JP5099571B2 - miRNA導入による新規hiPSC作製法 - Google Patents
miRNA導入による新規hiPSC作製法 Download PDFInfo
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- JP5099571B2 JP5099571B2 JP2011530189A JP2011530189A JP5099571B2 JP 5099571 B2 JP5099571 B2 JP 5099571B2 JP 2011530189 A JP2011530189 A JP 2011530189A JP 2011530189 A JP2011530189 A JP 2011530189A JP 5099571 B2 JP5099571 B2 JP 5099571B2
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- cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/65—MicroRNA
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011530189A JP5099571B2 (ja) | 2010-07-12 | 2011-06-28 | miRNA導入による新規hiPSC作製法 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010158194 | 2010-07-12 | ||
| JP2010158192 | 2010-07-12 | ||
| JP2010158192 | 2010-07-12 | ||
| JP2010158193 | 2010-07-12 | ||
| JP2010158194 | 2010-07-12 | ||
| JP2010158193 | 2010-07-12 | ||
| PCT/JP2011/064847 WO2012008302A1 (ja) | 2010-07-12 | 2011-06-28 | miRNA導入による新規hiPSC作製法 |
| JP2011530189A JP5099571B2 (ja) | 2010-07-12 | 2011-06-28 | miRNA導入による新規hiPSC作製法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012202509A Division JP2013034479A (ja) | 2010-07-12 | 2012-09-14 | miRNA導入による新規hiPSC作製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP5099571B2 true JP5099571B2 (ja) | 2012-12-19 |
| JPWO2012008302A1 JPWO2012008302A1 (ja) | 2013-09-09 |
Family
ID=45469308
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530189A Expired - Fee Related JP5099571B2 (ja) | 2010-07-12 | 2011-06-28 | miRNA導入による新規hiPSC作製法 |
| JP2011530188A Expired - Fee Related JP5099570B2 (ja) | 2010-07-12 | 2011-06-28 | siRNA導入による新規hiPSC作製法 |
| JP2012202509A Pending JP2013034479A (ja) | 2010-07-12 | 2012-09-14 | miRNA導入による新規hiPSC作製法 |
| JP2012202508A Pending JP2013046616A (ja) | 2010-07-12 | 2012-09-14 | siRNA導入による新規hiPSC作製法 |
| JP2013264240A Expired - Fee Related JP5845493B2 (ja) | 2010-07-12 | 2013-12-20 | miRNA導入による新規hiPSC作製法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530188A Expired - Fee Related JP5099570B2 (ja) | 2010-07-12 | 2011-06-28 | siRNA導入による新規hiPSC作製法 |
| JP2012202509A Pending JP2013034479A (ja) | 2010-07-12 | 2012-09-14 | miRNA導入による新規hiPSC作製法 |
| JP2012202508A Pending JP2013046616A (ja) | 2010-07-12 | 2012-09-14 | siRNA導入による新規hiPSC作製法 |
| JP2013264240A Expired - Fee Related JP5845493B2 (ja) | 2010-07-12 | 2013-12-20 | miRNA導入による新規hiPSC作製法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9476041B2 (enExample) |
| EP (2) | EP2594644B1 (enExample) |
| JP (5) | JP5099571B2 (enExample) |
| CN (2) | CN103189511B (enExample) |
| WO (2) | WO2012008302A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017073689A1 (ja) * | 2015-10-30 | 2017-05-04 | 国立大学法人鳥取大学 | Dna損傷を修復するrna分子 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012008302A1 (ja) | 2010-07-12 | 2012-01-19 | 国立大学法人鳥取大学 | miRNA導入による新規hiPSC作製法 |
| EP4086338A1 (en) | 2011-03-17 | 2022-11-09 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| WO2013059373A2 (en) | 2011-10-17 | 2013-04-25 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
| US10034902B2 (en) * | 2012-02-22 | 2018-07-31 | Exostem Biotec Ltd. | MicroRNAs for the generation of astrocytes |
| JP6748430B2 (ja) * | 2012-07-13 | 2020-09-02 | ミネルバ バイオテクノロジーズ コーポレーション | より未分化状態への細胞の誘導方法 |
