JP5139305B2 - ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体 - Google Patents
ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体 Download PDFInfo
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- JP5139305B2 JP5139305B2 JP2008534910A JP2008534910A JP5139305B2 JP 5139305 B2 JP5139305 B2 JP 5139305B2 JP 2008534910 A JP2008534910 A JP 2008534910A JP 2008534910 A JP2008534910 A JP 2008534910A JP 5139305 B2 JP5139305 B2 JP 5139305B2
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (9)
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| GB0520581.0 | 2005-10-10 | ||
| GB0520581A GB0520581D0 (en) | 2005-10-10 | 2005-10-10 | Novel compounds |
| GB0523045.3 | 2005-11-11 | ||
| GB0523045A GB0523045D0 (en) | 2005-11-11 | 2005-11-11 | Novel compounds |
| GB0603900.2 | 2006-02-27 | ||
| GB0603900A GB0603900D0 (en) | 2006-02-27 | 2006-02-27 | Novel compounds |
| GB0618336A GB0618336D0 (en) | 2006-09-18 | 2006-09-18 | Novel compounds |
| GB0618336.2 | 2006-09-18 | ||
| PCT/EP2006/009731 WO2007042239A1 (en) | 2005-10-10 | 2006-10-06 | Prolinamide derivatives as sodium channel modulators |
Publications (3)
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| JP2009511519A JP2009511519A (ja) | 2009-03-19 |
| JP2009511519A5 JP2009511519A5 (https=) | 2009-11-26 |
| JP5139305B2 true JP5139305B2 (ja) | 2013-02-06 |
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| US (2) | US7655693B2 (https=) |
| EP (1) | EP1934177B8 (https=) |
| JP (1) | JP5139305B2 (https=) |
| KR (1) | KR101282464B1 (https=) |
| AR (1) | AR056575A1 (https=) |
| AT (1) | ATE556049T1 (https=) |
| AU (1) | AU2006301470B2 (https=) |
| BR (1) | BRPI0616944B8 (https=) |
| CA (1) | CA2625642C (https=) |
| CR (1) | CR9898A (https=) |
| EA (1) | EA015736B1 (https=) |
| ES (1) | ES2387405T3 (https=) |
| IL (1) | IL192627A0 (https=) |
| MA (1) | MA29817B1 (https=) |
| NO (1) | NO20082145L (https=) |
| NZ (1) | NZ567051A (https=) |
| PE (1) | PE20070592A1 (https=) |
| PL (1) | PL1934177T3 (https=) |
| TW (1) | TW200730494A (https=) |
| WO (1) | WO2007042239A1 (https=) |
Families Citing this family (22)
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| US8143306B2 (en) * | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| EP1943216B1 (en) * | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| GB0701365D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) * | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| EP2461807A1 (en) * | 2009-08-05 | 2012-06-13 | Convergence Pharmaceuticals Limited | Co-therapy for the treatment of epilepsy and related disorders |
| DK2477964T5 (en) * | 2009-09-14 | 2015-05-26 | Convergence Pharmaceuticals | A process for the preparation of alpha-carboxamide |
| CA2828456C (en) | 2011-03-03 | 2021-05-04 | Zalicus Pharmaceuticals Ltd. | N-benzl-amino-carboxamide inhibitors of the sodium channel |
| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| CA2936886A1 (en) | 2014-02-27 | 2015-08-03 | Merck Patent Gmbh | Heterocyclic compounds as nav channel inhibitors and uses thereof |
| GB201417497D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
| GB201417499D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
| GB201417500D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
| ES2912881T3 (es) * | 2014-12-23 | 2022-05-30 | Convergence Pharmaceuticals | Procedimiento para preparar derivados de alfa-carboxamida pirrolidina |
| AU2017353841A1 (en) * | 2016-11-02 | 2019-05-30 | Biogen Ma Inc. | Novel dosage regimen |
| AU2018269924B2 (en) * | 2017-05-19 | 2022-07-07 | Biogen Ma Inc. | Novel crystalline forms |
| US11192856B2 (en) * | 2017-10-05 | 2021-12-07 | Biogen Inc. | Process for preparing alpha-carboxamide pyrrolidine derivatives |
