JP5113526B2 - レプチン拮抗薬 - Google Patents
レプチン拮抗薬 Download PDFInfo
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- JP5113526B2 JP5113526B2 JP2007542513A JP2007542513A JP5113526B2 JP 5113526 B2 JP5113526 B2 JP 5113526B2 JP 2007542513 A JP2007542513 A JP 2007542513A JP 2007542513 A JP2007542513 A JP 2007542513A JP 5113526 B2 JP5113526 B2 JP 5113526B2
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- Prior art keywords
- leptin
- seq
- human
- polypeptide
- antagonist
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/996,607 US7307142B2 (en) | 2004-11-26 | 2004-11-26 | Leptin antagonists |
| US10/996,607 | 2004-11-26 | ||
| PCT/IL2005/001250 WO2006056987A2 (en) | 2004-11-26 | 2005-11-24 | Leptin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521795A JP2008521795A (ja) | 2008-06-26 |
| JP2008521795A5 JP2008521795A5 (enExample) | 2009-02-05 |
| JP5113526B2 true JP5113526B2 (ja) | 2013-01-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542513A Expired - Fee Related JP5113526B2 (ja) | 2004-11-26 | 2005-11-24 | レプチン拮抗薬 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7307142B2 (enExample) |
| EP (1) | EP1814986B1 (enExample) |
| JP (1) | JP5113526B2 (enExample) |
| CN (1) | CN101189335B (enExample) |
| AT (1) | ATE498683T1 (enExample) |
| DE (1) | DE602005026432D1 (enExample) |
| ES (1) | ES2363011T3 (enExample) |
| WO (1) | WO2006056987A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8227408B2 (en) * | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
| CA2725143A1 (en) * | 2008-05-21 | 2009-11-26 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
| WO2010054017A1 (en) * | 2008-11-04 | 2010-05-14 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta |
| WO2010117785A1 (en) * | 2009-03-31 | 2010-10-14 | Temple University - Of The Commonwealth System Of Higher Education | Leptin antagonist and methods of use |
| BR112012026718A2 (pt) | 2010-04-22 | 2017-12-19 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | antagonista de leptina sintético, molécula de dna isolada, composição farmacêutica, método para o tratamento de uma doença ou condição, rato transgênico e método de varredura de uma substância tendo atividade terapêutica para uma doença ou distúrbio. |
| WO2014024189A1 (en) * | 2012-08-06 | 2014-02-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Pegylated high affinity leptins with increased biological activity |
| IT1423968B1 (enExample) * | 2014-04-28 | 2016-08-26 | ||
| US11123461B2 (en) | 2015-02-26 | 2021-09-21 | Remodeless Cv Ltd | Treatment of ischemia and reperfusion using leptin antagonist |
| US10926006B2 (en) | 2015-02-26 | 2021-02-23 | Remodeless Cv Ltd | Drug eluting stent |
| CA2977607A1 (en) * | 2015-02-26 | 2016-09-01 | Jacob Schneiderman | Methods and compositions relating to leptin antagonists |
| CN104829708B (zh) * | 2015-05-06 | 2017-11-28 | 广东省生物资源应用研究所 | 一条d螺旋区突变的瘦素活性肽及其编码基因和应用 |
| CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| AU2017359439B2 (en) * | 2016-11-08 | 2024-11-28 | Regeneron Pharmaceuticals, Inc. | Antigen-binding proteins that antagonize leptin receptor |
| AU2019249273A1 (en) | 2018-04-06 | 2020-10-15 | Regeneron Pharmaceuticals, Inc. | Methods of treatment using a leptin receptor agonist antibody |
| MX2021007394A (es) | 2018-12-18 | 2021-07-15 | Regeneron Pharma | Composiciones y metodos para aumentar el peso corporal y la masa muscular magra mediante el uso de antagonistas contra el receptor de leptina, gdf8 y activina a. |
| WO2024050285A2 (en) * | 2022-08-31 | 2024-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Leptin analogs for treating obesity and weight management |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| WO1997020933A2 (en) * | 1995-12-06 | 1997-06-12 | Schering Corporation | MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS |
| US20020160935A1 (en) | 2000-03-24 | 2002-10-31 | Smithkline Beecham Plc | Use of leptin antagonists for the treatment of diabetes |
| RU2201249C2 (ru) | 1996-09-20 | 2003-03-27 | Хехст Акциенгезелльшафт | Применение антагонистов лептина для лечения резистентности к инсулину при диабете ii типа |
| JP2004532618A (ja) * | 2001-02-06 | 2004-10-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 低減された免疫原性を有する修飾されたレプチン |
-
2004
- 2004-11-26 US US10/996,607 patent/US7307142B2/en not_active Expired - Fee Related
-
2005
- 2005-11-24 DE DE602005026432T patent/DE602005026432D1/de not_active Expired - Lifetime
- 2005-11-24 CN CN2005800471206A patent/CN101189335B/zh not_active Expired - Fee Related
- 2005-11-24 EP EP05809259A patent/EP1814986B1/en not_active Expired - Lifetime
- 2005-11-24 JP JP2007542513A patent/JP5113526B2/ja not_active Expired - Fee Related
- 2005-11-24 ES ES05809259T patent/ES2363011T3/es not_active Expired - Lifetime
- 2005-11-24 WO PCT/IL2005/001250 patent/WO2006056987A2/en not_active Ceased
- 2005-11-24 AT AT05809259T patent/ATE498683T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE498683T1 (de) | 2011-03-15 |
| WO2006056987A3 (en) | 2006-08-24 |
| ES2363011T3 (es) | 2011-07-18 |
| CN101189335A (zh) | 2008-05-28 |
| US20060154859A1 (en) | 2006-07-13 |
| EP1814986B1 (en) | 2011-02-16 |
| EP1814986A2 (en) | 2007-08-08 |
| JP2008521795A (ja) | 2008-06-26 |
| DE602005026432D1 (de) | 2011-03-31 |
| WO2006056987A2 (en) | 2006-06-01 |
| CN101189335B (zh) | 2012-01-11 |
| US7307142B2 (en) | 2007-12-11 |
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