JP5143023B2 - うつ病の検出および治療装置 - Google Patents
うつ病の検出および治療装置 Download PDFInfo
- Publication number
- JP5143023B2 JP5143023B2 JP2008551321A JP2008551321A JP5143023B2 JP 5143023 B2 JP5143023 B2 JP 5143023B2 JP 2008551321 A JP2008551321 A JP 2008551321A JP 2008551321 A JP2008551321 A JP 2008551321A JP 5143023 B2 JP5143023 B2 JP 5143023B2
- Authority
- JP
- Japan
- Prior art keywords
- depression
- implantable device
- circuit
- parameters
- nerve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001514 detection method Methods 0.000 title claims description 14
- 230000000638 stimulation Effects 0.000 claims description 29
- 230000001537 neural effect Effects 0.000 claims description 25
- 210000005036 nerve Anatomy 0.000 claims description 11
- 230000001430 anti-depressive effect Effects 0.000 claims description 8
- 239000000935 antidepressant agent Substances 0.000 claims description 8
- 229940005513 antidepressants Drugs 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 238000002560 therapeutic procedure Methods 0.000 claims description 8
- 239000003550 marker Substances 0.000 claims description 7
- 230000007383 nerve stimulation Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 230000008035 nerve activity Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 description 12
- 230000000747 cardiac effect Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 9
- 238000007726 management method Methods 0.000 description 9
- 230000002889 sympathetic effect Effects 0.000 description 9
- 208000024172 Cardiovascular disease Diseases 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 238000012377 drug delivery Methods 0.000 description 7
- 230000001734 parasympathetic effect Effects 0.000 description 7
- 230000001746 atrial effect Effects 0.000 description 6
- 210000003403 autonomic nervous system Anatomy 0.000 description 6
- 230000033764 rhythmic process Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 230000002861 ventricular Effects 0.000 description 5
- 208000010125 myocardial infarction Diseases 0.000 description 4
- 230000004007 neuromodulation Effects 0.000 description 4
- 238000004393 prognosis Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 210000001186 vagus nerve Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 210000002820 sympathetic nervous system Anatomy 0.000 description 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 102000004889 Interleukin-6 Human genes 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 2
- 208000001871 Tachycardia Diseases 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 210000001326 carotid sinus Anatomy 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000002837 heart atrium Anatomy 0.000 description 2
- 229940100601 interleukin-6 Drugs 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 2
- 229960002748 norepinephrine Drugs 0.000 description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 2
- 229940076279 serotonin Drugs 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 206010002388 Angina unstable Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 101800003265 Beta-thromboglobulin Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 108010074051 C-Reactive Protein Proteins 0.000 description 1
- 102100032752 C-reactive protein Human genes 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 101001116302 Homo sapiens Platelet endothelial cell adhesion molecule Proteins 0.000 description 1
- 102100035593 POU domain, class 2, transcription factor 1 Human genes 0.000 description 1
- 101710084414 POU domain, class 2, transcription factor 1 Proteins 0.000 description 1
- 102100036154 Platelet basic protein Human genes 0.000 description 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 1
- 102000004211 Platelet factor 4 Human genes 0.000 description 1
- 108090000778 Platelet factor 4 Proteins 0.000 description 1
- 206010049447 Tachyarrhythmia Diseases 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 108091008698 baroreceptors Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000013194 cardioversion Methods 0.000 description 1
