AU2006301470B2 - Prolinamide derivatives as sodium channel modulators - Google Patents

Prolinamide derivatives as sodium channel modulators Download PDF

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Publication number
AU2006301470B2
AU2006301470B2 AU2006301470A AU2006301470A AU2006301470B2 AU 2006301470 B2 AU2006301470 B2 AU 2006301470B2 AU 2006301470 A AU2006301470 A AU 2006301470A AU 2006301470 A AU2006301470 A AU 2006301470A AU 2006301470 B2 AU2006301470 B2 AU 2006301470B2
Authority
AU
Australia
Prior art keywords
compound
disorder
pharmaceutically acceptable
formula
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006301470A
Other languages
English (en)
Other versions
AU2006301470A1 (en
Inventor
Giuseppe Alvaro
Markus Bergauer
Riccardo Giovannini
Roberto Profeta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Convergence Pharmaceuticals Ltd
Original Assignee
Convergence Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520581A external-priority patent/GB0520581D0/en
Priority claimed from GB0523045A external-priority patent/GB0523045D0/en
Priority claimed from GB0603900A external-priority patent/GB0603900D0/en
Priority claimed from GB0618336A external-priority patent/GB0618336D0/en
Application filed by Convergence Pharmaceuticals Ltd filed Critical Convergence Pharmaceuticals Ltd
Publication of AU2006301470A1 publication Critical patent/AU2006301470A1/en
Assigned to Convergence Pharmaceuticals Limited reassignment Convergence Pharmaceuticals Limited Request for Assignment Assignors: GLAXO GROUP LIMITED
Application granted granted Critical
Publication of AU2006301470B2 publication Critical patent/AU2006301470B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU2006301470A 2005-10-10 2006-10-06 Prolinamide derivatives as sodium channel modulators Ceased AU2006301470B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0520581.0 2005-10-10
GB0520581A GB0520581D0 (en) 2005-10-10 2005-10-10 Novel compounds
GB0523045.3 2005-11-11
GB0523045A GB0523045D0 (en) 2005-11-11 2005-11-11 Novel compounds
GB0603900.2 2006-02-27
GB0603900A GB0603900D0 (en) 2006-02-27 2006-02-27 Novel compounds
GB0618336A GB0618336D0 (en) 2006-09-18 2006-09-18 Novel compounds
GB0618336.2 2006-09-18
PCT/EP2006/009731 WO2007042239A1 (en) 2005-10-10 2006-10-06 Prolinamide derivatives as sodium channel modulators

Publications (2)

Publication Number Publication Date
AU2006301470A1 AU2006301470A1 (en) 2007-04-19
AU2006301470B2 true AU2006301470B2 (en) 2012-06-14

Family

ID=37546777

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006301470A Ceased AU2006301470B2 (en) 2005-10-10 2006-10-06 Prolinamide derivatives as sodium channel modulators

Country Status (20)

Country Link
US (2) US7655693B2 (https=)
EP (1) EP1934177B8 (https=)
JP (1) JP5139305B2 (https=)
KR (1) KR101282464B1 (https=)
AR (1) AR056575A1 (https=)
AT (1) ATE556049T1 (https=)
AU (1) AU2006301470B2 (https=)
BR (1) BRPI0616944B8 (https=)
CA (1) CA2625642C (https=)
CR (1) CR9898A (https=)
EA (1) EA015736B1 (https=)
ES (1) ES2387405T3 (https=)
IL (1) IL192627A0 (https=)
MA (1) MA29817B1 (https=)
NO (1) NO20082145L (https=)
NZ (1) NZ567051A (https=)
PE (1) PE20070592A1 (https=)
PL (1) PL1934177T3 (https=)
TW (1) TW200730494A (https=)
WO (1) WO2007042239A1 (https=)

