JP5188184B2 - 局所的一酸化窒素供給装置およびその治療的使用方法 - Google Patents
局所的一酸化窒素供給装置およびその治療的使用方法 Download PDFInfo
- Publication number
- JP5188184B2 JP5188184B2 JP2007543585A JP2007543585A JP5188184B2 JP 5188184 B2 JP5188184 B2 JP 5188184B2 JP 2007543585 A JP2007543585 A JP 2007543585A JP 2007543585 A JP2007543585 A JP 2007543585A JP 5188184 B2 JP5188184 B2 JP 5188184B2
- Authority
- JP
- Japan
- Prior art keywords
- nitric oxide
- layer
- oxide delivery
- contact
- polymer layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
本発明の一実施例では、足に難治性開放性潰瘍(sore)を有する男性糖尿病患者を本発明によって治療した。患者は、皮膚および筋肉の組織損傷だけではなく、糖尿病に起因する血行不良によって引き起こされた神経障害も患っている。治療の結果、潰瘍は塞がり、患者は足の感覚も取り戻した。すなわち、血行不良によって誘発された神経障害が治癒した。
Claims (10)
- 局所的一酸化窒素送達装置であって、
少なくとも1つの一酸化窒素誘導体部分を含み、血流量を増加させる体の部分に接触した状態で配置することができる一酸化窒素送達パッチと、
前記装置の構成要素であるか、または、治療時に前記装置に添加される、活性化剤と、
を含み、
前記一酸化窒素送達パッチは、
上面および下面を有する第1超吸収層、
上面および下面を有し、上面が前記第1超吸収層の下面に接して設けられた繊維状ポリマー層、
上面および下面を有し、上面が前記繊維状ポリマー層の下面に接して設けられた第2超吸収層、および
上面および下面を有し、上面が前記第2超吸収層の下面に接して設けられ、少なくとも1つの一酸化窒素誘導体化されたポリマー材料を含む、活性ポリマー層、
を含み、
前記活性ポリマー層の下面が、血流量を増加させる体の部分に接触した状態で配置されたときに、血流量を増加させる体の部分に一酸化窒素を送達する、局所的一酸化窒素送達装置。 - 請求項1において、
前記一酸化窒素送達パッチの少なくとも一層が、繊維状ポリマー材料からなる、装置。 - 請求項1において、
前記一酸化窒素送達パッチの少なくとも一層が、ナノ繊維状ポリマー材料からなる、装置。 - 請求項1において、
前記活性ポリマー層が一酸化窒素誘導体化ポリマー材料からなる、装置。 - 請求項1において、
前記活性ポリマー層がジアゼニウムジオラート材料を含む、装置。 - 請求項1において、
前記活性ポリマー層が、直鎖ポリエチレンイミン、分岐ポリエチレンイミン、ポリエチレンイミンの共重合体、およびそれらの組み合わせから選ばれる一酸化窒素誘導体化ポリマーをさらに含む、装置。 - 請求項1において、
前記一酸化窒素送達パッチが、絆創膏、不織マット、織物マット、およびガーゼから選ばれる構成要素をさらに含む、装置。 - 請求項1において、
前記一酸化窒素送達パッチが、患者に直接紡糸された繊維をさらに含む、装置。 - 請求項8において、
前記患者に直接紡糸された繊維が、電界紡糸、ガスジェットナノ繊維法、湿式紡糸、乾式紡糸、溶融紡糸、およびゲル紡糸から選ばれる方法により紡糸された、装置。 - 請求項1において、
前記活性化剤がアスコルビン酸、水、体液、リンパ液、胆汁、メタノール、エタノール、プロパノール、ブタノール、ペンタノール、ヘキサノール、フェノール、ナフトール、リン酸塩、コハク酸塩、炭酸塩、酢酸塩、ギ酸塩、プロピオン酸塩、酪酸塩、脂肪酸、およびアミノ酸から選ばれる、装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63145404P | 2004-11-29 | 2004-11-29 | |
US60/631,454 | 2004-11-29 | ||
PCT/US2005/043051 WO2006058318A2 (en) | 2004-11-29 | 2005-11-29 | Topical nitric oxide donor devices |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008521509A JP2008521509A (ja) | 2008-06-26 |
JP2008521509A5 JP2008521509A5 (ja) | 2008-10-30 |
JP5188184B2 true JP5188184B2 (ja) | 2013-04-24 |
Family
ID=36498619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007543585A Expired - Fee Related JP5188184B2 (ja) | 2004-11-29 | 2005-11-29 | 局所的一酸化窒素供給装置およびその治療的使用方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20090214624A1 (ja) |
EP (1) | EP1827332A4 (ja) |
JP (1) | JP5188184B2 (ja) |
CN (1) | CN101065084A (ja) |
CA (1) | CA2588744A1 (ja) |
WO (1) | WO2006058318A2 (ja) |
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-
2005
- 2005-11-29 JP JP2007543585A patent/JP5188184B2/ja not_active Expired - Fee Related
- 2005-11-29 EP EP05826465A patent/EP1827332A4/en not_active Withdrawn
- 2005-11-29 CA CA002588744A patent/CA2588744A1/en not_active Abandoned
- 2005-11-29 CN CNA2005800406584A patent/CN101065084A/zh active Pending
- 2005-11-29 US US11/719,894 patent/US20090214624A1/en not_active Abandoned
- 2005-11-29 WO PCT/US2005/043051 patent/WO2006058318A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2006058318A3 (en) | 2006-08-17 |
US20090214624A1 (en) | 2009-08-27 |
EP1827332A2 (en) | 2007-09-05 |
EP1827332A4 (en) | 2010-03-17 |
CA2588744A1 (en) | 2006-06-01 |
JP2008521509A (ja) | 2008-06-26 |
WO2006058318A2 (en) | 2006-06-01 |
CN101065084A (zh) | 2007-10-31 |
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