- 210000001159 caudate nucleus Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 238000009532 heart rate measurement Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 description 1
- 210000005037 parasympathetic nerve Anatomy 0.000 description 1
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000002360 prefrontal effect Effects 0.000 description 1
- 210000001774 pressoreceptor Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000012474 protein marker Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/024—Measuring pulse rate or heart rate
- A61B5/02405—Determining heart rate variability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
- A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
- A61B5/4035—Evaluating the autonomic nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Psychology (AREA)
- Physiology (AREA)
- Developmental Disabilities (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Social Psychology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Educational Technology (AREA)
- Electrotherapy Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/275,682 US7606622B2 (en) | 2006-01-24 | 2006-01-24 | Method and device for detecting and treating depression |
| US11/275,682 | 2006-01-24 | ||
| PCT/US2007/001086 WO2007087192A2 (en) | 2006-01-24 | 2007-01-16 | Device for detecting and treating depression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524450A JP2009524450A (ja) | 2009-07-02 |
| JP2009524450A5 JP2009524450A5 (https=) | 2010-03-18 |
| JP5143023B2 true JP5143023B2 (ja) | 2013-02-13 |
Family
ID=38220982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551321A Expired - Fee Related JP5143023B2 (ja) | 2006-01-24 | 2007-01-16 | うつ病の検出および治療装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7606622B2 (https=) |
| EP (1) | EP1976593B1 (https=) |
| JP (1) | JP5143023B2 (https=) |
| AT (1) | ATE482744T1 (https=) |
| DE (1) | DE602007009483D1 (https=) |
| WO (1) | WO2007087192A2 (https=) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100312753B1 (ko) * | 1998-10-13 | 2002-04-06 | 윤종용 | 광시야각액정표시장치 |
| US9050469B1 (en) | 2003-11-26 | 2015-06-09 | Flint Hills Scientific, Llc | Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals |
| US8565867B2 (en) | 2005-01-28 | 2013-10-22 | Cyberonics, Inc. | Changeable electrode polarity stimulation by an implantable medical device |
| US9314633B2 (en) | 2008-01-25 | 2016-04-19 | Cyberonics, Inc. | Contingent cardio-protection for epilepsy patients |
| US8260426B2 (en) | 2008-01-25 | 2012-09-04 | Cyberonics, Inc. | Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device |
| US7794413B2 (en) * | 2005-04-19 | 2010-09-14 | Ev3, Inc. | Libraries and data structures of materials removed by debulking catheters |
| US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
| US7996079B2 (en) | 2006-01-24 | 2011-08-09 | Cyberonics, Inc. | Input response override for an implantable medical device |
| US7606622B2 (en) | 2006-01-24 | 2009-10-20 | Cardiac Pacemakers, Inc. | Method and device for detecting and treating depression |
| US7989207B2 (en) * | 2006-02-17 | 2011-08-02 | Tyco Healthcare Group Lp | Testing lumenectomy samples for markers of non-vascular diseases |
| EP2026874B1 (en) | 2006-03-29 | 2015-05-20 | Dignity Health | Vagus nerve stimulation system |
| US7869885B2 (en) | 2006-04-28 | 2011-01-11 | Cyberonics, Inc | Threshold optimization for tissue stimulation therapy |
| US7962220B2 (en) | 2006-04-28 | 2011-06-14 | Cyberonics, Inc. | Compensation reduction in tissue stimulation therapy |
| US20070282376A1 (en) | 2006-06-06 | 2007-12-06 | Shuros Allan C | Method and apparatus for neural stimulation via the lymphatic system |
| US7734341B2 (en) | 2006-06-06 | 2010-06-08 | Cardiac Pacemakers, Inc. | Method and apparatus for gastrointestinal stimulation via the lymphatic system |
| US8126538B2 (en) | 2006-06-06 | 2012-02-28 | Cardiac Pacemakers, Inc. | Method and apparatus for introducing endolymphatic instrumentation |
| US8905999B2 (en) | 2006-09-01 | 2014-12-09 | Cardiac Pacemakers, Inc. | Method and apparatus for endolymphatic drug delivery |