| US11149039B2 (en) | 2017-10-10 | 2021-10-19 | Biogen Inc. | Process for preparing spiro derivatives |
| CA3093401A1 (en) * | 2018-04-16 | 2019-10-24 | Biogen Ma Inc. | Methods of treating neuropathic pain |
| WO2020210486A1 (en) * | 2019-04-10 | 2020-10-15 | Biogen Inc. | Processes for preparing alpha-carboxamide pyrrolidine derivatives |
| CN114026066A (zh) * | 2019-04-10 | 2022-02-08 | 生物基因麻省公司 | 制备α-甲酰胺吡咯烷衍生物的方法 |
| WO2021154631A1 (en) | 2020-01-30 | 2021-08-05 | Javed Mohammad | Combination drug therapies for cns disorders |
Family Cites Families (25)
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| IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| US6201016B1 (en) | 1994-06-27 | 2001-03-13 | Cytomed Incorporated | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| US6136131A (en) * | 1998-06-02 | 2000-10-24 | Instrument Specialties Company, Inc. | Method of shielding and obtaining access to a component on a printed circuit board |
| TW502019B (en) | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
| GB0115517D0 (en) | 2001-06-25 | 2001-08-15 | Ferring Bv | Novel antidiabetic agents |
| TW200404796A (en) * | 2002-08-19 | 2004-04-01 | Ono Pharmaceutical Co | Nitrogen-containing compound |
| PE20050077A1 (es) | 2002-09-20 | 2005-03-01 | Hoffmann La Roche | Derivados de 4-pirrolidino-fenil-bencil-eter |
| MY142651A (en) | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
| US7589116B2 (en) | 2003-04-03 | 2009-09-15 | Merck & Co. Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
| CA2522476A1 (en) * | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| EP1524265A1 (en) * | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors |
| WO2005100334A1 (en) | 2004-04-14 | 2005-10-27 | Pfizer Products Inc. | Dipeptidyl peptidase-iv inhibitors |
| WO2006119390A1 (en) | 2005-05-04 | 2006-11-09 | Vertex Pharmaceuticals Incorporated | Pyridines useful as modulators of ion channels |
| JP2008540443A (ja) | 2005-05-04 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン |
| JP2008540665A (ja) | 2005-05-19 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なビアリール |
| EA013909B1 (ru) | 2005-09-09 | 2010-08-30 | Смитклайн Бичам Корпорейшн | Пиридиновые производные и их применение для лечения психотических расстройств |
| TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| EP1943216B1 (en) * | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| GB0701366D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
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- 2006-10-06 NZ NZ567051A patent/NZ567051A/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EA200801054A1 (ru) | 2008-08-29 |
| AU2006301470B2 (en) | 2012-06-14 |
| US20080280969A1 (en) | 2008-11-13 |
| US7655693B2 (en) | 2010-02-02 |
| US20100105754A1 (en) | 2010-04-29 |
| EP1934177B1 (en) | 2012-05-02 |
| AU2006301470A1 (en) | 2007-04-19 |
| BRPI0616944B8 (pt) | 2021-05-25 |
| CA2625642C (en) | 2013-12-24 |
| NO20082145L (no) | 2008-05-07 |
| KR20080059296A (ko) | 2008-06-26 |
| IL192627A0 (en) | 2011-08-01 |
| PE20070592A1 (es) | 2007-06-23 |
| BRPI0616944B1 (pt) | 2020-04-14 |
| PL1934177T3 (pl) | 2013-03-29 |
| CA2625642A1 (en) | 2007-04-19 |
| WO2007042239A1 (en) | 2007-04-19 |
| ATE556049T1 (de) | 2012-05-15 |
| US8153681B2 (en) | 2012-04-10 |
| EA015736B1 (ru) | 2011-10-31 |
| JP2009511519A (ja) | 2009-03-19 |
| KR101282464B1 (ko) | 2013-07-04 |
| BRPI0616944A2 (pt) | 2011-07-05 |
| ES2387405T3 (es) | 2012-09-21 |
| EP1934177A1 (en) | 2008-06-25 |
| AR056575A1 (es) | 2007-10-10 |
| TW200730494A (en) | 2007-08-16 |
| EP1934177B8 (en) | 2012-09-05 |
| NZ567051A (en) | 2011-03-31 |
| CR9898A (es) | 2008-07-29 |
| MA29817B1 (fr) | 2008-09-01 |
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