| US10265347B2 (en) | 2013-08-29 | 2019-04-23 | Norimasa Miura | Biomolecular group related to cell anti-aging |
| US20160289678A1 (en) * | 2013-11-22 | 2016-10-06 | Dcb-Usa Llc | Use of microrna 146-a in the diagnosis, treatment and prevention of picornavirus infection and microrna 146-a antagonists |
| CN104109670B (zh) * | 2014-03-12 | 2018-01-05 | 首都医科大学附属北京安定医院 | 一种双链siRNA分子及其应用 |
| SG11201610745XA (en) | 2014-06-27 | 2017-01-27 | Rhizen Pharmaceuticals Sa | Substituted chromene derivatives as selective dual inhibitors of pi3 delta and gamma protein kinases |
| EP3286335A4 (en) | 2015-04-24 | 2018-10-17 | The Johns Hopkins University | Compositions and methods related to characterizing proviral reservoirs |
| KR102011336B1 (ko) * | 2015-12-31 | 2019-08-16 | 인터올리고 주식회사 | 약물 전달 및 안정화를 위한 복합체 및 그 제조방법 |
| WO2018203553A1 (ja) * | 2017-05-02 | 2018-11-08 | 株式会社ペジィー・ファーマ | 分化細胞の品質改善方法 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006137514A1 (ja) * | 2005-06-23 | 2006-12-28 | Locomogene, Inc. | シノビオリンの発現もしくは機能阻害物質を有効成分とする癌治療剤、および癌治療剤のスクリーニング方法 |
| JP2008519606A (ja) * | 2004-11-12 | 2008-06-12 | アンビオン インコーポレーティッド | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2008545406A (ja) * | 2005-05-27 | 2008-12-18 | フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール | 遺伝子ベクター |
| WO2009057831A1 (ja) * | 2007-10-31 | 2009-05-07 | Kyoto University | 核初期化方法 |
| WO2009058907A2 (en) * | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
| WO2009058413A1 (en) * | 2007-10-29 | 2009-05-07 | Shi-Lung Lin | Generation of human embryonic stem-like cells using intronic rna |
| WO2009091659A2 (en) * | 2008-01-16 | 2009-07-23 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents |
| JP2009531019A (ja) * | 2006-01-05 | 2009-09-03 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
| WO2010058819A1 (ja) * | 2008-11-19 | 2010-05-27 | 学校法人 慶應義塾 | ヒト癌タンパク質MDM2とヒト癌抑制タンパク質p53との相互作用阻害ペプチド及びその使用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452594A4 (en) * | 2001-11-15 | 2007-01-10 | Kyowa Hakko Kogyo Kk | INDUCTOR FOR DIFFERENTIATING EMBRYOONAL STEM CELLS TO EODODERMAL CELLS, METHOD FOR OBTAINING THEM AND USE THEREOF |
| WO2004024940A2 (en) | 2002-09-16 | 2004-03-25 | University Of Southern California | Rna-mediated gene modulation |
| KR20050115231A (ko) | 2003-02-10 | 2005-12-07 | 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 | 포유동물 세포의 조절 |
| WO2006084275A2 (en) | 2005-02-04 | 2006-08-10 | Auburn University | Contact drug delivery system |
| JP4982757B2 (ja) * | 2005-04-15 | 2012-07-25 | 国立大学法人鳥取大学 | hTERT発現調節遺伝子 |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| KR101407707B1 (ko) | 2006-04-03 | 2014-06-19 | 산타리스 팔마 에이/에스 | Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 |
| KR101532442B1 (ko) | 2007-12-10 | 2015-06-29 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 효율적인 핵 초기화 방법 |
| CA2710713C (en) * | 2007-12-27 | 2017-09-19 | Protiva Biotherapeutics, Inc. | Silencing of polo-like kinase expression using interfering rna |
| CN101333524B (zh) * | 2008-06-25 | 2010-06-02 | 中山大学 | 一个小分子非编码RNA基因hsa-miR-101及其抗肿瘤用途 |
| CN101392251B (zh) * | 2008-11-03 | 2015-07-22 | 清华大学深圳研究生院 | 能诱导干细胞向成骨细胞分化的微小rna及其应用 |
| WO2012008302A1 (ja) | 2010-07-12 | 2012-01-19 | 国立大学法人鳥取大学 | miRNA導入による新規hiPSC作製法 |