| US9018019B2 (en) * | 2006-10-04 | 2015-04-28 | President And Fellows Of Harvard College | Engineered conductive polymer films to mediate biochemical interactions |
| US7869867B2 (en) | 2006-10-27 | 2011-01-11 | Cyberonics, Inc. | Implantable neurostimulator with refractory stimulation |
| US7974701B2 (en) | 2007-04-27 | 2011-07-05 | Cyberonics, Inc. | Dosing limitation for an implantable medical device |
| JP5309151B2 (ja) * | 2007-11-14 | 2013-10-09 | カーディアック ペースメイカーズ， インコーポレイテッド | 神経治療用システム |
| US8382667B2 (en) | 2010-10-01 | 2013-02-26 | Flint Hills Scientific, Llc | Detecting, quantifying, and/or classifying seizures using multimodal data |
| US8571643B2 (en) | 2010-09-16 | 2013-10-29 | Flint Hills Scientific, Llc | Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex |
| US8337404B2 (en) | 2010-10-01 | 2012-12-25 | Flint Hills Scientific, Llc | Detecting, quantifying, and/or classifying seizures using multimodal data |
| WO2009114627A2 (en) * | 2008-03-12 | 2009-09-17 | Ridge Diagnostics, Inc. | Inflammatory biomarkers for monitoring depression disorders |
| WO2009129462A2 (en) * | 2008-04-18 | 2009-10-22 | Medtronic, Inc. | Therapy target selection for psychiatric disorder therapy |
| EP2274050A2 (en) * | 2008-04-18 | 2011-01-19 | Medtronic, Inc. | Timing therapy evaluation trials |
| US9333350B2 (en) * | 2008-04-18 | 2016-05-10 | Medtronic, Inc. | Psychiatric disorder therapy control |
| WO2009129493A1 (en) * | 2008-04-18 | 2009-10-22 | Medtronic, Inc. | Analyzing a washout period characteristic for psychiatric disorder therapy delivery |
| DE102008020070A1 (de) * | 2008-04-22 | 2009-10-29 | Biotronik Crm Patent Ag | Neurostimulator |
| US8204603B2 (en) | 2008-04-25 | 2012-06-19 | Cyberonics, Inc. | Blocking exogenous action potentials by an implantable medical device |
| EP2644227B1 (en) | 2008-07-30 | 2016-12-28 | Ecole Polytechnique Fédérale de Lausanne | Apparatus for optimized stimulation of a neurological target |
| US8457747B2 (en) | 2008-10-20 | 2013-06-04 | Cyberonics, Inc. | Neurostimulation with signal duration determined by a cardiac cycle |
| US8417344B2 (en) | 2008-10-24 | 2013-04-09 | Cyberonics, Inc. | Dynamic cranial nerve stimulation based on brain state determination from cardiac data |
| US20100114237A1 (en) * | 2008-10-31 | 2010-05-06 | Medtronic, Inc. | Mood circuit monitoring to control therapy delivery |
| CA2743575C (en) | 2008-11-12 | 2017-01-31 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device |
| US9439566B2 (en) | 2008-12-15 | 2016-09-13 | Proteus Digital Health, Inc. | Re-wearable wireless device |
| US9659423B2 (en) | 2008-12-15 | 2017-05-23 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
| TWI503101B (zh) | 2008-12-15 | 2015-10-11 | 波提亞斯數位康健公司 | 與身體有關的接收器及其方法 |
| US20100191304A1 (en) | 2009-01-23 | 2010-07-29 | Scott Timothy L | Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation |
| GB0906057D0 (en) * | 2009-04-07 | 2009-05-20 | Cambridge Silicon Radio Ltd | Device security |
| US8239028B2 (en) * | 2009-04-24 | 2012-08-07 | Cyberonics, Inc. | Use of cardiac parameters in methods and systems for treating a chronic medical condition |
| US8827912B2 (en) | 2009-04-24 | 2014-09-09 | Cyberonics, Inc. | Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters |
| EP2466312B1 (en) * | 2009-08-12 | 2019-10-16 | Human Metabolome Technologies, Inc. | Phosphoethanolamine as biomarker of depression |
| CA2782710C (en) | 2009-12-01 | 2019-01-22 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device and methods of making and using the same |
| US8914115B2 (en) * | 2009-12-03 | 2014-12-16 | Medtronic, Inc. | Selecting therapy cycle parameters based on monitored brain signal |
| KR101798128B1 (ko) | 2010-02-01 | 2017-11-16 | 프로테우스 디지털 헬스, 인코포레이티드 | 데이터 수집 시스템 |
| EP2552536B1 (en) | 2010-04-01 | 2016-06-08 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Device for interacting with neurological tissue |
| US8831732B2 (en) | 2010-04-29 | 2014-09-09 | Cyberonics, Inc. | Method, apparatus and system for validating and quantifying cardiac beat data quality |
