JP5113526B2 - レプチン拮抗薬 - Google Patents
レプチン拮抗薬 Download PDFInfo
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- JP5113526B2 JP5113526B2 JP2007542513A JP2007542513A JP5113526B2 JP 5113526 B2 JP5113526 B2 JP 5113526B2 JP 2007542513 A JP2007542513 A JP 2007542513A JP 2007542513 A JP2007542513 A JP 2007542513A JP 5113526 B2 JP5113526 B2 JP 5113526B2
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- Prior art keywords
- leptin
- seq
- human
- polypeptide
- antagonist
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- Endocrinology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/996,607 | 2004-11-26 | ||
| US10/996,607 US7307142B2 (en) | 2004-11-26 | 2004-11-26 | Leptin antagonists |
| PCT/IL2005/001250 WO2006056987A2 (en) | 2004-11-26 | 2005-11-24 | Leptin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521795A JP2008521795A (ja) | 2008-06-26 |
| JP2008521795A5 JP2008521795A5 (enExample) | 2009-02-05 |
| JP5113526B2 true JP5113526B2 (ja) | 2013-01-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542513A Expired - Fee Related JP5113526B2 (ja) | 2004-11-26 | 2005-11-24 | レプチン拮抗薬 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7307142B2 (enExample) |
| EP (1) | EP1814986B1 (enExample) |
| JP (1) | JP5113526B2 (enExample) |
| CN (1) | CN101189335B (enExample) |
| AT (1) | ATE498683T1 (enExample) |
| DE (1) | DE602005026432D1 (enExample) |
| ES (1) | ES2363011T3 (enExample) |
| WO (1) | WO2006056987A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8227408B2 (en) * | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
| KR20110028457A (ko) * | 2008-05-21 | 2011-03-18 | 뉴로테즈 인코포레이티드 | 신경섬유 매듭과 연관된 신경변성 장애를 치료하는 방법 |
| CA2742600A1 (en) * | 2008-11-04 | 2010-05-14 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta |
| WO2010117785A1 (en) * | 2009-03-31 | 2010-10-14 | Temple University - Of The Commonwealth System Of Higher Education | Leptin antagonist and methods of use |
| MX2012012229A (es) * | 2010-04-22 | 2013-03-05 | Yissum Res Dev Co | Leptinas de alta afinidad y antagonistas de leptina. |
| WO2014024189A1 (en) * | 2012-08-06 | 2014-02-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Pegylated high affinity leptins with increased biological activity |
| IT1423968B1 (enExample) * | 2014-04-28 | 2016-08-26 | ||
| US10926006B2 (en) | 2015-02-26 | 2021-02-23 | Remodeless Cv Ltd | Drug eluting stent |
| CA2977607A1 (en) | 2015-02-26 | 2016-09-01 | Jacob Schneiderman | Methods and compositions relating to leptin antagonists |
| US11123461B2 (en) | 2015-02-26 | 2021-09-21 | Remodeless Cv Ltd | Treatment of ischemia and reperfusion using leptin antagonist |
| CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
| CN104829708B (zh) * | 2015-05-06 | 2017-11-28 | 广东省生物资源应用研究所 | 一条d螺旋区突变的瘦素活性肽及其编码基因和应用 |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| MA45801B1 (fr) * | 2016-11-08 | 2021-11-30 | Regeneron Pharma | Protéines de liaison à l'antigène qui sont des antagonistes du récepteur de leptine |
| SMT202500283T1 (it) | 2018-04-06 | 2025-09-12 | Regeneron Pharma | Un anticorpo agonista del recettore della leptina da utilizzare per aumentare la massa ossea in un soggetto affetto da disfunzione metabolica o ipoleptinemia |
| CN113195532B (zh) | 2018-12-18 | 2025-04-11 | 瑞泽恩制药公司 | 使用针对瘦素受体、gdf8和活化素a的拮抗剂增加体重和瘦肌肉质量的组合物和方法 |
| WO2024050285A2 (en) * | 2022-08-31 | 2024-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Leptin analogs for treating obesity and weight management |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| WO1997020933A2 (en) * | 1995-12-06 | 1997-06-12 | Schering Corporation | MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS |
| US20020160935A1 (en) * | 2000-03-24 | 2002-10-31 | Smithkline Beecham Plc | Use of leptin antagonists for the treatment of diabetes |
| JP2001500869A (ja) * | 1996-09-20 | 2001-01-23 | ヘキスト、アクチェンゲゼルシャフト | 第ｉｉ種糖尿病におけるインスリン耐性を治療するためのレプチンアンタゴニストの使用 |
| CN1491232A (zh) * | 2001-02-06 | 2004-04-21 | Ĭ��ר������˾ | 免疫原性减弱的经修饰肥胖蛋白 |
-
2004
- 2004-11-26 US US10/996,607 patent/US7307142B2/en not_active Expired - Fee Related
-
2005
- 2005-11-24 WO PCT/IL2005/001250 patent/WO2006056987A2/en not_active Ceased
- 2005-11-24 AT AT05809259T patent/ATE498683T1/de not_active IP Right Cessation
- 2005-11-24 CN CN2005800471206A patent/CN101189335B/zh not_active Expired - Fee Related
- 2005-11-24 EP EP05809259A patent/EP1814986B1/en not_active Expired - Lifetime
- 2005-11-24 DE DE602005026432T patent/DE602005026432D1/de not_active Expired - Lifetime
- 2005-11-24 JP JP2007542513A patent/JP5113526B2/ja not_active Expired - Fee Related
- 2005-11-24 ES ES05809259T patent/ES2363011T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006056987A3 (en) | 2006-08-24 |
| EP1814986B1 (en) | 2011-02-16 |
| EP1814986A2 (en) | 2007-08-08 |
| CN101189335B (zh) | 2012-01-11 |
| WO2006056987A2 (en) | 2006-06-01 |
| ATE498683T1 (de) | 2011-03-15 |
| US7307142B2 (en) | 2007-12-11 |
| US20060154859A1 (en) | 2006-07-13 |
| ES2363011T3 (es) | 2011-07-18 |
| CN101189335A (zh) | 2008-05-28 |
| JP2008521795A (ja) | 2008-06-26 |
| DE602005026432D1 (de) | 2011-03-31 |
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