C[n]1cncc1)c1F)ccc1F)=O Chemical compound CCN(CC)C(c(c(C[n]1cncc1)c1F)ccc1F)=O IFRMVYDJALWUEU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78710406P | 2006-03-29 | 2006-03-29 | |
| US60/787,104 | 2006-03-29 | ||
| PCT/US2007/064974 WO2007117982A2 (en) | 2006-03-29 | 2007-03-27 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531457A JP2009531457A (ja) | 2009-09-03 |
| JP2009531457A5 JP2009531457A5 (enExample) | 2010-04-22 |
| JP5197569B2 true JP5197569B2 (ja) | 2013-05-15 |
Family
ID=38477291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503206A Expired - Fee Related JP5197569B2 (ja) | 2006-03-29 | 2007-03-27 | 有機化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8153674B2 (enExample) |
| EP (2) | EP2001866A2 (enExample) |
| JP (1) | JP5197569B2 (enExample) |
| KR (1) | KR20080114769A (enExample) |
| CN (1) | CN101410389A (enExample) |
| AU (1) | AU2007234968A1 (enExample) |
| BR (1) | BRPI0709678A2 (enExample) |
| CA (1) | CA2644391A1 (enExample) |
| ES (1) | ES2442347T3 (enExample) |
| MX (1) | MX2008012402A (enExample) |
| RU (1) | RU2008142600A (enExample) |
| WO (1) | WO2007117982A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7541357B2 (en) | 2004-07-15 | 2009-06-02 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| EP2121652A1 (en) * | 2006-12-18 | 2009-11-25 | Novartis AG | 4-imidazolyl-1,2,3,4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors |
| JP2010513482A (ja) * | 2006-12-18 | 2010-04-30 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのイミダゾール類 |
| EP2095819A1 (en) | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
| JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
| CN103958478B (zh) * | 2011-11-30 | 2017-08-01 | 霍夫曼-拉罗奇有限公司 | 双环二氢异喹啉‑1‑酮衍生物 |
| MX350717B (es) * | 2011-11-30 | 2017-09-14 | Hoffmann La Roche | Nuevos derivados biciclicos de dihidroisoquinolin-1-ona. |
| EP2639212B1 (en) | 2012-03-13 | 2016-03-09 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin | Enantioselective organic anhydride reactions |
| HRP20181441T1 (hr) * | 2014-07-24 | 2018-11-02 | Boehringer Ingelheim International Gmbh | Inhibitori sintaze aldosterona |
| EP3250569B1 (en) * | 2015-01-30 | 2019-01-09 | Boehringer Ingelheim International GmbH | Aldosterone synthase inhibitors |
| AU2018230521B2 (en) | 2017-03-10 | 2022-02-03 | Embera Neurotherapeutics, Inc. | Pharmaceutical compositions and uses thereof |
| CN109232607A (zh) * | 2018-09-20 | 2019-01-18 | 沈阳药科大学 | 劳拉替尼的合成方法 |
| CN113767095A (zh) | 2019-05-01 | 2021-12-07 | 勃林格殷格翰国际有限公司 | (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯 |
| CA3236890A1 (en) | 2021-12-14 | 2023-06-22 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors for treating chronic kidney disease |
| CN120187713A (zh) * | 2022-11-23 | 2025-06-20 | 上海翰森生物医药科技有限公司 | 吡啶多环类化合物抑制剂、及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904300A (en) * | 1987-08-26 | 1990-02-27 | Ciba-Geigy Corp. | Imidazole derivatives |
| DE102004035322A1 (de) * | 2004-07-21 | 2006-02-16 | Universität des Saarlandes | Selektive Hemmstoffe humaner Corticoidsynthasen |
-
2007
- 2007-03-27 RU RU2008142600/04A patent/RU2008142600A/ru not_active Application Discontinuation
- 2007-03-27 CN CNA2007800110014A patent/CN101410389A/zh active Pending
- 2007-03-27 BR BRPI0709678-0A patent/BRPI0709678A2/pt not_active Application Discontinuation
- 2007-03-27 MX MX2008012402A patent/MX2008012402A/es not_active Application Discontinuation
- 2007-03-27 EP EP07759422A patent/EP2001866A2/en not_active Withdrawn
- 2007-03-27 WO PCT/US2007/064974 patent/WO2007117982A2/en not_active Ceased
- 2007-03-27 ES ES10179603.5T patent/ES2442347T3/es active Active
- 2007-03-27 AU AU2007234968A patent/AU2007234968A1/en not_active Abandoned
- 2007-03-27 EP EP10179603.5A patent/EP2301931B1/en not_active Not-in-force
- 2007-03-27 CA CA002644391A patent/CA2644391A1/en not_active Abandoned
- 2007-03-27 JP JP2009503206A patent/JP5197569B2/ja not_active Expired - Fee Related
- 2007-03-27 US US12/295,155 patent/US8153674B2/en not_active Expired - Fee Related
- 2007-03-27 KR KR1020087023643A patent/KR20080114769A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007234968A1 (en) | 2007-10-18 |
| MX2008012402A (es) | 2008-10-09 |
| BRPI0709678A2 (pt) | 2011-07-19 |
| RU2008142600A (ru) | 2010-05-10 |
| ES2442347T3 (es) | 2014-02-11 |
| JP2009531457A (ja) | 2009-09-03 |
| CA2644391A1 (en) | 2007-10-18 |
| EP2001866A2 (en) | 2008-12-17 |
| CN101410389A (zh) | 2009-04-15 |
| US20090182007A1 (en) | 2009-07-16 |
| WO2007117982A2 (en) | 2007-10-18 |
| US8153674B2 (en) | 2012-04-10 |
| WO2007117982A3 (en) | 2007-12-13 |
| EP2301931A1 (en) | 2011-03-30 |
| KR20080114769A (ko) | 2008-12-31 |
| EP2301931B1 (en) | 2013-10-16 |
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