-
2011
- 2011-06-28 WO PCT/JP2011/064847 patent/WO2012008302A1/ja not_active Ceased
- 2011-06-28 WO PCT/JP2011/064846 patent/WO2012008301A1/ja not_active Ceased
- 2011-06-28 JP JP2011530189A patent/JP5099571B2/ja not_active Expired - Fee Related
- 2011-06-28 US US13/809,880 patent/US9476041B2/en not_active Expired - Fee Related
- 2011-06-28 US US13/809,882 patent/US9790491B2/en not_active Expired - Fee Related
- 2011-06-28 CN CN201180043814.8A patent/CN103189511B/zh not_active Expired - Fee Related
- 2011-06-28 JP JP2011530188A patent/JP5099570B2/ja not_active Expired - Fee Related
- 2011-06-28 CN CN201180043810XA patent/CN103097535A/zh active Pending
- 2011-06-28 EP EP11806632.3A patent/EP2594644B1/en not_active Not-in-force
- 2011-06-28 EP EP11806631.5A patent/EP2594643B1/en not_active Not-in-force
-
2012
- 2012-09-14 JP JP2012202509A patent/JP2013034479A/ja active Pending
- 2012-09-14 JP JP2012202508A patent/JP2013046616A/ja active Pending
-
2013
- 2013-12-20 JP JP2013264240A patent/JP5845493B2/ja not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008519606A (ja) * | 2004-11-12 | 2008-06-12 | アンビオン インコーポレーティッド | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2008545406A (ja) * | 2005-05-27 | 2008-12-18 | フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール | 遺伝子ベクター |
| WO2006137514A1 (ja) * | 2005-06-23 | 2006-12-28 | Locomogene, Inc. | シノビオリンの発現もしくは機能阻害物質を有効成分とする癌治療剤、および癌治療剤のスクリーニング方法 |
| JP2009531019A (ja) * | 2006-01-05 | 2009-09-03 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
| WO2009058907A2 (en) * | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
| WO2009058413A1 (en) * | 2007-10-29 | 2009-05-07 | Shi-Lung Lin | Generation of human embryonic stem-like cells using intronic rna |
| WO2009057831A1 (ja) * | 2007-10-31 | 2009-05-07 | Kyoto University | 核初期化方法 |
| WO2009091659A2 (en) * | 2008-01-16 | 2009-07-23 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents |
| WO2010058819A1 (ja) * | 2008-11-19 | 2010-05-27 | 学校法人 慶應義塾 | ヒト癌タンパク質MDM2とヒト癌抑制タンパク質p53との相互作用阻害ペプチド及びその使用 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6011055351; 臨床薬理 Vol.40, No.Supplement, 20091118, p.S190 * |
| JPN6011055356; Cell Vol.131, No.5, 2007, p.861-872 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017073689A1 (ja) * | 2015-10-30 | 2017-05-04 | 国立大学法人鳥取大学 | Dna損傷を修復するrna分子 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103189511A (zh) | 2013-07-03 |
| CN103097535A (zh) | 2013-05-08 |
| JP2014097059A (ja) | 2014-05-29 |
| JP5099570B2 (ja) | 2012-12-19 |
| JPWO2012008301A1 (ja) | 2013-09-09 |
| JP2013046616A (ja) | 2013-03-07 |
| CN103189511B (zh) | 2016-10-12 |
| EP2594643B1 (en) | 2017-04-12 |
| EP2594644A1 (en) | 2013-05-22 |
| US9476041B2 (en) | 2016-10-25 |
| US9790491B2 (en) | 2017-10-17 |
| WO2012008302A1 (ja) | 2012-01-19 |
| JP2013034479A (ja) | 2013-02-21 |
| EP2594644A4 (en) | 2014-12-24 |
| EP2594644B1 (en) | 2016-08-10 |
| EP2594643A1 (en) | 2013-05-22 |
| EP2594643A4 (en) | 2014-12-24 |
| US20130190389A1 (en) | 2013-07-25 |
| JPWO2012008302A1 (ja) | 2013-09-09 |
| US20130184335A1 (en) | 2013-07-18 |
| JP5845493B2 (ja) | 2016-01-20 |
| WO2012008301A1 (ja) | 2012-01-19 |
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