| US8562536B2 (en) | 2010-04-29 | 2013-10-22 | Flint Hills Scientific, Llc | Algorithm for detecting a seizure from cardiac data |
| US8649871B2 (en) | 2010-04-29 | 2014-02-11 | Cyberonics, Inc. | Validity test adaptive constraint modification for cardiac data used for detection of state changes |
| US8679009B2 (en) | 2010-06-15 | 2014-03-25 | Flint Hills Scientific, Llc | Systems approach to comorbidity assessment |
| US8641646B2 (en) | 2010-07-30 | 2014-02-04 | Cyberonics, Inc. | Seizure detection using coordinate data |
| US12383190B2 (en) | 2011-03-04 | 2025-08-12 | Flint Hills Scientific, Llc | Detecting, assessing and managing extreme seizure events |
| US8684921B2 (en) | 2010-10-01 | 2014-04-01 | Flint Hills Scientific Llc | Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis |
| US8565886B2 (en) | 2010-11-10 | 2013-10-22 | Medtronic, Inc. | Arousal state modulation with electrical stimulation |
| US8706181B2 (en) | 2011-01-25 | 2014-04-22 | Medtronic, Inc. | Target therapy delivery site selection |
| US9504390B2 (en) | 2011-03-04 | 2016-11-29 | Globalfoundries Inc. | Detecting, assessing and managing a risk of death in epilepsy |
| EP2683291B1 (en) | 2011-03-11 | 2019-07-31 | Proteus Digital Health, Inc. | Wearable personal body associated device with various physical configurations |
| US8725239B2 (en) | 2011-04-25 | 2014-05-13 | Cyberonics, Inc. | Identifying seizures using heart rate decrease |
| US9402550B2 (en) | 2011-04-29 | 2016-08-02 | Cybertronics, Inc. | Dynamic heart rate threshold for neurological event detection |
| US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| WO2013016290A2 (en) * | 2011-07-22 | 2013-01-31 | President And Fellows Of Harvard College | Complexity based methods and systems for detecting depression |
| EP2736594B1 (en) | 2011-07-25 | 2016-09-14 | NeuroNexus Technologies, Inc. | Neuromodulation transfection system with passive fluid delivery |
| EP2736406B1 (en) | 2011-07-25 | 2019-09-04 | NeuroNexus Technologies, Inc. | Neuromodulation transfection system with means for active fluid delivery |
| WO2013016389A1 (en) | 2011-07-25 | 2013-01-31 | Neuronexus Technologies, Inc. | Opto-electrical device and method for artifact reduction |
| US9549677B2 (en) | 2011-10-14 | 2017-01-24 | Flint Hills Scientific, L.L.C. | Seizure detection methods, apparatus, and systems using a wavelet transform maximum modulus algorithm |
| US8600505B2 (en) | 2011-12-07 | 2013-12-03 | Cyberonics, Inc. | Implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US8577458B1 (en) | 2011-12-07 | 2013-11-05 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring |
| US8918190B2 (en) | 2011-12-07 | 2014-12-23 | Cyberonics, Inc. | Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction |
| US8630709B2 (en) | 2011-12-07 | 2014-01-14 | Cyberonics, Inc. | Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US8918191B2 (en) | 2011-12-07 | 2014-12-23 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration |
| US10188856B1 (en) | 2011-12-07 | 2019-01-29 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US8571654B2 (en) | 2012-01-17 | 2013-10-29 | Cyberonics, Inc. | Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction |
| US8700150B2 (en) | 2012-01-17 | 2014-04-15 | Cyberonics, Inc. | Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration |
| US10448839B2 (en) | 2012-04-23 | 2019-10-22 | Livanova Usa, Inc. | Methods, systems and apparatuses for detecting increased risk of sudden death |
| EP2685885B1 (de) * | 2012-06-05 | 2015-08-26 | Beurer GmbH | Stress- und burnoutanalyse- und diagnosegerät |
| US8688212B2 (en) | 2012-07-20 | 2014-04-01 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing bradycardia through vagus nerve stimulation |
| US9643008B2 (en) | 2012-11-09 | 2017-05-09 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for enhancing post-exercise recovery through vagus nerve stimulation |
| US8923964B2 (en) | 2012-11-09 | 2014-12-30 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for enhancing heart failure patient awakening through vagus nerve stimulation |
| US9452290B2 (en) | 2012-11-09 | 2016-09-27 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing tachyarrhythmia through vagus nerve stimulation |
| US10220211B2 (en) * | 2013-01-22 | 2019-03-05 | Livanova Usa, Inc. | Methods and systems to diagnose depression |
| US9643011B2 (en) | 2013-03-14 | 2017-05-09 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation |
| WO2014151929A1 (en) | 2013-03-15 | 2014-09-25 | Proteus Digital Health, Inc. | Personal authentication apparatus system and method |
| WO2015042411A1 (en) | 2013-09-20 | 2015-03-26 | Proteus Digital Health, Inc. | Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping |
| JP2016537924A (ja) | 2013-09-24 | 2016-12-01 | プロテウス デジタル ヘルス， インコーポレイテッド | 事前に正確に把握されていない周波数において受信された電磁信号に関する使用のための方法および装置 |
| EP2862509B1 (en) * | 2013-10-16 | 2021-01-06 | GM3 Co., Ltd. | Psychiatric symptom and psychiatric disorder onset risk evaluator using heart rate variability index |
| US9999773B2 (en) | 2013-10-30 | 2018-06-19 | Cyberonics, Inc. | Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters |
| US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
| US9511228B2 (en) | 2014-01-14 | 2016-12-06 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation |
| US9272143B2 (en) | 2014-05-07 | 2016-03-01 | Cyberonics, Inc. | Responsive neurostimulation for the treatment of chronic cardiac dysfunction |
| US9713719B2 (en) | 2014-04-17 | 2017-07-25 | Cyberonics, Inc. | Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction |
| US9415224B2 (en) | 2014-04-25 | 2016-08-16 | Cyberonics, Inc. | Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction |
| US9409024B2 (en) | 2014-03-25 | 2016-08-09 | Cyberonics, Inc. | Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction |
| US9950169B2 (en) | 2014-04-25 | 2018-04-24 | Cyberonics, Inc. | Dynamic stimulation adjustment for identification of a neural fulcrum |
| US11311718B2 (en) | 2014-05-16 | 2022-04-26 | Aleva Neurotherapeutics Sa | Device for interacting with neurological tissue and methods of making and using the same |
| WO2015173787A1 (en) | 2014-05-16 | 2015-11-19 | Aleva Neurotherapeutics Sa | Device for interacting with neurological tissue and methods of making and using the same |
| EP3145582B1 (en) | 2014-05-20 | 2020-10-21 | Nevro Corporation | Implanted pulse generators with reduced power consumption via signal strength/duration characteristics, and associated systems |
| US9737716B2 (en) | 2014-08-12 | 2017-08-22 | Cyberonics, Inc. | Vagus nerve and carotid baroreceptor stimulation system |
| US9770599B2 (en) | 2014-08-12 | 2017-09-26 | Cyberonics, Inc. | Vagus nerve stimulation and subcutaneous defibrillation system |
| US9533153B2 (en) | 2014-08-12 | 2017-01-03 | Cyberonics, Inc. | Neurostimulation titration process |
| JP6208372B2 (ja) * | 2014-08-26 | 2017-10-04 | 東洋紡株式会社 | うつ状態判別方法、及びうつ状態判定装置 |
| US9474894B2 (en) | 2014-08-27 | 2016-10-25 | Aleva Neurotherapeutics | Deep brain stimulation lead |
| US9403011B2 (en) | 2014-08-27 | 2016-08-02 | Aleva Neurotherapeutics | Leadless neurostimulator |
| US9884198B2 (en) | 2014-10-22 | 2018-02-06 | Nevro Corp. | Systems and methods for extending the life of an implanted pulse generator battery |
| US9504832B2 (en) | 2014-11-12 | 2016-11-29 | Cyberonics, Inc. | Neurostimulation titration process via adaptive parametric modification |
| JP6635507B2 (ja) * | 2015-02-27 | 2020-01-29 | 公立大学法人首都大学東京 | 精神状態判定方法及び精神状態判定プログラム |
| US9517344B1 (en) | 2015-03-13 | 2016-12-13 | Nevro Corporation | Systems and methods for selecting low-power, effective signal delivery parameters for an implanted pulse generator |
| US10300277B1 (en) | 2015-12-14 | 2019-05-28 | Nevro Corp. | Variable amplitude signals for neurological therapy, and associated systems and methods |
| US10420935B2 (en) | 2015-12-31 | 2019-09-24 | Nevro Corp. | Controller for nerve stimulation circuit and associated systems and methods |
| WO2017134587A1 (en) | 2016-02-02 | 2017-08-10 | Aleva Neurotherapeutics, Sa | Treatment of autoimmune diseases with deep brain stimulation |
| JP6784368B2 (ja) * | 2016-09-01 | 2020-11-11 | 東洋紡株式会社 | うつ状態判別方法及びうつ状態判定装置 |
