JP5149303B2 - 生体試料の連続分析 - Google Patents

生体試料の連続分析 Download PDF

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Publication number
JP5149303B2
JP5149303B2 JP2009537360A JP2009537360A JP5149303B2 JP 5149303 B2 JP5149303 B2 JP 5149303B2 JP 2009537360 A JP2009537360 A JP 2009537360A JP 2009537360 A JP2009537360 A JP 2009537360A JP 5149303 B2 JP5149303 B2 JP 5149303B2
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Japan
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sample
signal
probe
binding
target
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Expired - Fee Related
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Japanese (ja)
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JP2010510493A (ja
JP2010510493A5 (enExample
Inventor
パング,ツェンユー
フィルキンス,ロバート・ジョン
モンタルト,マイケル・クリストファー
ギンティ,フィオナ
ガーデス,マイケル・ジェイ
キャン,アリ
ブレスナハン,モーリーン・アン
スード,アヌープ
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General Electric Co
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General Electric Co
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Priority claimed from US11/560,599 external-priority patent/US7629125B2/en
Application filed by General Electric Co filed Critical General Electric Co
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Publication of JP2010510493A5 publication Critical patent/JP2010510493A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2009537360A 2006-11-16 2007-11-15 生体試料の連続分析 Expired - Fee Related JP5149303B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/560,599 2006-11-16
US11/560,599 US7629125B2 (en) 2006-11-16 2006-11-16 Sequential analysis of biological samples
US11/864,085 US7741045B2 (en) 2006-11-16 2007-09-28 Sequential analysis of biological samples
US11/864,085 2007-09-28
PCT/US2007/084800 WO2008064067A2 (en) 2006-11-16 2007-11-15 Method for the sequential analysis of different components in a single biological sample and reagents therefor

Publications (3)

Publication Number Publication Date
JP2010510493A JP2010510493A (ja) 2010-04-02
JP2010510493A5 JP2010510493A5 (enExample) 2011-01-27
JP5149303B2 true JP5149303B2 (ja) 2013-02-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009537360A Expired - Fee Related JP5149303B2 (ja) 2006-11-16 2007-11-15 生体試料の連続分析

