CA2839199C - Novel compound with amyloid affinity - Google Patents

Novel compound with amyloid affinity Download PDF

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Publication number
CA2839199C
CA2839199C CA2839199A CA2839199A CA2839199C CA 2839199 C CA2839199 C CA 2839199C CA 2839199 A CA2839199 A CA 2839199A CA 2839199 A CA2839199 A CA 2839199A CA 2839199 C CA2839199 C CA 2839199C
Authority
CA
Canada
Prior art keywords
pyridine
compound
triazole
mmol
iodo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2839199A
Other languages
English (en)
French (fr)
Other versions
CA2839199A1 (en
Inventor
Yuki Okumura
Yoshifumi Maya
Yoshinari Shoyama
Takako Onishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Publication of CA2839199A1 publication Critical patent/CA2839199A1/en
Application granted granted Critical
Publication of CA2839199C publication Critical patent/CA2839199C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2839199A 2011-06-24 2012-05-29 Novel compound with amyloid affinity Expired - Fee Related CA2839199C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011140069 2011-06-24
JP2011-140069 2011-06-24
PCT/JP2012/063726 WO2012176587A1 (ja) 2011-06-24 2012-05-29 新規アミロイド親和性化合物

Publications (2)

Publication Number Publication Date
CA2839199A1 CA2839199A1 (en) 2012-12-27
CA2839199C true CA2839199C (en) 2018-11-06

Family

ID=47422429

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2839199A Expired - Fee Related CA2839199C (en) 2011-06-24 2012-05-29 Novel compound with amyloid affinity

Country Status (11)

Country Link
US (1) US9211350B2 (OSRAM)
EP (1) EP2725027B1 (OSRAM)
JP (1) JP5167436B2 (OSRAM)
KR (1) KR101854228B1 (OSRAM)
CN (1) CN103596950B (OSRAM)
AU (1) AU2012274639B2 (OSRAM)
CA (1) CA2839199C (OSRAM)
ES (1) ES2619830T3 (OSRAM)
IN (1) IN2014DN00185A (OSRAM)
TW (1) TWI554511B (OSRAM)
WO (1) WO2012176587A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102410733B1 (ko) * 2014-08-29 2022-06-20 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
EP3684781A4 (en) * 2017-09-19 2022-06-29 The Governors of the University of Alberta Bioreductively-activated compounds, their prodrugs, radiopharmaceuticals, the compositions, and their applications in multimodal theranostic management of hypoxia diseases including cancer
JP6831802B2 (ja) * 2018-01-12 2021-02-17 上海富吉医療器械有限公司Ｓｈａｎｇｈａｉ Ｃｈａｒｔｗｅｌｌ Ｍｅｄｉｃａｌ Ｉｎｓｔｒｕｍｅｎｔ Ｃｏ．， Ｌｔｄ． 放射性核種標識化合物及びこれを含有するイメージング剤
WO2022244680A1 (ja) * 2021-05-18 2022-11-24 国立大学法人大阪大学 画像診断用磁気ナノ粒子及び画像診断用造影剤

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274119B1 (en) 1998-08-20 2001-08-14 The Regents Of The Univ. Of California Methods for labeling β-amyloid plaques and neurofibrillary tangles
RU2324686C2 (ru) 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
JP4317955B2 (ja) 2001-04-23 2009-08-19 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア アミロイド斑凝集阻害剤および診断用造影剤
AU2002323417B2 (en) 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
US8022075B2 (en) * 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
RU2008150377A (ru) 2006-05-19 2010-06-27 Нихон Меди-Физикс Ко., Лтд. (Jp) Новое соединение, обладающее сродством к амилоиду
KR20090025282A (ko) * 2006-06-21 2009-03-10 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
CN101595108A (zh) * 2006-11-30 2009-12-02 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
JP2010516672A (ja) 2007-01-22 2010-05-20 アストラゼネカ・アクチエボラーグ 新規なヘテロアリール置換されたイミダゾ［１，２−ａ］ピリジン誘導体
CN101903381A (zh) 2007-10-24 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CA2704027A1 (en) 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
US20100249419A1 (en) 2007-10-30 2010-09-30 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same
CN101909657A (zh) 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
TW200918103A (en) 2007-10-30 2009-05-01 Nihon Mediphysics Co Ltd Use of novel compound having affinity for amyloid, and process for production of the same
US20110076230A1 (en) * 2008-05-30 2011-03-31 Barrow James C Novel Substituted Indoles
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
JPWO2010128595A1 (ja) 2009-05-07 2012-11-01 富士フイルムＲｉファーマ株式会社 放射性ヨウ素標識イミダゾピリジン誘導体の製造法
ES2620177T3 (es) 2009-10-15 2017-06-27 Guerbet Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas
JP5272110B2 (ja) * 2011-05-20 2013-08-28 日本メジフィジックス株式会社 新規アミロイド親和性化合物

Also Published As

Publication number Publication date
AU2012274639A1 (en) 2014-02-06
JP5167436B2 (ja) 2013-03-21
WO2012176587A1 (ja) 2012-12-27
JPWO2012176587A1 (ja) 2015-02-23
EP2725027B1 (en) 2017-03-01
CN103596950A (zh) 2014-02-19
AU2012274639B2 (en) 2016-08-11
KR20140040735A (ko) 2014-04-03
US20140121377A1 (en) 2014-05-01
EP2725027A4 (en) 2015-02-25
KR101854228B1 (ko) 2018-05-03
EP2725027A1 (en) 2014-04-30
ES2619830T3 (es) 2017-06-27
IN2014DN00185A (OSRAM) 2015-07-10
US9211350B2 (en) 2015-12-15
CA2839199A1 (en) 2012-12-27
TW201300388A (zh) 2013-01-01
CN103596950B (zh) 2017-12-19
TWI554511B (zh) 2016-10-21

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EEER Examination request

Effective date: 20170105

MKLA Lapsed

Effective date: 20210531