| WO2018117064A1 (ja) * | 2016-12-21 | 2018-06-28 | 国立大学法人徳島大学 | うつ状態を呈する疾患を検査する方法 |
| JP6927492B2 (ja) * | 2017-09-12 | 2021-09-01 | 東洋紡株式会社 | 睡眠障害を判別する指標の作成方法および作成装置 |
| JP6927491B2 (ja) * | 2017-09-12 | 2021-09-01 | 東洋紡株式会社 | 精神神経状態を判別する指標の作成方法および作成装置 |
| JP6865438B2 (ja) * | 2017-09-12 | 2021-04-28 | 東洋紡株式会社 | 精神神経状態を判別する指標の作成方法および作成装置 |
| US10595735B2 (en) * | 2018-01-12 | 2020-03-24 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for personalized clinical applications of accelerated theta-burst stimulation |
| AU2019214966B2 (en) | 2018-01-30 | 2024-12-05 | Nevro Corp. | Efficient use of an implantable pulse generator battery, and associated systems and methods |
| US10702692B2 (en) | 2018-03-02 | 2020-07-07 | Aleva Neurotherapeutics | Neurostimulation device |
| EP3810259A4 (en) * | 2018-06-20 | 2025-07-02 | Inner Cosmos Inc | SYSTEMS AND METHODS FOR THE TREATMENT OF MOOD DISORDERS |
| US11058875B1 (en) | 2018-09-19 | 2021-07-13 | Nevro Corp. | Motor function in spinal cord injury patients via electrical stimulation, and associated systems and methods |
| US11590352B2 (en) | 2019-01-29 | 2023-02-28 | Nevro Corp. | Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods |
| US10933238B2 (en) | 2019-01-31 | 2021-03-02 | Nevro Corp. | Power control circuit for sterilized devices, and associated systems and methods |
| EP3920793A1 (en) | 2019-02-07 | 2021-12-15 | Inner Cosmos Inc. | Intracalvarial bci systems and methods for their making, implantation and use |
| WO2021144730A1 (en) | 2020-01-14 | 2021-07-22 | Inner Cosmos Inc. | Devices, systems and methods for cortical stimulation |
| JP2023545136A (ja) | 2020-10-12 | 2023-10-26 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 標的化神経変調のためのシステムおよび方法 |
| JP7337353B2 (ja) * | 2020-12-22 | 2023-09-04 | 東洋紡株式会社 | うつ状態であると判定するための、プロセッサを備える装置の作動方法、うつ状態判定システム、及びうつ状態判定装置 |
| EP4347001B1 (en) | 2021-05-25 | 2026-03-25 | Nevro Corp. | Modified high frequency neuromodulation signals, and associated systems |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539991A (en) * | 1983-02-11 | 1985-09-10 | Vitafin N.V. | Dual chamber pacemaker |
| US5299569A (en) * | 1991-05-03 | 1994-04-05 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
| WO1993002744A1 (en) | 1991-08-09 | 1993-02-18 | Cyberonics, Inc. | Treatment of anxiety disorders by nerve stimulation |
| JP3493196B2 (ja) * | 1992-06-24 | 2004-02-03 | サイベロニクス，インク． | 神経刺激による神経精神障害の治療 |
| US6141588A (en) * | 1998-07-24 | 2000-10-31 | Intermedics Inc. | Cardiac simulation system having multiple stimulators for anti-arrhythmia therapy |
| US6176242B1 (en) * | 1999-04-30 | 2001-01-23 | Medtronic Inc | Method of treating manic depression by brain infusion |
| US6356784B1 (en) * | 1999-04-30 | 2002-03-12 | Medtronic, Inc. | Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus |
| US6361522B1 (en) | 1999-10-21 | 2002-03-26 | Cardiac Pacemakers, Inc. | Drug delivery system for implantable cardiac device |
| US7300449B2 (en) * | 1999-12-09 | 2007-11-27 | Mische Hans A | Methods and devices for the treatment of neurological and physiological disorders |
| US20070203531A9 (en) * | 1999-12-03 | 2007-08-30 | Medtronic, Inc. | Heart rate variability control of gastric electrical stimulator |
| US6708064B2 (en) * | 2000-02-24 | 2004-03-16 | Ali R. Rezai | Modulation of the brain to affect psychiatric disorders |
| US6496731B1 (en) | 2000-04-14 | 2002-12-17 | Cardiac Pacemakers, Inc. | Highly specific technique for discriminating atrial fibrillation from atrial flutter |
| US8046076B2 (en) | 2000-06-20 | 2011-10-25 | Boston Scientific Neuromodulation Corporation | Treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion |
| US6810285B2 (en) * | 2001-06-28 | 2004-10-26 | Neuropace, Inc. | Seizure sensing and detection using an implantable device |
| US6622047B2 (en) * | 2001-07-28 | 2003-09-16 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation |
| US7885709B2 (en) * | 2001-08-31 | 2011-02-08 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation for treating disorders |