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US (1) US7741045B2 (enExample)
EP (2) EP2381257B1 (enExample)
JP (1) JP5149303B2 (enExample)
AT (1) ATE520026T1 (enExample)
AU (1) AU2007323794B2 (enExample)
CA (1) CA2669092C (enExample)
DK (1) DK2082226T3 (enExample)
ES (1) ES2459725T3 (enExample)
PL (1) PL2082226T3 (enExample)
PT (1) PT2082226E (enExample)
WO (1) WO2008064067A2 (enExample)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8060348B2 (en) * 2006-08-07 2011-11-15 General Electric Company Systems for analyzing tissue samples
US8131476B2 (en) * 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
US20080032321A1 (en) * 2006-08-07 2008-02-07 General Electric Company System and methods for analyzing images of tissue samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
EP2110076A1 (en) * 2008-02-19 2009-10-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Method and device for near-field dual-wave modality imaging
CA2731409C (en) 2008-07-25 2016-01-05 Daniel Razansky Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers
US9271654B2 (en) 2009-06-29 2016-03-01 Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Thermoacoustic imaging with quantitative extraction of absorption map
EP2459987A1 (en) 2009-07-27 2012-06-06 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Imaging device and method for optoacoustic imaging of small animals
US8269827B2 (en) * 2009-09-29 2012-09-18 General Electric Company System and methods for mapping fluorescent images into a bright field color space
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
WO2012058638A2 (en) 2010-10-29 2012-05-03 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
US20120271553A1 (en) * 2011-04-22 2012-10-25 Ge Global Research Analyzing the expression of biomarkers in cells with clusters
US8639013B2 (en) 2011-08-17 2014-01-28 General Electric Company System and methods for generating a brightfield image using fluorescent images
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
US8568991B2 (en) 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
EP2825882A1 (en) * 2012-03-16 2015-01-21 UMC Utrecht Holding B.V. Biomarkers for adverse cardiac remodeling
ES2678211T3 (es) 2012-03-27 2018-08-09 Ventana Medical Systems, Inc. Conjugados de señalización y procedimientos de uso
KR20140145141A (ko) 2012-03-30 2014-12-22 클래리언트 다이아그노스틱 서비시즈, 인크. 생물학적 샘플의 영상 생성 방법
US20140024024A1 (en) * 2012-07-17 2014-01-23 General Electric Company Methods of detecting dna, rna and protein in biological samples
EP2742854B1 (en) 2012-12-11 2021-03-10 iThera Medical GmbH Handheld device and method for tomographic optoacoustic imaging of an object
EP2754388B1 (en) 2013-01-15 2020-09-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH System and method for quality-enhanced high-rate optoacoustic imaging of an object
EP2965087B1 (en) 2013-03-06 2018-10-17 General Electric Company Methods of analyzing an h&e stained biological sample
EP3004372A1 (en) * 2013-06-04 2016-04-13 Roche Diagnostics GmbH Novel compounds useful for fret and methods related thereto
US20160161472A1 (en) 2013-07-30 2016-06-09 President And Fellows Of Harvard College Quantitative dna-based imaging and super-resolution imaging
US9778263B2 (en) 2013-11-13 2017-10-03 General Electric Company Quantitative in situ characterization of biological samples
RU2744046C2 (ru) * 2014-03-05 2021-03-02 Отолус Лимитед ХИМЕРНЫЙ АНТИГЕННЫЙ РЕЦЕПТОР (CAR) С АНТИГЕНСВЯЗЫВАЮЩИМИ ДОМЕНАМИ К КОНСТАНТНОЙ ОБЛАСТИ β Т-КЛЕТОЧНОГО РЕЦЕПТОРА
US11982672B2 (en) 2014-03-05 2024-05-14 Autolus Limited Methods
EP3117214B1 (en) * 2014-03-11 2020-05-06 President and Fellows of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
EP4273263A3 (en) 2014-07-30 2024-01-31 President and Fellows of Harvard College Systems and methods for determining nucleic acids
US9933431B2 (en) 2014-08-22 2018-04-03 Arizona Board Of Regents On Behalf Of Arizona State University System and method for iterative detection of biological molecules
EP3037820A1 (en) 2014-12-27 2016-06-29 Miltenyi Biotec GmbH Cell detection methods and reagents having a releasable labelling moiety
CN106338423B (zh) 2015-07-10 2020-07-14 三斯坎公司 组织学染色的空间复用
US10501777B2 (en) 2015-07-17 2019-12-10 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
CN114350752B (zh) 2015-07-17 2025-02-25 布鲁克空间生物学公司 在横切面组织的用户定义区域中的基因表达的同时定量
US20170241911A1 (en) 2016-02-22 2017-08-24 Miltenyi Biotec Gmbh Automated analysis tool for biological specimens
US10871490B2 (en) 2016-02-29 2020-12-22 Multenyi Biotec, gmbH Assay for detection of chimeric antigen receptor T cells
WO2017202962A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
JP7184651B2 (ja) 2016-06-29 2022-12-06 ミルテニー バイオテック ベー.フェー. ウント コー. カー・ゲー 生体試料のための多層式ディスポーザブルカートリッジ
CN106290878A (zh) * 2016-09-10 2017-01-04 天津大学 基于量子点的胰腺癌肿瘤标志物ca242免疫层析试纸条的制备方法
CN110050071A (zh) 2016-12-09 2019-07-23 乌尔蒂维尤股份有限公司 用于使用标记的核酸成像剂进行多路复用成像的改进方法
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
US20200150109A1 (en) 2017-05-05 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
WO2018218150A1 (en) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
EP3489684B1 (en) 2017-11-27 2024-06-26 Miltenyi Biotec B.V. & Co. KG Method for photobleaching stained cells
JP7372927B6 (ja) 2018-02-12 2023-11-27 ナノストリング テクノロジーズ,インコーポレイティド 遺伝子およびタンパク質の発現を検出する生体分子プローブおよびその検出方法
JP2020071152A (ja) * 2018-10-31 2020-05-07 ソニー株式会社 免疫染色方法、免疫染色システム、および免疫染色キット
CA3122569A1 (en) 2018-12-13 2020-06-18 President And Fellows Of Harvard College Amplification methods and systems for merfish and other applications
MX2021008121A (es) 2019-01-03 2021-12-10 Inst Nat Sante Rech Med Metodos y composiciones farmaceuticas para mejorar las respuestas inmunitarias dependientes de celulas t cd8+ en sujetos que sufren de cancer.
CN109770853B (zh) * 2019-01-30 2022-01-14 上海师范大学 一种斑马鱼伤口检测方法
US11633741B2 (en) 2019-03-19 2023-04-25 Miltenyi Biotec B.V. & Co. KG Slide chamber
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220160692A1 (en) 2019-04-09 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
WO2020216439A1 (en) 2019-04-23 2020-10-29 Miltenyi Biotec B.V. & Co. KG Reversible cell detection with conjugates having a linker for increased fluorescent brightness and an enzymatically releasable fluorescent moiety
CN114072676B (zh) 2019-06-03 2024-07-12 法国国家卫生及研究医学协会 调节治疗方案的方法
KR20220098147A (ko) * 2019-10-17 2022-07-11 씨2센스, 인크. 감지 및/또는 인증을 위한 발광 이미징
EP4045686A1 (en) 2019-10-17 2022-08-24 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for diagnosing nasal intestinal type adenocarcinomas
US20210116377A1 (en) 2019-10-17 2021-04-22 C2Sense, Inc. White light emissive species and related methods
WO2021170777A1 (en) 2020-02-28 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
EP3916388A1 (en) 2020-05-27 2021-12-01 Miltenyi Biotec B.V. & Co. KG Reagents for detection of chimeric antigen receptor cells
EP3916393B1 (en) * 2020-05-27 2023-01-25 Miltenyi Biotec B.V. & Co. KG Method for detection of cells by repetitive staining and destaining
EP4172621A1 (en) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
JP7741831B2 (ja) 2020-06-30 2025-09-18 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び/又は死亡のリスクを予測するための方法
KR20240012352A (ko) 2021-03-23 2024-01-29 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) T 세포 림프종의 진단 및 치료 방법
EP4320442A1 (en) 2021-04-09 2024-02-14 Neogenomics Laboratories, Inc. Perivascular accumulation of immune cells in the diagnosis and treatment of cancer
CN113684256B (zh) * 2021-08-30 2024-05-14 中国药科大学 基于绿色溶剂及可编程寡核苷酸探针的多重定位检测多种靶标的方法
WO2023143179A1 (zh) * 2022-01-28 2023-08-03 南京大学 一种对抗原样本的处理方法和应用
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
US20250035635A1 (en) 2022-03-17 2025-01-30 Institut National De La Sante Et De La Recherche Medicale Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer
WO2023198648A1 (en) 2022-04-11 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
US20260029402A1 (en) 2022-07-22 2026-01-29 Institut National de la Santé et de la Recherche Médicale Garp as a biomarker and biotarget in t-cell malignancies
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas
WO2024079192A1 (en) 2022-10-12 2024-04-18 Institut National de la Santé et de la Recherche Médicale Cd81 as a biomarker and biotarget in t-cell malignancies
DE102022131446A1 (de) * 2022-11-28 2024-05-29 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zum Aufbereiten von Daten zum Identifizieren von Analyten
EP4784299A1 (en) 2023-09-28 2026-08-05 Miltenyi Biotec B.V. & Co. KG Flow cell for sequencing

