JP5167436B2 - 新規アミロイド親和性化合物 - Google Patents

新規アミロイド親和性化合物 Download PDF

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Publication number
JP5167436B2
JP5167436B2 JP2012540219A JP2012540219A JP5167436B2 JP 5167436 B2 JP5167436 B2 JP 5167436B2 JP 2012540219 A JP2012540219 A JP 2012540219A JP 2012540219 A JP2012540219 A JP 2012540219A JP 5167436 B2 JP5167436 B2 JP 5167436B2
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Prior art keywords
pyridine
compound
pyridin
imidazo
iodo
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Japanese (ja)
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JPWO2012176587A1 (ja
Inventor
侑紀 奥村
啓史 眞矢
祥生 正山
崇子 大西
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Nihon Medi Physics Co Ltd
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Nihon Medi Physics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2012540219A 2011-06-24 2012-05-29 新規アミロイド親和性化合物 Active JP5167436B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2012540219A JP5167436B2 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011140069 2011-06-24
JP2011140069 2011-06-24
PCT/JP2012/063726 WO2012176587A1 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物
JP2012540219A JP5167436B2 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

Publications (2)

Publication Number Publication Date
JP5167436B2 true JP5167436B2 (ja) 2013-03-21
JPWO2012176587A1 JPWO2012176587A1 (ja) 2015-02-23

Family

ID=47422429

Family Applications (1)

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JP2012540219A Active JP5167436B2 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

Country Status (11)

Country Link
US (1) US9211350B2 (OSRAM)
EP (1) EP2725027B1 (OSRAM)
JP (1) JP5167436B2 (OSRAM)
KR (1) KR101854228B1 (OSRAM)
CN (1) CN103596950B (OSRAM)
AU (1) AU2012274639B2 (OSRAM)
CA (1) CA2839199C (OSRAM)
ES (1) ES2619830T3 (OSRAM)
IN (1) IN2014DN00185A (OSRAM)
TW (1) TWI554511B (OSRAM)
WO (1) WO2012176587A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3197277T3 (da) * 2014-08-29 2022-01-31 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
US20200276338A1 (en) * 2017-09-19 2020-09-03 The Governors Of The University Of Alberta Bioreductively-activated compounds, their prodrugs, radiopharmaceuticals, the compositions, and their applications in multimodal theranostic management of hypoxia diseases including cancer
JP6831802B2 (ja) * 2018-01-12 2021-02-17 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
JPWO2022244680A1 (OSRAM) * 2021-05-18 2022-11-24

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008065785A1 (en) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
WO2008091195A1 (en) * 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
WO2009057578A1 (ja) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物の使用及び製造方法
WO2010092111A2 (en) * 2009-02-11 2010-08-19 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
WO2011045415A2 (en) * 2009-10-15 2011-04-21 Guerbet New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2340394A1 (en) 1998-08-20 2000-03-02 Jorge R. Barrio Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles
HU230581B1 (hu) 2000-08-24 2017-01-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében
DE60217090T2 (de) 2001-04-23 2007-07-12 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel
KR100947913B1 (ko) 2001-08-27 2010-03-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 스틸벤 유도체 및 이것을 아밀로이드 플라크의 결합 및영상화에 사용하는 용도
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
ES2376491T3 (es) 2006-05-19 2012-03-14 Nihon Medi-Physics Co., Ltd. Compuesto que tiene afinidad por amiloide.
EP2213672A4 (en) 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
JP5313158B2 (ja) 2007-10-26 2013-10-09 日本メジフィジックス株式会社 新規アミロイド親和性化合物
TW200918103A (en) 2007-10-30 2009-05-01 Nihon Mediphysics Co Ltd Use of novel compound having affinity for amyloid, and process for production of the same
CA2704172A1 (en) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
WO2009155024A1 (en) * 2008-05-30 2009-12-23 Merck & Co., Inc. Novel substituted indoles
WO2010128595A1 (ja) 2009-05-07 2010-11-11 富士フイルムＲｉファーマ株式会社 放射性ヨウ素標識イミダゾピリジン誘導体の製造法
CN103534253B (zh) * 2011-05-20 2016-02-24 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的化合物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008065785A1 (en) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
WO2008091195A1 (en) * 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
WO2009057578A1 (ja) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物の使用及び製造方法
WO2010092111A2 (en) * 2009-02-11 2010-08-19 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
WO2011045415A2 (en) * 2009-10-15 2011-04-21 Guerbet New imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases

Also Published As

Publication number Publication date
KR20140040735A (ko) 2014-04-03
CN103596950A (zh) 2014-02-19
CA2839199A1 (en) 2012-12-27
AU2012274639A1 (en) 2014-02-06
EP2725027A4 (en) 2015-02-25
US9211350B2 (en) 2015-12-15
EP2725027A1 (en) 2014-04-30
US20140121377A1 (en) 2014-05-01
CA2839199C (en) 2018-11-06
KR101854228B1 (ko) 2018-05-03
IN2014DN00185A (OSRAM) 2015-07-10
JPWO2012176587A1 (ja) 2015-02-23
AU2012274639B2 (en) 2016-08-11
TWI554511B (zh) 2016-10-21
EP2725027B1 (en) 2017-03-01
WO2012176587A1 (ja) 2012-12-27
TW201300388A (zh) 2013-01-01
CN103596950B (zh) 2017-12-19
ES2619830T3 (es) 2017-06-27

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