| US6934583B2 (en) * | 2001-10-22 | 2005-08-23 | Pacesetter, Inc. | Implantable lead and method for stimulating the vagus nerve |
| US6978180B2 (en) * | 2003-01-03 | 2005-12-20 | Advanced Neuromodulation Systems, Inc. | System and method for stimulation of a person's brain stem |
| US7418290B2 (en) * | 2003-05-06 | 2008-08-26 | Aspect Medical Systems, Inc. | System and method of assessment of the efficacy of treatment of neurological disorders using the electroencephalogram |
| CA2432810A1 (en) | 2003-06-19 | 2004-12-19 | Andres M. Lozano | Method of treating depression, mood disorders and anxiety disorders by brian infusion |
| US7171258B2 (en) * | 2003-06-25 | 2007-01-30 | Cardiac Pacemakers, Inc. | Method and apparatus for trending a physiological cardiac parameter |
| US7263405B2 (en) | 2003-08-27 | 2007-08-28 | Neuro And Cardiac Technologies Llc | System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities |
| US20050113744A1 (en) | 2003-11-21 | 2005-05-26 | Cyberkinetics, Inc. | Agent delivery systems and related methods under control of biological electrical signals |
| DE102004025825A1 (de) * | 2004-05-24 | 2005-12-29 | Forschungszentrum Jülich GmbH | Vorrichtung zur Behandlung von Patienten mittels Hirnstimulation, ein elektronisches Bauteil sowie die Verwendung der Vorrichtung und des elektronischen Bauteils in der Medizin und medizinisches Behandlungsverfahren |
| US7587238B2 (en) * | 2005-03-11 | 2009-09-08 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
| US7606622B2 (en) | 2006-01-24 | 2009-10-20 | Cardiac Pacemakers, Inc. | Method and device for detecting and treating depression |
-
2006
- 2006-01-24 US US11/275,682 patent/US7606622B2/en not_active Expired - Fee Related
-
2007
- 2007-01-16 EP EP07762594A patent/EP1976593B1/en not_active Not-in-force
- 2007-01-16 DE DE602007009483T patent/DE602007009483D1/de active Active
- 2007-01-16 WO PCT/US2007/001086 patent/WO2007087192A2/en not_active Ceased
- 2007-01-16 AT AT07762594T patent/ATE482744T1/de not_active IP Right Cessation
- 2007-01-16 JP JP2008551321A patent/JP5143023B2/ja not_active Expired - Fee Related
-
2009
- 2009-10-14 US US12/578,842 patent/US8391984B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1976593B1 (en) | 2010-09-29 |
| ATE482744T1 (de) | 2010-10-15 |
| US20070173901A1 (en) | 2007-07-26 |
| WO2007087192A2 (en) | 2007-08-02 |
| WO2007087192A3 (en) | 2007-09-20 |
| US20100049263A1 (en) | 2010-02-25 |
| DE602007009483D1 (de) | 2010-11-11 |
| US7606622B2 (en) | 2009-10-20 |
| EP1976593A2 (en) | 2008-10-08 |
| JP2009524450A (ja) | 2009-07-02 |
| US8391984B2 (en) | 2013-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5143023B2 (ja) | うつ病の検出および治療装置 | |
| US11179560B2 (en) | Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation | |
| JP4357302B2 (ja) | 不整脈の発作に関連した再発スコアを提供するプロセッサで実施されるソフトウェアシステム | |
| US8068911B2 (en) | System and method for regulating cardiopulmonary triggered therapy to the brain | |
| US8485979B2 (en) | System and method for monitoring or treating nervous system disorders | |
| US20070239230A1 (en) | System and method for regulating cardiac triggered therapy to the brain | |
| US20100198308A1 (en) | Closed-loop neurostimulation to treat pulmonary edema | |
| US20070239060A1 (en) | System and method for regulating cardiac triggered therapy to the brain | |
| CN106470598A (zh) | 用于检测医疗治疗的系统 | |
| US11654277B2 (en) | Nerve stimulation devices and methods |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100113 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100113 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111226 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120323 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120330 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120621 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20121105 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20121120 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20151130 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D03 |
|
| LAPS | Cancellation because of no payment of annual fees |