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3130513B2 (ja) * 1989-04-19 2001-01-31 イビデン株式会社 生体活性物質測定用装置
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE4421891C2 (de) 1994-06-23 1996-05-15 Helmut Prof Dr Med Feucht Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
DE19709348C2 (de) 1996-05-29 1999-07-01 Schubert Walter Dr Md Automatisches Multi-Epitop-Ligand-Kartierungsverfahren
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
WO2000003034A2 (en) 1998-07-10 2000-01-20 Chromagen, Inc. Novel polycyclic aromatic fluorogenic substrates for hydrolases
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
WO2000058507A1 (en) 1999-03-30 2000-10-05 Solexa Ltd. Polynucleotide sequencing
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
DE10014685B4 (de) 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
WO2001086296A2 (en) 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
WO2002079771A1 (en) 2001-03-30 2002-10-10 The Samuel Roberts Noble Foundation, Inc. Silver destaining method
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US20020173053A1 (en) 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
US20040241688A1 (en) 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003291249A1 (en) 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
US20040241776A1 (en) 2003-05-22 2004-12-02 Agdia, Inc. Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes
WO2006012302A2 (en) * 2004-06-28 2006-02-02 Exagen Diagnostics, Inc. Methods for rna fluorescence in situ hybridization
JP2007033159A (ja) * 2005-07-25 2007-02-08 Assay Corp 蛍光分子で標識された測定対象物質
EP1950566A4 (en) * 2005-11-10 2008-11-26 Univ Toyama Nat Univ Corp METHOD FOR EVALUATING BINDING CHARACTERISTICS OF BIOSUBSTANCES AND BIOSUBSTANCE-BINDING SUBSTANCES
US8305579B2 (en) * 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples

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Publication number Publication date
US20080118934A1 (en) 2008-05-22
PT2082226E (pt) 2011-10-31
EP2381257B1 (en) 2014-03-26
WO2008064067A2 (en) 2008-05-29
AU2007323794A1 (en) 2008-05-29
EP2082226A2 (en) 2009-07-29
AU2007323794B2 (en) 2013-08-22
WO2008064067A3 (en) 2008-07-10
ATE520026T1 (de) 2011-08-15
PL2082226T3 (pl) 2012-01-31
EP2381257A1 (en) 2011-10-26
CA2669092C (en) 2016-07-26
EP2082226B1 (en) 2011-08-10
ES2459725T3 (es) 2014-05-12
US7741045B2 (en) 2010-06-22
CA2669092A1 (en) 2008-05-29
DK2082226T3 (da) 2011-11-14
JP2010510493A (ja) 2010-04-02

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