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US8143306B2 (en) * 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
EP1943216B1 (en) * 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
GB0701365D0 (en) * 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
EP2461807A1 (en) * 2009-08-05 2012-06-13 Convergence Pharmaceuticals Limited Co-therapy for the treatment of epilepsy and related disorders
DK2477964T5 (en) * 2009-09-14 2015-05-26 Convergence Pharmaceuticals A process for the preparation of alpha-carboxamide
CA2828456C (en) 2011-03-03 2021-05-04 Zalicus Pharmaceuticals Ltd. N-benzl-amino-carboxamide inhibitors of the sodium channel
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
CA2936886A1 (en) 2014-02-27 2015-08-03 Merck Patent Gmbh Heterocyclic compounds as nav channel inhibitors and uses thereof
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
ES2912881T3 (es) * 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
AU2017353841A1 (en) * 2016-11-02 2019-05-30 Biogen Ma Inc. Novel dosage regimen
AU2018269924B2 (en) * 2017-05-19 2022-07-07 Biogen Ma Inc. Novel crystalline forms
US11192856B2 (en) * 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives
US11149039B2 (en) 2017-10-10 2021-10-19 Biogen Inc. Process for preparing spiro derivatives
CA3093401A1 (en) * 2018-04-16 2019-10-24 Biogen Ma Inc. Methods of treating neuropathic pain
WO2020210486A1 (en) * 2019-04-10 2020-10-15 Biogen Inc. Processes for preparing alpha-carboxamide pyrrolidine derivatives
CN114026066A (zh) * 2019-04-10 2022-02-08 生物基因麻省公司 制备α-甲酰胺吡咯烷衍生物的方法
WO2021154631A1 (en) 2020-01-30 2021-08-05 Javed Mohammad Combination drug therapies for cns disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1524265A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors

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IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6136131A (en) * 1998-06-02 2000-10-24 Instrument Specialties Company, Inc. Method of shielding and obtaining access to a component on a printed circuit board
TW502019B (en) 1999-03-26 2002-09-11 Cocensys Inc Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
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GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
TW200404796A (en) * 2002-08-19 2004-04-01 Ono Pharmaceutical Co Nitrogen-containing compound
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US7589116B2 (en) 2003-04-03 2009-09-15 Merck & Co. Inc. Biaryl substituted pyrazoles as sodium channel blockers
CA2522476A1 (en) * 2003-04-18 2004-11-04 Merck & Co., Inc. Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
WO2005100334A1 (en) 2004-04-14 2005-10-27 Pfizer Products Inc. Dipeptidyl peptidase-iv inhibitors
WO2006119390A1 (en) 2005-05-04 2006-11-09 Vertex Pharmaceuticals Incorporated Pyridines useful as modulators of ion channels
JP2008540443A (ja) 2005-05-04 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン
JP2008540665A (ja) 2005-05-19 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なビアリール
EA013909B1 (ru) 2005-09-09 2010-08-30 Смитклайн Бичам Корпорейшн Пиридиновые производные и их применение для лечения психотических расстройств
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) * 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP1524265A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors

Also Published As

Publication number Publication date
EA200801054A1 (ru) 2008-08-29
US20080280969A1 (en) 2008-11-13
US7655693B2 (en) 2010-02-02
US20100105754A1 (en) 2010-04-29
EP1934177B1 (en) 2012-05-02
AU2006301470A1 (en) 2007-04-19
BRPI0616944B8 (pt) 2021-05-25
CA2625642C (en) 2013-12-24
NO20082145L (no) 2008-05-07
KR20080059296A (ko) 2008-06-26
IL192627A0 (en) 2011-08-01
PE20070592A1 (es) 2007-06-23
BRPI0616944B1 (pt) 2020-04-14
PL1934177T3 (pl) 2013-03-29
CA2625642A1 (en) 2007-04-19
WO2007042239A1 (en) 2007-04-19
ATE556049T1 (de) 2012-05-15
US8153681B2 (en) 2012-04-10
EA015736B1 (ru) 2011-10-31
JP2009511519A (ja) 2009-03-19
KR101282464B1 (ko) 2013-07-04
BRPI0616944A2 (pt) 2011-07-05
ES2387405T3 (es) 2012-09-21
EP1934177A1 (en) 2008-06-25
AR056575A1 (es) 2007-10-10
JP5139305B2 (ja) 2013-02-06
TW200730494A (en) 2007-08-16
EP1934177B8 (en) 2012-09-05
NZ567051A (en) 2011-03-31
CR9898A (es) 2008-07-29
MA29817B1 (fr) 2008-09-01

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PC1 Assignment before grant (sect. 113)

Owner name: CONVERGENCE PHARMACEUTICALS LIMITED

Free format text: FORMER APPLICANT(S): GLAXO GROUP LIMITED

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired